Biography

Dr. Yoon K Loke is Senior Lecturer in Clinical Pharmacology at the University of East Anglia, and Co-Convenor of the Cochrane Adverse Effects Methods Group. He has extensive experience in conducting systematic reviews of adverse effects, and is the lead author of Chapter 14 in the Cochrane Handbook of Systematic Reviews. His main interests are in assessing harmful effects from drugs such as the proton pump inhibitors, thiazolidinediones, and inhalers for airway disease. He also serves as Chair of the NIHR HTA Elective and Emergency Specialist Care Panel, and European Editor for the British Journal of Clinical Pharmacology.

Dr. Loke’s main interest is on how systematic review methodology can be used to answer clinically relevant questions on the adverse effects of medication.

Career History

Clinical Lecturer in Clinical Pharmacology & Therapeutics, University of Oxford 1997-2003

Research interests

  • Systematic reviews and meta-analysis
  • Adverse effects
  • Indirect comparisons

Research

I am a co-convenor of the Cochrane Adverse Effects Methods Group, and my special interest is in developing methods for evaluating data on adverse effects.  

Selected publications

  1. Singh S, Loke YK, Enright PL, Furberg CD. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials. BMJ. 2011 Jun 14;342:d3215. doi: 10.1136/bmj.d3215.
  2. Golder S, Loke YK, Bland M. Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview. PLoS Med. 2011;8(5)
  3. Loke YK, Kwok CS, Singh S. Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ. 2011;342:d1309
  4. Loke YK, Singh S, Furberg CD. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ. 2009;180(1):32-9.
  5. Song F, Loke YK, Walsh T, Glenny AM, Eastwood AJ, Altman DG. Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews. BMJ. 2009;338:b1147. doi:10.1136/bmj.b114
  6. Singh S, Amin AV, Loke YK. Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis. Arch Intern Med 2009:169: 219-229.
  7. Singh S, Loke YK, Furberg CD. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2008;300(12):1439-50.
  8. Singh S, Loke YK, Furberg CD. Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis JAMA 2007;298: 1189-95
  9. Loke YK, Price D, Derry S, Aronson JK. Case reports of suspected adverse drug reactions--systematic literature survey of follow-up. BMJ 2006;332:335-9.
  10. Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 2000;321:1183-7

Academic Background

  • MBBS (London) 1990
  • MRCP (UK) 1993
  • Certificate of Completion of Specialist Training (Clinical Pharmacology and General Internal Medicine), 2001
  • MD (London) 2003

All Publications

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Loke, Y.

(2015)

Single dose piroxicam in acute postoperative pain: a quantitative systematic review (Cochrane Review)

In: The Cochrame Library, Issue 4.

Oxford: Update Software

UEA Repository

(Chapter)


Yates, M., Loke, Y. K., Watts, R. A., Macgregor, A. J.

(2014)

Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis : meta-analysis

in Clinical rheumatology

33.

pp. 227-236

Full Text UEA Repository

(Article)


Song, F., Hooper, L., Loke, Y.

(2013)

Publication bias: what is it? How do we measure it? How do we avoid it?

in Open Access Journal of Clinical Trials

2013.

pp. 71-81

Full Text UEA Repository

(Article)


Isa, A., Loke, Y., Smith, J., Papageorgiou, A., Hunter, P.

(2013)

Mediational effects of self-efficiacy dimensions in the relationship between knowledge of dengue and dengue preventative behaviour with respect to control of dengue outbreaks: A structural quation model of a cross-sectional survey

in PLoS Neglected Tropical Diseases

UEA Repository

(Article)


Beales, I. L. P., Hensley, A., Loke, Y.

(2013)

Reduced esophageal cancer incidence in statin users, particularly with cyclo-oxygenase inhibition

in World journal of gastrointestinal pharmacology and therapeutics

4.

pp. 69-79

Full Text UEA Repository

(Article)


Xiong, T., Parekh-Bhurke, S., Loke, Y. K., Abdelhamid, A., Sutton, A. J., Eastwood, A. J., Holland, R., Chen, Y., Walsh, T., Glenny, A., Song, F., Quality Assurance, Health Care

(2013)

Overall similarity and consistency assessment scores are not sufficiently accurate for predicting discrepancy between direct and indirect comparison estimates

in Journal of Clinical Epidemiology

66.

pp. 184-91

Full Text UEA Repository

(Article)


Jennings, B. A., Loke, Y. K., Skinner, J., Keane, M., Chu, G. S., Turner, R., Epurescu, D., Barrett, A., Willis, G.

(2013)

Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines

in PLoS ONE

8.

pp. e78053

Full Text UEA Repository

(Article)


White, J. R., Bettencourt-Silva, J. H., Potter, J. F., Loke, Y. K., Myint, P. K.

(2013)

Changes in antiplatelet use prior to incident ischaemic stroke over 7 years in a UK centre and the association with stroke subtype

in Age and Ageing

42.

pp. 594-8

Full Text UEA Repository

(Article)


Kwok, C. S., Jeevanantham, V., Dawn, B., Loke, Y. K.

