Biography

PhD Positions

Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Susan gained her BPharm from the University of Nottingham in 1991, qualified as a Pharmacist (RPSGB) in 1992 before receiving her PhD in Medicinal Chemistry, from the University of Bath in 1995 for a thesis entitled "Synthesis of Biodegradable Polymers for Delivery of Diagnostic Agents". She gained Post-Doctoral experience at the Institute of Macromolecular Chemistry, Prague (Royal Society European Fellowship), Johannes Gutenberg Universität, Mainz and the Inorganic Chemistry Laboratory, Oxford before taking up the Kinerton Lectureship of Organic Chemistry at Trinity College, Dublin.  She joined the School in April 2003 as Lecturer of Medicinal Chemistry and was promoted to Senior lecturer in 2008.

She is currently the Chair of the University South East Asia Dialogue Group and was the Associate Dean for Admissions for the Faculty of Science from 2011 till 2016

 

  • 2008 - to date Senior Lecturer in Medicinal Chemistry,  School of Pharmacy, University of East Anglia
  • 2011 - 2016 Associate Dean For Admissions,  Faculty of Science, University of East Anglia
  • 2003 – 2008 Lecturer in Medicinal Chemistry,  School of Pharmacy, University of East Anglia
  • 2001-2003 Kinerton Lecturer of  Organic Chemistry,  School of Chemistry, Trinity College Dublin
  • 1999-2001 Post-Doctoral Research Assistant, Inorganic Chemistry Laboratory, University of Oxford
  • 1997-1999 Post Doctoral Research Fellow, Department of Chemistry, University of Mainz, Germany
  • 1996-1997 Royal Society European Post Doctoral Research Fellow, Institute of Macromolecular Chemistry, Academy of Sciences, Prague, Czech Republic
  • 1992-1995 PhD Medicinal Chemistry, University of Bath
  • 1991-1992 Pre Registration Pharmacist, John Radcliffe Hospital, Oxford
  • 1988 - 1991 BPharm (Hons) Pharmacy. First Class, University of Nottingham

Selected Publications

K. Buffet, I. Nierengarten, N. Galanos,E. Gillon, M. Holler,A. Imberty, S. E. Matthews, S. Vidal, S. P. Vincent,J.-F. Nierengarten

Pillar[5]arene-based glycoclusters: synthesis and multivalent binding to pathogenic bacterial lectins

Chem. Eur. J., 2016, 22, 2955-2963

 

A. M. Boukerb, A. Rousset, N. Galanos, J.-B. Méar, M. Thepaut, T. Grandjean, E. Gillon, S. Cecioni, C. Abderrahmen, K. Faure, D. Redelberger, E. Kipnis, R. Dessein, S. Havet, B. Drablade, S. E. Matthews, S. de Bentzmann, B. Guéry, B. Cournoyer, A. Imberty, S. Vidal

Anti-adhesive properties of glycoclusters against Pseudomonas aeruginosa lung infection

J. Med. Chem., 2014, 57, 10275-10289

 

Y. Brissonnet, C. Ortiz-Mellet, S. Morandat, D. Deniaud, S. E. Matthews,  S. Vidal, K. El Kirat S. G. Gouin

Topological effects and binding modes operating with multivalent iminosugar-based glycoclusters and glycosidases

J. Am. Chem. Soc. 2013, 135, 18427-18435

 

S. Cecioni, J.-P. Praly, S. E. Matthews M. Wimmerová, A. Imberty, S. Vidal

Rational design and synthesis of optimized glycoclusters for multivalent lectin-carbohydrate interactions: Influence of the linker arm.

Chem. Eur. J. 2012, 18, 6250-6263   

Highlighted Publications

See All

Buffet, K., Nierengarten, I., Galanos, N., Gillon, E., Holler, M., Imberty, A., Matthews, S. E., Vidal, S., Vincent, S. P., Nierengarten, J.

