Career History

Career Summary

2015-present

2007-2015

 

Senior Lecturer, Norwich Medical School, UEA

Lecturer, Norwich Medical School, UEA

 

 

1994-2005

   Senior Scientist and Group Leader, Institute for Animal Health, Pirbright UK.

 
1991-1994

   Research Assistant Professor, Harvard Medical School, Boston, Massachussetts, USA

 
1987-1991

   Postdoctoral Fellow, Harvard Medical School, Boston, Massachussets, USA

 
1984-1987

   Postdoctoral Fellow, St Louis University Medical School, St Louis, Missouri, USA

 
1984

   PhD Biochemistry, Imperial College, University of London

 
1980

   BSc Biochemistry, Imperial College, University of London.

 

Biography

After completing her PhD in biochemistry and genetics in London, Penny moved to Washington University Medical School, St Louis as a postdoc with Bill Sly, to study lysosomal storage diseases and the intracellular trafficking of lysosomal enzymes by the mannose 6-phosphate receptor.  As one of the first labs to clone the gene for a lysosomal enzyme, beta-glucuronidase, it was later pivitol in gene replacement therapy for this lysosomal storage disease.  She subsequently moved to Harvard Medical School, Boston to the angiogenesis group of Mike Klagsbrun and Judah Folkman to investigate vascular growth factors in development, injury and vascular remodelling during pulmonary hypertension.  Then recruited as a Senior Scientist to the Institute for Animal Health, Pirbright, she investigated viral proteins which inhibit inflammatory and innate immune responses during viral infection.   Currently at Norwich Medical School, University of East Anglia, she studies innate immune responses to viruses, including interferon signalling, RNA interference, stress and autophagy.  This includes state-of-the art tissue engineering to grow mouse intestinal organoids or "mini-guts" in culture from stem cells to investigate responses to viral infection and inflammatory stimuli associated with Crohn’s disease by global transcriptomic and proteomic analysis.

 

 

All Publications

Wileman, T., Netherton, C., Powell, P.

(2016)

Virus Factories and Mini-Organelles Generated for Virus Replication,

in Encyclopedia of Cell Biology.

Elsevier

pp. 819–827

Full Text

(Entry for encyclopedia/dictionary)

(Published)


Nasef, N. A., Mehta, S., Powell, P., Marlow, G., Wileman, T., Ferguson, L. R.

(2015)

Extracts of Feijoa Inhibit Toll-Like Receptor 2 Signaling and Activate Autophagy Implicating a Role in Dietary Control of IBD,

in PLoS ONE

10

(6)

article no. e0130910

Full Text UEA Repository

(Article)

(Published)


Jefferson, M., Donaszi-ivanov, A., Pollen, S., Dalmay, T., Saalbach, G., Powell, P. P.

(2014)

Host Factors interacting with the Pestivirus N terminal protease, Npro are Components of the Ribonucleoprotein Complex,

in Journal of Virology

88

(18)

pp. 10340-10353

Full Text UEA Repository

(Article)

(Published)


Jefferson, M., Whelband, M., Mohorianu, I., Powell, P. P.

(2014)

The pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.),

in PLoS ONE

9

(2)

article no. e88838

Full Text UEA Repository

(Article)

(Published)


Donaszi-Ivanov, A., Mohorianu, I., Dalmay, T., Powell, P. P.

(2013)

Small RNA analysis in Sindbis virus infected human HEK293 cells,

in PLoS ONE

8

(12)

article no. e84070

Full Text UEA Repository

(Article)

(Published)


Zhou, Z., Mogensen, M. M., Powell, P. P., Curry, S., Wileman, T.

(2013)

Foot-and-mouth disease virus 3C protease induces fragmentation of the Golgi compartment and blocks intra-Golgi transport,

in Journal of Virology

87

(21)

pp. 11721-11729

Full Text UEA Repository

(Article)

(Published)


Goldspink, D., Gadsby, J., Bellett, G., Keynton, J., Tyrrell, B., Lund, E., Powell, P., Thomas, P., Mogensen, M.

(2013)

The microtubule end-binding protein EB2 is a central regulator of microtubule reorganisation in apico-basal epithelial differentiation,

in Journal of Cell Science

126

(Pt 17)

pp. 4000-4014

Full Text UEA Repository

(Article)

(Published)


Roberts, R., Al-Jamal, W., Whelband, M., Thomas, P., Jefferson, M., van den Bossche, J., Powell, P. P., Kostarelos, K., Wileman, T.

(2013)

Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery,

in Autophagy

9

(5)

pp. 667-682

Full Text UEA Repository

(Article)

(Published)


Greatorex, J. S., Page, R. F., Curran, M. D., Digard, P., Enstone, J. E., Wreghitt, T., Powell, P., Sexton, D., Vivancos, R., Nguyen-Van-Tam, J. S.

(2010)

Effectiveness of common household cleaning agents in reducing the viability of human influenza A/H1N1,

in PLoS ONE

5

(2)

article no. e8987

Full Text UEA Repository

(Article)

(Published)


Doceul, V., Charleston, B., Crooke, H., Reid, E., Powell, P., Seago, J.

(2008)

The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor,

in Journal of General Virology

89

(8)

pp. 1881-1889

Full Text UEA Repository

(Article)

(Published)


Tennant, L. M., Renard, C., Chardon, P., Powell, P. P.

(2007)

Regulation of porcine classical and nonclassical MHC class I expression,

in Immunogenetics

59

(5)

pp. 377-89

Full Text UEA Repository

(Article)

(Published)


Tennant, L., Renard, C., Chardon, P., Powell, P.

