Biography

Andrew studied for his B.Sc.(Adv.) at the Australian National University and received a First Class Honours degree in 2009. He began his Ph.D. studies in 2010 with Assoc. Prof. Russell Barrow at the Research School of Chemistry as an Alan Sargeson Scholar, focusing on the elucidation and synthesis of biologically significant fungal metabolites from traditional medicinal sources, completing his thesis in 2013. In 2014, he won an Endeavour Research Fellowship to train with Assoc. Prof. Gregory Dake at the University of British Columbia, Department of Chemistry, Vancouver, Canada. Whilst at UBC Andrew investigated new organometallic mediated transformations for the preparation of interesting natural products.

In 2015, Andrew moved to the University of East Anglia, School of Pharmacy to work with Dr Lesley Howell, examining the protein-protein interaction of Mcl-1 and NOXA, proteins which regulate apoptosis and are commonly exploited by a variety of cancers. In 2016, Andrew began working with Head of School Prof. Mark Searcey, on the ability of flavonoid metabolites to act as anti-inflammatory agents, and the ability of actinomycin D analogues on trinucleotide repeat disorders.

Andrew took up a position as an Independent Research Fellow in the School of Pharmacy in February 2017, where his research interests include developing new methodology to target protein-protein interactions, the development of new pharmaceutical leads and chemical probes for protein-protein interactions, and the investigation of DNA binders which target trinucleotide repeat disorders.

All Publications

Mills, S., Howell, L., Beekman, A., Stokes, L., Mueller, A.

(2018)

Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4,

in Cellular Signalling

42

pp. 88–96

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Beekman, A. M., O'Connell, M. A., Howell, L. A.

(2017)

Peptide-Directed Binding for the Discovery of Modulators of α-Helix-Mediated Protein-Protein Interactions: Proof-of-Concept Studies with the Apoptosis Regulator Mcl-1,

in Angewandte Chemie International Edition

56

(35)

pp. 10446–10450

Full Text UEA Repository

(Article)

(Published)


Myrtle, J. D., Beekman, A. M., Barrow, R. A.

(2016)

Ravynic acid, an antibiotic polyeneyne tetramic acid from Penicillium sp. elucidated through synthesis,

in Organic & Biomolecular Chemistry

14

(35)

pp. 8253-8260

Full Text UEA Repository

(Article)

(Published)


Beekman, A. M., O'Connell, M. A., Howell, L. A.

(2016)

Identification of small-molecule inhibitors of the antiapoptotic protein myeloid cell leukaemia-1 (Mcl-1),

in ChemMedChem

11

(8)

pp. 840–844

Full Text

(Letter)

(Published)


Howell, L., Beekman, A.

(2016)

Small molecule and peptide inhibitors of the pro-survival protein Mcl-1,

in ChemMedChem

11

(8)

pp. 802–813

Full Text UEA Repository

(Article)

(Published)


Beekman, A. M., Wossa, S. W., Kevo, O., Ma, P., Barrow, R. A.

(2015)

Discovery and Synthesis of Boletopsins 13 and 14, Brominated Fungal Metabolites of Terrestrial Origin,

in Journal of Natural Products

78

(8)

pp. 2133-2135

Full Text UEA Repository

(Article)

(Published)


Beekman, A. M., Barrow, R. A.

(2015)

Syntheses of Cytosporones A, C, J, K, and N, Metabolites from Medicinal Fungi,

in Australian Journal of Chemistry

68

(10)

pp. 1583-1592

Full Text UEA Repository

(Article)

(Published)


Beekman, A. M., Barrow, R. A.

(2014)

Fungal Metabolites as Pharmaceuticals,

in Australian Journal of Chemistry

67

(6)

pp. 827-843

Full Text UEA Repository

(Article)

(Published)


Beekman, A. M., Barrow, R. A.

(2014)

Syntheses of the Fungal Metabolites Boletopsins 7, 11, and 12 from the Papua New Guinea Medicinal Mushroom Boletopsis sp.,

in The Journal of Organic Chemistry

79

(3)

pp. 1017-1024

Full Text UEA Repository

(Article)

(Published)


Beekman, A. M., Barrow, R. A.

(2013)

Stereochemical assignment of the fungal metabolites Pestalotiopsones D and E through enantiopure synthesis,

in Journal of Natural Products

76

(11)

pp. 2054-2059

Full Text UEA Repository

(Article)

(Published)


Wossa, S. W., Beekman, A. M., Ma, P., Kevo, O., Barrow, R. A.

(2013)

Identification of Boletopsin 11 and 12, Antibiotics from the Traditionally Used Fungus Boletopsis sp.,

in Asian Journal of Organic Chemistry

2

(7)

pp. 565-567

Full Text UEA Repository

(Article)

(Published)


Beekman, A. M., Castillo Martinez, E., Barrow, R. A.

(2013)

First syntheses of the biologically active fungal metabolites pestalotiopsones A, B, C and F,

in Organic & Biomolecular Chemistry

11

(7)

pp. 1109-1115

Full Text UEA Repository

(Article)

(Published)