(2016)

Pillar[5]arene-based glycoclusters: synthesis and multivalent binding to pathogenic bacterial lectins,

in Chemistry - A European Journal

22.

pp. 2955-2963

Full Text UEA Repository

(Article)

(Published)


Boukerb, A., Rousset, A., Galanos, N., Méar, J., Thépaut, M., Grandjean, T., Gillon, E., Cecioni, S., Abderrahmen, C., Faure, K., Redelberger, D., Kipnis, E., Dessein, R., Havet, S., Darblade, B., Matthews, S., De Bentzmann, S., Guéry, B., Cournoyer, B., Imberty, A., Vidal, S.

(2014)

Antiadhesive properties of glycoclusters against Pseudomonas aeruginosa lung infection,

in Journal of Medicinal Chemistry

57.

pp. 10275-10289

Full Text UEA Repository

(Article)

(Published)


Brissonnet, Y., Ortiz Mellet, C., Morandat, S., Garcia Moreno, M. I., Deniaud, D., Matthews, S., Vidal, S., Sestak, S., El Kirat, K., Gouin, S. G.

(2013)

Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases,

in Journal of the American Chemical Society

135.

pp. 18427-18435

Full Text UEA Repository

(Article)

(Published)


Cecioni, S., Lalor, R., Blanchard, B., Praly, J., Imberty, A., Matthews, S. E., Vidal, S.

(2009)

Achieving High Affinity towards a Bacterial Lectin through Multivalent Topological Isomers of Calix[4]arene Glycoconjugates,

in Chemistry - A European Journal

15.

pp. 13232-13240

Full Text UEA Repository

(Article)

(Published)


Lalor, R., Baillie-Johnson, H., Redshaw, C., Matthews, S., Mueller, A.

(2008)

Cellular Uptake of a Fluorescent Calix[4]arene Derivative,

in Journal of the American Chemical Society

130.

pp. 2892-2893

Full Text UEA Repository

(Article)

(Published)


All Publications

See Highlights
<- Page 1 of 3 ->

Sheng, Q., Neaverson, J. C., Mahmoud, T., Stevenson, C. E. M., Matthews, S. E., Waller, Z. A. E.

(2017)

Identification of new DNA i-motif binding ligands through a fluorescent intercalator displacement assay,

in Organic & Biomolecular Chemistry

15

(27)

pp. 5669-5673

Full Text UEA Repository

(Article)

(Published)


Cominetti, M. M. D., Hughes, D. L., Matthews, S. E.

(2016)

Open-resorcinarenes, a new family of multivalent scaffolds,

in Organic & Biomolecular Chemistry

14

(43)

pp. 10161-10164

Full Text UEA Repository

(Article)

(Published)


Matthews, S. E.

(2016)

Calixsugars: Finally Reaching Their Therapeutic Potential?,

in Calixarenes and Beyond.

Springer International Publishing

pp. 559-600

ISBN 978-3-319-31865-3

Full Text

(Other chapter contribution)

(Published)


Buttress, J., Day, D., Courtney, J., Lawrence, E., Hughes, D., Blagg, R., Crossley, A., Matthews, S., Redshaw, C., Bulman Page, P., Wildgoose, G.

(2016)

“Janus” Calixarenes: Double-Sided Molecular Linkers for Facile, Multianchor Point, Multifunctional, Surface Modification,

in Langmuir

32

(31)

pp. 7806–7813

Full Text UEA Repository

(Article)

(Published)


Galanos, N., Gillon, E., Imberty, A., Matthews, S., Vidal, S.

(2016)

Pentavalent pillar[5]arene-based glycoclusters and their multivalent binding to pathogenic bacterial lectins,

in Organic & Biomolecular Chemistry

14

pp. 3476-3481

Full Text UEA Repository

(Article)

(Published)


Buffet, K., Nierengarten, I., Galanos, N., Gillon, E., Holler, M., Imberty, A., Matthews, S. E., Vidal, S., Vincent, S. P., Nierengarten, J.

