Biography

Dr. Yoon K Loke is Senior Lecturer in Clinical Pharmacology at the University of East Anglia, and Co-Convenor of the Cochrane Adverse Effects Methods Group. He has extensive experience in conducting systematic reviews of adverse effects, and is the lead author of Chapter 14 in the Cochrane Handbook of Systematic Reviews. His main interests are in assessing harmful effects from drugs such as the proton pump inhibitors, thiazolidinediones, and inhalers for airway disease. He also serves as Chair of the NIHR HTA Elective and Emergency Specialist Care Panel, and European Editor for the British Journal of Clinical Pharmacology.

Dr. Loke’s main interest is on how systematic review methodology can be used to answer clinically relevant questions on the adverse effects of medication.

Career History

Clinical Lecturer in Clinical Pharmacology & Therapeutics, University of Oxford 1997-2003

Research interests

  • Systematic reviews and meta-analysis
  • Adverse effects
  • Indirect comparisons

Research

I am a co-convenor of the Cochrane Adverse Effects Methods Group, and my special interest is in developing methods for evaluating data on adverse effects.  

Selected publications

  1. Singh S, Loke YK, Enright PL, Furberg CD. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials. BMJ. 2011 Jun 14;342:d3215. doi: 10.1136/bmj.d3215.
  2. Golder S, Loke YK, Bland M. Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview. PLoS Med. 2011;8(5)
  3. Loke YK, Kwok CS, Singh S. Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ. 2011;342:d1309
  4. Loke YK, Singh S, Furberg CD. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ. 2009;180(1):32-9.
  5. Song F, Loke YK, Walsh T, Glenny AM, Eastwood AJ, Altman DG. Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews. BMJ. 2009;338:b1147. doi:10.1136/bmj.b114
  6. Singh S, Amin AV, Loke YK. Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis. Arch Intern Med 2009:169: 219-229.
  7. Singh S, Loke YK, Furberg CD. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2008;300(12):1439-50.
  8. Singh S, Loke YK, Furberg CD. Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis JAMA 2007;298: 1189-95
  9. Loke YK, Price D, Derry S, Aronson JK. Case reports of suspected adverse drug reactions--systematic literature survey of follow-up. BMJ 2006;332:335-9.
  10. Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 2000;321:1183-7

Academic Background

  • MBBS (London) 1990
  • MRCP (UK) 1993
  • Certificate of Completion of Specialist Training (Clinical Pharmacology and General Internal Medicine), 2001
  • MD (London) 2003

Highlighted Publications

See All

Singh, S., Loke, Y., Spangler, J., Furberg, C.

(2011)

Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis,

in CMAJ

183.

pp. 1359-1366

UEA Repository

(Article)

(Published)


Loke, Y., Cavallazzi, R., Singh, S.

(2011)

Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies,

in Thorax

66.

pp. 699-708

UEA Repository

(Article)

(Published)


Golder, S., Loke, Y., Bland, M.

(2011)

Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview,

in PLoS Medicine

8.

Full Text UEA Repository

(Article)

(Published)


Loke, Y., Kwok, C., Singh, S.

(2011)

Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies,

in British Medical Journal (BMJ)

342.

pp. d1309

UEA Repository

(Article)

(Published)


Singh, S., Loke, Y., Enright, P., Furberg, C.

(2011)

Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials,

in British Medical Journal (BMJ)

342.

pp. d3215-d3215

Full Text UEA Repository

(Article)

(Published)


Singh, S., Amin, A., Loke, Y.

(2009)

Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis,

in Archives of Internal Medicine

169.

pp. 219-229

Full Text UEA Repository

(Article)

(Published)


Singh, S., Loke, Y., Furberg, C.

(2008)

Inhaled anticholonergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis,

in JAMA: The Journal of the American Medical Association

300.

pp. 1439-1450

Full Text UEA Repository

(Article)

(Published)


Singh, S., Loke, Y., Furberg, C.

(2007)

Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis,

in JAMA: The Journal of the American Medical Association

298.

pp. 1189-1195

Full Text UEA Repository

(Article)

(Published)


All Publications

See Highlights
<- Page 1 of 9 ->

Loke, Y. K., Mattishent, K.

