Academic Background

Professional Qualifications and professional memberships

  • MSc in Medical Statistics (University of Leicester)
  • PhD in Economics (University of Nottingham)
  • PGCHE in Higher Education (University of Nottingham)
  • PGCert in Health Services Research (University of Nottingham)
  • MSc in Health Economics (University of York)
  • BA(Hons) Economics (University of Kent)
  • Member of the UK Health Economics Study Group

 

Research interests

  • Health economics
  • Economic evaluation methodology and application
  • Outcome measurement including non-monetary preference based methods
  • Economics of Dermatology
  • Economics of Falls prevention
  • Economics of Rehabilitation 

Career summary

Tracey is a Professor of Health Economics within Norwich Medical School at UEA, having been Reader and Senior Lecturer in Health economics within the same School. Prior to this Tracey has been a Senior Lecturer in Health Economics within the Pharmacy School at UEA, Lecturer in Health Economics within the Medical Faculty at the University of Nottingham, and an assistant economist at the Department of Health.

 

Awards 

  • Jan 2015 to April 2020 NIHR Career Development Fellowship
  • July 2011 - Best paper award – SWET trial results presented at British Association of Dermatologists’ Annual Conference
  • July 2009 - The Society for Academic Primary Care Award for best submitted abstract: A randomised controlled trial assessing effects of weight loss and quadriceps strengthening exercises on pain and function in overweight people with knee pain.
  • 9-11th September 2008 - ESRC Bursary for training to attend the Regression Methods for Health Economic Evaluation, University of York (£1,000)
  • 13th June 2007 - The 2007 ISSLS Prize in Clinical Science, awarded at the 34th ISSLS Meeting in Hong Kong. “Steele N, Freeman B, Sach T, Hegarty J, Soegaard R. Cost-Effectiveness of Two Forms of Circumferential Lumbar Fusion: A Prospective, Randomised, Controlled Trial.” ($11,000)
  • October – December 2005 - Honorary Lecturer at the University of Melbourne, Australia. Visit funded by a Universitas 21 Staff fellowship. Based in the Program Evaluation Unit. (£3,121)
  • 2004 - Young Investigator award at the Tenth National Osteoporosis Society Conference, 28 November - 1 December 2004, in Harrogate. (£300)
  • 1999 - Magellan award for exam performance, MSc in Health Economics 

Selected conference presentations

Exploring the use of value of information methods to prioritise research to address the treatment uncertainties identified by the James Lind Alliance Priority Setting Partnerships. Sach T and McManus E. Poster presentation at ISPOR 18th Annual European Conference, Milan, Italy, 9-11th November 2015.

Resource use measurement in trial conducted in care homes: A study of level-of agreement between data collected from GP records and care home records. Sach T, Desborough J, Houghton J, Holland R. Poster presentation at ISPOR 18th Annual European Conference, Milan, Italy, 9-11th November 2015.

Could value of information methods be useful in prioritising research to address the treatment uncertainties identified by James Lind Alliance Priority setting partnerships? Sach T. Oral presentation at the REWARD / EQUATOR Conference: Increasing value and reducing waste in biomedical research, Edinburgh, UK 28-30 September 2015.

Economic biopsy: Why and how should we undertake economic research into eczema? Sach T. Poster presentation at the 8th Georg Rajka Symposium on Atopic Dermatitis (ISAD 2014, 21st-23rd May).

Micro costing intervention costs and a comparison of wider resource use data collection from GP records and care home records in a RCT of Multi-professional clinical medication reviews in care homes for the elderly. Sach T. Oral presentation at ‘Creating Guidance for Costing Methodology within Clinical Trials’, Workshop Funded by MRC Network of Hubs for Trials Methodology Research, St Catherine’s College Oxford, 10th October 2013

Economic evaluation of Cluster RCTs: comparison of methods when applied to highly imbalanced cluster size. Irvine L, Sach T, Barton G, Clark A, Sackley C. Health Economics Study Group meeting, Warwick University, June 2013.

