Biography

Professor Bill Fraser was born and educated in Glasgow, graduating from Glasgow University with BSc (Hons) MBChB and MD (Hons). He trained in Glasgow’s teaching hospitals before spending time as a consultant/travelling fellow in Canada.

Career History

Bill Fraser supervises a very active research group investigating the diagnosis and treatment of metabolic bone disease including osteoporosis and Paget’s Disease of bone. He is on the Editorial Board of several journals, a Director of the Supra Regional Assay Service for bone metabolism and calcium homeostasis, and a Medical Advisor to the National Osteoporosis Society. He was a recent recipient of the ACB Foundation Award and presenter of the John Ireland Lecture.

Royal Liverpool University Hospital

  • 1991 appointed Senior Lecturer in Chemical Pathology and Head of the Metabolic Bone Disease Unit 
  • 1998 promoted to Reader
  • 2001 Professor
  • 2008 Head of the Unit of Clinical Chemistry
  • August 2008 appointed Director of the Masters in Research for Clinical Science
  • 2010 Head of Department of Musculoskeletal Biology     

Norwich Medical School, University of East Anglia

  • May 2011 Professor of Medicine 

     


 

 

Highlighted Publications

See All
<- Page 1 of 15 ->

Eddington, H., Hudson, J. E., Oliver, R. L., Fraser, W. D., Hutchison, A. J., Kalra, P. A.

(2014)

Variability in parathyroid hormone assays confounds clinical practice in chronic kidney disease patients

in Annals of Clinical Biochemistry

51.

pp. 228-236

Full Text UEA Repository

(Article)


Kemp, J. P., Sayers, A., Paternoster, L., Evans, D. M., Deere, K., St Pourcain, B., Timpson, N. J., Ring, S. M., Lorentzon, M., Lehtimäki, T., Eriksson, J., Kähönen, M., Raitakari, O., Laaksonen, M., Sievänen, H., Viikari, J., Lyytikäinen, L., Smith, G. D., Fraser, W. D., Vandenput, L., Ohlsson, C., Tobias, J. H.

(2014)

Does bone resorption stimulate periosteal expansion? : A cross sectional analysis of β-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT

in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

29.

pp. 1015–1024

Full Text UEA Repository

(Article)


Luo, Z., Julien, P., Wei, S., Audibert, F., Smith, G. N., Fraser, W. D.

(2014)

Plasma cotinine indicates an increased risk of preeclampsia in previous and passive smokers

in American Journal of Obstetrics and Gynecology

210.

pp. 232.e1–232.e5

Full Text UEA Repository

(Article)


Williams, D. M., Fraser, A., Sayers, A., Fraser, W. D., Hyppönen, E., Smith, G. D., Sattar, N., Lawlor, D. A.

(2014)

Associations of childhood 25-hydroxyvitamin D2 and D3 and cardiovascular risk factors in adolescence : prospective findings from the Avon Longitudinal Study of Parents and Children

in European journal of preventive cardiology

21.

pp. 281-90

Full Text UEA Repository

(Article)


Pacheco-Pantoja, E. L., Fraser, W. D., Wilson, P. J. M., Gallagher, J. A.

(2014)

Differential effects of adiponectin in osteoblast-like cells

in Journal of receptor and signal transduction research

Full Text UEA Repository

(Article)


Macdonald, H. M., Wood, A. D., Fraser, W. D., Simpson, W. G.

(2014)

Vitamin D status and ill health

in The Lancet Diabetes & Endocrinology

2.

pp. e8-e9

Full Text UEA Repository

(Article)


Cobley, J. N., Sakellariou, G. K., Owens, D. J., Murray, S., Waldron, S., Gregson, W., Fraser, W. D., Burniston, J. G., Iwanejko, L. A., McArdle, A., Morton, J. P., Jackson, M. J., Close, G. L.

(2014)

Lifelong training preserves some redox-regulated adaptive responses after an acute exercise stimulus in aged human skeletal muscle

in Free radical biology & medicine

70.

pp. 23-32

Full Text UEA Repository

(Article)


Gregson, C. L., Poole, K. E. S., McCloskey, E. V., Duncan, E. L., Rittweger, J., Fraser, W. D., Smith, G. D., Tobias, J. H.