(2016)

Pillar[5]arene-based glycoclusters: synthesis and multivalent binding to pathogenic bacterial lectins,

in Chemistry - A European Journal

22

(9)

pp. 2955-2963

Full Text UEA Repository

(Article)

(Published)


Boukerb, A., Rousset, A., Galanos, N., Méar, J., Thépaut, M., Grandjean, T., Gillon, E., Cecioni, S., Abderrahmen, C., Faure, K., Redelberger, D., Kipnis, E., Dessein, R., Havet, S., Darblade, B., Matthews, S., De Bentzmann, S., Guéry, B., Cournoyer, B., Imberty, A., Vidal, S.

(2014)

Antiadhesive properties of glycoclusters against Pseudomonas aeruginosa lung infection,

in Journal of Medicinal Chemistry

57

(24)

pp. 10275-10289

Full Text UEA Repository

(Article)

(Published)


Ukhatskaya, E., Kurkov, S., Rodik, R., Kalchenko, V., Matthews, S., Jansook, P., Loftsson, T.

(2014)

Surface activity and self-aggregation ability of three cationic quaternized aminocalix[4]arenes,

in Journal of Inclusion Phenomena and Macrocyclic Chemistry

79

(3)

pp. 473-483

Full Text UEA Repository

(Article)

(Published)


Ukhatskaya, E., Kurkov, S., Matthews, S., Loftsson, T.

(2014)

Antifungal drug solubilizing activity and self-aggregation ability of cationic aminocalix[4]arene in comparison to SBEβCD: effect of addition of water-soluble polymer,

in Journal of Inclusion Phenomena and Macrocyclic Chemistry

79

(1-2)

pp. 47-55

Full Text UEA Repository

(Article)

(Published)


Ukhatskaya, E., Kurkov, S., Hjálmarsdóttir, M., Karginov, V., Matthews, S., Rodik, R., Kalchenko, V., Loftsson, T.

(2013)

Cationic quaternized aminocalix[4]arenes: Cytotoxicity, haemolytic and antibacterial activities,

in International Journal of Pharmaceutics

458

(1)

pp. 25-30

Full Text UEA Repository

(Article)

(Published)


Lincheneau, C., Quinlan, E., Kitchen, J., McCabe, T., Matthews, S., Gunnlaugsson, T.

(2013)

Delayed lanthanide luminescent Tb(III) complexes formed from lower rim amide functionalised calix[4]arenes,

in Supramolecular Chemistry

25

(12)

pp. 869-880

Full Text UEA Repository

(Article)

(Published)


Brissonnet, Y., Ortiz Mellet, C., Morandat, S., Garcia Moreno, M. I., Deniaud, D., Matthews, S., Vidal, S., Sestak, S., El Kirat, K., Gouin, S. G.

(2013)

Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases,

in Journal of the American Chemical Society

135

(49)

pp. 18427-18435

Full Text UEA Repository

(Article)

(Published)


Ukhatskaya, E., Kurkov, S., Matthews, S., Loftsson, T.

(2013)

Encapsulation of drug molecules into Calix[n]arene Nanobaskets. Role of Aminocalix[n]arenes in biopharmaceutical field,

in Journal of Pharmaceutical Sciences

102

(10)

pp. 3485-3512

Full Text UEA Repository

(Article)

(Published)


Cecioni, S., Praly, J., Matthews, S., Wimmerová, M., Imberty, A., Vidal, S.

(2012)

Rational Design and Synthesis of Optimized Glycoclusters for Multivalent Lectin-Carbohydrate Interactions: Influence of the Linker Arm.,

in Chemistry - A European Journal

18

(20)

pp. 6250-6263

Full Text UEA Repository

(Article)

(Published)


Cecioni, S., Matthews, S., Blanchard, H., Praly, J., Imberty, A., Vidal, S.