A comparison of hypothetical versus real willingness to pay for ion-exchange water softeners in the context of childhood atopic eczema. Sach T. Paper presented at the UK Health Economics Study Group joint meeting with the Welsh Health Economics Study Group. Bangor University, 29th June-1st July 2011.

All Publications

<- Page 1 of 4 ->

McManus, E., Sach, T.

(2017)

Comment on "Replicating Health Economic Models: Firm Foundations or a House of Cards?",

in Pharmacoeconomics

35

(11)

pp. 1187–1188

Full Text

(Comment/debate)

(Published)


Turner, D., Carter, T., Sach, T., Guo, B., Callaghan, P.

(2017)

Cost-effectiveness of a preferred intensity exercise programme for young people with depression compared with treatment as usual: an economic evaluation alongside a clinical trial in the UK,

in BMJ Open

7

article no. e016211

Full Text UEA Repository

(Article)

(Published)


Tordrup, D., Chouaid, C., Cuijpers, P., Dab, W., van Dongen, J. M., Espin, J., Jonsson, B., Leonard, C., McDaid, D., McKee, M., Pereira Miquel, J., Patel, A., Reginster, J., Ricciadi, W., Rutten-van Molken, M., Prevolnik Rupel, V., Sach, T., Sassi, F., Waugh, N., Bertollini, R.

(2017)

Priorities for Health Economic Methodological Research: Results of an Expert Consultation,

in International Journal of Technology Assessment in Health Care

Full Text UEA Repository

(Article)

(E-pub ahead of print)


McManus, E., Sach, T., Levell, N.

(2017)

The Use of Decision–Analytic Models in Atopic Eczema: A Systematic Review and Critical Appraisal,

in Pharmacoeconomics

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Mcmanus, E., Sach, T., Levell, N. J.

(2017)

Are vitiligo treatments cost-effective? A systematic review,

in British Journal of Dermatology

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Chalmers, J. R., Haines, R. H., Mitchell, E. J., Thomas, K. S., Brown, S. J., Ridd, M., Lawton, S., Simpson, E. L., Cork, M. J., Sach, T. H., Bradshaw, L. E., Montgomery, A. A., Boyle, R. J., Williams, H. C.

(2017)

Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): Protocol for a randomised controlled trial,

in Trials

18

article no. 343

Full Text UEA Repository

(Article)

(Published)


Thomas, K. S., Bradshaw, L. E., Sach, T. H., Cowdell, F., Batchelor, J. M., Lawton, S., Harrison, E. F., Haines, R. H., Ahmed, A., Dean, T., Burrows, N. P., Pollock, I., Buckley, H. K., Williams, H. C., Llewellyn, J., Crang, C., Grundy, J. D., Guiness, J., Gribbin, A., Wake, E. V., Mitchell, E. J., Brown, S. J., Montgomery, A. A.

(2017)

Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial,

in Health Technology Assessment

21

(16)

Full Text UEA Repository

(Article)

(Published)


Thomas, K. S., Bradshaw, L. E., Sach, T. H., Batchelor, J. M., Lawton, S., Harrison, E. F., Haines, R. H., Ahmed, A., Williams, H. C., Dean, T., Burrows, N. P., Pollock, I., Llewelyn, J., Crang, C., Grundy, J. D., Guiness, J., Gribbin, A., Mitchell, E. J., Cowdell, F., Brown, S. J., Montgomery, A. A.

(2017)

Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial),

in PLoS Medicine

14

(4)

article no. e1002280

Full Text UEA Repository

(Article)

(Published)


Heinl, D., Prinsen, C., Sach, T., Drucker, A., Ofenloch, R., Flohr, C., Apfelbacher, C.

(2017)

Measurement properties of quality-of-life measurement instruments for infants, children and adolescents with eczema: a systematic review,

in British Journal of Dermatology

176

(4)

pp. 878–889

Full Text UEA Repository

(Article)

(Published)


Sahota, O., Pulikottil-Jacob, R., Marshall, F., Montgomery, A., Tan, W., Sach, T., Logan, P., Kendrick, D., Watson, A., Walker, M., Waring, J.