(2014)

Elevated circulating sclerostin concentrations in individuals with High Bone Mass, with and without LRP5 mutations

in The Journal of Clinical Endocrinology and Metabolism

pp. jc20133958

Full Text UEA Repository

(Article)


Wood, A. D., Secombes, K. R., Thies, F., Aucott, L. S., Black, A. J., Reid, D. M., Mavroeidi, A., Simpson, W. G., Fraser, W. D., Macdonald, H. M.

(2014)

A parallel group double-blind RCT of vitamin D3 assessing physical function : is the biochemical response to treatment affected by overweight and obesity?

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

25.

pp. 305-15

Full Text UEA Repository

(Article)


Esapa, C. T., Nesbit, M. A., Head, R. A., Evans, H., Lath, D., Scudamore, C. L., Hough, T. A., Podrini, C., Hannan, F. M., Fraser, W. D., Croucher, P. I., Brown, M. A., Brown, S. D. M., Cox, R. D., Thakker, R. V., Disease Models, Animal, Mice, Inbred C3H, Mice, Inbred C57BL, Promoter Regions, Genetic

(2014)

An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess

in Endocrinology

155.

pp. 908-22

Full Text UEA Repository

(Article)


Whitelaw, D. C., Scally, A. J., Tuffnell, D. J., Davies, T. J., Fraser, W. D., Bhopal, R. S., Wright, J., Lawlor, D. A.

(2014)

Associations of circulating calcium and 25-hydroxyvitamin D with glucose metabolism in pregnancy: a cross-sectional study in European and South Asian women

in The Journal of Clinical Endocrinology and Metabolism

pp. jc.2013-2896

Full Text UEA Repository

(Article)


Scott, J. P. R., Sale, C., Greeves, J. P., Casey, A., Dutton, J., Fraser, W. D.

(2014)

Treadmill Running Reduces Parathyroid Hormone Concentrations During Recovery Compared With a Nonexercising Control Group

in The Journal of Clinical Endocrinology and Metabolism

99.

pp. 1774-1782

Full Text UEA Repository

(Article)


Owens, D. J., Webber, D., Impey, S. G., Tang, J., Donovan, T. F., Fraser, W. D., Morton, J. P., Close, G. L.

(2014)

Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males

in European Journal of Applied Physiology

114.

pp. 1309-1320

Full Text UEA Repository

(Article)


Steer, C. D., Sayers, A., Kemp, J., Fraser, W. D., Tobias, J. H.

(2014)

Birth weight is positively related to bone size in adolescents but inversely related to cortical bone mineral density: Findings from a large prospective cohort study

in Bone

65.

pp. 77-82

Full Text UEA Repository

(Article)


Tang, J., Galitzer, H., Washbourne, C., Piec, I., Wang, N., Burshtien, G., Phillip Schwartz, P., Caraco, Y., Ehud Arbit, E., Fraser, W.

(2014)

First in Man Studies of Pharmacokinetic Profiles of a Novel Oral PTH(1-34)

(Poster)


Piec, I., Washbourne, C., Tang, J., Fraser, W.

(2014)

How accurate is your sclerostin measurement? Comparison between two commercially available sclerostin ELISA kits.

(Poster)


Tang, J., Washbourne, C., Budnik-Zawilska, M., Piec, I., Fraser, W.

(2014)

Assessment of C3-Epi-25-Hydroxyvitamin D concentration in adult serum: LC-MS/MS determination using [2H3] 3-epi-25OHD3 internal standard and NIST traceable commercial 3-epi-25OHD calibrators.

Full Text

(Poster)


Xu, P., Billmeier, M., Mohorianu, I., Green, D., Fraser, W., Dalmay, T.

(2014)

An improved protocol for small RNA library construction using High Definition adapters.

in Methods in Next Generation Sequencing

UEA Repository

(Article)


Close, G., Russell, J., Cobley, J., Owens, D., Wilson, G., Gregson, W., Fraser, W., Morton, J.

