Next generation therapeutics Next generation therapeutics

Our research is focused on the design and development of new molecules, new materials and new delivery systems for the treatment of complex diseases: from discovery of novel pharmaceutical agents and understanding of mechanisms of their action to application of future generation of pharmaceutical materials and formulation approaches for advanced drug delivery.

Key challenges in development of novel therapeutics are addressed by the combination of fundamental understanding of structure and mechanisms of action of pharmaceuticals at different length scales: from molecular and supramolecular organisation up to interactions with cells and tissues. The multidisciplinary character of our research teams, extensive links with our academic and industrial collaborators and state of the art research facilities both in UEA and wider NRP enable us to make significant impact in several key areas of modern pharmaceutical science.

Key areas of research within Next Generation Therapeutics are:

  • Novel pharmaceutical materials: polymers, porous solids and soft colloids
  • Nanomedicines and nanopharmaceutics
  • Peptide based pharmaceutics: novel anticancer, antimalarial and antimicrobial agents
  • Targeted anticancer pharmaceutics
  • New classes of antibiotics
  • Gene delivery and DNA-based therapeutics
  • Combinatorial chemistry and advanced synthetic approaches towards new medicines
  • Understanding structure and predicting properties of therapeutics

This theme is led by Professor Yaroslav Khimyak.

Dr Wafa Al-Jamal

Dr Wafa Al-Jamal

  • Multifunctional theranostics
  • Stimuli-responsive nanomaterials for biomedical applications
  • Smart viral and non-viral vectors for gene therapy

Dr Jesús Angulo

Dr Jesus Angulo

  • Biological NMR spectroscopy and molecular modelling: ligand screening of biological targets, structure and dynamics of receptor-ligand interactions; development of ligand based NMR techniques.
  • Biological molecular modelling: molecular dynamics and protein-ligand docking calculations applied to structural glycobiology and drug discovery.
  • Methodological improvement/development of ligand based NMR techniques ("on-cell" receptor-ligand interactions, virus-ligand studies; SSTD
  • NMR for kinetics of chemical exchange in organic molecules)
  • Carbohydrates in drug delivery. Polysaccharide-based hydrogels: structure, role of water in gelation, guest-hydrogel interactions

Dr László Fábián

Dr Laszlo Fabian

  • Design of multi-component solids, understanding and control of transformations between solid forms of drugs
  • Structural informatics and Molecular modelling of materials: using structural information to explain and design materials properties
  • Structural and physichochemical characterisation of pharmaceutical materials

Prof Ganesan

Prof Ganesan

  • Solution and solid-phase synthesis
  • Combinatorial chemistry
  • Lead discovery, optimization, and physiochemical properties of drug molecules

Dr Chris Hamilton

Dr Chris Hamilton

 

  • Chemical and biochemical functions of low molecular weight thiols in Gram positive bacteria.
  • Redox mechanisms of bioactive organosulfur metabolites from garlic
  • Mechanistic enzymology

Prof Yaroslav Khimyak

  • NMR elucidation of structure and dynamics of materials with limited long-range ordering and soft solids
  • Polymer based and amorphous pharmaceutical systems for drug delivery: understanding of intermolecular interactions
  • Porous solids, hydrogels and colloidal biomaterials

Dr Susan Matthews

Dr Susan Matthews

  • Development of small molecule antibiotics and antioxidants, and anti-adhesive antibiotics based on macrocyclic platforms
  • Gene delivery through functionalised multicalixarenes
  • Site-specific pro-drug systems for anti-cancer agents

Dr Paul McDermott

Dr Paul McDermott

  • Synthesis of Symplostatin 4 analogues for QSAR studies
  • Synthesis of Simocyclinone D8 analogues as potential antibiotics

Dr Chris Morris

  • Phage display identification and validation of cancer biomarkers
  • Experimental peptide therapeutics for skin cancer and lung infection
  • Triggered delivery systems for antibiotic delivery through lung mucus and biofilms

Prof Mark Searcey

Prof Mark Searcey

  • Design and synthesis of new anticancer, antimicrobial and anti-inflammatory agents
  • Targeting of cytotoxic drugs using proteins and antibodies
  • Development of peptides, proteins and polymers as therapeutic agents

Dr Sheng Qi

  • Emerging manufacturing processes for the fabrication of novel drug delivery systems and devices
  • Delivery strategies for poorly water-soluble drugs
  • Amorphous pharmaceuticals

Dr Andrew Round

  • Developing Sliding Contact Force Spectroscopy for mapping sequences in glycans and synthetic copolymers
  • Nanoscale approaches to understanding the mucus barrier in drug delivery
  • Studying drug-matrix interactions at the single molecule level

Dr Aram Saeed

  • Acellular 3D biomaterial matrices for use in cellular expansion (In vitro use)
  • 3D printing of complex cellular organisation and tissue-like patterns
  • Design, synthesis and characterisation of polymeric nanoparticulate drug delivery system and “Smart” nanomaterials with controlled-release features

Dr Zoë Waller

Dr Zoë Waller

  • Targeting alternative DNA structures with small molecule ligands/drugs
  • Development of new ligands to target genetic diseases
  • Using DNA as a drug-delivery agent