Natural Sciences faculty members Natural Sciences faculty members

Dr Stephen Ashworth - Head of Natural Sciences, Year in Industry and Year Abroad co-ordinator 

Stephen teaches modules in physics as part of the Natural Sciences Degree Programme and has supervised final year Natural Sciences projects.
See Stephen's full profile on the School of Chemistry website.

Dr Martin Loftus - Director of Learning & Teaching  

Martin teaches modules in astrophysics as part of the Natural Sciences Degree Programme and has supervised final year Natural Sciences projects in pulsars and galaxies.
See Martin's full profile on the School of Chemistry website.

Dr Mark Cooker - Natural Sciences Teaching Executive

Mark is a senior lecturer in the School of Mathematics. His research is in fluid dynamics, especially the mathematics of water wave impact and splashes. Mark lectures mathematicians and scientists in applied mathematics modules at all levels. He has also supervised project work in areas such as the diffusion of heat, acoustics, water-wave motion, liquid sloshing in containers, and impact.
See Mark's full profile on the School of Mathematics website.

Dr Steven Hayward and Dr Chris Greenman - Project co-ordinators

Steven graduated in Physics from the University of Bristol and gained a PhD in Molecular Biology from the University of Edinburgh.  His research focuses on protein structure, dynamics and function employing a variety of computational approaches including simulation and bioinformatics methods.  See Steven's full profile on the School of Computing Sciences website.

Chris has a mathematics degree from Durham University, and a mathematics PhD from the University of Edinburgh, utilizing number theory to study the spacing distributions of quantized harmonic oscillators.
See Chris's full profile on the School of Mathematics website.

Dr Adrian Matthews - Admissions Director

Adrian is a Professor of Meteorology and has a wide range of research interests, mainly in meteorology and oceanography with a focus on the tropics.  These include research into fundamental processes through observational data analysis and numerical modelling.

See Adrian's full profile on the School of Environmental Science website.

Dr Michael Wormstone - Coursework Director

Michael is a Senior Lecturer in the School of Biological Sciences. His research utilises human cells and tissue to study human eye disease. In particular, he is interested in wound-healing events that follow cataract surgery, which lead to a secondary visual loss. His laboratory aims to further our understanding of the cell and molecular mechanisms underpinning wound healing in the eye and identify novel targets for future therapeutic development.

See Michael's full profile on the School of Biological Sciences website.

Dr Garth Jones - Senior advisor & SSLC

Garth is a physical chemist who uses computational and theoretical techniques and is principally interested in excited state dynamics of molecules and light-molecule interactions. He develops mixed quantum-classical approaches to perform simulations of important processes in physical chemistry such as electron transfer, electronic energy transfer and photodissociation.
See Garth's full profile on the School of Chemistry website.

Dr Alex Baker - Year in Europe co-ordinator

Alex's research interests have developed into the fields of marine and atmospheric iodine biogeochemistry and the atmospheric transport of nutrients and trace metals and their impact on the marine carbon cycle. 
See Alex's full profile on the School of Environmental Science website.

Dr Susan Matthews - Pharmacy Research Projects Coordinator

Susan's research interests are at the interface of chemistry and biology focusing on the development of smart drug delivery systems.
See Sue's full profile on the School of Pharmacy website.

Dr Ben Milner - Natural Sciences Teaching Executive 

Ben teaches modules on sound and image processing and on electronics. He has supervised final year Natural Sciences projects on audio processing and in particular on estimating the fundamental frequency of musical instruments. 
See Ben's full profile on the School of Computing Sciences website.

Dr Tom Clarke - Chair of Exam Board

Tom teaches on modules in BIO and CHE as part of the biochemistry program and his research on mineral respiring bacteria covers multiple natural science disciplines including microbiology, chemistry and geology.
See Tom's full profile on the School of Biological Sciences website.

Career History

He has a mathematics degree from Durham University, and a mathematics PhD from the University of Edinburgh, utilizing number theory to study the spacing distributions of quantized harmonic oscillators. He was a lecturer at Bolton University Maths Department for five years, after which two years of mathematical consultancy in industry took place, examining problems varying from satellite positioning algorithms to machine learning approaches to drug discovery. He then spent seven years at the Sanger Institute, developing statistical and mathematical techniques required to analyse cancer genomic data. He then joined the School of Computing Sciences in 2011.

