Biography

Dr. Yoon K Loke is Senior Lecturer in Clinical Pharmacology at the University of East Anglia, and Co-Convenor of the Cochrane Adverse Effects Methods Group. He has extensive experience in conducting systematic reviews of adverse effects, and is the lead author of Chapter 14 in the Cochrane Handbook of Systematic Reviews. His main interests are in assessing harmful effects from drugs such as the proton pump inhibitors, thiazolidinediones, and inhalers for airway disease. He also serves as Chair of the NIHR HTA Elective and Emergency Specialist Care Panel, and European Editor for the British Journal of Clinical Pharmacology.

Dr. Loke’s main interest is on how systematic review methodology can be used to answer clinically relevant questions on the adverse effects of medication.

Career History

Clinical Lecturer in Clinical Pharmacology & Therapeutics, University of Oxford 1997-2003

Research interests

  • Systematic reviews and meta-analysis
  • Adverse effects
  • Indirect comparisons

Research

I am a co-convenor of the Cochrane Adverse Effects Methods Group, and my special interest is in developing methods for evaluating data on adverse effects.  

Selected publications

  1. Singh S, Loke YK, Enright PL, Furberg CD. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials. BMJ. 2011 Jun 14;342:d3215. doi: 10.1136/bmj.d3215.
  2. Golder S, Loke YK, Bland M. Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview. PLoS Med. 2011;8(5)
  3. Loke YK, Kwok CS, Singh S. Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ. 2011;342:d1309
  4. Loke YK, Singh S, Furberg CD. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ. 2009;180(1):32-9.
  5. Song F, Loke YK, Walsh T, Glenny AM, Eastwood AJ, Altman DG. Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews. BMJ. 2009;338:b1147. doi:10.1136/bmj.b114
  6. Singh S, Amin AV, Loke YK. Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis. Arch Intern Med 2009:169: 219-229.
  7. Singh S, Loke YK, Furberg CD. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2008;300(12):1439-50.
  8. Singh S, Loke YK, Furberg CD. Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis JAMA 2007;298: 1189-95
  9. Loke YK, Price D, Derry S, Aronson JK. Case reports of suspected adverse drug reactions--systematic literature survey of follow-up. BMJ 2006;332:335-9.
  10. Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 2000;321:1183-7

Academic Background

  • MBBS (London) 1990
  • MRCP (UK) 1993
  • Certificate of Completion of Specialist Training (Clinical Pharmacology and General Internal Medicine), 2001
  • MD (London) 2003

Highlighted Publications

See All

Singh, S., Loke, Y., Enright, P., Furberg, C.

(2011)

Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials

Full Text UEA Repository

(Article)


Loke, Y., Kwok, C., Singh, S.

(2011)

Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies

UEA Repository

(Article)


Golder, S., Loke, Y., Bland, M.

(2011)

Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview

Full Text UEA Repository

(Article)


Loke, Y., Cavallazzi, R., Singh, S.

(2011)

Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies

UEA Repository

(Article)


Singh, S., Loke, Y., Spangler, J., Furberg, C.

(2011)

Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis

UEA Repository

(Article)


Singh, S., Amin, A., Loke, Y.

(2009)

Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis

Full Text UEA Repository

(Article)


Singh, S., Loke, Y., Furberg, C.

(2008)

Inhaled anticholonergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

Full Text UEA Repository

(Article)


Singh, S., Loke, Y., Furberg, C.

(2007)

Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis

Full Text UEA Repository

(Article)


All Publications

See Highlights
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Thirumala, P. D., Carnovale, G., Loke, Y., Habeych, M. E., Crammond, D. J., Balzer, J. R., Sekula, R. F.

(2017)

Brainstem Auditory Evoked Potentials' Diagnostic Accuracy for Hearing Loss: Systematic Review and Meta-Analysis

Full Text UEA Repository

(Article)


Myint, P. K., Bachmann, M. O., Loke, Y. K., Musgrave, S. D., Price, G. M., Hale, R., Metcalf, A. K., Turner, D. A., Day, D. J., Warburton, E. A., Potter, J. F.

(2017)

Important factors in predicting mortality outcome from stroke: findings from the Anglia Stroke Clinical Network Evaluation Study

Full Text UEA Repository

(Article)


Mattishent, K., Loke, Y. K.

(2016)

Bi-directional interaction between hypoglycaemia and cognitive impairment in elderly patients treated with glucose-lowering agents: a systematic review and meta-analysis

Full Text UEA Repository

(Article)


Bulluck, H., Sirker, A., Loke, Y. K., Garcia-Dorado, D., Hausenloy, D. J.

(2016)

Clinical benefit of adenosine as an adjunct to reperfusion in ST-elevation myocardial infarction patients: An updated meta-analysis of randomized controlled trials

Full Text UEA Repository

(Article)


Beales, I., Dearman, L., Vardi, I., Loke, Y.

