Biography

PhD Positions

Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Anja obtained a degree in Biology at the University of the Saar in Saarbruecken, Germany in 1995. She then went on to undertake a PhD at the Institute of Virology at the University Hospital in Homburg/Saar, Germany. After finishing her PhD she carried out postdoctoral research with Philip Strange at the University of Reading (1999-2002) and then joined the group of James Pease at Imperial College London (2003-2004). She joined UEA in August 2004 as a Lecturer in Molecular Pharmacology and was promoted to Senior Lecturer in 2009.

Anja's primary research interest is the investigation of cell signalling mechanisms of chemokine receptors which are a subgroup of G-protein-coupled receptors. She is interested in how the expression of these receptors is regulated on the cell surface and how they activate heterotrimeric G-proteins and other intracellular signalling pathways to induce cell migration.

Selected Publications

Differential regulation of chemotaxis: Role of Gβγ in chemokine receptor-induced cell migration
Kerr JS, Jacques RO, Moyano Cardaba C, Tse T, Sexton D, Mueller A Cell Signal. 2013, April; 25(4): 729–735,
DOI:10.1016/j.cellsig.2012.12.015.

Cellular uptake studies of two hexanuclear, carboxylate bridged, zinc ring structures using fluorescence microscopy
Redshaw C, Elsegood MR, Frese JW, Ashby S, Chao Y, Mueller A.
Chem Commun (Camb). 2012 Jul 7;48(53):6627-9. Epub 2012 May 1
DOI: 10.1039/C2CC32060F

Stable and Sensitive Probes for Lysosomes: Cell-Penetrating Fluorescent Calix[4]arenes Accumulate in Acidic Vesicles.
Mueller, A., Lalor, R., Moyano Cardaba, C, Matthews, S.E.
Cytometry A. 2011 Feb;79(2):126-36.
DOI: 10.1002/cyto.a.21002. Epub 2010 Dec 23.

Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells.
Moyano Cardaba, C, Mueller A
Biochem Pharmacol, 2009; 78; 974-982,
DOI:10.1016/j.bcp.2009.06.003

CCR5 internalisation and signalling have different dependence on membrane lipid raft integrity.
Moyano Cardaba, C, Kerr JS, Mueller A
Cell Signalling, 2008; 20; 1687-1694
DOI: 10.1016/j.cellsig.2008.05.014

CXCL4-induced migration of activated T-lymphocytes is mediated by the chemokine receptor CXCR3.
Mueller A, Meiser A, McDonagh EM, Fox JM, Petit S, Xanthou G, Williams TJ, Pease JE.
J Leukoc Biol. 2008 Jan 3; [Epub ahead of print]
DOI: 10.1189/jlb.1006645

The CXC chemokine MIG/CXCL9 is important in innate immunity against Streptococcus pyogenes.
Egesten A, Eliasson M, Johansson HM, Olin AI, Morgelin M, Mueller A, Pease JE, Frick IM, Bjorck L.
Journal of Infectious Diseases, 2007 195, 684-693
DOI:10.1086/510857
 

Career History

  • 1999-2002 Postdoc, School of Animal and Microbial Sciences, University of Reading
  • 2002-2004 Postodc, Department of Leukocyte Biology, Imperial College London
  • 2004-2009 Lectuer in Molecular Pharmacology, University of East Anglia, Norwich
  • 2009 - Senior Lecturer in Molecular Pharmacology, University of East Anglia, Norwich

All Publications

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Mills, S., Howell, L., Beekman, A., Stokes, L., Mueller, A.

(2017)

Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4,

in Cellular Signalling

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Mills, S. C., Goh, P. H., Kudatsih, J., Ncube, S., Gurung, R., Maxwell, W., Mueller, A.

(2016)

Cell migration towards CXCL12 in leukemic cells compared to breast cancer cells,

in Cellular Signalling

28

(4)

pp. 316-324

Full Text UEA Repository

(Article)

(Published)


Jacques, R. O., Mills, S. C., Cazzonatto Zerwes, P., Fagade, F. O., Green, J. E., Downham, S., Sexton, D. W., Mueller, A.

(2015)

Dynamin function is important for CC-chemokine receptor induced cell migration,

in Cell Biochemistry and Function

33

(6)

pp. 407-414

Full Text UEA Repository

(Article)

(Published)


Redshaw, C., Watkins, S., Humphrey, S. M., Bulman Page, P. C., Ashby, S., Chao, Y., Herbert, C. J., Mueller, A.

(2013)

Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation,

in RSC Advances

3

(46)

pp. 23963-23966

Full Text UEA Repository

(Article)

(Published)


Ahire, J. H., Chambrier, I., Mueller, A., Bao, Y., Chao, Y.

(2013)

Synthesis of D-Mannose Capped Silicon Nanoparticles and Their Interactions with MCF-7 Human Breast Cancerous Cells,

in ACS Applied Materials & Interfaces

5

(15)

pp. 7384-7391

Full Text UEA Repository

(Article)

(Published)


Khabbazi, S., Jacques, R., Moyano Cardaba, C., Mueller, A.

(2013)

Janus kinase 2 and signal transducer and activator of transcription 3 activation is not essential for CCL3-, CCL5- or CCL8-induced chemotaxis,

in Cell Biochemistry and Function

31

(4)

pp. 312-318

Full Text UEA Repository

(Article)

(Published)


Kerr, J., Jacques, R., Moyano Cardaba, C., Tse, T., Sexton, D., Mueller, A.

(2013)

Differential regulation of chemotaxis: Role of Gβγ in chemokine receptor-induced cell migration,

in Cellular Signalling

25

(4)

pp. 729-735

Full Text UEA Repository

(Article)

(Published)


Redshaw, C., Elsegood, M., Frese, J., Ashby, S., Chao, Y., Mueller, A.