(2017)

The Community In-reach Rehabilitation and Care Transition (CIRACT) clinical and cost-effectiveness randomisation controlled trial in older people admitted to hospital as an acute medical emergency,

in Age and Ageing

46

(1)

pp. 26-32

Full Text UEA Repository

(Article)

(Published)


Chalmers, J., Simpson, E., Apfelbacher, C., Thomas, K., von Kobyletzki, L., Schmitt, J., Singh, J., Svensson, Å., Williams, H., Abuabara, K., Aoki, V., Ardeleanu, M., Awici-Rasmussen, M., Barbarot, S., Berents, T., Block, J., Bragg, A., Burton, T., Bjerring Clemmensen, K., Creswell-Melville, A., Dinesen, M., Drucker, A., Eckert, L., Flohr, C., Garg, M., Gerbens, L., Graff, A., Hanifin, J., Heinl, D., Humphreys, R., Ishii, H., Kataoka, Y., Leshem, Y., Marquort, B., Massuel, M., Merhand, S., Mizutani, H., Murota, H., Murrell, D., Nakahara, T., Nasr, I., Nograles, K., Ohya, Y., Osterloh, I., Pander, J., Prinsen, C., Purkins, L., Ridd, M., Sach, T., Schuttelaar, M. A., Shindo, S., Smirnova, J., Sulzer, A., Synnøve Gjerde, E., Takaoka, R., Vestby Talmo, H., Tauber, M., Torchet, F., Volke, A., Wahlgren, C., Weidinger, S., Weisshaar, E., Wollenberg, A., Yamaga, K., Zhao, C., Spuls, P.

(2016)

Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative),

in British Journal of Dermatology

175

(1)

pp. 69–79

Full Text UEA Repository

(Article)

(Published)


Sach, T., Mcmanus, E., Mcmonagle, C., Levell, N.

(2016)

Economic evidence for the prevention and treatment of atopic eczema: a protocol for a systematic review,

in Systematic Reviews

5

article no. 90

Full Text UEA Repository

(Article)

(Published)


Heinl, D., Prinsen, C., Deckert, S., Chalmers, J., Drucker, A., Ofenloch, R., Humphreys, R., Sach, T., Chamlin, S., Schmitt, J., Apfelbacher, C.

(2016)

Measurement properties of adult quality-of-life measurement instruments for eczema: a systematic review,

in Allergy

71

(3)

pp. 358-370

Full Text UEA Repository

(Article)

(Published)


Heinl, D., Prinsen, C., Drucker, A., Ofenloch, R., Humpreys, R., Sach, T., Flohr, C., Apfelbacher, C.

(2016)

Measurement properties of quality of life measurement instruments for infants, children and adolescents with eczema: protocol for a systematic review,

in Systematic Reviews

5

(25)

Full Text UEA Repository

(Article)

(Published)


Whynes, D., Sach, T.

(2016)

Sex, benevolence and willingness to pay for screening,

in International Journal of Social Economics

43

(10)

pp. 982-997

Full Text UEA Repository

(Article)

(Published)


Sach, T., McManus, E.

(2015)

PRM271 - Exploring the use of value of information methods to prioritise research to address the treatment uncertainties identified by the James Lind Alliance Priority Setting Partnerships,

in Value in Health

18

(7)

pp. A730

Full Text

(Abstract)

(Published)


Sach, T. H., Desborough, J., Houghton, J., Holland, R.

(2015)

Applying micro-costing methods to estimate the costs of pharmacy interventions: An illustration using multi-professional clinical medication reviews in care homes for older people,

in International Journal of Pharmacy Practice

23

(4)

pp. 237–247

Full Text UEA Repository

(Article)

(Published)


Apfelbacher, C., Henil, D., Prinsen, C., Deckert, S., Chalmers, J., Ofenloch, R., Humphreys, R., Sach, T., Chamlin, S., Schmitt, J.