(2017)

Strengths and limitations of healthcare databases in the evaluation of hypoglycaemia,

in Diabetes, Obesity & Metabolism

19

(10)

pp. 1337–1338

Full Text UEA Repository

(Article)

(Published)


Golder, S., Wright, K., Loke, Y. K.

(2017)

The feasibility of a search filter for the adverse effects of non-drug interventions in MEDLINE and Embase,

in Research Synthesis Methods

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Godinho, M. M., Junqueira, D. R., Castro, M. L., Loke, Y., Golder, S., Neto, H. P.

(2017)

Safety of transcranial direct current stimulation: Evidence based update 2016,

in Brain Stimulation

10

(5)

pp. 983-985

Full Text

(Comment/debate)

(Published)


Chan, W. Y., Clark, A. B., Wilson, A. M., Loke, Y. K.

(2017)

The effect of co-trimoxazole on serum potassium concentration: safety evaluation of a randomized controlled trial,

in British Journal of Clinical Pharmacology

83

(8)

pp. 1808–1814

Full Text UEA Repository

(Article)

(Published)


Thomas, T., Loke, Y., Beales, I. L. P.

(2017)

Systematic Review and Meta-analysis: Use of Statins Is Associated with a Reduced Incidence of Oesophageal Adenocarcinoma,

in Journal of Gastrointestinal Cancer

Full Text UEA Repository

(Article)

(Published)


Cooney, L., Loke, Y. K., Golder, S., Kirkham, J., Jorgensen, A., Sinha, I., Hawcutt, D.

(2017)

Overview of systematic reviews of therapeutic ranges: methodologies and recommendations for practice,

in BMC Medical Research Methodology

17

article no. 84

Full Text UEA Repository

(Article)

(Published)


Ring, A., Schall, R., Loke, Y. K., Day, S.

(2017)

Statistical reporting of clinical pharmacology research,

in British Journal of Clinical Pharmacology

83

(6)

pp. 1159–1162

Full Text

(Editorial)

(Published)


Peryer, G., Minns Lowe, C., Loke, Y., Sackley, C.

(2017)

Standard operating procedures for managing adverse events in trials that do not involve an investigational medicinal product: a protocol for a Delphi consensus study,

Full Text

(Abstract)

(Published)


Peel, A. M., Crossman-Barnes, C., Tang, J., Fowler, S., Davies, G., Wilson, A., Loke, Y.

(2017)

Biomarkers in adult asthma: a systematic review of 8-isoprostane in exhaled breath condensate,

in Journal of Breath Research

11

(1)

article no. 016011

Full Text UEA Repository

(Article)

(Published)


Thirumala, P. D., Crammond, D. J., Loke, Y. K., Cheng, H. L., Huang, J., Balzer, J. R.

(2017)

Diagnostic accuracy of motor evoked potentials to detect neurological deficit during idiopathic scoliosis correction: a systematic review,

in Journal of Neurosurgery: Spine

26

(3)

pp. 374-383

Full Text UEA Repository

(Article)

(Published)


Myint, P. K., Bachmann, M. O., Loke, Y. K., Musgrave, S. D., Price, G. M., Hale, R., Metcalf, A. K., Turner, D. A., Day, D. J., Warburton, E. A., Potter, J. F.

(2017)

Important factors in predicting mortality outcome from stroke: findings from the Anglia Stroke Clinical Network Evaluation Study,

in Age and Ageing

46

(1)

pp. 83-90

Full Text UEA Repository

(Article)

(Published)


Thirumala, P. D., Carnovale, G., Loke, Y., Habeych, M. E., Crammond, D. J., Balzer, J. R., Sekula, R. F.