Research Opportunities

Enquiries are welcome (email me) from potential PhD students. He would be keen to recruit anyone interested in stochastic processes, statistical physics, combinatorics and/or their applications to population genetic, genome rearrangement, or evolutionary processes.

 

 

 

All Publications

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Fishwick, C., Higgins, J., Percival-Alwyn, L., Hustler, A., Pearson, J., Bastkowski, S., Moxon, S., Swarbreck, D., Greenman, C. D., Southgate, J.

(2017)

Heterarchy of transcription factors driving basal and luminal cell phenotypes in human urothelium,

in Cell Death and Differentiation

24

pp. 809-818

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(Article)

(Published)


Greenman, C.

(2017)

A Path Integral Approach to Age Dependent Branching Processes,

in Journal of Statistical Mechanics: Theory and Experiment

2017

(March)

article no. 033101

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(Article)

(Published)


Behjati, S., Gundem, G., Wedge, D. C., Roberts, N. D., Tarpey, P. S., Cooke, S. L., Van Loo, P., Alexandrov, L. B., Ramakrishna, M., Davies, H., Nik-Zainal, S., Hardy, C., Latimer, C., Raine, K. M., Stebbings, L., Menzies, A., Jones, D., Shepherd, R., Butler, A. P., Teague, J. W., Jorgensen, M., Khatri, B., Pillay, N., Shlien, A., Futreal, P. A., Badie, C., Cooper, C. S., Eeles, R. A., Easton, D., Foster, C., Neal, D. E., Brewer, D. S., Hamdy, F., Lu, Y., Lynch, A. G., Massi, C. E., Ng, A., Whitaker, H. C., Yu, Y., Zhang, H., Bancroft, E., Berney, D., Camacho, N., Corbishley, C., Dadaev, T., Dennis, N., Dudderidge, T., Edwards, S., Fisher, C., Ghori, J., Gnanapragasam, V. J., Greenman, C., Hawkins, S., Hazell, S., Howat, W., Karaszi, K., Kay, J., Kote-Jarai, Z., Kremeyer, B., Kumar, P., Lambert, A., Leongamornlert, D., Livni, N., Luxton, H., Matthews, L., Mayer, E., Merson, S., Nicol, D., Ogden, C., O’Meara, S., Pelvender, G., Shah, N. C., Tavare, S., Thomas, S., Thompson, A., Verrill, C., Warren, A., Zamora, J., McDermott, U., Bova, G. S., Richardson, A. L., Flanagan, A. M., Stratton, M. R., Campbell, P. J.

(2016)

Mutational signatures of ionizing radiation in second malignancies,

in Nature Communications

7

article no. 12605

Full Text UEA Repository

(Article)

(Published)


Chou, T., Greenman, C. D.

(2016)

A hierarchical kinetic theory of birth, death, and fission in age-structured interacting populations,

in Journal of Statistical Physics

164

(1)

pp. 49-76

Full Text UEA Repository

(Article)

(Published)


Beerenwenko, N., Greenman, C., Lagergren, J.

(2016)

Computational Cancer Biology: An Evolutionary Perspective,

in PLoS Computational Biology

12

(2)

article no. e1004717

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(Article)

(Published)


Greenman, C., Chou, T.

(2016)

Kinetic theory of age-structured stochastic birth-death processes,

in Physical Review E

93

(1)

article no. 012112

Full Text UEA Repository

(Article)

(Published)


Greenman, C., Cooke, S., Marshall, J., Stratton, M., Campbell, P.

(2016)

Modeling the evolution space of breakage fusion bridge cycles with a stochastic folding process,

in Journal of Mathematical Biology

72

(1)

pp. 47-86

Full Text UEA Repository

(Article)

(Published)


Chedom, D. F., Murcia, P. R., Greenman, C. D.

(2015)

Inferring the clonal structure of viral populations from time series sequencing,

in PLoS Computational Biology

11

(11)

article no. e1004344

Full Text UEA Repository

(Article)

(Published)


Penso-Dolfin, L., Wu, T., Greenman, C.