(2015)

Measurement properties of adult quality-of-life measurement instruments for eczema: protocol for a systematic review,

in Systematic Reviews

4

article no. 48

Full Text UEA Repository

(Article)

(Published)


Watson, A., Charlesworth, L., Jacob, R., Kendrick, D., Logan, P., Marshall, F., Montgomery, A., Sach, T., Tan, W., Walker, M., Waring, J., Whitham, D., Sahota, O.

(2015)

The Community In-Reach and Care Transition (CIRACT) clinical and cost-effectiveness study: Study protocol for a randomised controlled trial,

in Trials

16

article no. 41

Full Text UEA Repository

(Article)

(Published)


<- Page 1 of 4 ->

Key Research Interests

I am currently working on a research project funded as part of an NIHR Career Development Fellowship (1st January 2015 until 30th April 2020, 60% FTE).

The project is exploring how to prioritise research for an entire clinical area (atopic eczema) using value of information methods.

In 2009 Chalmers and Glasziou1 estimated “that the dividends from tens of billions of dollars of investment in research are lost every year because of correctable problems”. These problems included research not tackling the most important questions, using poor design and failure to publish. The James Lind Alliance was established in 2004 to bring patients, carers and health professionals together to identify and prioritise the most important treatment uncertainties for specific health conditions using largely qualitative methods. In 2012 the Eczema priority setting partnership prioritised 14 treatment uncertainties (http://www.lindalliance.org/Eczema_JLA_Priority_Setting_Partnership.asp). However, numerous research questions could fit within each treatment uncertainty and since research funding is limited the project aims to test the potential for value of information methods to help prioritise eczema research questions (value of information methods quantify the expected value from reducing uncertainty and this information can be used to inform which research questions and study design should be prioritised).

 

As part of the project I will be collaborating with researchers at the University of Nottingham via it’s internationally renowned Centre for Evidence Based Dermatology (http://www.nottingham.ac.uk/research/groups/cebd/index.aspx), the University of Bristol as an affiliate member of the ConDuCT-II collaboration (which stands for Collaboration and innovation in Difficult and Complex randomised controlled Trials In Invasive procedures) which is part of the MRC's Network of Hubs for Trials Methodology Research, and with researchers based in the Health Economics and Health Technology Assessment (HEHTA) group at the University of Glasgow.

 

The project aims to demonstrate the merit of using value of information methods to prioritise the treatment uncertainties identified by James Lind Alliance Priority Setting Partnerships (http://www.lindalliance.org/), help inform better allocation of research resources in eczema research and improve the quality of economic research into eczema.

  

1Chalmers I, Glasziou P. Avoidable waste in the production and reporting of research evidence. Lancet 2009; 374: 86-89.

 

I have maintained involvement in a number of economic evaluations alongside clinical trials. I am an experienced collaborator, leading the health economic aspects within numerous NIHR funded clinical trials. Open to new collaborations.

 

Current on-going projects include: 

  • A randomised controlled trial to determine whether skin barrier enhancement with emollients can prevent eczema in high risk children (BEEP). (Williams H, Chalmers J, Ridd M, Yang M, Leighton M, Sach T, Thornton J, Thomas K, Boyle R, cork M, Simpson E, Lawton S. Study funded by the NIHR Health Technology Assessment Programme)
     
  • Home Interventions and Light therapy for the treatment of vitiligo (HI-Light Vitiligo Trial). (Thomas K, Batchelor J, Williams H, Eleftheriadou V, Ravencroft, Yang M, Duley L, Whitham D, Whitton M, Santer M, Sach T, Chalmers J, Rogers A. Study funded by the NIHR Health Technology Assessment Programme). Trial website: http://www.nottingham.ac.uk/research/groups/cebd/projects/hi-light-trial-for-vitiligo.aspx

 

  • Methotrexate versus Ciclosporin in the treatment of severe atopic eczema in children: An Economic Evaluation. Sach T, Flohr C, Wagner A, Jones A, Williamson P. NIHR RfPB, 32 months)

