Office: CAP 2.49 Email: d.craig@uea.ac.uk Tel: +44 (0)1603-592023 School Position: Professor of Pharmaceutics

STUDENTSHIP AVAILABLE:  The Use of Novel Thermal Methods to Predict Drug Stability

Duncan Craig obtained a BPharm (Hons) University of Bath (1984) and went on to read for a PhD University of London (1989) in the area of drug dispersions in water-miscible polymers for drug delivery, with particular interest in developing novel thermal and dielectric techniques for physical characterisation. From 1988 to 1999 Duncan held a range of posts from Teaching and Research Assistant to Reader at the School of Pharmacy, University of London. In 1999 he moved to a Chair in Biophysical Pharmacy, School of Pharmacy, Queen's University Belfast and in 2003 became the Head of Pharmacy and Chair in Pharmaceutics, School of Chemical Sciences and Pharmacy, University of East Anglia. In 2009 he became the first Head of School for the newly founded School of Pharmacy.

His research involves the study of drug delivery systems, with particular emphasis on rational formulation by understand the underpinning physical properties of delivery systems in relation to performance. This work has involved the introduction of a number of physical analytical techniques into the pharmaceutical arena, including dielectric analysis, modulated temperature DSC and nanothermal analysis. More specifically, he has worked extensively in the areas of:

• characterising amorphous pharmaceutical materials, whereby new imaging and thermal techniques have been developed to quantify and map amorphous regions in otherwise crystalline samples
• developing drug dispersions in polymers as delivery systems, with particular recent emphasis on hot melt extruded systems
• understanding the relationship between formulation strategies and biological performance, with recent emphasis on developing startegies for the delivery of proteins and poorly soluble low molecular weight molecules to the gastrointestinal tract
   

Selected Publications

Physicochemical properties of the amorphous drug, cast films, and spray dried powders to predict formulation probability of success for solid dispersions: Etravirine.
Weuts, I., Van Dycke, F., Voorspoels, J., dr Cort, S., Stokbroekx, S., Leemans, R., Brewster, M., Xu, D., Segmuller, B., Tsz, A., Turner, A., Roberts, C.,J., Davies, M.C., Qi, S., Craig, D.Q.M., Reading, M.
J.Pharm.Sci., 100, 260-274 (2011) 
DOI: 10.1002/jps.22242

Characterization and quantification of amorphous material in milled and spray dried salbutamol sulfate: a comparison of thermal, spectroscopic and water vapour sorption approaches.
Grisedale, L.C., Matthew J. Jamieson,M.J., Peter S. Belton, P.S., Susan A. Barker, S.A. and Duncan Q.M. Craig, D.Q.M.
J.Pharm.Sci., 100, 3114-3129 (2011) 
DOI: 10.1002/jps.22484

Characterisation of the thermal properties of ethylcellulose using scanning and quasi isothermal calorimetric approaches.
Lai,H.L., Craig,D.Q.M. 
Int.J.Pharm., 386, 178-184 (2010)
DOI: 10.1016/j.ijpharm.2009.11.013

Ibuprofen-loaded poly(α-caprolactone) layered silicate nanocomposites prepared by hot melt extrusion.
Campbell,K., Craig,D.Q.M. and McNally, A.
J.Mat.Sci.: Mat.Med., 21, 2307-2316 (2010)

The use of dynamic vapour sorption methods for the characterisation of water uptake in amorphous trehalose.
Hunter, N.E., Frampton, C.S., Craig, D.Q.M. and Belton, P.B.
Carbohyd Res., 345, 1938-1944 (2010)
DOI: 10.1016/j.carres.2010.06.011