(2015)

The Combinatorics of Tandem Duplication,

in Discrete Applied Mathematics

194

pp. 1–22

Full Text UEA Repository

(Article)

(Published)


Kelly, S., Greenman, C., Cook, P. R., Papantonis, A.

(2015)

Exon skipping is correlated with exon circularization,

in Journal of Molecular Biology

427

(15)

pp. 2414-2417

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(Article)

(Published)


Cooper, C., Eeles, R. A., Wedge, D. C., Van loo, P., Gundem, G., Alexandrov, L., Kreymer, B., Butler, A., Lynch, A., Edwards, S. E., Camacho, N., Massie, C. E., Kote-Jarai, Z., Dennis, N., Merson, S., Leongamornlert, D. A., Zamora, J., Kay, J., Luxton, H. J., Corbishley, C., Thomas, S., Nik-zainal, S., O'Meara, S., Matthews, L., Clark, J., Hurst, R., Mithen (IFR), R., Bristow (Ontario Cancer Inst. CA), R., Boutros, P. C., Fraser, M., Cooke, S., Raine, K., Jones, D., Menzies, A., Stebbings, L., Hinton, J., Teague, J., Mclaren, S., Mudie, L., Hardy, C., Anderson, E., Joseph, O., Goody, V., Robinson, B., Maddison, M., Gamble, S., Greenman, C., Berney, D., Hazell, S., Livni, N., Fisher, C., Ogden, C., Kumar, P., Thompson, A., Woodhouse, C. J., Nicol, D., Mayer, E., Dudderidge, T., Shah, N., Gnanapragasam (Cambridge), V., Voet, T., Campbell, P., Futreal, P. A., Easton, D. F., Warren, A. Y., Foster, C. S., Stratton, M. R., Whitaker, H. C., Mcdermott, U., Brewer, D., Neal, D. E.

(2015)

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue,

in Nature Genetics

47

pp. 367–372

Full Text

(Letter)

(Published)


Roshan, A., Jones, P., Greenman, C.

(2014)

Exact, time-independent estimation of clone size distributions in normal and mutated cells,

in Journal of The Royal Society Interface

11

(99)

article no. 20140654

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(Article)

(Published)


Newman, S., Howarth, K. D., Greenman, C., Bignell, G. R., Tavaré, S., Edwards, P. A. W.

(2013)

The Relative Timing of Mutations in a Breast Cancer Genome,

in PLoS ONE

8

(6)

article no. e64991

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(Article)

(Published)


McBride, D. J., Etemadmoghadam, D., Cooke, S. L., Alsop, K., George, J., Butler, A., Cho, J., Galappaththige, D., Greenman, C., Howarth, K. D., Lau, K. W., Ng, C. K., Raine, K., Teague, J., Wedge, D. C., Caubit, X., Stratton, M. R., Brenton, J. D., Campbell, P. J., Futreal, P. A., Bowtell, D. D.

(2012)

Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes,

in The Journal of Pathology

227

(4)

pp. 446-455

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(Article)

(Published)


Greenman, C. D.

(2012)

Haploinsufficient Gene Selection in Cancer,

in Science

337

(6090)

pp. 47-48

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(Article)

(Published)


Stephens, P. J., Tarpey, P. S., Davies, H., Van Loo, P., Greenman, C., Wedge, D. C., Zainal, S. N., Martin, S., Varela, I., Bignell, G. R., Yates, L. R., Papaemmanuil, E., Beare, D., Butler, A., Cheverton, A., Gamble, J., Hinton, J., Jia, M., Jayakumar, A., Jones, D., Latimer, C., Lau, K. W., Mclaren, S., Mcbride, D. J., Menzies, A., Mudie, L., Raine, K., Rad, R., Spencer Chapman, M., Teague, J., Easton, D., Langerød, A., Lee, M. T. M., Shen, C., Tee, B. T. K., Huimin, B. W., Broeks, A., Vargas, A. C., Turashvili, G., Martens, J., Fatima, A., Miron, P., Chin, S., Thomas, G., Boyault, S., Mariani, O., Lakhani, S. R., Van De Vijver, M., Van ‘t Veer, L., Foekens, J., Desmedt, C., Sotiriou, C., Tutt, A., Caldas, C., Reis-Filho, J. S., Aparicio, S. A. J. R., Salomon, A. V., Børresen-Dale, A., Richardson, A., Campbell, P. J., Futreal, P. A., Stratton, M. R.

