Biography

Professor Michael Müller is Director of the Norwich Research Park Food and Health Alliance and a Professor of Nutrigenomics and Systems Nutrition. He is a renowned expert in the area of molecular nutrition related to lipid homeostasis, nutrigenomics and nutritional systems biology and his work is focussed on the molecular mechanisms underlying genome-wide effects of foods (specific bioactive components or nutrients) on immuno-metabolic health and plasticity.

Professor Muller was a member of the editorial boards of numerous journals, i.e. “BMC Genomics” (associate editor), "European Journal of Nutrition" (section editor "Nutrigenomics") and “PLOS One” (academic editor), visiting professor at Nanijng Agricultural University and (co)author of more than 230 peer-reviewed publications with more than 10500 citations.  As promoter he has supervised 24 PhD students, has an H-factor of 59 and is a member of the “Faculty of 1000” (Biology/Physiology).

Career History

1988 – 1994 German Cancer Research Center, Division of Tumorbiochemistry, Heidelberg/Germany. Postdoctoral fellow and scientific employee at the German Cancer Research Center.

1994 - Nov 2000 University Hospital Groningen, Division of Gastroenterology and Hepatology, Groningen/The Netherlands. Associate professor, senior scientist and research leader (“Regulation of transport proteins in normal and diseased liver”)

2000 – 2013 University Wageningen, Nutrition, Metabolism and Genomics group, Wageningen/ The Netherlands. Full professor and Chair of Nutrition, Metabolism and Genomics at Wageningen University/The Netherlands. From 2003-2009 he was Scientific Director of the Nutrigenomics Consortium.  From 2010-2013 he was Scientific Director of the Netherlands Nutrigenomics Center.  He was board member of the NUGO. 

2014 – now University of East Anglia Norwich/UK. Full Professor at the Norwich Medical School (Molecular Nutrition and Nutrigenomics) and Director of the Food and Health Alliance (FAHA; Norwich Research Park). He is also interim director of NUGO.

Academic Background

1983 - 1988 University Freiburg/Germany
PhD thesis project

1979 - 1983 University Freiburg/Germany
Examination as chemist (Diplomchemiker)

1976 - 1979 University Dortmund/Germany
Pre examination chemistry

All Publications

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Hangelbroek, R. W., Fazelzadeh, P., Tieland, M., Boekschoten, M. V., Hooiveld, G. J., van Duynhoven, J. P., Timmons, J. A., Verdijk, L. B., de Groot, L. C., van Loon, L. J., Müller, M.

(2016)

Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness

in Journal of Cachexia, Sarcopenia and Muscle

Full Text UEA Repository

(Article)


Cubero, F. J., Zoubek, M. E., Peng, J., Hu, W., Zhao, G., Nevzorova, Y. A., Al Masaoudi, M., Bechmann, L. P., Boekschoten, M. V., Muller, M., Preisinger, C., Gassler, N., Canbay, A. E., Luedde, T., Davis, R. J., Liedtke, C., Trautwein, C.

(2016)

Combined activities of JNK1 and JNK2 in hepatocytes protect against toxic liver injury

in Gastroenterology

150.

pp. 968-981

Full Text UEA Repository

(Article)


Song, S., Hooiveld, G. J., Li, M., Zhao, F., Zhang, W., Xu, X., Muller, M., Li, C., Zhou, G.

(2016)

Dietary soy and meat proteins induce distinct physiological and gene expression changes in rats

in Scientific Reports

6.

Full Text UEA Repository

(Article)


Fazelzadeh, P., Hangelbroek, R. W. J., Tieland, M., de Groot, L. C., Verdijk, L. B., van Loon, L. J. C., Smilde, A. K., Alves, R. D. A. M., Vervoort, J., Muller, M., van Duynhoven, J. P. M., Boekschoten, M. V.

(2016)

The muscle metabolome differs between healthy and frail older adults

in Journal of Proteome Research

15.

pp. 499-509

Full Text UEA Repository

(Article)


Song, S., Hooiveld, G. J., Li, M., Zhao, F., Zhang, W., Xu, X., Muller, M., Li, C., Zhou, G.

(2016)

Distinct physiological, plasma amino acid, and liver transcriptome responses to purified dietary beef, chicken, fish, and pork proteins in young rats

in Molecular Nutrition & Food Research

60.

pp. 1199-1205

Full Text UEA Repository

(Article)


Nyima, T., Muller, M., Hooiveld, G. J., Morine, M. J., Scotti, M.

(2016)

Nonlinear transcriptomic response to dietary fat intake in the small intestine of C57BL/6J mice

in BMC Genomics

17.

Full Text UEA Repository

(Article)


Matualatupauw, J. C., Radonjic, M., van de Rest, O., de Groot, L., Geleijnse, J., Müller, M., Afman, L.

(2016)

Apolipoprotein E genotype status affects habitual human blood mononuclear cell gene expression and its response to fish oil intervention

in Molecular Nutrition & Food Research

60.

pp. 1649-1660

Full Text UEA Repository

(Article)


Steegenga, W. T., Mischke, M., Lute, C., Boekschoten, M. V., Lendvai, A., Pruis, M. G., Verkade, H. J., van de Heijning, B. J., Boekhorst, J., Timmerman, H. M., Plösch, T., Muller, M., Hooiveld, G. J.

(2016)

Maternal exposure to a Western-style diet causes differences in intestinal microbiota composition and gene expression of suckling mouse pups

in Molecular Nutrition & Food Research

Full Text UEA Repository

(Article)


Strong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., Fernandez, E., Flurkey, K., Hamilton, K. L., Lamming, D. W., Javors, M. A., Pedro de Magalhães, J., Marinez, P. A., McCord, J. M., Miller, B. F., Muller, M., Nelson, J. F., Ndukum, J., Rainger, G. E., Richardson, A., Sabatini, D. M., Salmon, A. B., Simpkins, J. W., Steegenga, W. T., Nadon, N. L., Harrison, D. E.