(2013)

Assessment of vitamin D concentration in non-supplemented professional athletes and healthy adults during the winter months in the UK: implications for skeletal muscle function

in Journal of Sports Sciences

31.

pp. 344-353

Full Text UEA Repository

(Article)


Wilson, G., Fraser, W., Sharma, A., Eubank, M., Drust, B., Morton, J., Close, G.

(2013)

Markers of bone health, renal function, liver function, anthropometry and perception of mood : A comparison between flat and national hunt jockeys

in International Journal of Sports Medicine

34.

pp. 453-459

Full Text UEA Repository

(Article)


<- Page 1 of 15 ->

All Publications

See Highlights
<- Page 1 of 15 ->

Eddington, H., Hudson, J. E., Oliver, R. L., Fraser, W. D., Hutchison, A. J., Kalra, P. A.

(2014)

Variability in parathyroid hormone assays confounds clinical practice in chronic kidney disease patients

in Annals of Clinical Biochemistry

51.

pp. 228-236

Full Text UEA Repository

(Article)


Kemp, J. P., Sayers, A., Paternoster, L., Evans, D. M., Deere, K., St Pourcain, B., Timpson, N. J., Ring, S. M., Lorentzon, M., Lehtimäki, T., Eriksson, J., Kähönen, M., Raitakari, O., Laaksonen, M., Sievänen, H., Viikari, J., Lyytikäinen, L., Smith, G. D., Fraser, W. D., Vandenput, L., Ohlsson, C., Tobias, J. H.

(2014)

Does bone resorption stimulate periosteal expansion? : A cross sectional analysis of β-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT

in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

29.

pp. 1015–1024

Full Text UEA Repository

(Article)


Luo, Z., Julien, P., Wei, S., Audibert, F., Smith, G. N., Fraser, W. D.

(2014)

Plasma cotinine indicates an increased risk of preeclampsia in previous and passive smokers

in American Journal of Obstetrics and Gynecology

210.

pp. 232.e1–232.e5

Full Text UEA Repository

(Article)


Williams, D. M., Fraser, A., Sayers, A., Fraser, W. D., Hyppönen, E., Smith, G. D., Sattar, N., Lawlor, D. A.

(2014)

Associations of childhood 25-hydroxyvitamin D2 and D3 and cardiovascular risk factors in adolescence : prospective findings from the Avon Longitudinal Study of Parents and Children

in European journal of preventive cardiology

21.

pp. 281-90

Full Text UEA Repository

(Article)


Pacheco-Pantoja, E. L., Fraser, W. D., Wilson, P. J. M., Gallagher, J. A.

(2014)

Differential effects of adiponectin in osteoblast-like cells

in Journal of receptor and signal transduction research

Full Text UEA Repository

(Article)


Macdonald, H. M., Wood, A. D., Fraser, W. D., Simpson, W. G.

(2014)

Vitamin D status and ill health

in The Lancet Diabetes & Endocrinology

2.

pp. e8-e9

Full Text UEA Repository

(Article)


Cobley, J. N., Sakellariou, G. K., Owens, D. J., Murray, S., Waldron, S., Gregson, W., Fraser, W. D., Burniston, J. G., Iwanejko, L. A., McArdle, A., Morton, J. P., Jackson, M. J., Close, G. L.

(2014)

Lifelong training preserves some redox-regulated adaptive responses after an acute exercise stimulus in aged human skeletal muscle

in Free radical biology & medicine

70.

pp. 23-32

Full Text UEA Repository

(Article)


Gregson, C. L., Poole, K. E. S., McCloskey, E. V., Duncan, E. L., Rittweger, J., Fraser, W. D., Smith, G. D., Tobias, J. H.

(2014)

Elevated circulating sclerostin concentrations in individuals with High Bone Mass, with and without LRP5 mutations

in The Journal of Clinical Endocrinology and Metabolism

pp. jc20133958

Full Text UEA Repository

(Article)


Wood, A. D., Secombes, K. R., Thies, F., Aucott, L. S., Black, A. J., Reid, D. M., Mavroeidi, A., Simpson, W. G., Fraser, W. D., Macdonald, H. M.

