Biography

Dr. Yoon K Loke is Senior Lecturer in Clinical Pharmacology at the University of East Anglia, and Co-Convenor of the Cochrane Adverse Effects Methods Group. He has extensive experience in conducting systematic reviews of adverse effects, and is the lead author of Chapter 14 in the Cochrane Handbook of Systematic Reviews. His main interests are in assessing harmful effects from drugs such as the proton pump inhibitors, thiazolidinediones, and inhalers for airway disease. He also serves as Chair of the NIHR HTA Elective and Emergency Specialist Care Panel, and European Editor for the British Journal of Clinical Pharmacology.

Dr. Loke’s main interest is on how systematic review methodology can be used to answer clinically relevant questions on the adverse effects of medication.

Career History

Clinical Lecturer in Clinical Pharmacology & Therapeutics, University of Oxford 1997-2003

Research interests

  • Systematic reviews and meta-analysis
  • Adverse effects
  • Indirect comparisons

Research

I am a co-convenor of the Cochrane Adverse Effects Methods Group, and my special interest is in developing methods for evaluating data on adverse effects.  

Selected publications

  1. Singh S, Loke YK, Enright PL, Furberg CD. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials. BMJ. 2011 Jun 14;342:d3215. doi: 10.1136/bmj.d3215.
  2. Golder S, Loke YK, Bland M. Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview. PLoS Med. 2011;8(5)
  3. Loke YK, Kwok CS, Singh S. Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ. 2011;342:d1309
  4. Loke YK, Singh S, Furberg CD. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ. 2009;180(1):32-9.
  5. Song F, Loke YK, Walsh T, Glenny AM, Eastwood AJ, Altman DG. Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews. BMJ. 2009;338:b1147. doi:10.1136/bmj.b114
  6. Singh S, Amin AV, Loke YK. Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis. Arch Intern Med 2009:169: 219-229.
  7. Singh S, Loke YK, Furberg CD. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2008;300(12):1439-50.
  8. Singh S, Loke YK, Furberg CD. Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis JAMA 2007;298: 1189-95
  9. Loke YK, Price D, Derry S, Aronson JK. Case reports of suspected adverse drug reactions--systematic literature survey of follow-up. BMJ 2006;332:335-9.
  10. Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 2000;321:1183-7

Academic Background

  • MBBS (London) 1990
  • MRCP (UK) 1993
  • Certificate of Completion of Specialist Training (Clinical Pharmacology and General Internal Medicine), 2001
  • MD (London) 2003

Highlighted Publications

See All

Singh, S., Loke, Y., Spangler, J., Furberg, C.

(2011)

Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis

in CMAJ

183.

pp. 1359-1366

UEA Repository

(Article)


Loke, Y., Cavallazzi, R., Singh, S.

(2011)

Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies

in Thorax

66.

pp. 699-708

UEA Repository

(Article)


Golder, S., Loke, Y., Bland, M.

(2011)

Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview

in PLoS Medicine

8.

Full Text UEA Repository

(Article)


Loke, Y., Kwok, C., Singh, S.

(2011)

Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies

in British Medical Journal (BMJ)

342.

pp. d1309

UEA Repository

(Article)


Singh, S., Loke, Y., Enright, P., Furberg, C.

(2011)

Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials

in British Medical Journal (BMJ)

342.

pp. d3215-d3215

Full Text UEA Repository

(Article)


Singh, S., Amin, A., Loke, Y.

(2009)

Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis

in Archives of Internal Medicine

169.

pp. 219-229

Full Text UEA Repository

(Article)


Singh, S., Loke, Y., Furberg, C.

(2008)

Inhaled anticholonergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

in JAMA

300.

pp. 1439-1450

Full Text UEA Repository

(Article)


Singh, S., Loke, Y., Furberg, C.

(2007)

Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis

in JAMA

298.

pp. 1189-1195

Full Text UEA Repository

(Article)


All Publications

See Highlights
<- Page 1 of 8 ->

Mattishent, K., Loke, Y. K.

(2016)

Bi-directional interaction between hypoglycaemia and cognitive impairment in elderly patients treated with glucose-lowering agents: a systematic review and meta-analysis

in Diabetes, Obesity & Metabolism

18.

pp. 135–141

Full Text UEA Repository

(Article)


Bulluck, H., Sirker, A., Loke, Y. K., Garcia-Dorado, D., Hausenloy, D. J.

(2016)

Clinical benefit of adenosine as an adjunct to reperfusion in ST-elevation myocardial infarction patients: An updated meta-analysis of randomized controlled trials

in International Journal of Cardiology

202.

pp. 228-237

Full Text UEA Repository

(Article)


Beales, I., Dearman, L., Vardi, I., Loke, Y.

(2016)

Reduced risk of Barrett’s esophagus in statin users: case–control study and meta-analysis

in Digestive Diseases and Sciences

61.

pp. 238-246

Full Text UEA Repository

(Article)


Mattishent, K., Kwok, C. S., Mahtani, A., Pelpola, K., Myint, P. K., Loke, Y. K.

(2016)

Prognostic indices for early mortality in ischaemic stroke – meta-analysis

in Acta Neurologica Scandinavica

133.

pp. 41-48

Full Text UEA Repository

(Article)


Thirumala, P. D., Muralidharan, A., Loke, Y. K., Habeych, M., Crammond, D., Balzer, J.

(2016)

Value of intraoperative neurophysiological monitoring to reduce neurological complications in patients undergoing anterior cervical spine procedures for cervical spondylotic myelopathy

in Journal of Clinical Neuroscience

25.

pp. 27-35

Full Text

(Scientific review)


Kwok, C. S., Loke, Y. K., Welch, A. A., Luben, R. N., Lentjes, M. A., Boekholdt, S. M., Pfister, R., Mamas, M. A., Wareham, N. J., Khaw, K., Myint, P. K.

(2016)

Habitual chocolate consumption and the risk of incident heart failure among healthy men and women

in Nutrition, Metabolism and Cardiovascular Diseases

26.

pp. 722-734

Full Text UEA Repository

(Article)


Loke, Y. K.

(2016)

The thorough QT study - do we need more of the same?

in British Journal of Clinical Pharmacology

81.

pp. 400-401

Full Text

(Editorial)


Kwok, C. S., Rashid, M., Beynon, R., Barker, D., Patwala, A., Morley-davies, A., Satchithananda, D., Nolan, J., Myint, P. K., Buchan, I., Loke, Y. K., Mamas, M. A.

(2016)

Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis

in Heart

102.

pp. 672-680

Full Text UEA Repository

(Article)


Mattishent, K., Loke, Y. K.

(2016)

Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients

in Journal of Diabetes and its Complications

30.

pp. 811-818

Full Text UEA Repository

(Article)


Thirumala, P. D., Cheng, H. L., Loke, Y. K., Kojo Hamilton, D., Balzer, J., Crammond, D. J.

(2016)

Diagnostic accuracy of somatosensory evoked potential monitoring during scoliosis fusion

in Journal of Clinical Neuroscience

30.

pp. 8–14

Full Text UEA Repository

(Article)


Brainard, J., Loke, Y., Salter, C., Koos, T., Csizmadia, P., Makai, A., Gacs, B., Szepes, M.

(2016)

Healthy ageing in Europe: prioritizing interventions to improve health literacy

in BMC Research Notes

9.

Full Text UEA Repository

(Article)


Mannu, G. S., Honney, K., Spooner, R., Clark, A. B., Bettencourt-Silva, J. H., Zaman, M. J. S., Loke, Y. K., Myint, P. K.

(2016)

Incidentally raised cardiac Troponin I has a worse prognosis in older patients compared to those with normal cardiac Troponin I and patients with Acute Coronary Syndrome: A Cohort Study

in Gerontology

32.

pp. 581-587

Full Text UEA Repository

(Article)


Kwok, C. S., Tiong, D., Pradhan, A., Andreou, A. Y., Nolan, J., Bertrand, O. F., Curzen, N., Urban, P., Myint, P. K., Zaman, A. G., Loke, Y. K., Mamas, M. A.

(2016)

Meta-Analysis of the Prognostic Impact of Anemia in Patients Undergoing Percutaneous Coronary Intervention

in The American Journal of Cardiology

118.

pp. 610–620

Full Text

(Scientific review)


Loke, Y., Mattishent, K.

(2016)

How to appraise clinical trials: Commissioned clinical review

Elsevier

Full Text

(Commissioned report)


Thirumala, P. D., Carnovale, G., Loke, Y., Habeych, M. E., Crammond, D. J., Balzer, J. R., Sekula, R. F.

(2016)

Brainstem Auditory Evoked Potentials' Diagnostic Accuracy for Hearing Loss: Systematic Review and Meta-Analysis

in Journal of Neurological Surgery Part B

Full Text UEA Repository

(Article)


Brainard, J., Howard Wilsher, S., Salter, C., Loke, Y. K.

(2016)

Methodological review: quality of randomized controlled trials in health literacy

in BMC Health Services Research

16.

Full Text UEA Repository

(Article)


Killeen, T., Skinner, J., Loke, Y., Jennings, B.

(2016)

Student Selected Components - a modern curriculum to complement a systems-based medical degree

in MedEdPublish

5.

Full Text UEA Repository

(Article)


Barlas, R. S., Honney, K., Loke, Y. K., McCall, S. J., Bettencourt-Silva, J. H., Clark, A. B., Bowles, K. M., Metcalfe, A. K., Mamas, M. A., Potter, J. F., Myint, P. K.

(2016)

Impact of hemoglobin levels and anemia on mortality in acute stroke: analysis of UK regional registry data, systematic review and meta-analysis

in Journal of the American Heart Association

5.

Full Text UEA Repository

(Article)


Geboers, B., Brainard, J., Loke, Y., Jansen, C. J., Salter, C., Reijneveld, S. A., de Winter, A. F.

(2015)

The association of health literacy with adherence in older 2 adults, and its role in interventions: a systematic meta-review

in BMC Public Health

15.

Full Text UEA Repository

(Article)


<- Page 1 of 8 ->

External Activities and Indicators of Esteem

  • European Editor, British Journal of Clinical Pharmacology (2008 - ongoing)
  • Co-convenor Cochrane Adverse Effects Methods Group (2007 - ongoing)
  • Bruce Squires Award from the CMAJ for the Best Research Paper of the Year; Singh S, Loke YK, Spangler JG, Furberg CD. Risk of serious adverse cardiovascular events with Varenicline- A Systematic Review and Meta-Analysis of Randomized Controlled Trials. CMAJ 2011; 1831359-66. (2013)
  • Chair of the NIHR HTA Elective and Emergency Specialist Care Panel (2013 - ongoing)

Administrative Posts

  • Module 13 (Emergency Care) Lead for Year 5 Medical Students.
  • Theme Lead for Clinical Pharmacology