Biography

Phd Positions

Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Sheng obtained her BEng. (Hons) in Industrial Pharmacy in 2001 (China Pharmaceutical University). After completing her PhD in 2004 (Queen’s University of Belfast) in the area of lipid based microparticulate drug delivery systems, Sheng worked as a postdoctoral scientist studying the structure and stability of amorphous polymer-drug dispersions. In 2007 Sheng joined the School of Pharmacy at UEA as a lecturer and was promoted to senior lecturer in 2013.  Sheng has worked closely with leading pharmaceutical and excipient companies in the areas of pharmaceutical processing, physicochemical characterisation, and formulation development.

Sheng’s current research interests mainly focus on gaining a fundamental understanding of the behaviour of drug-polymer/lipid dispersions in solid (phase behaviour) and liquid (in biological fluids) states, and developing new approaches for stabilising supersaturated drug dispersions. By working with industrial partners as well as cross-discipline collaborators, her group is aiming to contribute to the interdisciplinary research area of enhancing drug absorption via tailoring the physical chemistry of drug formulations.

Current research interests include

  • Hot melt extrusion/injection moulding for drug delivery
  • Electrospinning and electrospray-formulation design and processing control
  • Drug-polymer/lipid solubility and miscibility
  • Phase separation behaviour of polymer-drug dispersions
  • Polymer facilitated drug solubilisation in biological fluids
  • Lipid-based liquid crystalline platform for drug delivery
  • Effect of manufacturing processes on stability of amorphous pharmaceuticals

Selected Publications

Microstructure of an Immiscible Polymer Blend and Its Stabilization Effect on Amorphous Solid Dispersions
Ziyi Yang, Kathrin Nollenberger, Jessica Albers, Duncan Craig, and Sheng Qi
Molecular Pharmaceutics, Articles ASAP
Publication Date (Web): May 13, 2013 (Article)
DOI: 10.1021/mp400209w

Phase separation in pharmaceutical solid dispersion thin films under high humidity: improved spatial understanding using probe based thermal and spectroscopic nano-characterisation methods.
Sheng Qi, Jonathan G. Moffat, Ziyi Yang.
Molecular Pharmaceutics, 2013.
DOI: 10.1021/mp300557q

Stabilisation of amorphous drugs under high humidity using pharmaceutical thin films.
Yuen Chuen Ng, Ziyi Yang, William James McAuley, Sheng Qi.
European Journal of Pharmaceutics and Biopharmaceutics, 2013.
DOI: 10.1016/j.ejpb.2013.01.008

Insights into the role of polymer-surfactant complexes in drug solubilisation/stabilisation during drug release from solid dispersions.
Sheng Qi, Steve Roser, Karen J. Edler, Claudia Pigliacelli, Ilse Weuts, Marcus Brewster.
Pharmaceutical Research, 2013, 30(1) 290-302
DOI: 10.1007/s11095-012-0873-7

The Development of Modulated, Quasi-Isothermal and Ultraslow Thermal Methods as a Means of Characterizing the ? to ? Indomethacin Polymorphic Transformation.
Sheng Qi, Duncan Q. M. Craig.
Molecular Pharmaceutics, 2012, 9 (5): 1087–1099
DOI: 10.1021/mp2003412

Compositional analysis of low quantities of phase separation in hot melt extruded solid dispersions: a combined atomic force microscopy, photothermal Fourier-transform infrared microspectroscopy and localised thermal analysis approach.
Sheng Qi, Peter Belton, Kathrin Nollenberger, Andreas Gryczke, Duncan Q.M. Craig
Pharmaceutical Research, 2011, 1-16
DOI: 10.1007/s11095-011-0461-2

All Publications

<- Page 1 of 4 ->

Tipduangta, P., Takieddin, K., Fábián, L., Belton, P., Qi, S.

(2018)

Towards controlling the crystallisation behaviour of fenofibrate melt: triggers of crystallisation and polymorphic transformation,

in RSC Advances

8

(24)

pp. 13513-13525

Full Text UEA Repository

(Article)

(Published)


Alhijjaj, M., Belton, P., Qi, S.

(2017)

A multi-technique characterization of the stability of surfactant containing solid dispersion based buccal patches prepared by hot melt injection moulding,

in International Journal of Pharmaceutics

528

(1-2)

pp. 547–562

Full Text UEA Repository

(Article)

(Published)


Alhijjaj, M., Yassin, S., Reading, M., Zeitler, J. A., Belton, P., Qi, S.

(2017)

Characterization of heterogeneity and spatial distribution of phases in complex solid dispersions by thermal analysis by structural characterization and X-ray micro computed tomography,

in Pharmaceutical Research

34

(5)

pp. 971–989

Full Text UEA Repository

(Article)

(Published)


Edwards, A., Qi, S., Liu, F., Brown, M. B., McAuley, W. J.

