Career History

Dr Paul Crichton

2016-present        Lecturer, Norwich Medical School, University of East Anglia, Norwich, UK.

2008-2016            Investigator Scientist, MRC Mitochondrial Biology Unit, Cambridge, UK

2005-2008            MRC Career Development Fellow, MRC Mitochondrial Biology Unit, Cambridge, UK

2001-2004            PhD Biochemistry, University of Sussex, UK

All Publications

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Springett, R., King, M. S., Crichton, P. G., Kunji, E. R. S.

(2017)

Modelling the free energy profile of the mitochondrial ADP/ATP carrier,

in Biochimica et Biophysica Acta

1858

(11)

pp. 906-914

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Harborne, S. P. D., King, M. S., Crichton, P. G., Kunji, E. R. S.

(2017)

Calcium regulation of the human mitochondrial ATP-Mg/Pi carrier SLC25A24 uses a locking pin mechanism,

in Scientific Reports

7

article no. 45383

Full Text UEA Repository

(Article)

(Published)


Crichton, P. G., Lee, Y., Kunji, E. R. S.

(2017)

The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism,

in Biochimie

134

pp. 35–50

Full Text UEA Repository

(Article)

(Published)


Kunji, E. R., Aleksandrova, A., King, M. S., Majd, H., Ashton, V. L., Cerson, E., Springett, R., Kibalchenko, M., Tavoulari, S., Crichton, P. G., Ruprecht, J. J.

(2016)

The transport mechanism of the mitochondrial ADP/ATP carrier,

in Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

1863

(10)

pp. 2379-2393

Full Text UEA Repository

(Article)

(Published)


King, M. S., Kerr, M., Crichton, P. G., Springett, R., Kunji, E. R.

(2016)

Formation of a cytoplasmic salt bridge network in the matrix state is a fundamental step in the transport mechanism of the mitochondrial ADP/ATP carrier,

in Biochimica et Biophysica Acta - Bioenergetics

1857

(1)

pp. 14-22

Full Text UEA Repository

(Article)

(Published)


Lee, Y., Willers, C., Kunji, E. R. S., Crichton, P. G.

(2015)

Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin,

in Proceedings of the National Academy of Sciences of the United States of America (PNAS)

112

(22)

pp. 6973-6978

Full Text UEA Repository

(Article)

(Published)


Crichton, P. G., Lee, Y., Ruprecht, J. J., Cerson, E., Thangaratnarajah, C., King, M. S., Kunji, E. R. S.

(2015)

Trends in thermostability provide information on the nature of substrate, inhibitor, and lipid interactions with mitochondrial carriers,

in Journal of Biological Chemistry

290

(13)

pp. 8206-8217

Full Text UEA Repository

(Article)

(Published)


Ruprecht, J. J., Hellawell, A. M., Harding, M., Crichton, P. G., McCoy, A. J., Kunji, E. R. S.

(2014)

Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism,

in Proceedings of the National Academy of Sciences of the United States of America (PNAS)

111

(4)

pp. E426–E434

Full Text UEA Repository

(Article)

(Published)


Crichton, P. G., Harding, M., Ruprecht, J. J., Lee, Y., Kunji, E. R. S.

(2013)

Lipid, detergent, and coomassie blue G-250 affect the migration of small membrane proteins in blue native gels: Mitochondrial carriers migrate as monomers not dimers,

in Journal of Biological Chemistry

288

(30)

pp. 22163-22173

Full Text UEA Repository

(Article)

(Published)


Oelkrug, R., Goetze, N., Exner, C., Lee, Y., Ganjam, G. K., Kutschke, M., Müller, S., Stöhr, S., Tschöp, M. H., Crichton, P. G., Heldmaier, G., Jastroch, M., Meyer, C. W.

(2013)

Brown fat in a protoendothermic mammal fuels eutherian evolution,

in Nature Communications

4

article no. 2140

Full Text UEA Repository

(Article)

(Published)


Crichton, P. G., Parker, N., Vidal-Puig, A. J., Brand, M. D.

(2010)

Not all mitochondrial carrier proteins support permeability transition pore formation: no involvement of uncoupling protein 1,

in Bioscience Reports

30

(3)

pp. 187-192

Full Text UEA Repository

(Article)

(Published)


Kunji, E. R. S., Crichton, P. G.

(2010)

Mitochondrial carriers function as monomers,

in Biochimica et Biophysica Acta - Bioenergetics

1797

(6-7)

pp. 817-831

Full Text UEA Repository

(Article)

(Published)


Crichton, P. G., Albury, M. S., Affourtit, C., Moore, A. L.

(2010)

Mutagenesis of the Sauromatum guttatum alternative oxidase reveals features important for oxygen binding and catalysis,

in Biochimica et Biophysica Acta - Bioenergetics

1797

(6-7)

pp. 732-737

Full Text UEA Repository

(Article)

(Published)


Parker, N., Crichton, P. G., Vidal-Puig, A. J., Brand, M. D.

(2009)

Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria,

in Journal of Bioenergetics and Biomembranes

41

article no. 335

Full Text UEA Repository

(Article)

(Published)


Moore, A. L., Carré, J. E., Affourtit, C., Albury, M. S., Crichton, P. G., Kita, K., Heathcote, P.

(2008)

Compelling EPR evidence that the alternative oxidase is a diiron carboxylate protein,

in Biochimica et Biophysica Acta - Bioenergetics

1777

(4)

pp. 327-330

Full Text UEA Repository

(Article)

(Published)


Affourtit, C., Crichton, P. G., Parker, N., Brand, M. D.

(2007)

Novel Uncoupling Proteins,

in Mitochondrial Biology: New Perspectives : Novartis Foundation Symposium 287.

Wiley

pp. 70-80

ISBN 9780470066577

Full Text UEA Repository

(Chapter)

(Published)


Crichton, P. G., Affourtit, C., Moore, A. L.

(2007)

Identification of a mitochondrial alcohol dehydrogenase in Schizosaccharomyces pombe: new insights into energy metabolism,

in Biochemical Journal

401

(2)

pp. 459-464

Full Text UEA Repository

(Article)

(Published)


Moore, A. L., Albury, M. S., Crichton, P. G.

(2006)

‘Green’ …yet wasting energy? - mitochondrial respiration in plants,

in The Biochemist

28

(4)

pp. 13-16

UEA Repository

(Article)

(Published)


Crichton, P. G., Affourtit, C., Albury, M. S., Carré, J. E., Moore, A. L.

(2005)

Constitutive activity of Sauromatum guttatum alternative oxidase in Schizosaccharomyces pombe implicates residues in addition to conserved cysteines in α-keto acid activation,

in FEBS Letters

579

(2)

pp. 331-336

Full Text UEA Repository

(Article)

(Published)


Moore, A. L., Albury, M. S., Crichton, P. G., Affourtit, C.

(2002)

Function of the alternative oxidase: Is it still a scavenger?,

in Trends in Plant Science

7

(11)

pp. 478-481

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

Mitochondria are central to energy metabolism in our cells. My interests cover the molecular and bioenergetic processes that occur in mitochondria and how they relate to our health. Membrane proteins are fundamental to mitochondrial energy transduction and uncoupling proteins (UCP1-5), in particular, are a current research focus of mine. UCP1 is the protein in mammals that allows brown adipose tissue to burn off calories as heat in response to cold temperatures. If activated in humans, UCP1-dependent thermogenesis has the capacity to contribute significantly to energy expenditure and help combat obesity and related disease. My research aims to resolve the molecular and structural mechanisms that underlie UCP activity and regulation and, importantly, the function that these unusual proteins may play in pathophysiology and prevention of disease.