Biography

PhD Positions

Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Julie Sanderson obtained her BSc (Hons) in Pharmacology, University of Leeds, 1986 and her PhD in ocular physiology from the School of Biological Sciences, University of East Anglia, 1991. She then held research associate and senior demonstrator positions in the School of Biological Sciences, University of East Anglia, before being appointed to a post as a Lecturer in Pharmacology in the School of Chemical Sciences and Pharmacy, University of East Anglia in 2004.  She is currently a Senior Lecturer in Pharmaceutical Cell Biology in the School of Pharmacy.

Research interests include: ocular cell biology, pharmacology and pathophysiology including purinoceptor signalling in the retina (neural retina and the retinal pigment epithelium), molecular mechanisms underlying visual field loss in glaucoma and mechanisms of cataract formation. A central theme is calcium cell signalling.

Selected Publications

Human organotypic retinal cultures (HORCs) as a chronic experimental model for investigation of retinal ganglion cell degeneration.
Osborne, A., Hopes, M., Wright, P., Broadway, D. C., Sanderson, J.
Experimental Eye Research, 2016, 143, pp. 28-38
DOI:  10.1016/j.exer.2015.09.012

Hydrostatic Pressure does not cause detectable changes to Survival of Human Retinal Ganglion.
Osborne, A., Aldarwesh, A., Rhodes, J. D., Broadway, D. C., Everitt, C., Sanderson.
J.PLoS One, 2015. 10(1): e0115591.
DOI: 10.1371/journal.pone.0115591
DOI: 10.1371/journal.pone.0115591

Purines in the eye : recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.
Sanderson, J., Dartt, D., Trinkaus-Randall, V., Pintor, J., Civan, M., Delamere, N., Fletcher, E., Salt, T., Grosche, A., Mitchell, C.
Experimental Eye Research, 2014, 127.pp. 270-279.
DOI: 10.1016/j.exer.2014.08.009

P2X7 receptor activation mediates retinal ganglion cell death in a human retina model of ischemic neurodegeneration.
Niyadurupola, N., Sidaway, P., Ma, N., Sanderson, J., Broadway, D., Rhodes, J.
Investigative Ophthalmology & Visual Science, 2013, 54. pp. 2163-2170.
DOI: 10.1167/iovs.12-10968

The development of human organotypic retinal cultures (HORCs) to study retinal neurodegeneration
Niyadurupola N, Sidaway P, Osborne A, Broadway DC, Sanderson J.
Br. J. Ophthalmol. 2011, 95, 720-726.
DOI:10.1136/bjo.2010.181404

Highlighted Publications

See All

Sanderson, J., Dartt, D., Trinkaus-Randall, V., Pintor, J., Civan, M., Delamere, N., Fletcher, E., Salt, T., Grosche, A., Mitchell, C.

(2014)

Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.,

in Experimental Eye Research

127.

pp. 270-279

Full Text UEA Repository

(Article)

(Published)


Niyadurupola, N., Sidaway, P., Ma, N., Sanderson, J., Broadway, D., Rhodes, J.

(2013)

P2X7 receptor activation mediates retinal ganglion cell death in a human retina model of ischemic neurodegeneration,

in Investigative Ophthalmology & Visual Science

54.

pp. 2163-2170

Full Text UEA Repository

(Article)

(Published)


Niyadurupola, N., Sidaway, P., Osborne, A., Broadway, D., Sanderson, J.

(2011)

The development of human organotypic retinal cultures (HORCs) to study retinal neurodegeneration,

in British Journal of Ophthalmology

10.

pp. 720-726

Full Text UEA Repository

(Article)

(Published)


All Publications

See Highlights
<- Page 1 of 2 ->

Osborne, A., Hopes, M., Wright, P., Broadway, D. C., Sanderson, J.

(2016)

Human organotypic retinal cultures (HORCs) as a chronic experimental model for investigation of retinal ganglion cell degeneration,

in Experimental Eye Research

143

pp. 28-38

Full Text UEA Repository

(Article)

(Published)


Osborne, A., Aldarwesh, A., Rhodes, J. D., Broadway, D. C., Everitt, C., Sanderson, J.

(2015)

Hydrostatic pressure does not cause detectable changes to survival of human retinal ganglion,

in PLoS ONE

10

(1)

article no. e0115591

Full Text UEA Repository

(Article)

(Published)


Sanderson, J., Dartt, D., Trinkaus-Randall, V., Pintor, J., Civan, M., Delamere, N., Fletcher, E., Salt, T., Grosche, A., Mitchell, C.

(2014)

Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.,

in Experimental Eye Research

127

pp. 270-279

Full Text UEA Repository

(Article)

(Published)


Niyadurupola, N., Sidaway, P., Ma, N., Sanderson, J., Broadway, D., Rhodes, J.

