Biography

PhD Positions

Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

László obtained his first degree in Chemistry from the Eötvös Loránd University in Budapest. He joined the crystallography group at the Chemical Research Centre of the Hungarian Academy of Science to pursue a doctoral degree. After completing his PhD in 2000, he remained with the same group as a post-doctoral scientist. He moved to the Cambridge Crystallographic Data Centre in 2006 to work on the design of cocrystals. This work was part of a large collaborative project, the Pfizer Institute for Pharmaceutical Materials Science. He continued his research on pharmaceutical cocrystals at University College Cork before joining UEA in 2011.

László’s main research area is the solid state chemistry of pharmaceutical compounds. Drugs can have several solid forms, which have different properties. Current projects focus on predicting what solid forms a particular drug can form, on the design of new multi-component forms (cocrystals, salts, solvates) and on understanding how molecular and structural characteristics influence the properties of solid materials.

Selected publications

A model for a solvent-free synthetic organic research laboratory: click-mechanosynthesis and structural characterization of thioureas without bulk solvents
Vjekoslav Štrukil, Marina D. Igrc, László Fábián, Mirjana Eckert-Maksić, Scott L. Childs, David G. Reid, Melinda J. Duer, Ivan Halasz, Cristina Mottillo and Tomislav Friščić
Green Chem., 2012,14, 2462-2473
DOI: 10.1039/C2GC35799B

Tunable recognition of the steroid α-face by adjacent π-electron density.
T. Friščić, R.W. Lancaster, L. Fábián and P.G. Karamertzanis
Proc. Natl. Acad. Sci. USA, 2010, 107, 13216-13221.
DOI: 10.1073/pnas.0915142107

Improving Mechanical Properties of Crystalline Solids by Cocrystal Formation: New Compressible Forms of Paracetamol.
S. Karki, T. Friščić, L. Fábián, P.R. Laity, G.M. Day, W. Jones
Adv. Mater., 2009, 21, 3905-3909.
DOI: 10.1002/adma.200900533

Cambridge Structural Database Analysis of Molecular Complementarity in Cocrystals.
L. Fábián
Cryst. Growth. Des., 2009, 9, 1436-1443.
DOI: 10.1021/cg800861m

Organic crystal hydrates: what are the important factors for formation.
L. Infantes, L. Fábián, W.D.S. Motherwell
CrystEngComm, 2007, 9, 65-71.
DOI: 10.1039/B612529H

All Publications

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Guo, M., Wang, K., Qiao, N., Fábián, L., Sadiq, G., Li, M.

(2017)

Insight into Flufenamic Acid Cocrystal Dissolution in the Presence of a Polymer in Solution: from Single Crystal to Powder Dissolution,

in Molecular Pharmaceutics

14

(12)

pp. 4583–4596

Full Text UEA Repository

(Article)

(Published)


Nartowski, K., Malhotra, D., Hawarden, L., Sibik, J., Iuga, D., Zeitler, J. A., Fabian, L., Khimyak, Y.

(2016)

19F NMR Spectroscopy as a Highly Sensitive Method for the Direct Monitoring of Confined Crystallization within Nanoporous Materials,

in Angewandte Chemie International Edition

128

(31)

pp. 9050-9054

Full Text UEA Repository

(Article)

(Published)


Takieddin, K., Khimyak, Y., Fabian, L.

(2016)

Prediction of Hydrate and Solvate Formation Using Statistical Models,

in Crystal Growth & Design

16

(1)

pp. 70-81

Full Text UEA Repository

(Article)

(Published)


Eddleston, M., Arhangelskis, M., Fabian, L., Tizzard, G., Coles, S. J., Jones, W.

(2016)

Investigation of an amide-pseudo amide hydrogen bonding motif within a series of theophylline:amide cocrystals,

in Crystal Growth & Design

16

(1)

pp. 51-58

Full Text UEA Repository

(Article)

(Published)


Tipduangta, P., Belton, P., Fabian, L., Wang, L. Y., Tang, H., Eddledton, M., Qi, S.

(2016)

Electrospun polymer blend nanofibers for tuneable drug delivery: the role of transformative phase separation on controlling the release rate,

in Molecular Pharmaceutics

13

(1)

pp. 25-39

Full Text UEA Repository

(Article)

(Published)


Nartowski, K. P., Tedder, J., Braun, D. E., Fabian, L., Khimyak, Y. Z.

(2015)

Building solids inside nano-space: from confined amorphous through confined solvate to confined ‘metastable’ polymorph,

in Physical Chemistry Chemical Physics

17

(38)

pp. 24761-24773

Full Text UEA Repository

(Article)

(Published)


Tipduangta, P., Takieddin, K., Fabian, L., Belton, P., Qi, S.

(2015)

A New Low Melting-point Polymorph of Fenofibrate Prepared via Talc Induced Heterogeneous Nucleation,

in Crystal Growth & Design

15

(10)

pp. 5011–5020

Full Text UEA Repository

(Article)

(Published)


Sarcevica, I., Orola, L., Nartowski, K., Khimyak, Y., Round, A., Fabian, L.

(2015)

Mechanistic and kinetic insight into spontaneous cocrystallisation of isoniazid and benzoic acid,

in Molecular Pharmaceutics

12

(8)

pp. 2981–2992

Full Text UEA Repository

(Article)

(Published)


Pina, M. F., Zhao, M., Pinto, J. F., Sousa, J. J., Frampton, C. S., Diaz, V., Suleiman, O., Fábián, L., Craig, D. Q. M.