(2017)

Rationalising polymer selection for supersaturated film forming systems produced by an aerosol spray for the transdermal delivery of methylphenidate,

in European Journal of Pharmaceutics and Biopharmaceutics

114

pp. 164–174

Full Text UEA Repository

(Article)

(Published)


Reading, M., Qi, S., Alhijjaj, M.

(2017)

Local Thermal Analysis by Structural Characterization (TASC),

in Thermal Physics and Thermal Analysis : From Macro to Micro, Highlighting Thermodynamics, Kinetics and Nanomaterials.

Springer

pp. 1-10

ISBN 978-3-319-45897-7

Full Text UEA Repository

(Chapter)

(Published)


Albarahmieh, E., Qi, S., Craig, D. Q. M.

(2016)

Hot melt extruded transdermal films based on amorphous solid dispersions in Eudragit RS PO: The inclusion of hydrophilic additives to develop moisture-activated release systems,

in International Journal of Pharmaceutics

514

(1)

pp. 270–281

Full Text UEA Repository

(Article)

(Published)


Alhijjaj, M., Belton, P., Qi, S.

(2016)

An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing,

in European Journal of Pharmaceutics and Biopharmaceutics

108

pp. 111–125

Full Text UEA Repository

(Article)

(Published)


Yang, X., Ding, Y., Ji, T., Zhao, X., Wang, H., Zhao, X., Zhao, R., Wei, J., Qi, S., Nie, G.

(2016)

Improvement of the in vitro safety profile and cytoprotective efficacy of amifostine against chemotherapy by PEGylation strategy,

in Biochemical Pharmacology

108

pp. 11-21

Full Text UEA Repository

(Article)

(Published)


Qi, S., Craig, D.

(2016)

Recent developments in micro- and nanofabrication techniques for the preparation of amorphous pharmaceutical dosage forms,

in Advanced Drug Delivery Reviews

100

pp. 67-84

Full Text UEA Repository

(Article)

(Published)


Bouman, J., Belton, P., Venema, P., van der Linden, E., de Vries, R., Qi, S.

(2016)

Controlled release from zein matrices: Interplay of drug hydrophobicity and pH,

in Pharmaceutical Research

33

(3)

pp. 673-685

Full Text UEA Repository

(Article)

(Published)


Che Rose, L., Bear, J. C., Southern, P., McNaughter, P. D., Piggott, R. B., Parkin, I. P., Qi, S., Hills, B. P., Mayes, A. G.

(2016)

On-demand, magnetic hyperthermia-triggered drug delivery: Optimisation for the GI tract,

in Journal of Materials Chemistry B

4

(9)

pp. 1704-1711

Full Text UEA Repository

(Article)

(Published)


Che Rose, L., Bear, J. C., McNaughter, P., Southern, P., Piggott, R. B., Parkin, I. P., Qi, S., Mayes, A.

(2016)

A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia,

in Scientific Reports

6

article no. 20271

Full Text UEA Repository

(Article)

(Published)


Tipduangta, P., Belton, P., Fabian, L., Wang, L. Y., Tang, H., Eddledton, M., Qi, S.

(2016)

Electrospun polymer blend nanofibers for tuneable drug delivery: the role of transformative phase separation on controlling the release rate,

in Molecular Pharmaceutics

13

(1)

pp. 25-39

Full Text UEA Repository

(Article)

(Published)


Qi, S.

(2016)

Processing-Induced Disorder in Pharmaceutical Materials,

in Disordered Pharmaceutical Materials.

Wiley

pp. 467-491

ISBN 9783527331253

Full Text UEA Repository

(Chapter)

(Published)


Dudognon, E., Qi, S.

(2016)

Disorders in Pharmaceutical Polymers,

in Disorders in Pharmaceutical Materials.

Wiley

pp. 201-241

ISBN 9783527331253

Full Text UEA Repository

(Chapter)

(Published)


Qi, S.

(2016)

Thermal Analysis of Pharmaceuticals,

in Analytical Techniques in the Pharmaceutical Sciences.

Springer-Verlag New York

pp. 363-387

ISBN 978-1-4939-4029-5

Full Text UEA Repository

(Chapter)

(Published)


Chan, S., Qi, S., Craig, D. Q.

(2015)

An Investigation into the Influence of Drug-Polymer Interactions on the Miscibility, Processability and Structure of Polyvinylpyrrolidone-Based Hot Melt Extrusion Formulations,

in International Journal of Pharmaceutics

496

(1)

pp. 95-106

Full Text UEA Repository

(Article)

(Published)


Codoni, D., Cowan, J., Bradley, J., O'Connell, M., McAuley, W., Qi, S.