(2012)

Synthesis of lactosylated glycoclusters and inhibition studies with plant and human lectins,

in Carbohydrate Research

356

pp. 132-141

Full Text UEA Repository

(Article)

(Published)


Bouthenet, E., Oh, K., Park, S., Nagi, N., Lee, H., Matthews, S.

(2011)

Synthesis and antimicrobial activity of brominated resorcinol dimers,

in Bioorganic & Medicinal Chemistry Letters

23

(23)

pp. 7142-7145

Full Text UEA Repository

(Article)

(Published)


Sicard, D., Cecioni, S., Iazykov, M., Chevolot, Y., Matthews, S., Praly, J., Souteyrand, E., Imberty, A., Vidal, S., Phaner-Goutorbe, M.

(2011)

AFM investigation of Pseudomonas aeruginosa lectin LecA (PA-IL) filaments induced by multivalent glycoclusters,

in Chemical Communications

47

(33)

pp. 9483-9485

Full Text UEA Repository

(Article)

(Published)


Soomro, Z., Cecioni, S., Blanchard, H., Praly, J., Imberty, A., Vidal, S., Matthews, S.

(2011)

CuAAC synthesis of resorcin[4]arene-based glycoclusters as multivalent ligands of lectins,

in Organic & Biomolecular Chemistry

9

(19)

pp. 6587-6597

Full Text UEA Repository

(Article)

(Published)


Mueller, A., Lalor, R., Moyano Cardaba, C., Matthews, S.

(2011)

Stable and sensitive probes for lysosomes: Cell-penetrating fluorescent calix[4]arenes accumulate in acidic vesicles,

in Cytometry Part A

79A

(2)

pp. 126-136

Full Text UEA Repository

(Article)

(Published)


Kim, J., Park, S., Kim, S., Thuery, P., Souane, R., Matthews, S. E., Vicens, J.

(2010)

A Pyrenyl-Appended Triazole-Based Calix[4]arene as a Fluorescent Sensor for Iodide Ion,

in Bulletin of the Korean Chemical Society

31

(3)

pp. 624-629

Full Text UEA Repository

(Article)

(Published)


<- Page 1 of 3 ->

Key Research Interests

Research is focused on the interface between chemistry and biology and particularly on the use of supramolecular systems for drug and gene delivery and in novel antibacterial treatments. Current projects include:

  • Gene delivery through functionalised multicalixarenes
  • Cell imaging using fluorescently labelled macrocycles
  • Anti-adhesives as an approach to antibacterial treatment
  • Site-specific pro-drug systems for new anti-cancer agents
  • New antibiotics related to algae extracts
  • New cation and anion receptors based on calixarenes
  • Synthesis of new macrocyclic systems


Research Funding

Royal Society
Matthews S. E., Vidal S. University of Lyon
Can topology of multivalent ligands induce selectivity among lectins ?
1/02/10-31/01/12

Whitelaw Frater Cancer Trust
Redshaw C, Mueller A, Matthews S. E.
Boracalixarenes
01/10/09 30/09/10

Nuffield Foundation
Mueller A, Matthews S. E.
Investigation into gene transfection with functionalised multicalixarenes
31/07/09 – 10-Aug-07

Royal Society
Mueller A, Matthews S. E.
Evaluation of the uptake of fluorescent labelled multicalixarenes and dendriplexes into mammalian cells
1/05/08-30/04/09

Association for International Cancer Research
Matthews, SE, Mueller A
Novel transfection vectors for the delivery of siRNA
1/04/08 – 31/03/11

Royal Society Travel Grant
Matthews, S. E.
XIth International Seminar on Inclusion Compounds, Kiev, Ukraine
June 07

Nuffield Foundation
Matthews S. E., Mayes A Exploring the Role of Multivalency in DNA Binding using Novel Multi-Calix[4]arene Dendrimers
18/06/07-10/08/07