(2014)

A parallel group double-blind RCT of vitamin D3 assessing physical function : is the biochemical response to treatment affected by overweight and obesity?

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

25.

pp. 305-15

Full Text UEA Repository

(Article)


Esapa, C. T., Nesbit, M. A., Head, R. A., Evans, H., Lath, D., Scudamore, C. L., Hough, T. A., Podrini, C., Hannan, F. M., Fraser, W. D., Croucher, P. I., Brown, M. A., Brown, S. D. M., Cox, R. D., Thakker, R. V., Disease Models, Animal, Mice, Inbred C3H, Mice, Inbred C57BL, Promoter Regions, Genetic

(2014)

An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess

in Endocrinology

155.

pp. 908-22

Full Text UEA Repository

(Article)


Whitelaw, D. C., Scally, A. J., Tuffnell, D. J., Davies, T. J., Fraser, W. D., Bhopal, R. S., Wright, J., Lawlor, D. A.

(2014)

Associations of circulating calcium and 25-hydroxyvitamin D with glucose metabolism in pregnancy: a cross-sectional study in European and South Asian women

in The Journal of Clinical Endocrinology and Metabolism

pp. jc.2013-2896

Full Text UEA Repository

(Article)


Scott, J. P. R., Sale, C., Greeves, J. P., Casey, A., Dutton, J., Fraser, W. D.

(2014)

Treadmill Running Reduces Parathyroid Hormone Concentrations During Recovery Compared With a Nonexercising Control Group

in The Journal of Clinical Endocrinology and Metabolism

99.

pp. 1774-1782

Full Text UEA Repository

(Article)


Owens, D. J., Webber, D., Impey, S. G., Tang, J., Donovan, T. F., Fraser, W. D., Morton, J. P., Close, G. L.

(2014)

Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males

in European Journal of Applied Physiology

114.

pp. 1309-1320

Full Text UEA Repository

(Article)


Steer, C. D., Sayers, A., Kemp, J., Fraser, W. D., Tobias, J. H.

(2014)

Birth weight is positively related to bone size in adolescents but inversely related to cortical bone mineral density: Findings from a large prospective cohort study

in Bone

65.

pp. 77-82

Full Text UEA Repository

(Article)


Tang, J., Galitzer, H., Washbourne, C., Piec, I., Wang, N., Burshtien, G., Phillip Schwartz, P., Caraco, Y., Ehud Arbit, E., Fraser, W.

(2014)

First in Man Studies of Pharmacokinetic Profiles of a Novel Oral PTH(1-34)

(Poster)


Piec, I., Washbourne, C., Tang, J., Fraser, W.

(2014)

How accurate is your sclerostin measurement? Comparison between two commercially available sclerostin ELISA kits.

(Poster)


Tang, J., Washbourne, C., Budnik-Zawilska, M., Piec, I., Fraser, W.

(2014)

Assessment of C3-Epi-25-Hydroxyvitamin D concentration in adult serum: LC-MS/MS determination using [2H3] 3-epi-25OHD3 internal standard and NIST traceable commercial 3-epi-25OHD calibrators.

Full Text

(Poster)


Xu, P., Billmeier, M., Mohorianu, I., Green, D., Fraser, W., Dalmay, T.

(2014)

An improved protocol for small RNA library construction using High Definition adapters.

in Methods in Next Generation Sequencing

UEA Repository

(Article)


Close, G., Russell, J., Cobley, J., Owens, D., Wilson, G., Gregson, W., Fraser, W., Morton, J.

(2013)

Assessment of vitamin D concentration in non-supplemented professional athletes and healthy adults during the winter months in the UK: implications for skeletal muscle function

in Journal of Sports Sciences

31.

pp. 344-353

Full Text UEA Repository

(Article)


Wilson, G., Fraser, W., Sharma, A., Eubank, M., Drust, B., Morton, J., Close, G.

(2013)

Markers of bone health, renal function, liver function, anthropometry and perception of mood : A comparison between flat and national hunt jockeys

in International Journal of Sports Medicine

34.

pp. 453-459

Full Text UEA Repository

(Article)


<- Page 1 of 15 ->