  • Supporting self-care for eczema in the community. Santer M, Thomas K, Little P, William H, Muller I, Yardley L, Chalmers J, Ridd M, Stuart B, Firkins L, Sach T, Lawton S, Roberts A, Wood W, Ratib S, Snell T. (NIHR Programme Grants for Applied Research, 5.5. years)

  • RETurn to work After stroKE (RETAKE). Radford K, Bowen A, Farrin A, McKevitt C, Sach T, Walker M, O’Connor R, Watkins C. (NIHR HTA, 01/01/2017 for 54 months)

  • A multi-centre cluster randomised controlled trial to evaluate the Guide to Action Care Home fall prevention programme in care homes for older people.(FinCH). Logan P, Gladman J, Gordon A, Conroy S, Sach T, Robertson K, Clark A, Leighton P, Armstrong S, Ward M, Marie Swart A, Williams W, Godfrey M. (NIHR HTA, 36 months)


      
       

Selected publications

  • Turner D, Carter T, Sach T, Guo B, Callaghan P. Cost-effectiveness of a preferred intensity exercise programme for young people with depression compared with treatment as usual: an economic evaluation alongside a clinical trial in the UK. BMJ Open. 2017 Nov 26;7(11):e016211. doi: 10.1136/bmjopen-2017-016211. 

  • Crossman-Barnes CJ, Peel A, Fong-Soe-Khioe R, Sach T, Wilson A, Barton G. Economic evidence for nonpharmacological asthma management interventions: A systematic review. Allergy. 2017 Nov 6. doi: 10.1111/all.13337. 

  • Tordrup D, Chouaid C, Cuijpers P, Dab W, van Dongen JM, Espin J, Jönsson B, Léonard C, McDaid D, McKee M, Miguel JP, Patel A, Reginster JY, Ricciardi W, Molken MR, Rupel VP, Sach T, Sassi F, Waugh N, Bertollini R. Priorities for health economic methodological research: Results of an expert consultation. Int J Technol Assess Health Care. 2017 Oct 30:1-11. doi: 10.1017/S0266462317000666.

  • McManus E, Sach T. Comment on "Replicating Health Economic Models: Firm Foundations or a House of Cards?" Pharmacoeconomics. 2017 Nov;35(11):1187-1188. doi: 10.1007/s40273-017-0576-3. 

  • McManus E, Sach T, Levell N. The Use of Decision-Analytic Models in Atopic Eczema: A Systematic Review and Critical Appraisal. Pharmacoeconomics. 2017 Sep 1. doi: 10.1007/s40273-017-0564-7. 

  • McManus E, Sach T, Levell NJ. Are vitiligo treatments cost-effective? A systematic review. Br J Dermatol. 2017 Aug 10. doi: 10.1111/bjd.15881.

  • Thomas KS, Bradshaw LE, Sach TH, Batchelor JM, Lawton S, Harrison EF, Haines RH, Ahmed A, Williams HC, Dean T, Burrows NP, Pollock I, Llewellyn J, Crang C, Grundy JD, Guiness J, Gribbin A, Mitchell EJ, Cowdell F, Brown SJ, Montgomery AA; UK Dermatology Clinical Trials Network’s CLOTHES Trial Team. Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial). PLoS Med. 2017 Apr 11;14(4):e1002280. doi: 10.1371/journal.pmed.1002280.

  • Thomas KS, Bradshaw LE, Sach TH, Cowdell F, Batchelor JM, Lawton S, Harrison EF, Haines RH, Ahmed A, Dean T, Burrows NP, Pollock I, Buckley HK, Williams HC, Llewellyn J, Crang C, Grundy JD, Guiness J, Gribbin A, Wake EV, Mitchell EJ, Brown SJ, Montgomery AA. Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial. Health Technol Assess. 2017 Apr;21(16):1-260. doi: 10.3310/hta21160.

