Biography

Dr. Yoon K Loke is Senior Lecturer in Clinical Pharmacology at the University of East Anglia, and Co-Convenor of the Cochrane Adverse Effects Methods Group. He has extensive experience in conducting systematic reviews of adverse effects, and is the lead author of Chapter 14 in the Cochrane Handbook of Systematic Reviews. His main interests are in assessing harmful effects from drugs such as the proton pump inhibitors, thiazolidinediones, and inhalers for airway disease. He also serves as Chair of the NIHR HTA Elective and Emergency Specialist Care Panel, and European Editor for the British Journal of Clinical Pharmacology.

Dr. Loke’s main interest is on how systematic review methodology can be used to answer clinically relevant questions on the adverse effects of medication.

Career History

Clinical Lecturer in Clinical Pharmacology & Therapeutics, University of Oxford 1997-2003

Research interests

  • Systematic reviews and meta-analysis
  • Adverse effects
  • Indirect comparisons

Research

I am a co-convenor of the Cochrane Adverse Effects Methods Group, and my special interest is in developing methods for evaluating data on adverse effects.  

Selected publications

  1. Singh S, Loke YK, Enright PL, Furberg CD. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials. BMJ. 2011 Jun 14;342:d3215. doi: 10.1136/bmj.d3215.
  2. Golder S, Loke YK, Bland M. Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview. PLoS Med. 2011;8(5)
  3. Loke YK, Kwok CS, Singh S. Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ. 2011;342:d1309
  4. Loke YK, Singh S, Furberg CD. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ. 2009;180(1):32-9.
  5. Song F, Loke YK, Walsh T, Glenny AM, Eastwood AJ, Altman DG. Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews. BMJ. 2009;338:b1147. doi:10.1136/bmj.b114
  6. Singh S, Amin AV, Loke YK. Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis. Arch Intern Med 2009:169: 219-229.
  7. Singh S, Loke YK, Furberg CD. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2008;300(12):1439-50.
  8. Singh S, Loke YK, Furberg CD. Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis JAMA 2007;298: 1189-95
  9. Loke YK, Price D, Derry S, Aronson JK. Case reports of suspected adverse drug reactions--systematic literature survey of follow-up. BMJ 2006;332:335-9.
  10. Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 2000;321:1183-7

Academic Background

  • MBBS (London) 1990
  • MRCP (UK) 1993
  • Certificate of Completion of Specialist Training (Clinical Pharmacology and General Internal Medicine), 2001
  • MD (London) 2003

Highlighted Publications

See All

Singh, S., Loke, Y., Spangler, J., Furberg, C.

(2011)

Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis

in CMAJ

183.

pp. 1359-1366

UEA Repository

(Article)


Loke, Y., Cavallazzi, R., Singh, S.

(2011)

Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies

in Thorax

66.

pp. 699-708

UEA Repository

(Article)


Golder, S., Loke, Y., Bland, M.

(2011)

Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview

in PLoS Medicine

8.

Full Text UEA Repository

(Article)


Loke, Y., Kwok, C., Singh, S.

(2011)

Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies

in British Medical Journal (BMJ)

342.

pp. d1309

UEA Repository

(Article)


Singh, S., Loke, Y., Enright, P., Furberg, C.

(2011)

Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials

in British Medical Journal (BMJ)

342.

pp. d3215-d3215

Full Text UEA Repository

(Article)


Singh, S., Amin, A., Loke, Y.

(2009)

Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis

in Archives of Internal Medicine

169.

pp. 219-229

Full Text UEA Repository

(Article)


Singh, S., Loke, Y., Furberg, C.

(2008)

Inhaled anticholonergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

in JAMA

300.

pp. 1439-1450

Full Text UEA Repository

(Article)


Singh, S., Loke, Y., Furberg, C.

(2007)

Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis

in JAMA

298.

pp. 1189-1195

Full Text UEA Repository

(Article)


All Publications

See Highlights
<- Page 1 of 7 ->

Mattishent, K., Loke, Y. K.

(2016)

Bi-directional interaction between hypoglycaemia and cognitive impairment in elderly patients treated with glucose-lowering agents: a systematic review and meta-analysis

in Diabetes, Obesity & Metabolism

18.

pp. 135–141

Full Text UEA Repository

(Article)


Bulluck, H., Sirker, A., Loke, Y. K., Garcia-Dorado, D., Hausenloy, D. J.

(2016)

Clinical benefit of adenosine as an adjunct to reperfusion in ST-elevation myocardial infarction patients: An updated meta-analysis of randomized controlled trials

in International Journal of Cardiology

202.

pp. 228-237

Full Text UEA Repository

(Article)


Geboers, B., Brainard, J., Loke, Y., Jansen, C. J., Salter, C., Reijneveld, S. A., de Winter, A. F.

(2015)

The association of health literacy with adherence in older 2 adults, and its role in interventions: a systematic meta-review

in BMC Public Health

15.

Full Text UEA Repository

(Article)


Brainard, J., Salter, C., Howard Wilsher, S., Loke, Y.

(2015)

Healthy Ageing in Europe: Prioritizing Interventions to improve Health Literacy

UEA Repository

(Paper)


Jennings, B. A., Shakespeare, T., Loke, Y. K.

(2015)

Scanning the human genome and the horizon: the potential and pitfalls of pharmacogenetics and stratified medicine

in British Journal of General Practice

65.

pp. 284 -285

Full Text

(Editorial)


Bulluck, H., Kwok, C. S., Ryding, A. D., Loke, Y. K.

