Biography

Marcus Flather graduated from the Royal Free Hospital School of Medicine, University of London in 1982 and trained in general medicine and cardiology in London and Oxford. In 1988 he joined the Department of Cardiovascular Medicine and the Clinical Trial Service Unit at the University of Oxford as a British Heart Foundation Junior Research Fellow with Peter Sleight, Rory Collins and Richard Peto working on the large scale ISIS trials in acute myocardial infarction.

In 1993 he moved to McMaster University in Hamilton, Canada, to work with Salim Yusuf as a Clinical Research Scholar on international trials in acute coronary syndromes including the OASIS programme, and undertook formal training in clinical trials and epidemiology. In 1996 he took up the post of Director of the new Clinical Trials and Evaluation Unit (CTEU) at the Royal Brompton and Harefield Hospitals where the Unit developed an international reputation in the design and management of randomised trials in cardiovascular and respiratory diseases.

In September 2011 he took up the post of Professor of Medicine and Clinical Trials at the University of East Anglia and Director of Research at the Norfolk and Norwich University Hospitals NHS Foundation Trust in Norwich. Marcus Flather is a Fellow of the Royal College of Physicians (UK) and holds a certificate of higher specialist training in Cardiology and General (Internal) Medicine in the UK (CCST). He has about 200 peer reviewed publications, is a recognised expert in clinical trials and has more than 20 years experience of collaborating with industry partners in drug and device development.


All Publications

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Benedetto, U., Altman, D. G., Flather, M., Gerry, S., Gray, A., Lees, B., Taggart, D. P.

(2018)

Incidence and clinical implications of intraoperative BITA grafts conversion. Insights from the Arterial Revascularization Trial,

in Journal of Thoracic and Cardiovascular Surgery

155

(6)

pp. 2346-2355.e6

Full Text UEA Repository

(Article)

(Published)


Beygui, F., Van Belle, E., Ecollan, P., Machecourt, J., Hamm, C. W., Lopez De Sa, E., Flather, M., Verheugt, F. W. A., Vicaut, E., Zannad, F., Pittl, B., Montalescot, G.

(2018)

Individual participant data analysis of two trials on aldosterone blockade in myocardial infarction,

in Heart

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Benedetto, U., Altman, D. G., Gerry, S., Gray, A., Lees, B., Flather, M., Taggart, D. P.

(2018)

Off-pump versus on-pump coronary artery bypass grafting: Insights from the Arterial Revascularization Trial,

in Journal of Thoracic and Cardiovascular Surgery

155

(4)

pp. 1545-1553.e7

Full Text UEA Repository

(Article)

(Published)


Head, S. J., Milojevic, M., Daemen, J., Ahn, J., Boersma, E., Christiansen, E. H., Domanski, M. J., Farkouh, M. E., Flather, M., Fuster, V., Hlatky, M. A., Holm, N. R., Hueb, W. A., Kamalesh, M., Kim, Y., Mäkikallio, T., Mohr, F. W., Papageorgiou, G., Park, S., Rodriguez, A. E., Sabik, J. F., Stables, R. H., Stone, G. W., Serruys, P. W., Kappetein, A. P.

(2018)

Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data,

in Lancet

391

(10124)

pp. 939-948

Full Text UEA Repository

(Article)

(Published)


Benedetto, U., Altman, D. G., Gerry, S., Gray, A., Lees, B., Angelini, G. D., Flather, M., Taggart, D. P.

(2018)

Safety of Perioperative Aprotinin Administration During Isolated Coronary Artery Bypass Graft Surgery: Insights From the ART (Arterial Revascularization Trial),

in Journal of the American Heart Association

7

(5)

article no. e007570

Full Text UEA Repository

(Article)

(Published)


Timmis, A., Townsend, N., Gale, C., Grobbee, D., Maniadakis, N., Flather, M., Wilkins, E., Wright, F., Vos, R., Bax, J., Blum, M., Pinto, F., Vardas, P.

(2018)

European Society of Cardiology: Cardiovascular Disease Statistics 2017,

in European Heart Journal

39

(7)

pp. 508–579

Full Text UEA Repository

(Article)

(Published)


Adamson, P. D., Hunter, A., Williams, M. C., Shah, A. S., McAllister, D. A., Pawade, T. A., Dweck, M. R., Mills, N. L., Berry, C., Boon, N. A., Clark, E., Flather, M., Forbes, J., McLean, S., Roditi, G., van Beek, E. J., Timmis, A. D., Newby, D. E.

(2018)

Diagnostic and prognostic benefits of computed tomography coronary angiography using the 2016 National Institute for Health and Care Excellence guidance within a randomised trial,

in Heart

104

pp. 207-214

Full Text UEA Repository

(Article)

(Published)


Adamson, P. D., Hunter, A., Madsen, D. M., Shah, A. S., McAllister, D. A., Pawade, T. A., Williams, M. C., Berry, C., Boon, N. A., Flather, M., Forbes, J., McLean, S., Roditi, G., Timmis, A. D., van Beek, E. J., Dweck, M. R., Mickley, H., Mills, N. L., Newby, D. E.

(2018)

High-Sensitivity Cardiac Troponin I and the Diagnosis of Coronary Artery Disease in Patients With Suspected Angina Pectoris,

in Circulation: Cardiovascular Quality and Outcomes

11

(2)

article no. e004227

Full Text UEA Repository

(Article)

(Published)


Cleland, J. G. F., Bunting, K. V., Flather, M. D., Altman, D. G., Holmes, J., Coats, A. J. S., Manzano, L., McMurray, J. J. V., Ruschitzka, F., van Veldhuisen, D. J., Von Lueder, T. G., Böhm, M., Andersson, B., Kjekshus, J., Packer, M., Rigby, A. S., Rosano, G., Wedel, H., Hjalmarson, Å., Wikstrand, J., Kotecha, D.