(2013)

No consistent evidence of differential cardiovascular risk amongst proton-pump inhibitors when used with clopidogrel : meta-analysis

in International journal of cardiology

167.

pp. 965-74

Full Text UEA Repository

(Article)


Abdelhamid, A., Loke, Y., Parekh, S., Chen, Y., Sutton, A., Eastwood, A., Holland, R., Song, F.

(2012)

Use of indirect comparison methods in systematic reviews: a survey of Cochrane review authors

in Research Synthesis Methods

Full Text UEA Repository

(Article)


Loke, Y., Hinz, I., Wang, X., Rowlands, G., Scott, D., Salter, C.

(2012)

Impact of health literacy in patients with chronic musculoskeletal disease--systematic review

in PLoS ONE

7.

pp. e40210

Full Text UEA Repository

(Article)


Loke, Y., Hinz, I., Wang, X., Salter, C., Diabetes Mellitus, Type 2

(2012)

Systematic review of consistency between adherence to cardiovascular or diabetes medication and health literacy in older adults

in The Annals of Pharmacotherapy

46.

pp. 863-872

Full Text UEA Repository

(Article)


Myint, P. K., Kwok, C. S., Majumdar, S. R., Eurich, D. T., Clark, A. B., España, P. P., Man, S. Y., Huang, D. T., Yealy, D. M., Angus, D. C., Capelastegui, A., Rainer, T. H., Marrie, T. J., Fine, M. J., Loke, Y. K.

(2012)

The International Community-Acquired Pneumonia (CAP) Collaboration Cohort (ICCC) study : rationale, design and description of study cohorts and patients

in BMJ Open

2.

Full Text UEA Repository

(Article)


Loke, Y. K., Brown, J. W. L., Kwok, C. S., Niruban, A., Myint, P. K., Sleep Apnea, Obstructive

(2012)

Association of obstructive sleep apnea with risk of serious cardiovascular events : a systematic review and meta-analysis

in Circulation. Cardiovascular quality and outcomes

5.

pp. 720-8

Full Text UEA Repository

(Article)


Kwok, C. S., Arthur, A. K., Anibueze, C. I., Singh, S., Cavallazzi, R., Loke, Y. K., Enterocolitis, Pseudomembranous

(2012)

Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics : meta-analysis

in The American Journal of Gastroenterology

107.

pp. 1011-9

Full Text UEA Repository

(Article)


Jennings, B. A., Kwok, C. S., Willis, G., Matthews, V., Wawruch, P., Loke, Y. K., Databases, Genetic, Gene Expression Regulation, Neoplastic

(2012)

Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis

in Pharmacogenetics and genomics

22.

pp. 290-304

Full Text UEA Repository

(Article)


Loke, Y. K., Data Interpretation, Statistical, Models, Biological, Pharmacology, Clinical

(2012)

Adverse drug reactions

in British Journal of Clinical Pharmacology

73.

pp. 908-11

Full Text UEA Repository

(Article)


Kwok, C. S., Loke, Y. K.

(2012)

Inconsistencies surrounding the risk of adverse outcomes with concomitant use of clopidogrel and proton pump inhibitors

in Expert opinion on drug safety

11.

pp. 275-84

Full Text UEA Repository

(Article)


Kwok, C. S., Loke, Y. K.

(2012)

Effects of proton pump inhibitors on platelet function in patients receiving clopidogrel : a systematic review

in Drug safety : an international journal of medical toxicology and drug experience

35.

pp. 127-39

Full Text UEA Repository

(Article)


Kwok, C. S., Yeong, J. K., Turner, R. M., Cavallazzi, R., Singh, S., Loke, Y. K., Anti-Inflammatory Agents, Non-Steroidal

(2012)

Statins and associated risk of pneumonia : a systematic review and meta-analysis of observational studies

in European Journal of Clinical Pharmacology

68.

pp. 747-55

Full Text UEA Repository

(Article)


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Teaching Interests

My current teaching activity is aimed at the improving the prescribing skills of medical students. I was awarded a UEA Teaching Fellowship 2004 for work on reducing prescribing errors.

I am a member of the British Pharmacological Society, and have worked on the society funded project that resulted in a publication of a systematic review on educational interventions for teaching prescribing in medical students.


 

External Activities and Indicators of Esteem

  • European Editor, British Journal of Clinical Pharmacology (2008 - ongoing)
  • Co-convenor Cochrane Adverse Effects Methods Group (2007 - ongoing)
  • Bruce Squires Award from the CMAJ for the Best Research Paper of the Year; Singh S, Loke YK, Spangler JG, Furberg CD. Risk of serious adverse cardiovascular events with Varenicline- A Systematic Review and Meta-Analysis of Randomized Controlled Trials. CMAJ 2011; 1831359-66. (2013)
  • Chair of the NIHR HTA Elective and Emergency Specialist Care Panel (2013 - ongoing)

Administrative Posts

  • Module 13 (Emergency Care) Lead for Year 5 Medical Students.
  • Theme Lead for Clinical Pharmacology