(2016)

Reduced risk of Barrett’s esophagus in statin users: case–control study and meta-analysis

Full Text UEA Repository

(Article)


Mattishent, K., Kwok, C. S., Mahtani, A., Pelpola, K., Myint, P. K., Loke, Y. K.

(2016)

Prognostic indices for early mortality in ischaemic stroke – meta-analysis

Full Text UEA Repository

(Article)


de Boer, A., Cohen, A., Ferro, A., Flockhart, D., Gilchrist, A., Isbister, G., Loke, Y., Ross, S., Somogyi, A., Webb, A.

(2016)

Editors' report for 2015, December 2015

Full Text

(Abstract)


Thirumala, P. D., Muralidharan, A., Loke, Y. K., Habeych, M., Crammond, D., Balzer, J.

(2016)

Value of intraoperative neurophysiological monitoring to reduce neurological complications in patients undergoing anterior cervical spine procedures for cervical spondylotic myelopathy

Full Text

(Literature review)


Kwok, C. S., Loke, Y. K., Welch, A. A., Luben, R. N., Lentjes, M. A., Boekholdt, S. M., Pfister, R., Mamas, M. A., Wareham, N. J., Khaw, K., Myint, P. K.

(2016)

Habitual chocolate consumption and the risk of incident heart failure among healthy men and women

Full Text UEA Repository

(Article)


Loke, Y. K.

(2016)

The thorough QT study - do we need more of the same?

Full Text

(Editorial)


Kwok, C. S., Rashid, M., Beynon, R., Barker, D., Patwala, A., Morley-davies, A., Satchithananda, D., Nolan, J., Myint, P. K., Buchan, I., Loke, Y. K., Mamas, M. A.

(2016)

Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis

Full Text UEA Repository

(Article)


Mattishent, K., Loke, Y. K.

(2016)

Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients

Full Text UEA Repository

(Article)


Thirumala, P. D., Cheng, H. L., Loke, Y. K., Kojo Hamilton, D., Balzer, J., Crammond, D. J.

(2016)

Diagnostic accuracy of somatosensory evoked potential monitoring during scoliosis fusion

Full Text UEA Repository

(Article)


Brainard, J., Loke, Y., Salter, C., Koos, T., Csizmadia, P., Makai, A., Gacs, B., Szepes, M.

(2016)

Healthy ageing in Europe: prioritizing interventions to improve health literacy

Full Text UEA Repository

(Article)


Mannu, G. S., Honney, K., Spooner, R., Clark, A. B., Bettencourt-Silva, J. H., Zaman, M. J. S., Loke, Y. K., Myint, P. K.

(2016)

Incidentally raised cardiac Troponin I has a worse prognosis in older patients compared to those with normal cardiac Troponin I and patients with Acute Coronary Syndrome: A Cohort Study

Full Text UEA Repository

(Article)


Golder, S., Loke, Y. K., Wright, K., Sterrantino, C.

(2016)

Most systematic reviews of adverse effects did not include unpublished data

Full Text UEA Repository

(Article)


Kwok, C. S., Tiong, D., Pradhan, A., Andreou, A. Y., Nolan, J., Bertrand, O. F., Curzen, N., Urban, P., Myint, P. K., Zaman, A. G., Loke, Y. K., Mamas, M. A.

(2016)

Meta-Analysis of the Prognostic Impact of Anemia in Patients Undergoing Percutaneous Coronary Intervention

Full Text

(Literature review)


Loke, Y., Mattishent, K.

(2016)

How to appraise clinical trials: Commissioned clinical review

Full Text

(Commissioned report)


Brainard, J., Howard Wilsher, S., Salter, C., Loke, Y. K.

(2016)

Methodological review: quality of randomized controlled trials in health literacy

Full Text UEA Repository

(Article)


Killeen, T., Skinner, J., Loke, Y., Jennings, B.

(2016)

Student Selected Components - a modern curriculum to complement a systems-based medical degree

Full Text UEA Repository

(Article)


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Teaching Interests

My current teaching activity is aimed at the improving the prescribing skills of medical students. I was awarded a UEA Teaching Fellowship 2004 for work on reducing prescribing errors.

I am a member of the British Pharmacological Society, and have worked on the society funded project that resulted in a publication of a systematic review on educational interventions for teaching prescribing in medical students.


 

External Activities and Indicators of Esteem

  • European Editor, British Journal of Clinical Pharmacology (2008 - ongoing)
  • Co-convenor Cochrane Adverse Effects Methods Group (2007 - ongoing)
  • Bruce Squires Award from the CMAJ for the Best Research Paper of the Year; Singh S, Loke YK, Spangler JG, Furberg CD. Risk of serious adverse cardiovascular events with Varenicline- A Systematic Review and Meta-Analysis of Randomized Controlled Trials. CMAJ 2011; 1831359-66. (2013)
  • Chair of the NIHR HTA Elective and Emergency Specialist Care Panel (2013 - ongoing)

Administrative Posts

  • Module 13 (Emergency Care) Lead for Year 5 Medical Students.
  • Theme Lead for Clinical Pharmacology