(2018)

Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials,

in European Heart Journal

39

(1)

pp. 26–35

Full Text UEA Repository

(Article)

(Published)


Timmis, A. D., Gale, C. P., Flather, M., Maniadakis, N., Vardas, P.

(2018)

Cardiovascular disease statistics from the European atlas: inequalities between high- and middle-income member countries of the ESC,

in European Heart Journal - Quality of Care and Clinical Outcomes

4

(1)

pp. 1-3

Full Text

(Editorial)

(Published)


Pedro Ferreira, J., Duarte, K., Montalescot, G., Pitt, B., Lopez de Sa, E., Hamm, C. W., Flather, M., Verheugt, F., Shi, H., Turgonyi, E., Orri, M., Rossignol, P., Vincent, J., Zannad, F.

(2018)

Effect of eplerenone on extracellular cardiac matrix biomarkers in patients with acute ST-elevation myocardial infarction without heart failure: insights from the randomized double-blind REMINDER Study,

in Clinical Research in Cardiology

107

(1)

pp. 49–59

Full Text UEA Repository

(Article)

(Published)


Gray, A. M., Murphy, J., Altman, D. G., Benedetto, U., Campbell, H., Flather, M., Gerry, S., Lees, B., Taggart, D. P.

(2017)

One-year costs of bilateral or single internal mammary grafts in the Arterial Revascularisation Trial,

in British Medical Journal (BMJ)

103

pp. 1719-1726

Full Text UEA Repository

(Article)

(Published)


Vedin, O., Hagström, E., Östlund, O., Avezum, A., Budaj, A., Flather, M. D., Harrington, R. A., Koenig, W., Soffer, J., Siegbahn, A., Steg, P. G., A.H. Stewart, R., Wallentin, L., White, H. D., Held, C.

(2017)

Associations between tooth loss and prognostic biomarkers and the risk for cardiovascular events in patients with stable coronary heart disease,

in International Journal of Cardiology

245

pp. 271–276

Full Text UEA Repository

(Article)

(Published)


Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., Kastelein, J. J., Cornel, J. H., Pais, P., Pella, D., Genest, J., Cifkova, R., Lorenzatti, A., Forster, T., Kobalava, Z., Vida-Simiti, L., Flather, M., Shimokawa, H., Ogawa, H., Dellborg, M., Troquay, R. P., Rossi, P. R., Libby, P., Glynn, R. J.

(2017)

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease,

in New England Journal of Medicine

377

(12)

pp. 1119-1131

Full Text UEA Repository

(Article)

(Published)


Benedetto, U., Altman, D. G., Gerry, S., Gray, A., Lees, B., Flather, M., Taggart, D. P.

(2017)

Impact of dual antiplatelet therapy after coronary artery bypass surgery on 1-year outcomes in the Arterial Revascularization Trial,

in European Journal of Cardio-Thoracic Surgery

52

(3)

pp. 456–461

Full Text UEA Repository

(Article)

(Published)


Curtain, J. P., Yu, M., Clark, A. B., Gollop, N. D., Bettencourt-Silva, J. H., Metcalf, A. K., Bowles, K. M., Flather, M. D., Potter, J. F., Myint, P. K.

(2017)

Determinants of Length of Stay Following Total Anterior Circulatory Stroke,

in BMC Geriatrics

2

(3)

article no. 26

Full Text UEA Repository

(Article)

(Published)


Taggart, D. P., Altman, D. G., Flather, M. D., Gerry, S., Gray, A. M., Lees, B., Benedetto, U.

(2017)

Associations between adding a radial artery graft to single and bilateral internal thoracic artery grafts and outcomes. Insights from the Arterial Revascularization Trial,

in Circulation

136

(5)

pp. 454-463

Full Text UEA Repository

(Article)

(Published)


Williams, M. C., Hunter, A., Shah, A., Assi, V., Lewis, S., Mangion, K., Berry, C., Boon, N. A., Clark, E., Flather, M., Forbes, J., McLean, S., Roditi, G., van Beek, E. J., Timmis, A. D., Newby, D. E.

(2017)

Symptoms and quality of life in patients with suspected angina undergoing CT coronary angiography: a randomised controlled trial,

in Heart

103

(13)

pp. 995-1001

Full Text UEA Repository

(Article)

(Published)


Kotecha, D., Flather, M. D., Altman, D. G., Holmes, J., Rosano, G., Wikstrand, J., Packer, M., Coats, A. J., Manzano, L., Böhm, M., van Veldhuisen, D. J., Andersson, B., Wedel, H., von Lueder, T. G., Rigby, A. S., Hjalmarson, Å., Kjekshus, J., Cleland, J. G.

(2017)

Heart Rate and Rhythm and the Benefit of Beta-Blockers in Patients With Heart Failure,

in Journal of the American College of Cardiology

69

(24)

pp. 2885–2896

Full Text UEA Repository

(Article)

(Published)


Saunders, P., Tsipouri, V., Keir, G. J., Ashby, D., Flather, M. D., Parfrey, H., Babalis, D., Renzoni, E. A., Denton, C. P., Wells, A. U., Maher, T. M.

(2017)

Rituximab versus cyclophosphamide for the treatment of connective tissue disease-associated interstitial lung disease (RECITAL): study protocol for a randomised controlled trial,

in Trials

18

article no. 275

Full Text UEA Repository

(Article)

(Published)


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