(2013)

P2X7 receptor activation mediates retinal ganglion cell death in a human retina model of ischemic neurodegeneration,

in Investigative Ophthalmology & Visual Science

54

(3)

pp. 2163-2170

Full Text UEA Repository

(Article)

(Published)


Wang, L., Eldred, J. A., Sidaway, P., Sanderson, J., Smith, A. J. O., Bowater, R. P., Reddan, J. R., Wormstone, I. M.

(2012)

Sigma 1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lens,

in Mechanisms of Ageing and Development

133

(11-12)

pp. 665-674

Full Text UEA Repository

(Article)

(Published)


Rhodes, J., Lott, M., Russell, S., Moulton, V., Sanderson, J., Wormstone, I., Broadway, D.

(2012)

Activation of the innate immune response and interferon signalling in myotonic dystrophy type 1 and type 2 cataracts,

in Human Molecular Genetics

21

(4)

pp. 852-862

Full Text UEA Repository

(Article)

(Published)


Niyadurupola, N., Sidaway, P., Osborne, A., Broadway, D., Sanderson, J.

(2011)

The development of human organotypic retinal cultures (HORCs) to study retinal neurodegeneration,

in British Journal of Ophthalmology

10

pp. 720-726

Full Text UEA Repository

(Article)

(Published)


Rhodes, J., Breck, O., Waagbo, R., Bjerkas, E., Sanderson, J.

(2010)

N-acetylhistidine, a novel osmolyte in the lens of Atlantic salmon (Salmo salar L.),

in AJP - Regulatory, Integrative and Comparative Physiology

299

(4)

pp. R1075-R1081

Full Text UEA Repository

(Article)

(Published)


Tröβe, C., Rhodes, J., Sanderson, J., Breck, O., Waagbø, R.

(2010)

Effect of plant-based feed ingredients on osmoregulation in the Atlantic salmon lens,

in Comparative Biochemistry and Physiology - Part B Biochemistry & Molecular Biology

155

(4)

pp. 354-362

Full Text UEA Repository

(Article)

(Published)


Radreau, P., Rhodes, J., Mithen, R., Kroon, P., Sanderson, J.

(2009)

Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells,

in Experimental Eye Research

89

(6)

pp. 995-1002

Full Text UEA Repository

(Article)

(Published)


Rhodes, J., Sanderson, J.

(2009)

The mechanisms of calcium homeostasis and signalling in the lens,

in Experimental Eye Research

88

(2)

pp. 226-234

Full Text UEA Repository

(Article)

(Published)


Lee, H. Y. Y., Morton, J. D., Sanderson, J., Bickerstaffe, R., Robertson, L. J. G.

(2008)

The involvement of calpains in opacification induced by Ca2+-overload in ovine lens culture,

in Veterinary Ophthalmology

11

(6)

pp. 347-355

Full Text UEA Repository

(Article)

(Published)


Tovell, V., Sanderson, J.

(2008)

Distinct P2Y Receptor Subtypes Regulate Calcium Signaling in Human Retinal Pigment Epithelial Cells,

in Investigative Ophthalmology & Visual Science

49

(1)

pp. 350-357

Full Text UEA Repository

(Article)

(Published)


Chen, Y. I., Barker, S. A., Sanderson, J.

(2007)

Drug delivery to the posterior segment of the eye using sub-conjunctival injection of thermo-setting gel formulations,

in Journal of Pharmacy and Pharmacology

59

pp. 146

UEA Repository

(Article)

(Published)


Morris, J. M., Barker, S. A., Sanderson, J.

(2007)

The creation of a vitreous humour replacement: hydrogel formulations and freeze drying of the porcine vitreous humour,

in Journal of Pharmacy and Pharmacology

59

pp. 139

UEA Repository

(Article)

(Published)


Breck, O., Bjerkas, E., Sanderson, J., Waagbo, R., Campbell, P.

(2005)

Dietary histidine affects lens protein turnover and synthesis of N-acetylhistidine in Atlantic salmon (Salmo salar L.) undergoing parr-smolt transformation,

in Aquaculture Nutrition

11

(5)

pp. 321-332

Full Text UEA Repository

(Article)

(Published)


Breck, O., Bjerkas, E., Campbell, P., Rhodes, J. D., Sanderson, J., Waagbo, R.

(2005)

Histidine nutrition and genotype affect cataract development in Atlantic salmon, Salmo salar L.,

in Journal of Fish Diseases

28

(6)

pp. 357-371

Full Text UEA Repository

(Article)

(Published)


Collison, D., Tovell, V., Coombes, L., Duncan, G., Sanderson, J.

(2005)

Potentiation of ATP-induced Ca(2+) mobilisation in human retinal pigment epithelial cells,

in Experimental Eye Research

80

(4)

pp. 465-475

Full Text UEA Repository

(Article)

(Published)


Wang, L., Prescott, A., Spruce, B., Sanderson, J., Duncan, G.