Whitelaw Frater Cancer Trust
Mueller A, Matthews S. E., Redshaw C
Investigation of cell trafficking of calixarenes
01/10/06 – 31/3/08

Royal Society Travel Grant
Matthews, S. E.
IVth International Symposium "Design and Synthesis of Supramolecular Architectures”, Kazan, Russia,
May 06

Nuffield Foundation
Matthews S.E., Mueller A
Exploring the Role of Multivalency in DNA Binding using Novel Multi-Calix[4]arene Dendrimers
31/07/06 – 22/09/06

Association for International Cancer Research
Matthews, S. E.
Development of novel calix(4)sugars as lectin-specific drug delivery systems
01/10/03 – 30/09/06

Enterprise Ireland
Matthews, S. E.
Functionalisaation of resorcin[4]arenes: routes to constrained supramolecular hosts for waste remediation
01/10/02 – 01/03/06

Trinity College Provost’s Academic Development Fund
Matthews, S. E.
Investigating the potential of calix[4]sugars in drug delivery
01/06/02 – 01/04/03

Research Group Membership

Current group members:

  • Qiran Sheng


Past group members:

  • Marco Cominetti
  • Zoe Karthauser
  • Simone Atzori
  • Archana Sekhar
  • Zahid Soomro
  • Estelle Payerne
  • Ruth Lalor
  • Deborah Moore
  • Eoin Quinlan

Teaching Interests

I teach Medicinal Chemistry and Molecular pharmaceutics from Year 2 onwards.

Current teaching responsibilities include:

  • PHA5001Y Drug Design and Mechanism of Drug Action
  • PHA6004Y Evidence based care of Cardiovascular and Renal Disease
  • PHA6012Y Therapeutic Approaches to Gastrointestinal Diseases and Cancer
  • PHA7001B Neurology and Mental Health
  • PHA7003B Special Topics for Pharmacists
  • PHA7004Y Pharmaceutical Research Project

External Activities and Indicators of Esteem

Learned Societies

  • Fellow of the Royal Society of Chemistry and Chartered Chemist.
  • Member of the Royal Pharmaceutical Society of Great Britain
  • General Pharmaceutical Council Registered Pharmacist
  • Member of the American Chemical Society

Patents

  • Glycomimetic compounds as anti-infectious agents against pathogenic lectins, A Imberty, S Vidal, B Guery, S.E. Matthews, K Faure, S Cecioni, December 2010

  • Bromophenol compound, method for producing thereof and composition comprising the same, Hyi-Seung Lee, Seungil Park, Susan E. Matthews, Elise Bouthenet, September 2011

Invited Reviews/Book chapters

  • Calix[4]sugars: finally realising their therapeutic potential? Matthews SE in Calixarenes and Beyond, Eds P. Neri, J. L. Sessler, M-X Wang, Springer, 2016
  • Encapsulation of drug molecules into calix[n]arene nanobaskets. Role ofaminocalix[n]arenes in biopharmaceutical field, Ukhatskaya, E, Kurkov, S. Matthews, SE and Loftsson T, J. Pharm. Sci., 2013, 102, 3485-512
  • O-alkyl resorcarenes: Where are we now?, Moore D and Matthews SE J. Incl. Phenom. Macrocylc. Chem, 2009, 65, 137-155
  • Calix[4]tubes and calix[4]semitubes, Matthews SE and Beer PD in Calixarenes in the NanoWorld Eds. Vicens J, Harrowfield J, Springer, 2007
  • Calixarene-based anion receptors, Matthews SE and Beer PD Supramolecular Chemistry, 2006, 17 411-435.
  • Calixarene-based anion receptors, Matthews SE and Beer PD in Calixarenes 2001, Eds Asfari Z, Böhmer V, Harrowfield, J, Vicens J, Kluwer 2003

 

Administrative Posts

 

Chair of South East Asia Dialogue Group