All Publications

Shafat, M. S., Oellerich, T., Mohr, S., Robinson, S. D., Edwards, D. R., Marlein, C. R., Piddock, R. E., Fenech, M., Zaitseva, L., Abdul-Aziz, A., Turner, J., Watkins, J. A., Lawes, M., Bowles, K. M., Rushworth, S. A.

(2017)

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment,

in Blood

129

(10)

pp. 1320-1332

Full Text UEA Repository

(Article)

(Published)


Chen, L., Kostadima, M., Martens, J. H. A., Canu, G., Garcia, S. P., Turro, E., Downes, K., Macaulay, I. C., Bielczyk-Maczynska, E., Coe, S., Farrow, S., Poudel, P., Burden, F., Jansen, S. B., Astle, W. J., Attwood, A., Bariana, T., de Bono, B., Breschi, A., Chambers, J. C., Choudry, F. A., Clarke, L., Coupland, P., van der Ent, M., Erber, W. N., Jansen, J. H., Favier, R., Fenech, M. E., Foad, N., Freson, K., van Geet, C., Gomez, K., Guigo, R., Hampshire, D., Kelly, A. M., Kerstens, H. H., Kooner, J. S., Laffan, M., Lentaigne, C., Labalette, C., Martin, T., Meacham, S., Mumford, A., Nürnberg, S. T., Palumbo, E., van der Reijden, B. A., Richardson, D., Sammut, S. J., Slodkowicz, G., Tamuri, A. U., Vasquez, L., Voss, K., Watt, S., Westbury, S., Flicek, P., Loos, R., Goldman, N., Bertone, P., Read, R. J., Richardson, S., Cvejic, A., Soranzo, N., Ouwehand, W. H., Stunnenburg, H. G., Frontini, M., Rendon, A.

(2014)

Transcriptional diversity during lineage commitment of human blood progenitors,

in Science

345

(6204)

Full Text UEA Repository

(Article)

(Published)


Rosell, M., Kaforou, M., Frontini, A., Okolo, A., Chan, Y., Nikolopoulou, E., Millership, S., Fenech, M., Macintyre, D., Turner, J., Moore, J., Blackburn, E., Gullick, W., Cinti, S., Montana, G., Parker, M., Christian, M.

(2014)

Brown and White Adipose Tissues. Intrinsic differences in gene expression and response to cold exposure in mice.,

in American Journal of Physiology - Endocrinology and Metabolism

306

article no. E945-E964

Full Text UEA Repository

(Article)

(Published)


Kumaravel, B., Bachmann, M., Murray, N., Dhatariya, K., Fenech, M., John, W., Scarpello, T., Sampson, M.

(2012)

Use of haemoglobin A1c to detect impaired fasting glucose or Type 2 diabetes in a United Kingdom community based population,

in Diabetes Research and Clinical Practice

96

(2)

pp. 211-216

Full Text UEA Repository

(Article)

(Published)


Mackay, J., Fenech, M., