Biography

Dr. Yoon K Loke is Senior Lecturer in Clinical Pharmacology at the University of East Anglia, and Co-Convenor of the Cochrane Adverse Effects Methods Group. He has extensive experience in conducting systematic reviews of adverse effects, and is the lead author of Chapter 14 in the Cochrane Handbook of Systematic Reviews. His main interests are in assessing harmful effects from drugs such as the proton pump inhibitors, thiazolidinediones, and inhalers for airway disease. He also serves as Chair of the NIHR HTA Elective and Emergency Specialist Care Panel, and European Editor for the British Journal of Clinical Pharmacology.

Dr. Loke’s main interest is on how systematic review methodology can be used to answer clinically relevant questions on the adverse effects of medication.

Career History

Clinical Lecturer in Clinical Pharmacology & Therapeutics, University of Oxford 1997-2003

Research interests

  • Systematic reviews and meta-analysis
  • Adverse effects
  • Indirect comparisons

Research

I am a co-convenor of the Cochrane Adverse Effects Methods Group, and my special interest is in developing methods for evaluating data on adverse effects.  

Selected publications

  1. Singh S, Loke YK, Enright PL, Furberg CD. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials. BMJ. 2011 Jun 14;342:d3215. doi: 10.1136/bmj.d3215.
  2. Golder S, Loke YK, Bland M. Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview. PLoS Med. 2011;8(5)
  3. Loke YK, Kwok CS, Singh S. Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ. 2011;342:d1309
  4. Loke YK, Singh S, Furberg CD. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ. 2009;180(1):32-9.
  5. Song F, Loke YK, Walsh T, Glenny AM, Eastwood AJ, Altman DG. Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews. BMJ. 2009;338:b1147. doi:10.1136/bmj.b114
  6. Singh S, Amin AV, Loke YK. Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis. Arch Intern Med 2009:169: 219-229.
  7. Singh S, Loke YK, Furberg CD. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2008;300(12):1439-50.
  8. Singh S, Loke YK, Furberg CD. Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis JAMA 2007;298: 1189-95
  9. Loke YK, Price D, Derry S, Aronson JK. Case reports of suspected adverse drug reactions--systematic literature survey of follow-up. BMJ 2006;332:335-9.
  10. Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 2000;321:1183-7

Academic Background

  • MBBS (London) 1990
  • MRCP (UK) 1993
  • Certificate of Completion of Specialist Training (Clinical Pharmacology and General Internal Medicine), 2001
  • MD (London) 2003

Highlighted Publications

See All
<- Page 1 of 6 ->

Yates, M., Loke, Y. K., Watts, R. A., Macgregor, A. J.

(2014)

Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis : meta-analysis

in Clinical rheumatology

33.

pp. 227-236

Full Text UEA Repository

(Article)


Golder, S., Loke, Y. K., Zorzela, L.

(2014)

Comparison of search strategies in systematic reviews of adverse effects to other systematic reviews

in Health information and libraries journal

31.

pp. 92-105

Full Text UEA Repository

(Article)


Bellis, J. R., Pirmohamed, M., Nunn, A. J., Loke, Y. K., De, S., Golder, S., Kirkham, J. J.

(2014)

Dexamethasone and haemorrhage risk in paediatric tonsillectomy : a systematic review and meta-analysis

in British journal of anaesthesia

113.

pp. 23-42

Full Text UEA Repository

(Article)


Kwok, C. S., Bulluck, H., Ryding, A. D., Loke, Y. K.

(2014)

Benefits and harms of extending the duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stents : a meta-analysis

in The Scientific World Journal

2014.

Full Text UEA Repository

(Article)


Mattishent, K., Thavarajah, M., Blanco, P., Gilbert, D., Wilson, A. M., Loke, Y. K.

(2014)

Meta-Review: Adverse Effects of Inhaled Corticosteroids Relevant to Older Patients

in Drugs

74.

pp. 539-547

Full Text UEA Repository

(Article)


Kwok, C. S., Pradhan, A., Khan, M. A., Anderson, S. G., Keavney, B. D., Myint, P. K., Mamas, M. A., Loke, Y. K.

(2014)

Bariatric surgery and its impact on cardiovascular disease and mortality : a systematic review and meta-analysis

in International journal of cardiology

173.

pp. 20-8

Full Text UEA Repository

(Article)


Loke, Y. K., Pradhan, S., Yeong, J. K., Kwok, C. S.

(2014)

Comparative coronary risks of apixaban, rivaroxaban and dabigatran : a meta-analysis and adjusted indirect comparison

in British Journal of Clinical Pharmacology

Full Text UEA Repository

(Article)


Loke, Y. K.

(2014)

Use of databases for clinical research

in Archives of Disease in Childhood

99.

pp. 587-589

Full Text UEA Repository

(Article)


Zorzela, L., Golder, S., Liu, Y., Pilkington, K., Hartling, L., Joffe, A., Loke, Y., Vohra, S.

(2014)

Quality of reporting in systematic reviews of adverse events : systematic review

in BMJ

348.

pp. f7668

UEA Repository

(Article)


Myint, P. K., Clark, A. B., Kwok, C. S., Loke, Y. K., Yeong, J. K., Luben, R. N., Wareham, N. J., Khaw, K., Aged, 80 and over

(2014)

Bone mineral density and incidence of stroke : European prospective investigation into cancer-norfolk population-based study, systematic review, and meta-analysis

in Stroke; a journal of cerebral circulation

45.

pp. 373-82

Full Text UEA Repository

(Article)


Turner, R. M., Kwok, C. S., Chen-Turner, C., Maduakor, C. A., Singh, S., Loke, Y. K.

(2014)

Thiazolidinediones and associated risk of Bladder Cancer : a Systematic Review and Meta-analysis

in British Journal of Clinical Pharmacology

78.

pp. 258–273

Full Text UEA Repository

(Article)


Atkins, C. P., Loke, Y. K., Wilson, A. M.

(2014)

Outcomes in idiopathic pulmonary fibrosis : a meta-analysis from placebo controlled trials

in Respiratory medicine

108.

pp. 376-87

Full Text UEA Repository

(Article)


Song, F., Loke, Y., Hooper, L.

(2014)

Why are medical and health-related studies not being published? A systematic review of reasons given by investigators

in PLoS ONE

9.

Full Text UEA Repository

(Article)


Kwok, C., Umar, S., Myint, P., Mamas, M., Loke, Y.

(2014)

Vegetarian diet, Seventh Day Adventists and risk of cardiovascular mortality : A systematic review and meta-analysis

in International journal of cardiology

176.

Full Text UEA Repository

(Article)


Moja, L., Lucenteforte, E., Kwag, K. H., Bertele, V., Campomori, A., Chakravarthy, U., D'Amico, R., Dickersin, K., Kodjikian, L., Lindsley, K., Loke, Y., Maguire, M., Martin, D. F., Mugelli, A., Mühlbauer, B., Püntmann, I., Reeves, B., Rogers, C., Schmucker, C., Subramanian, M. L., Virgili, G.

(2014)

Systemic safety of bevacizumab versus ranibizumab for neovascular age-related macular degeneration

in Cochrane Database of Systematic Reviews

9.

Full Text UEA Repository

(Article)


Loke, Y. K., Singh, S., Furberg, C. D., Pulmonary Disease, Chronic Obstructive

(2014)

Tiotropium and the risk of death in COPD

in The New England Journal of Medicine

370.

pp. 480-481

Full Text

(Letter)


Song, F., Hooper, L., Loke, Y.

(2013)

Publication bias: what is it? How do we measure it? How do we avoid it?

in Open Access Journal of Clinical Trials

2013.

pp. 71-81

Full Text UEA Repository

(Article)


Isa, A., Loke, Y., Smith, J., Papageorgiou, A., Hunter, P.

(2013)

Mediational Effects of Self-Efficacy Dimensions in the Relationship between Knowledge of Dengue and Dengue Preventive Behaviour with Respect to Control of Dengue Outbreaks : A Structural Equation Model of a Cross-Sectional Survey

in PLoS Neglected Tropical Diseases

7.

Full Text UEA Repository

(Article)


Beales, I. L. P., Hensley, A., Loke, Y.

(2013)

Reduced esophageal cancer incidence in statin users, particularly with cyclo-oxygenase inhibition

in World journal of gastrointestinal pharmacology and therapeutics

4.

pp. 69-79

Full Text UEA Repository

(Article)


Xiong, T., Parekh-Bhurke, S., Loke, Y. K., Abdelhamid, A., Sutton, A. J., Eastwood, A. J., Holland, R., Chen, Y., Walsh, T., Glenny, A., Song, F., Quality Assurance, Health Care

(2013)

Overall similarity and consistency assessment scores are not sufficiently accurate for predicting discrepancy between direct and indirect comparison estimates

in Journal of Clinical Epidemiology

66.

pp. 184-91

Full Text UEA Repository

(Article)


<- Page 1 of 6 ->

All Publications

See Highlights
<- Page 1 of 6 ->

Yates, M., Loke, Y. K., Watts, R. A., Macgregor, A. J.

(2014)

Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis : meta-analysis

in Clinical rheumatology

33.

pp. 227-236

Full Text UEA Repository

(Article)


Golder, S., Loke, Y. K., Zorzela, L.

(2014)

Comparison of search strategies in systematic reviews of adverse effects to other systematic reviews

in Health information and libraries journal

31.

pp. 92-105

Full Text UEA Repository

(Article)


Bellis, J. R., Pirmohamed, M., Nunn, A. J., Loke, Y. K., De, S., Golder, S., Kirkham, J. J.

(2014)

Dexamethasone and haemorrhage risk in paediatric tonsillectomy : a systematic review and meta-analysis

in British journal of anaesthesia

113.

pp. 23-42

Full Text UEA Repository

(Article)


Kwok, C. S., Bulluck, H., Ryding, A. D., Loke, Y. K.

(2014)

Benefits and harms of extending the duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stents : a meta-analysis

in The Scientific World Journal

2014.

Full Text UEA Repository

(Article)


Mattishent, K., Thavarajah, M., Blanco, P., Gilbert, D., Wilson, A. M., Loke, Y. K.

(2014)

Meta-Review: Adverse Effects of Inhaled Corticosteroids Relevant to Older Patients

in Drugs

74.

pp. 539-547

Full Text UEA Repository

(Article)


Kwok, C. S., Pradhan, A., Khan, M. A., Anderson, S. G., Keavney, B. D., Myint, P. K., Mamas, M. A., Loke, Y. K.

(2014)

Bariatric surgery and its impact on cardiovascular disease and mortality : a systematic review and meta-analysis

in International journal of cardiology

173.

pp. 20-8

Full Text UEA Repository

(Article)


Loke, Y. K., Pradhan, S., Yeong, J. K., Kwok, C. S.

(2014)

Comparative coronary risks of apixaban, rivaroxaban and dabigatran : a meta-analysis and adjusted indirect comparison

in British Journal of Clinical Pharmacology

Full Text UEA Repository

(Article)


Loke, Y. K.

(2014)

Use of databases for clinical research

in Archives of Disease in Childhood

99.

pp. 587-589

Full Text UEA Repository

(Article)


Zorzela, L., Golder, S., Liu, Y., Pilkington, K., Hartling, L., Joffe, A., Loke, Y., Vohra, S.

(2014)

Quality of reporting in systematic reviews of adverse events : systematic review

in BMJ

348.

pp. f7668

UEA Repository

(Article)


Myint, P. K., Clark, A. B., Kwok, C. S., Loke, Y. K., Yeong, J. K., Luben, R. N., Wareham, N. J., Khaw, K., Aged, 80 and over

(2014)

Bone mineral density and incidence of stroke : European prospective investigation into cancer-norfolk population-based study, systematic review, and meta-analysis

in Stroke; a journal of cerebral circulation

45.

pp. 373-82

Full Text UEA Repository

(Article)


Turner, R. M., Kwok, C. S., Chen-Turner, C., Maduakor, C. A., Singh, S., Loke, Y. K.

(2014)

Thiazolidinediones and associated risk of Bladder Cancer : a Systematic Review and Meta-analysis

in British Journal of Clinical Pharmacology

78.

pp. 258–273

Full Text UEA Repository

(Article)


Atkins, C. P., Loke, Y. K., Wilson, A. M.

(2014)

Outcomes in idiopathic pulmonary fibrosis : a meta-analysis from placebo controlled trials

in Respiratory medicine

108.

pp. 376-87

Full Text UEA Repository

(Article)


Song, F., Loke, Y., Hooper, L.

(2014)

Why are medical and health-related studies not being published? A systematic review of reasons given by investigators

in PLoS ONE

9.

Full Text UEA Repository

(Article)


Kwok, C., Umar, S., Myint, P., Mamas, M., Loke, Y.

(2014)

Vegetarian diet, Seventh Day Adventists and risk of cardiovascular mortality : A systematic review and meta-analysis

in International journal of cardiology

176.

Full Text UEA Repository

(Article)


Moja, L., Lucenteforte, E., Kwag, K. H., Bertele, V., Campomori, A., Chakravarthy, U., D'Amico, R., Dickersin, K., Kodjikian, L., Lindsley, K., Loke, Y., Maguire, M., Martin, D. F., Mugelli, A., Mühlbauer, B., Püntmann, I., Reeves, B., Rogers, C., Schmucker, C., Subramanian, M. L., Virgili, G.

(2014)

Systemic safety of bevacizumab versus ranibizumab for neovascular age-related macular degeneration

in Cochrane Database of Systematic Reviews

9.

Full Text UEA Repository

(Article)


Loke, Y. K., Singh, S., Furberg, C. D., Pulmonary Disease, Chronic Obstructive

(2014)

Tiotropium and the risk of death in COPD

in The New England Journal of Medicine

370.

pp. 480-481

Full Text

(Letter)


Song, F., Hooper, L., Loke, Y.

(2013)

Publication bias: what is it? How do we measure it? How do we avoid it?

in Open Access Journal of Clinical Trials

2013.

pp. 71-81

Full Text UEA Repository

(Article)


Isa, A., Loke, Y., Smith, J., Papageorgiou, A., Hunter, P.

(2013)

Mediational Effects of Self-Efficacy Dimensions in the Relationship between Knowledge of Dengue and Dengue Preventive Behaviour with Respect to Control of Dengue Outbreaks : A Structural Equation Model of a Cross-Sectional Survey

in PLoS Neglected Tropical Diseases

7.

Full Text UEA Repository

(Article)


Beales, I. L. P., Hensley, A., Loke, Y.

(2013)

Reduced esophageal cancer incidence in statin users, particularly with cyclo-oxygenase inhibition

in World journal of gastrointestinal pharmacology and therapeutics

4.

pp. 69-79

Full Text UEA Repository

(Article)


Xiong, T., Parekh-Bhurke, S., Loke, Y. K., Abdelhamid, A., Sutton, A. J., Eastwood, A. J., Holland, R., Chen, Y., Walsh, T., Glenny, A., Song, F., Quality Assurance, Health Care

(2013)

Overall similarity and consistency assessment scores are not sufficiently accurate for predicting discrepancy between direct and indirect comparison estimates

in Journal of Clinical Epidemiology

66.

pp. 184-91

Full Text UEA Repository

(Article)


<- Page 1 of 6 ->

Teaching Interests

My current teaching activity is aimed at the improving the prescribing skills of medical students. I was awarded a UEA Teaching Fellowship 2004 for work on reducing prescribing errors.

I am a member of the British Pharmacological Society, and have worked on the society funded project that resulted in a publication of a systematic review on educational interventions for teaching prescribing in medical students.


 

External Activities and Indicators of Esteem

  • European Editor, British Journal of Clinical Pharmacology (2008 - ongoing)
  • Co-convenor Cochrane Adverse Effects Methods Group (2007 - ongoing)
  • Bruce Squires Award from the CMAJ for the Best Research Paper of the Year; Singh S, Loke YK, Spangler JG, Furberg CD. Risk of serious adverse cardiovascular events with Varenicline- A Systematic Review and Meta-Analysis of Randomized Controlled Trials. CMAJ 2011; 1831359-66. (2013)
  • Chair of the NIHR HTA Elective and Emergency Specialist Care Panel (2013 - ongoing)

Administrative Posts

  • Module 13 (Emergency Care) Lead for Year 5 Medical Students.
  • Theme Lead for Clinical Pharmacology