  • Sahota O, Pulikottil-Jacob R, Marshall F, Montgomery A, Tan W, Sach T, Logan P, Kendrick D, Watson A, Walker M, Waring J. The Community In-reach Rehabilitation and Care Transition (CIRACT) clinical and cost-effectiveness randomisation controlled trial in older people admitted to hospital as an acute medical emergency. Age Ageing. 2017 Jan 6;46(1):26-32. doi: 10.1093/ageing/afw149

  • Heinl D, Prinsen CAC, Sach T, Drucker AM, Ofenloch R, Flohr C, Apfelbacher C. Measurement properties of quality-of-life measurement instruments for infants, children and adolescents with eczema: a systematic review. Br J Dermatol. 2017 Apr;176(4):878-889. doi: 10.1111/bjd.14966.

  • Heinl D, Prinsen CA, Deckert S, Chalmers JR, Drucker AM, Ofenloch R, Humphreys R, Sach T, Chamlin SL, Schmitt J, Apfelbacher C. Measurement properties of adult quality-of-life measurement instruments for eczema: a systematic review. Allergy. 2016 Mar;71(3):358-70. doi: 10.1111/all.12806
  • Sach TH, McManus E, Mcmonagle C, Levell. Economic evidence for the prevention and treatment of atopic eczema: a protocol for a systematic review. Syst Rev. 2016 May 27;5:90. doi: 10.1186/s13643-016-0262-0

  • Sach TH, Desborough J, Houghton J, Holland R; CAREMED study team. Applying micro-costing methods to estimate the costs of pharmacy interventions: an illustration using multi-professional clinical medication reviews in care homes for older people. Int J Pharm Pract. 2014 Nov 6. doi: 10.1111/ijpp.12162

  •  Whynes D and Sach T. Sex, benevolence and willingness to pay for screening. International Journal of Social Economics (2016);43(10):982-997.

 

 

Teaching Interests

Contribute lectures to MED-M07D Health Economics and MED-M12E Economic Evaluation in Health Care

Supervision of MSc in Health Economics dissertation students

Supervision of postgraduate research degree students in areas to do with health economics and economic evaluation.  Current students are studing topics on the Replication of health economic models; Quality of life measurement in asthma; Economic modelling of Cystic Fibrosis; and the iterative approach to decision making in the context of the cost effectiveness of very brief interventions to promote physical activity. Previous students have studied the cost effectiveness of specialist home care for those with dementia and Health care financing equity in Malaysia.

External Activities and Indicators of Esteem

  • Member of the expert panel for the NIHR Research Methods: Funding for Masters Studentships in the Economics of Health (2017)
  • Member of the NIHR HTA General board (2016-)
  • Core Member of the NIHR HTA Themed calls board (2013-2016)
  • NIHR Research methods fellowships and internship funding panel (2014, 2015, 2016, 2017)
  • Member of the Expert Review Panel for NIHR Research Methods Economics of Health – Round 4 (2017)
  • NIHR Systematic Reviews Fellowships funding panel (2015)
  • Member of the high-level expert panel of the Research Agenda for Health Economic Evaluation (RAHEE) project conducted by the World Health Organisation representation to the European Union (3rd-5th Feb 2015) (http://www.euro.who.int/en/about-us/organization/office-locations/who-representation-to-the-european-union,-brussels,-belgium/research-agenda-for-health-economic-evaluation-rahee-project)
  • Participated in the Harmonising Outcome Measures for Eczema (HOME) IV meeting in Malmo, Sweden (April 2015)(http://www.nottingham.ac.uk/homeforeczema/index.aspx)
  • Member of the Public Health Interventions Advisory Committee for NICE (2007-2012)
  • Honorary Lecturer in Health Economics, University of Nottingham, UK (2007-)
  • Senior Fellow, The Institute of Mental Health, Nottingham (2006-)
  • Member of the ESRC college of expert reviewers (2010-)
  • Grant and report reviewer for the UK Health Technology Assessment programme
  • Referee for the various journals including the British Medical Journal, European Journal of Health Economics, Health Economics, International Journal of Obesity, Medical Decision Making, Pharmacoeeconomics, Social Science and Medicine, Quality of Life Research, and Value in Health.

Key Responsibilities

  • PGR lead for the Health Economics Group
  • MSc in Health Economics Advisor