(2007)

Regulation of porcine classical and non classical MHC class I expression,

in Immunogenetics

59

(5)

pp. 377-389

UEA Repository

(Article)

(Published)


La Rocca, S., Herbert, R., Crooke, H., Drew, T., Wileman, T., Powell, P.

(2005)

Loss of interferon regulatory factor 3 in cells infected with classical swine fever virus involves the N-terminal protease, Npro,

in Journal of Virology

79

(11)

pp. 7239-7247

UEA Repository

(Article)

(Published)


Bensaude, E., Turner, J., Wakeley, P., Sweetman, D., Pardieu, C., Drew, T., Wileman, T., Powell, P.

(2004)

Classical swine fever virus induces proinflammatory cytokines and tissue factor expression and inhibits apoptosis and interferon synthesis during the establishment of long-term infection of porcine vascular endothelial cells,

in Journal of General Virology

85

(4)

pp. 1029-1037

UEA Repository

(Article)

(Published)


Vallee, I., Tait, S., Powell, P.

(2001)

African swine fever virus infection of procine aortic endothelial cells leads to inhibition of inflammatory responses, activation of the thrombotic state and apoptosis,

in Journal of Virology

75

(21)

pp. 10372-10382

UEA Repository

(Article)

(Published)


Key Research Interests

  • Viral evasion of the innate immune response
  • Viral proteins that inhibit interferon, RNA interference and inflammatory pathways
  • Stress responses to viral infection
  • Regulation of the innate immune response by autophagy
  • Autophagy pathways as a barrier to gene delivery into cells
  • Innate immunity in the small intestine
  • Innate signalling during gut differentiation from stem cells into small intestinal crypts
  • Use of next generation sequencing (NGS) to detect anti-viral resistance and small viral RNAs

 

 

Highlighted publications

Jefferson M, Donaszi-Ivanov A, Pollen S, Dalmay T, Saalbach G and Powell P. P. (2014) Host Factors interacting with the Pestivirus N terminal protease, Npro are Components of the Ribonucleoprotein Complex in Journal of Virology published ahead of print 25 June 2014,doi:10.1128/JVI.00984-14 

Jefferson, M., Whelband, M., Mohorianu, I., Powell, P. P. (2014) The Pestivirus N Terminal Protease Npro Redistributes to Mitochondria and Peroxisomes Suggesting New Sites for Regulation of IRF3 by Npro in PLoS ONE 9(2):e88838. Full Text UEA Repository

Donaszi-Ivanov, A., Mohorianu, I., Dalmay, T., Powell, P. P. (2013) Small RNA analysis in Sindbis virus infected human HEK293 cells in PLoS ONE 8 (12):e84070 Full Text UEA Repository

Zhou, Z., Mogensen, M. M., Powell, P. P., Curry, S., Wileman, T., Microscopy, Fluorescence (2013) Foot-and-mouth disease virus 3C protease induces fragmentation of the Golgi compartment and blocks intra-Golgi transport in Journal of Virology 87. pp. 11721-11729 Full Text UEA Repository

Goldspink, D., Gadsby, J., Bellett, G., Keynton, J., Tyrrell, B., Lund, E., Powell, P., Thomas, P., Mogensen, M. (2013) The microtubule end-binding protein EB2 is a central regulator of microtubule reorganisation in apico-basal epithelial differentiation in Journal of Cell Science 126.pp. 4000-4014 Full Text UEA Repository

Roberts, R., Al-Jamal, W., Whelband, M., Thomas, P., Jefferson, M., van den Bossche, J., Powell, P. P., Kostarelos, K., Wileman, T. (2013) Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery in Autophagy 9. pp. 667-682 Full Text UEA Repository

Greatorex, J. S., Page, R. F., Curran, M. D., Digard, P., Enstone, J. E., Wreghitt, T., Powell, P., Sexton, D., Vivancos, R., Nguyen-Van-Tam, J. S., RNA, Viral, Influenza A Virus, H1N1 Subtype (2010)Effectiveness of common household cleaning agents in reducing the viability of human influenza A/H1N1 in PLoS ONE 5.pp. e8987 Full Text UEA Repository Doceul, V., Charleston, B., Crooke, H., Reid, E., Powell, P., Seago, J. (2008) The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor in Journal of General Virology 89. pp. 1881-1889Full Text UEA Repository

Tennant, L., Renard, C., Chardon, P., Powell, P. (2007) Regulation of porcine classical and non classical MHC class I expression in Immunogenetics 59. pp. 377-389 UEA Repository

La Rocca, S., Herbert, R., Crooke, H., Drew, T., Wileman, T., Powell, P. (2005) Loss of interferon regulatory factor 3 in cells infected with classical swine fever virus involves the N-terminal protease, Nproin Journal of Virology 79. pp. 7239-7247 UEA Repository

Teaching Interests

2015-present Director of Postgraduate Research, Norwich Medical School

 I teach on the MBBS medical degree program at Norwich Medical School in the following:

  • Biochemistry lead for the MBBS degree
  • Year 2 Module 3 Lead Haematology and Dermatology.
  • SSS Biochemistry theme lead
  • Bioscience lead for Year 2.
  • Year 2 assessement group and Year 2 exam board 
  • Year 1 PBL group
  • Mentor for SSS as a pathway to research
  • Supervisor for MSc and PhD students
  • PhD Examiner
  • Medical school admissions

Professional Activities

Membership

1996-2014  American Society Microbiology

1994-2014 Society General Microbiology

1994-2005 British Society Immunology

1994-2005 British Society Cell Biology

1980-2005 Biochemiical Society