(2016)

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

in Aging Cell

Full Text UEA Repository

(Article)


Rusli, F., Deelen, J., Andriyani, E., Boekschoten, M. V., Lute, C., van den Akker, E. B., Muller, M., Beekman, M., Steegenga, W. T.

(2016)

Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice

in Scientific Reports

6.

Full Text UEA Repository

(Article)


Van Bussel, I. P. G., Jolink-Stoppelenburg, A., De Groot, C. P. G. M., Müller, M. R., Afman, L. A.

(2016)

Differences in genome-wide gene expression response in peripheral blood mononuclear cells between young and old men upon caloric restriction

in Genes & Nutrition

11.

Full Text UEA Repository

(Article)


Cubero, F. J., Zhao, G., Nevzorova, Y. A., Hatting, M., Masaoudi, M. A., Verdier, J., Peng, J., Schaefer, F. M., Hermanns, N., Boekschoten, M. V., Grouls, C., Gassler, N., Kiessling, F., Muller, M., Davis, R. J., Liedtke, C., Trautwein, C.

(2015)

Hematopoietic cells-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury

in Journal of Hepatology

62.

pp. 140-149

Full Text UEA Repository

(Article)


Rusli, F., Boekschoten, M. V., Zubia, A. A., Lute, C., Müller, M., Steegenga, W. T.

(2015)

A weekly alternating diet between caloric restriction and medium fat protects the liver from fatty liver development in middle-aged C57BL/6J mice

in Molecular Nutrition & Food Research

59.

pp. 533–543

Full Text UEA Repository

(Article)


Hemmerling, J., Jansen, J., Müller, M., Haller, D.

(2015)

Fetal gut laser microdissection in combination with RNA preamplification enables epithelial-specific transcriptional profiling

in Journal of Immunological Methods

416.

pp. 189–192

Full Text UEA Repository

(Article)


Haksier, E., Boekschoten, M. V., Hu, W., Haybaeck, J., Gassler, N., Muller, M., Liedtke, C., Trautwein, C.

(2015)

p21 ablation in liver enhances DNA damage, cholestasis and carcinogenesis

in Cancer Research

75.

Full Text UEA Repository

(Article)


van Norren, K., Rusli, F., van Dijk, M., Lute, C., Nagel, J., Dijk, F., Boekschoten, M., Luiking, Y., Witkamp, R. F., Muller, M., Steegenga, W. T.

(2015)

Behavioural changes are a major contributing factor in the reduction of sarcopenia in calorie-restricted ageing mice

in Journal of Cachexia, Sarcopenia and Muscle

6.

pp. 253–268

Full Text UEA Repository

(Article)


Gruber, L., Hemmerling, J., Schuppel, V., Muller, M., Boekschoten, M. V., Haller, D.

(2015)

Maternal high-fat diet accelerates development of CD-like ileitis in TNF-ARE/WT offspring without affecting fetal epithelial gene expression

in Inflammatory Bowel Diseases

21.

pp. 2016-2025

Full Text UEA Repository

(Article)


Esser, D., van Dijk, S., Oosterink, E., Lopez, S., Muller, M., Afman, L.

(2015)

High fat challenges with different fatty acids affect distinct atherogenic gene expression pathways in immune cells from lean and obese subjects

in Molecular Nutrition & Food Research

59.

pp. 1563–1572

Full Text UEA Repository

(Article)


Lange, K., Hugenholtz, F., Jonathan, M., Schols, H., Kleerebezem, M., Smidt, H., Muller, M., Hooiveld, G.

(2015)

Comparison of the effects of five dietary fibres on mucosal transcriptional profiles and luminal microbiota composition and SCFA concentrations in murine colon

in Molecular Nutrition & Food Research

59.

pp. 1590-1602

Full Text UEA Repository

(Article)


Ijssennagger, N., Belzer, C., Hooiveld, G. J., Dekker, J., van Mil, S. W. C., Müller, M., Kleerebezem, M., van der Meer, R.

(2015)

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon

in Proceedings of the National Academy of Sciences of the United States of America (PNAS)

112.

pp. 10038-10043

Full Text UEA Repository

(Article)


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Key Research Interests

Molecular nutrition related to lipid homeostasis, nutrigenomics and nutritional systems biology.  

Molecular mechanisms underlying genome-wide effects of foods (specific bioactive components or nutrients) on metabolic health and plasticity.

External Activities and Indicators of Esteem

Visiting professor at Nanijng Agricultural University (China)

Review editor “Frontiers in Genomics”

Former activities: Associate Editor of “BMC Genomics”, Section editor "Nutrigenomics” of  "European Journal of Nutrition", Academic editor of “PLOS ONE”

 

Member of the International Adivisory Board of COSBI (The Microsoft Research - University of Trento Centre for Computational and Systems Biology) 2013-2016.

Member of the International Advisory Board of Biopolis S.L. Valencia, Spain.

Member of the Scientific Committee of the Fondazione Umberto Veronesi.

Reviewer of articles submitted to Journal of Hepatology, Diabetes, Nature Reviews Genetics, Nature Reviews Gastroenterology, Hepatology, Cancer Research, Faseb Journal, American Journal of Clinical Nutrition.

Reviewer of grant applications submitted to INSERM & ANR (France, also function as rapporteur), NWO (The Netherlands), Swiss National Science Foundation, DFG (Germany), ERC (EU), Qatar Research Foundation and many others.