(2014)

An Investigation into the Dehydration Behavior of Paroxetine HCl Form I Using a Combination of Thermal and Diffraction Methods: The Identification and Characterization of a New Anhydrous Form,

in Crystal Growth & Design

14

(8)

pp. 3774-3782

Full Text UEA Repository

(Article)

(Published)


Eccles, K., Morrison, R., Stokes, S., O'Mahoney, G., Hayes, J., Kelly, D., O'Boyle, N., Fabian, L., Moynihan, H., Maguire, A., Lawrence, S.

(2012)

Utilizing Sulfoxide...Iodine Halogen Bonding for Cocrystallization,

in Crystal Growth & Design

12

pp. 2969-2977

UEA Repository

(Article)

(Published)


Fabian, L., Frišcic, T.

(2012)

Chapter 5. Shape and Polarity in Co-crystal Formation: Database Analysis and Experimental Validation,

in Pharmaceutical Salts and Co-crystals.

Royal Society of Chemistry

pp. 89-109

ISBN 978-1-84973-158-4

Full Text UEA Repository

(Chapter)

(Published)


Galcera, J., Friscic, T., Hejczyk, K., Fabian, L., Clarke, S., Day, G., Molins, E., Jones, W.

(2012)

Isostructural organic binary-host frameworks with tuneable and diversely decorated inclusion cavities,

in CrystEngComm

14

(23)

pp. 7898

Full Text UEA Repository

(Article)

(Published)


Pina, M., Pinto, J., Sousa, J., Fabian, L., Zhao, M., Craig, D.

(2012)

Identification and Characterization of Stoichiometric and Nonstoichiometric Hydrate Forms of Paroxetine HCl: Reversible Changes in Crystal Dimensions as a Function of Water Absorption,

in Molecular Pharmaceutics

9

(12)

pp. 3515-3525

Full Text UEA Repository

(Article)

(Published)


Štrukil, V., Igrc, M., Fabian, L., Eckert-Maksić, M., Childs, S., Reid, D., Duer, M., Halasz, I., Mottillo, C., Friščić, T.

(2012)

A model for a solvent-free synthetic organic research laboratory: click-mechanosynthesis and structural characterization of thioureas without bulk solvents,

in Green Chemistry

14

(9)

pp. 2462

Full Text UEA Repository

(Article)

(Published)


Fabian, L., Hamill, N., Eccles, K., Moynihan, H., Maguire, A., McCausland, L., Lawrence, S.

(2011)

Cocrystals of Fenamic Acids with Nicotinamide,

in Crystal Growth & Design

11

(8)

pp. 3522-3528

Full Text UEA Repository

(Article)

(Published)


Eccles, K., Deasy, R., Fabian, L., Braun, D., Maguire, A., Lawrence, S.

(2011)

Expanding the crystal landscape of isonicotinamide: concomitant polymorphism and co-crystallisation,

in CrystEngComm

13

(23)

pp. 6923

Full Text UEA Repository

(Article)

(Published)


Eccles, K., Deasy, R., Fabian, L., Maguire, A., Lawrence, S.

(2011)

The Use of Co-crystals for the Determination of Absolute Stereochemistry: An Alternative to Salt Formation,

in The Journal of Organic Chemistry

76

(4)

pp. 1159-1162

Full Text UEA Repository

(Article)

(Published)


Kelley, S., Fabian, L., Brock, C.

(2011)

Failures of fractional crystallization: ordered co-crystals of isomers and near isomers,

in Acta Crystallographica Section B

67

(1)

pp. 79-93

Full Text UEA Repository

(Article)

(Published)


Beldon, P. J., Fabian, L., Stein, R. S., Thirumurugan, A., Cheetham, A. K., Friščić, T.

(2010)

Rapid Room-Temperature Synthesis of Zeolitic Imidazolate Frameworks by Using Mechanochemistry,

in Angewandte Chemie International Edition

49

(50)

pp. 9640-9643

Full Text UEA Repository

(Article)

(Published)


Štrukil, V., Fabian, L., Reid, D. G., Duer, M. J., Jackson, G. J., Eckert-Maksić, M., Friščić, T.

(2010)

Towards an environmentally-friendly laboratory: dimensionality and reactivity in the mechanosynthesis of metal–organic compounds,

in Chemical Communications

46

(48)

pp. 9191-9193

Full Text UEA Repository

(Article)

(Published)


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External Activities and Indicators of Esteem

Refereeing

  • Co-editor of Acta Crystallographica, Section E
  • Regular refereeing for CrystEngComm, Crystal Growth & Design, Journal of Chemical Research

Learned Societies

  • Member of the British Crystallographic Association
  • Member of the American Chemical Society

Conference organisation

  • 22nd European Crystallographic Meeting, Budapest, Hungary, 2002

Invited talks

  • Hungarian Chemical Society, Balatonszemes, Hungary, 2013
  • 27th European Crystallographic Meeting, Bergen, Norway, 2012
  • 26th European Crystallographic Meeting, Darmstadt, Germany, 2010
  • IQPC Pharmaceutical Co-crystals, Amsterdam, 2008 and 2009
  • 237th American Chemical Society National Meeting and Exposition, Salt Lake City, 2009