Biography

Dr. Yoon K Loke is Senior Lecturer in Clinical Pharmacology at the University of East Anglia, and Co-Convenor of the Cochrane Adverse Effects Methods Group. He has extensive experience in conducting systematic reviews of adverse effects, and is the lead author of Chapter 14 in the Cochrane Handbook of Systematic Reviews. His main interests are in assessing harmful effects from drugs such as the proton pump inhibitors, thiazolidinediones, and inhalers for airway disease. He also serves as Chair of the NIHR HTA Elective and Emergency Specialist Care Panel, and European Editor for the British Journal of Clinical Pharmacology.

Dr. Loke’s main interest is on how systematic review methodology can be used to answer clinically relevant questions on the adverse effects of medication.

Career History

Clinical Lecturer in Clinical Pharmacology & Therapeutics, University of Oxford 1997-2003

Research interests

  • Systematic reviews and meta-analysis
  • Adverse effects
  • Indirect comparisons

Research

I am a co-convenor of the Cochrane Adverse Effects Methods Group, and my special interest is in developing methods for evaluating data on adverse effects.  

Selected publications

  1. Singh S, Loke YK, Enright PL, Furberg CD. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials. BMJ. 2011 Jun 14;342:d3215. doi: 10.1136/bmj.d3215.
  2. Golder S, Loke YK, Bland M. Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview. PLoS Med. 2011;8(5)
  3. Loke YK, Kwok CS, Singh S. Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ. 2011;342:d1309
  4. Loke YK, Singh S, Furberg CD. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ. 2009;180(1):32-9.
  5. Song F, Loke YK, Walsh T, Glenny AM, Eastwood AJ, Altman DG. Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews. BMJ. 2009;338:b1147. doi:10.1136/bmj.b114
  6. Singh S, Amin AV, Loke YK. Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis. Arch Intern Med 2009:169: 219-229.
  7. Singh S, Loke YK, Furberg CD. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2008;300(12):1439-50.
  8. Singh S, Loke YK, Furberg CD. Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis JAMA 2007;298: 1189-95
  9. Loke YK, Price D, Derry S, Aronson JK. Case reports of suspected adverse drug reactions--systematic literature survey of follow-up. BMJ 2006;332:335-9.
  10. Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 2000;321:1183-7

Academic Background

  • MBBS (London) 1990
  • MRCP (UK) 1993
  • Certificate of Completion of Specialist Training (Clinical Pharmacology and General Internal Medicine), 2001
  • MD (London) 2003

Highlighted Publications

See All

Singh, S., Loke, Y., Spangler, J., Furberg, C.

(2011)

Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis,

in CMAJ

183.

pp. 1359-1366

UEA Repository

(Article)

(Published)


Loke, Y., Cavallazzi, R., Singh, S.

(2011)

Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies,

in Thorax

66.

pp. 699-708

UEA Repository

(Article)

(Published)


Golder, S., Loke, Y., Bland, M.

(2011)

Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview,

in PLoS Medicine

8.

Full Text UEA Repository

(Article)

(Published)


Loke, Y., Kwok, C., Singh, S.

(2011)

Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies,

in British Medical Journal (BMJ)

342.

pp. d1309

UEA Repository

(Article)

(Published)


Singh, S., Loke, Y., Enright, P., Furberg, C.

(2011)

Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials,

in British Medical Journal (BMJ)

342.

pp. d3215-d3215

Full Text UEA Repository

(Article)

(Published)


Singh, S., Amin, A., Loke, Y.

(2009)

Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis,

in Archives of Internal Medicine

169.

pp. 219-229

Full Text UEA Repository

(Article)

(Published)


Singh, S., Loke, Y., Furberg, C.

(2008)

Inhaled anticholonergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis,

in JAMA: The Journal of the American Medical Association

300.

pp. 1439-1450

Full Text UEA Repository

(Article)

(Published)


Singh, S., Loke, Y., Furberg, C.