(2017)

Brainstem Auditory Evoked Potentials' Diagnostic Accuracy for Hearing Loss: Systematic Review and Meta-Analysis,

in Journal of Neurological Surgery Part B

78

(01)

pp. 043-051

Full Text UEA Repository

(Article)

(Published)


Sterne, J. A., Hernán, M. A., Reeves, B. C., Savović, J., Berkman, N. D., Viswanathan, M., Henry, D., Altman, D. G., Ansari, M. T., Boutron, I., Carpenter, J. R., Chan, A., Churchill, R., Deeks, J. J., Hróbjartsson, A., Kirkham, J., Jüni, P., Loke, Y. K., Pigott, T. D., Ramsay, C. R., Regidor, D., Rothstein, H. R., Sandhu, L., Santaguida, P. L., Schünemann, H. J., Shea, B., Shrier, I., Tugwell, P., Turner, L., Valentine, J. C., Waddington, H., Waters, E., Wells, G. A., Whiting, P. F., Higgins, J. P.

(2016)

ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions,

in BMJ

355

article no. i4919

Full Text UEA Repository

(Article)

(Published)


Mannu, G. S., Honney, K., Spooner, R., Clark, A. B., Bettencourt-Silva, J. H., Zaman, M. J. S., Loke, Y. K., Myint, P. K.

(2016)

Incidentally raised cardiac Troponin I has a worse prognosis in older patients compared to those with normal cardiac Troponin I and patients with Acute Coronary Syndrome: A Cohort Study,

in Gerontology

32

(6)

pp. 581-587

Full Text UEA Repository

(Article)

(Published)


Golder, S., Loke, Y. K., Wright, K., Norman, G.

(2016)

Reporting of adverse events in published and unpublished studies of health care interventions: A systematic review,

in PLoS Medicine

13

(9)

article no. e1002127

Full Text UEA Repository

(Article)

(Published)


Golder, S., Loke, Y. K., Wright, K., Sterrantino, C.

(2016)

Most systematic reviews of adverse effects did not include unpublished data,

in Journal of Clinical Epidemiology

77

pp. 125–133

Full Text UEA Repository

(Article)

(Published)


Abdelhamid, A., Loke, Y., Abubakar, I., Song, F.

(2016)

Antibiotics for eradicating meningococcal carriages: Network meta-analysis and investigation of evidence inconsistency,

in World Journal of Meta-Analysis

4

(4)

pp. 77-87

Full Text UEA Repository

(Article)

(Published)


Kwok, C. S., Tiong, D., Pradhan, A., Andreou, A. Y., Nolan, J., Bertrand, O. F., Curzen, N., Urban, P., Myint, P. K., Zaman, A. G., Loke, Y. K., Mamas, M. A.

(2016)

Meta-Analysis of the Prognostic Impact of Anemia in Patients Undergoing Percutaneous Coronary Intervention,

in The American Journal of Cardiology

118

(4)

pp. 610–620

Full Text

(Literature review)

(Published)


Kwok, C. S., Loke, Y. K., Welch, A. A., Luben, R. N., Lentjes, M. A., Boekholdt, S. M., Pfister, R., Mamas, M. A., Wareham, N. J., Khaw, K., Myint, P. K.

(2016)

Habitual chocolate consumption and the risk of incident heart failure among healthy men and women,

in Nutrition, Metabolism and Cardiovascular Diseases

26

(8)

pp. 722-734

Full Text UEA Repository

(Article)

(Published)


<- Page 1 of 9 ->

Teaching Interests

My current teaching activity is aimed at the improving the prescribing skills of medical students. I was awarded a UEA Teaching Fellowship 2004 for work on reducing prescribing errors.

I am a member of the British Pharmacological Society, and have worked on the society funded project that resulted in a publication of a systematic review on educational interventions for teaching prescribing in medical students.


 

External Activities and Indicators of Esteem

  • European Editor, British Journal of Clinical Pharmacology (2008 - ongoing)
  • Co-convenor Cochrane Adverse Effects Methods Group (2007 - ongoing)
  • Bruce Squires Award from the CMAJ for the Best Research Paper of the Year; Singh S, Loke YK, Spangler JG, Furberg CD. Risk of serious adverse cardiovascular events with Varenicline- A Systematic Review and Meta-Analysis of Randomized Controlled Trials. CMAJ 2011; 1831359-66. (2013)
  • Chair of the NIHR HTA Elective and Emergency Specialist Care Panel (2013 - ongoing)

Administrative Posts

  • Module 13 (Emergency Care) Lead for Year 5 Medical Students.
  • Theme Lead for Clinical Pharmacology