(2015)

Safety of short-term dual antiplatelet therapy after drug-eluting stents: An updated meta-analysis with direct and adjusted indirect comparison of randomized control trials

in International Journal of Cardiology

181.

pp. 331-339

Full Text UEA Repository

(Article)


Golder, S., Norman, G., Loke, Y. K.

(2015)

Systematic review on the prevalence, frequency and comparative value of adverse events data in social media

in British Journal of Clinical Pharmacology

80.

pp. 878-888

Full Text UEA Repository

(Article)


Gorst, C., Kwok, C. S., Aslam, S., Buchan, I., Kontopantelis, E., Myint, P. K., Heatlie, G., Loke, Y., Rutter, M. K., Mamas, M. A.

(2015)

Long-term glycemic variability and risk of adverse outcomes: a systematic review and meta-analysis

in Diabetes Care

38.

pp. 2354-2369

UEA Repository

(Article)


Kok, K., Loke, Y., Southgate, J.

(2015)

Upper gastrointestinal bleed associated with cholinesterase inhibitor use

in BMJ Case Reports

Full Text UEA Repository

(Article)


Kwok, C. S., Boekholdt, S. M., Lentjes, M. A. H., Loke, Y. K., Luben, R. N., Yeong, J. K., Wareham, N. J., Myint, P. K., Khaw, K.

(2015)

Habitual chocolate consumption and risk of cardiovascular disease among healthy men and women

in Heart

101.

pp. 1279-1287

Full Text UEA Repository

(Article)


Kwok, C. S., Khan, M. A., Rao, S. V., Kinnaird, T., Sperrin, M., Buchan, I., de Belder, M. A., Ludman, P. F., Nolan, J., Loke, Y. K., Mamas, M. A.

(2015)

Access and non–access site bleeding after percutaneous coronary intervention and risk of subsequent mortality and major adverse cardiovascular events: Systematic review and meta-analysis

in Circulation: Cardiovascular Interventions

Full Text UEA Repository

(Article)


Kwok, C. S., Shoamanesh, A., Copley, H. C., Myint, P. K., Loke, Y. K., Benavente, O. R.

(2015)

Efficacy of antiplatelet therapy in secondary prevention following lacunar stroke: Pooled analysis of randomized trials

in Stroke

46.

pp. 1014-1023

Full Text UEA Repository

(Article)


Loke, Y. K., Blanco, P., Thavarajah, M., Wilson, A. M.

(2015)

Impact of inhaled corticosteroids on growth in children with asthma: systematic review and meta-analysis

in PLoS ONE

10.

Full Text UEA Repository

(Article)


Loke, Y. K., Gilbert, D., Thavarajah, M., Blanco, P., Wilson, A. M.

(2015)

Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis

in BMJ Open

5.

Full Text UEA Repository

(Article)


Schmucker, C. M., Rücker, G., Sommer, H., Virgili, G., Loke, Y. K., Oeller, P., Agostini, H., Ehlken, C.

(2015)

Treatment as required versus regular monthly treatment in the management of neovascular age-related macular degeneration: a systematic review and meta-analysis

in PLoS ONE

10.

Full Text UEA Repository

(Article)


Geboers, B., Brainard, J. S., Loke, Y. K., Jansen, C. J. M., Salter, C., Reijneveld, S. A., de Winter, A. F.

(2015)

Erratum to: The association of health literacy with adherence in older adults, and its role in interventions: a systematic meta-review

in BMC Public Health

15.

Full Text UEA Repository

(Article)


Yates, M., Loke, Y. K., Watts, R. A., Macgregor, A. J.

(2014)

Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis

in Clinical Rheumatology

33.

pp. 227-236

Full Text UEA Repository

(Article)


Golder, S., Loke, Y. K., Zorzela, L.

(2014)

Comparison of search strategies in systematic reviews of adverse effects to other systematic reviews

in Health Information and Libraries Journal

31.

pp. 92-105

Full Text UEA Repository

(Article)


Bellis, J. R., Pirmohamed, M., Nunn, A. J., Loke, Y. K., De, S., Golder, S., Kirkham, J. J.

(2014)

Dexamethasone and haemorrhage risk in paediatric tonsillectomy: a systematic review and meta-analysis

in British Journal of Anaesthesia

113.

pp. 23-42

Full Text UEA Repository

(Article)


Kwok, C. S., Bulluck, H., Ryding, A. D., Loke, Y. K.

(2014)

Benefits and harms of extending the duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stents: a meta-analysis

in The Scientific World Journal

2014.

Full Text UEA Repository

(Article)


<- Page 1 of 7 ->

Teaching Interests

My current teaching activity is aimed at the improving the prescribing skills of medical students. I was awarded a UEA Teaching Fellowship 2004 for work on reducing prescribing errors.

I am a member of the British Pharmacological Society, and have worked on the society funded project that resulted in a publication of a systematic review on educational interventions for teaching prescribing in medical students.


 

External Activities and Indicators of Esteem

  • European Editor, British Journal of Clinical Pharmacology (2008 - ongoing)
  • Co-convenor Cochrane Adverse Effects Methods Group (2007 - ongoing)
  • Bruce Squires Award from the CMAJ for the Best Research Paper of the Year; Singh S, Loke YK, Spangler JG, Furberg CD. Risk of serious adverse cardiovascular events with Varenicline- A Systematic Review and Meta-Analysis of Randomized Controlled Trials. CMAJ 2011; 1831359-66. (2013)
  • Chair of the NIHR HTA Elective and Emergency Specialist Care Panel (2013 - ongoing)

Administrative Posts

  • Module 13 (Emergency Care) Lead for Year 5 Medical Students.
  • Theme Lead for Clinical Pharmacology