(2007)

Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis,

in JAMA: The Journal of the American Medical Association

298.

pp. 1189-1195

Full Text UEA Repository

(Article)

(Published)


All Publications

See Highlights
<- Page 1 of 9 ->

Thirumala, P. D., Carnovale, G., Loke, Y., Habeych, M. E., Crammond, D. J., Balzer, J. R., Sekula, R. F.

(2017)

Brainstem Auditory Evoked Potentials' Diagnostic Accuracy for Hearing Loss: Systematic Review and Meta-Analysis,

in Journal of Neurological Surgery Part B

78

(01)

pp. 043-051

Full Text UEA Repository

(Article)

(Published)


Myint, P. K., Bachmann, M. O., Loke, Y. K., Musgrave, S. D., Price, G. M., Hale, R., Metcalf, A. K., Turner, D. A., Day, D. J., Warburton, E. A., Potter, J. F.

(2017)

Important factors in predicting mortality outcome from stroke: findings from the Anglia Stroke Clinical Network Evaluation Study,

in Age and Ageing

46

(1)

pp. 83-90

Full Text UEA Repository

(Article)

(Published)


Peel, A. M., Crossman-Barnes, C., Tang, J., Fowler, S., Davies, G., Wilson, A., Loke, Y.

(2017)

Biomarkers in adult asthma: a systematic review of 8-isoprostane in exhaled breath condensate,

in Journal of Breath Research

11

(1)

article no. 016011

Full Text UEA Repository

(Article)

(Published)


Thirumala, P. D., Crammond, D. J., Loke, Y. K., Cheng, H. L., Huang, J., Balzer, J. R.

(2017)

Diagnostic accuracy of motor evoked potentials to detect neurological deficit during idiopathic scoliosis correction: a systematic review,

in Journal of Neurosurgery: Spine

26

(3)

pp. 374-383

Full Text UEA Repository

(Article)

(Published)


Chan, W. Y., Clark, A. B., Wilson, A. M., Loke, Y. K.

(2017)

The effect of co-trimoxazole on serum potassium concentration: safety evaluation of a randomized controlled trial,

in British Journal of Clinical Pharmacology

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Ring, A., Schall, R., Loke, Y. K., Day, S.

(2017)

Statistical reporting of clinical pharmacology research,

in British Journal of Clinical Pharmacology

83

(6)

pp. 1159–1162

Full Text

(Editorial)

(E-pub ahead of print)


Loke, Y. K., Mattishent, K.

(2017)

Strengths and Limitations of Healthcare Databases in the Evaluation of Hypoglycaemia,

in Diabetes, Obesity & Metabolism

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Peryer, G., Minns Lowe, C., Loke, Y., Sackley, C.

(2017)

Standard operating procedures for managing adverse events in trials that do not involve an investigational medicinal product: a protocol for a Delphi consensus study,

Full Text

(Abstract)

(Published)


Mattishent, K., Loke, Y. K.

(2016)

Bi-directional interaction between hypoglycaemia and cognitive impairment in elderly patients treated with glucose-lowering agents: a systematic review and meta-analysis,

in Diabetes, Obesity & Metabolism

18

(2)

pp. 135–141

Full Text UEA Repository

(Article)

(Published)


Bulluck, H., Sirker, A., Loke, Y. K., Garcia-Dorado, D., Hausenloy, D. J.

(2016)

Clinical benefit of adenosine as an adjunct to reperfusion in ST-elevation myocardial infarction patients: An updated meta-analysis of randomized controlled trials,

in International Journal of Cardiology

202

pp. 228-237

Full Text UEA Repository

(Article)

(Published)


Beales, I., Dearman, L., Vardi, I., Loke, Y.

(2016)

Reduced risk of Barrett’s esophagus in statin users: case–control study and meta-analysis,

in Digestive Diseases and Sciences

61

(1)

pp. 238-246

Full Text UEA Repository

(Article)

(Published)


Mattishent, K., Kwok, C. S., Mahtani, A., Pelpola, K., Myint, P. K., Loke, Y. K.