(2015)

Disc-shaped polyoxyethylene glycol glycerides gel nanoparticles as novel protein delivery vehicles,

in International Journal of Pharmaceutics

496

(2)

pp. 1015-1025

Full Text UEA Repository

(Article)

(Published)


Alhijjaj, M., Bouman, J., Wellner, N., Belton, P., Qi, S.

(2015)

Creating drug solubilisation compartments via phase separation in multi-component buccal patches prepared by direct hot melt extrusion-injection moulding,

in Molecular Pharmaceutics

12

(12)

pp. 4349-4362

Full Text UEA Repository

(Article)

(Published)


Rustemkyzy, C., Belton, P., Qi, S.

(2015)

Preparation and Characterisation of Ultra-Fast Dissolving Orodispersible Films for Treating and Preventing Iodine Deficiency in the Paediatric Population,

in Journal of Agricultural and Food Chemistry

63

(44)

pp. 9831-9838

Full Text UEA Repository

(Article)

(Published)


<- Page 1 of 4 ->

Key Research Interests

Material science:

  • Solubility enhancement of poorly soluble drugs
  • Drug-polymer/lipid solubility and miscibility
  • Phase separation behaviour of polymer-drug dispersions
  • Polymer facilitated drug solubilisation in biological fluids
  • Microstructure and geometry controlled drug delivery system
  • Pharmaceutical applications of novel natural polymers

Pharmaceutical process engineering science:

  • Pharmaceutical hot melt extrusion and injection moulding
  • Electrohydrodynamic processes for micro and nanoscale formulations manufacturing
  • FDM 3D printing of pharmaceutical solid dosage forms
  • Freeze drying of low density matrix system

Research Funding

Norwich Research Park (NRP) Translation Fund (PI)
Development of electrospun therapeutic masks; Jan 2017- Oct 2017
£50,000

INTERREG (EU) (PI)
Innovative Multi-component Drug Design (IMODE) ; Oct 2016-Oct 2019
£592,900.39

Imode logo 

Royal Society & Newton Foundation (co-PI)
Oral cancer therapy; Mar 2016-Mar 2019
£120,000

Royal Society (PI)
International Exchange Grant: Engineering nanostructured bio-responsive matrices for oral delivery of chemotherapy
Mar 2015-Mar 2017
£12,000

UEA proof-of-concept fund (PI)
Drug eluting contact lenses for galucoma treatment 2015-2016
£23,460.36

INTERREG (EU) (PI)
Advanced Material and Pharmaceutical Technology Cluster
Jan 2014-July 2015
£38,000

INTERREG (EU) (co-PI)
IDEA: Improving drugs efficacy and availability
Jun 2009-Jun 2013
£160,218.39

Evonik Industries (Germany) (PI)
Drug-polymer miscibility and its relationship with the physicochemical stability of solid dispersions
Oct 2009-Sep 2012
£75,202.01

Evonik Industries (Germany) (PI)
Nano-characterisation of hot melt extruded formulations
Jan 2007-Apr 2009
£23,040.55

External Activities and Indicators of Esteem

Refereeing

  • Pharmaceutical Research
  • Molecular Pharmaceutics
  • Advances in Polymer Sciences
  • Journal of Colloid and Interfacial Science
  • Crystal Growth & Design (ACS)

 

Invited talks

  • April 2010: Academy of Pharmaceutical Sciences (ACS)-Amorphous III Conference, Nottingham, UK
  • June 2010: the 12th International Workshop on Physical Characterisation of Pharmaceutical Solids, Lille, France
  • August 2010: China Pharmaceutical University, Nanjing, China
  • September 2010: TA Instruments workshop on Pharmaceutical Application of Thermal Analysis, London, UK
  • October 2011: American Association of Pharmaceutical Scientists (AAPS) on Advanced Characterisation of Hot Melt Extruded Formulations, Washington, USA
  • November 2011: Evonik workshop on Pharmaceutical Hot Melt Extrusion, Frankford, Germany
  • November 2011: RSC Thermal method group meeting ‘The Use of Thermal Methods in Formulation – How Heat Can Help’, Syngenta Jealotts Hill Research Centre, Bracknell, UK
  • July 2012: Tianjin Institute of Pharmaceutical Research, Tianjin, China
  • June 2012: Academy of Pharmaceutical Sciences (ACS)-Amorphous IV Conference: Hot melt extrusion and powder technology, Greenwich, UK
  • May 2013: Aston University, Birmingham, UK
  • June 2013: IDEA Conference, Lille, France
    September 2013: UK-Pharm Sci, Edinburgh, UK
  • March 2014: RSC Thermal Method Group TAC conference, GSK Ware, Hertfordshire, UK
  • June 2014: 16th International workshop on solid-state characterization of pharmaceutical material (IWPCPS), Prague, Czech Republic