(2012)

The landscape of cancer genes and mutational processes in breast cancer,

in Nature

486

(7403)

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(Article)

(Published)


Nik-Zainal, S., Alexandrov, L., Wedge, D., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L., Menzies, A., Martin, S., Leung, K., Chen, L., Leroy, C., Ramakrishna, M., Rance, R., Lau, K., Mudie, L., Varela, I., McBride, D., Bignell, G., Cooke, S., Shlien, A., Gamble, J., Whitmore, I., Maddison, M., Tarpey, P., Davies, H., Papaemmanuil, E., Stephens, P., McLaren, S., Butler, A., Teague, J., Jönsson, G., Garber, J., Silver, D., Miron, P., Fatima, A., Boyault, S., Langerød, A., Tutt, A., Martens, J., Aparicio, S., Borg, Å., Salomon, A., Thomas, G., Børresen-Dale, A., Richardson, A., Neuberger, M., Futreal, P., Campbell, P., Stratton, M.

(2012)

Mutational Processes Molding the Genomes of 21 Breast Cancers,

in Cell

149

(5)

pp. 979-993

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Greenman, C. D., Pleasance, E. D., Newman, S., Yang, F., Fu, B., Nik-zainal, S., Jones, D., Lau, K. W., Carter, N., Edwards, P. A. W., Futreal, P. A., Stratton, M. R., Campbell, P. J.

(2012)

Estimation of rearrangement phylogeny for cancer genomes,

in Genome Research

22

(2)

pp. 346-361

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(Article)

(Published)


Greenman, C.

(2012)

Estimation of Rearrangement Phylogeny in Cancer,

in Genome Research

22

pp. 346-361

UEA Repository

(Article)

(Published)


Garnett, M. J., Edelman, E. J., Heidorn, S. J., Dastur, A., Lau, K. W., Greninger, P., Thompson, I. R., Luo, X., Soares, J., Liu, Q., Iorio, F., Surdez, D., Chen, L., Milano, R. J., Bignell, G. R., Tam, A. T., Davies, H., Stevenson, J. A., Barthorpe, S., Lutz, S. R., Kogera, F., Lawrence, K., Mclaren-douglas, A., Mitropoulos, X., Mironenko, T., Thi, H., Richardson, L., Zhou, W., Jewitt, F., Zhang, T., O’brien, P., Boisvert, J. L., Price, S., Hur, W., Yang, W., Deng, X., Butler, A., Choi, H. G., Chang, J. W., Baselga, J., Stamenkovic, I., Engelman, J. A., Sharma, S. V., Delattre, O., Saez-rodriguez, J., Gray, N. S., Settleman, J., Futreal, P. A., Haber, D. A., Stratton, M. R., Ramaswamy, S., Mcdermott, U., Benes, C. H., Greenman, C.

(2012)

Systematic identification of genomic markers of drug sensitivity in cancer cells,

in Nature

483

(7391)

pp. 570-575

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(Article)

(Published)


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Key Research Interests

Chris Greenman is part of the Computational Biology and the Machine Learning and Statistics research groups. Recent areas of interest include; the development of techniques from statistical physics applied to age-dependent branching processes, including (quantum) field theoretic methods, applications to cell populations and mutation processes, combinatorial approaches to counting and representing genomic rearrangement processes, cancer and viral evolutionary processes.  

Selected Recent Papers:

  • Greenman C D, Second quantization approaches for stochastic age-structured birth-death processes, http://arxiv.org/abs/1512.05431, 2016.

  • Greenman C D and Chou T, Kinetic theory of age-structured stochastic birth-death processes, Phys. Rev. E 93, 012112, 2016.

  • Penso-Dolfin L, Wu T, Greenman C D, The Combinatorics of Tandem Duplication, Discrete Applied Mathematics, 194, pp. 1–22, 2015.

  • Chedom D F, Murcia P R, Greenman C D, Inferring the Clonal Structure of Viral Populations from Time Series Sequencing, PLoS Computational Biology, 11, 2015.

 

Teaching Interests

Advanced Statistics, Computing Principles, Natural Science Project Coordinator.