(2016)

Prognostic indices for early mortality in ischaemic stroke – meta-analysis,

in Acta Neurologica Scandinavica

133

(1)

pp. 41-48

Full Text UEA Repository

(Article)

(Published)


de Boer, A., Cohen, A., Ferro, A., Flockhart, D., Gilchrist, A., Isbister, G., Loke, Y., Ross, S., Somogyi, A., Webb, A.

(2016)

Editors' report for 2015, December 2015,

in British Journal of Clinical Pharmacology

81

(1)

pp. 6-7

Full Text

(Abstract)

(Published)


Thirumala, P. D., Muralidharan, A., Loke, Y. K., Habeych, M., Crammond, D., Balzer, J.

(2016)

Value of intraoperative neurophysiological monitoring to reduce neurological complications in patients undergoing anterior cervical spine procedures for cervical spondylotic myelopathy,

in Journal of Clinical Neuroscience

25

pp. 27-35

Full Text

(Literature review)

(Published)


Kwok, C. S., Loke, Y. K., Welch, A. A., Luben, R. N., Lentjes, M. A., Boekholdt, S. M., Pfister, R., Mamas, M. A., Wareham, N. J., Khaw, K., Myint, P. K.

(2016)

Habitual chocolate consumption and the risk of incident heart failure among healthy men and women,

in Nutrition, Metabolism and Cardiovascular Diseases

26

(8)

pp. 722-734

Full Text UEA Repository

(Article)

(Published)


Loke, Y. K.

(2016)

The thorough QT study - do we need more of the same?,

in British Journal of Clinical Pharmacology

81

(3)

pp. 400-401

Full Text

(Editorial)

(Published)


Kwok, C. S., Rashid, M., Beynon, R., Barker, D., Patwala, A., Morley-davies, A., Satchithananda, D., Nolan, J., Myint, P. K., Buchan, I., Loke, Y. K., Mamas, M. A.

(2016)

Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis,

in Heart

102

(9)

pp. 672-680

Full Text UEA Repository

(Article)

(Published)


Mattishent, K., Loke, Y. K.

(2016)

Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients,

in Journal of Diabetes and its Complications

30

(5)

pp. 811-818

Full Text UEA Repository

(Article)

(Published)


Thirumala, P. D., Cheng, H. L., Loke, Y. K., Kojo Hamilton, D., Balzer, J., Crammond, D. J.

(2016)

Diagnostic accuracy of somatosensory evoked potential monitoring during scoliosis fusion,

in Journal of Clinical Neuroscience

30

pp. 8–14

Full Text UEA Repository

(Article)

(Published)


Brainard, J., Loke, Y., Salter, C., Koos, T., Csizmadia, P., Makai, A., Gacs, B., Szepes, M.

(2016)

Healthy ageing in Europe: prioritizing interventions to improve health literacy,

in BMC Research Notes

9

article no. 270

Full Text UEA Repository

(Article)

(Published)


<- Page 1 of 9 ->

Teaching Interests

My current teaching activity is aimed at the improving the prescribing skills of medical students. I was awarded a UEA Teaching Fellowship 2004 for work on reducing prescribing errors.

I am a member of the British Pharmacological Society, and have worked on the society funded project that resulted in a publication of a systematic review on educational interventions for teaching prescribing in medical students.


 

External Activities and Indicators of Esteem

  • European Editor, British Journal of Clinical Pharmacology (2008 - ongoing)
  • Co-convenor Cochrane Adverse Effects Methods Group (2007 - ongoing)
  • Bruce Squires Award from the CMAJ for the Best Research Paper of the Year; Singh S, Loke YK, Spangler JG, Furberg CD. Risk of serious adverse cardiovascular events with Varenicline- A Systematic Review and Meta-Analysis of Randomized Controlled Trials. CMAJ 2011; 1831359-66. (2013)
  • Chair of the NIHR HTA Elective and Emergency Specialist Care Panel (2013 - ongoing)

Administrative Posts

  • Module 13 (Emergency Care) Lead for Year 5 Medical Students.
  • Theme Lead for Clinical Pharmacology