(2005)

Sigma receptor antagonists inhibit human lens cell growth and induce pigmentation.,

in Investigative Ophthalmology and Visual Science

46

pp. 1403-1408

Full Text UEA Repository

(Article)

(Published)


Lee, H., Morton, J., robertson, L., Sanderson, J.

(2004)

Opacification induced by calcium overload in sheep lens culture.,

in Investigative Ophthalmology and Visual Science

45

pp. 2652

UEA Repository

(Article)

(Published)


<- Page 1 of 2 ->

Key Research Interests

Role of calpain in cataract formation
Collaborators: Dr Michael Wormstone, School of Biological Sciences, UEA.

In cortical cataract, calcium increases I the lens cells which leads to activation of downstream calcium-mediated processes.  This project uses a model of calcium-induced opacification in the human lens as a model of cortical cataract to investigate the potential anti-cataract activity of inhibitors targeting the calcium-activated protease calpain.

Funding: Calpain Therapeutics

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Retinal Cell Signalling Mechanisms underlying visual loss in Glaucoma.
Collaborators: Mr David Broadway Consultant Ophthalmologist, Norfolk & Norwich University Hospital.

This project aims to look at mechanisms causing cell death in retinal ganglion cells as occurs in glaucoma. Glaucoma is a debilitating disease, which leads ultimately to blindness. Vision is lost due to death of retinal ganglion cells. In this project we are investigating mechanisms mediating neuronal cell death and potential neuroprotective strategies.  Research primarily utilises our recently developed human retina explant culture model (Human Retinal Organotypic Cultures; HORCs).  We are investigating the triggering mechanisms for glaucomatous neurodegeneration, looking specifically at the effects of pressure, mechanical strain and ischaemia on RGC death.   We are also investigating downstream mechanisms, with a specific interest in signalling via ATP, investigating the mechanisms whereby stress-induced release of ATP from retinal cells contributes to neuronal cell death.  We are particularly interested in the P2X7 receptor, which is a known mediator of neuronal cell death.

Current research personnel: Dr Phillip Wright, Matthew Felgate, Sofia Habib.

Funding:  Humane Research Trust, NNUH Glaucoma Research Fund.

------

Development of an in vitro model for assessment of drug toxicity in the human retina.
Collaborators: Dr Guy Healing and Dr Janet Kelsall, AstraZeneca UK.

This project aims to assess our human organotypic retinal culture (HORC) model, to determine its potential as a model for determining retinal toxicity.  Retinal toxicity is a significant reason for failure of new drugs to progress to clinical studies.  The development of an in vitro model that uses human tissue could therefore be of great benefit.

Current research personnel: Dr Phillip Wright

Funding: AstraZeneca UK.

------

Research Funding

  • The Humane Research Trust
  • The Norwich Glaucoma Research Fund
  • AstraZeneca UK
  • Calpain Therapeutics

 

Research Group Membership

Current Members  

Philip Wright

Phillip Wright
Post Doctoral Scientist

Sofia Habib
Clinical Fellow

Matt Felgate

Matt Felgate
PhD student

Recent past members

Andy Osborne
Post Doctoral Scientist

Dr Marina Hopes
Clinical Fellow

Dr Ning Ma
PhD student

Amal Al Darwesh

Amal Al Darwesh

 

External Activities and Indicators of Esteem

Consultancies

  • Calpain Therapeutics.  Assessment of potential of calpain inhibitors as anti-cataract drugs.
  • Pfizer. Novel ocular delivery devices.
  • Evotec. In vitro evaluation of lens toxicity.
  • Biologie Servier. In vitro evaluations of lens toxicity.
  • Novatis UK Ltd. In vitro study of lens toxicology.
  • Marine Harvest. Cataracts in farmed salmon.
  • BBC television programme looking at the human body "Dr Alice Roberts:  Don't die young".

Invited Reviews

  • Sanderson, J., Dartt, D., Trinkaus-Randall, V., Pintor, J., Civan, M., Delamere, N., Fletcher, E., Salt, T., Grosche, A., Mitchell, C (2014).  Purines in the eye : recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.  Exp. Eye Res, 127.pp. 270-279.
  • Rhodes, JD & Sanderson J. (2009) The Mechanisms of Calcium Homeostasis and Signalling in the Lens.  Exp. Eye Res. 88: 226-234.
  • Sanderson, J & McLauchlan, R. (2003) The Role of Flavonoids in Protection against Cataract. In Phytochemicals in Health and Disease. Eds. Bao, Y-P & Fenwick, R., 227-240.

Learned Societies

  • Association for Research in Vision and Ophthalmology
  • International Society for Ocular Cell Biology