(2012)

Cellular uptake studies of two hexanuclear, carboxylate bridged, zinc ring structures using fluorescence microscopy,

in Chemical Communications

48

(53)

pp. 6627-6629

Full Text UEA Repository

(Article)

(Published)


Redshaw, C., Elsegood, M., Wright, J., Baillie-Johnson, H., Yamato, T., Giovanni, S., Mueller, A.

(2012)

Cellular uptake of a fluorescent vanadyl sulfonylcalix[4]arene,

in Chemical Communications

48

(8)

pp. 1129-1131

Full Text UEA Repository

(Article)

(Published)


Moyano, C., Jacques, R., Barrett, J., Hassell, K., Kavanagh, A., Remington, F., Tse, T., Mueller, A.

(2012)

CCL3 induced migration occurs independently of intracellular calcium release,

in Biochemical and Biophysical Research Communications

418

(1)

pp. 17-21

Full Text UEA Repository

(Article)

(Published)


Mueller, A., Lalor, R., Moyano Cardaba, C., Matthews, S.

(2011)

Stable and sensitive probes for lysosomes: Cell-penetrating fluorescent calix[4]arenes accumulate in acidic vesicles,

in Cytometry Part A

79A

(2)

pp. 126-136

Full Text UEA Repository

(Article)

(Published)


Howell, L., Gulam, R., Mueller, A., O'Connell, M., Searcey, M.

(2010)

Design and synthesis of threading intercalators to target DNA,

in Bioorganic & Medicinal Chemistry Letters

1

(20)

pp. 6956-6959

Full Text UEA Repository

(Article)

(Published)


Howell, L., Howman, A., O'Connell, M., Mueller, A., Searcey, M.

(2009)

Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry,

in Bioorganic & Medicinal Chemistry Letters

19

(20)

pp. 5880-5883

Full Text UEA Repository

(Article)

(Published)


Cardaba, C. M., Mueller, A.

(2009)

Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells,

in Biochemical Pharmacology

78

(8)

pp. 974-982

Full Text UEA Repository

(Article)

(Published)


Kerr, J., Mueller, A.

(2009)

Functional selectivity of CCR5 interaction with heterotrimeric G-proteins,

in FEBS Journal

276

pp. 237-237

UEA Repository

(Article)

(Published)


Cardaba, C. M., Kerr, J. S., Mueller, A.

(2008)

CCR5 internalisation and signalling have different dependence on membrane lipid raft integrity,

in Cellular Signalling

20

(9)

pp. 1687-1694

Full Text UEA Repository

(Article)

(Published)


Meiser, A., Mueller, A., Wise, E. L., McDonagh, E. M., Petit, S. J., Saran, N., Clark, P. C., Williams, T. J., Pease, J. E.

(2008)

The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor,

in Journal of Immunology

180

(10)

pp. 6713-6724

UEA Repository

(Article)

(Published)


Lalor, R., Baillie-Johnson, H., Redshaw, C., Matthews, S., Mueller, A.

(2008)

Cellular Uptake of a Fluorescent Calix[4]arene Derivative,

in Journal of the American Chemical Society

130

(10)

pp. 2892-2893

Full Text UEA Repository

(Article)

(Published)


Mueller, A., Meiser, A., McDonagh, E. M., Fox, J. M., Petit, S. J., Xanthou, G., Williams, T. J., Pease, J. E.

(2008)

CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3,

in Journal of Leukocyte Biology

83

(4)

pp. 875-882

Full Text UEA Repository

(Article)

(Published)


Egesten, A., Eliasson, M., Johansson, H. M., Olin, A. I., Morgelin, M., Mueller, A., Pease, J. E., Frick, I. M., Bjorck, L.

(2007)

The CXC chemokine MIG/CXCL9 is important in innate immunity against Streptococcus pyogenes,

in Journal of Infectious Diseases

195

(5)

pp. 684-693

Full Text UEA Repository

(Article)

(Published)


<- Page 1 of 2 ->

Key Research Interests

Current investigations are centred on the chemokine receptors and their ability to bind a variety of ligands and induce specific cellular responses, including cell migration.

Regulation of cell surface expression of chemokine receptors and receptor trafficking

We aim to understand the mechanisms how chemokine receptor cell surface expression is regulated and how internalization and recycling of receptors influences migration patterns of cells. 

How do chemokine receptors induce cell migration

The chemokine receptors CCR5 and CXCR4 act as a co-receptor for the HIV virus and have also been implicated in migration of cancerous cells. Our main interest lies in understanding the signal transduction induced by these two receptors. It is well known that chemokine receptor activation leads to an increase in the release of intracellular calcium and ultimately cell migration. We want to investigate how the receptors can activate cell migration and determine which signaling networks are involved in this. With the aid of pharmacological inhibitors we already have identified different signalling networks which are involved in migration. In the future we want to concentrate on specific proteins like ?-arrestins, which play a critical role in cell migration. We aim to understand how different chemokine receptor can activate migration in cells and which signalling networks play a role in chemotaxis.

Current Group members:

  • Shirley Mills (PhD student)
  • Goh-Hui Poh (PhD student)
  • Gerald Keil (PhD student)
  • Thais Jovenazzo (SwB student)
  • Xiaoxi Chen (PGT student)
  • Alexander Baus (Erasmus exchange student)

Former group members:

  • Jason Kerr (PhD student 2006-2010)
  • Clara Moyano Cardaba (PhD student 2007-2011)
  • Richard Jacques (PhD student 2009-2013)

Key Responsibilities

  • Director of Learning and Teaching
  • Head of Pharmacology Teaching

 

Administrative Posts

  • Director of Learning and Teaching
  • Head of Pharmacology teaching
  • Module coordinator for Applied Immunology and infectious diseases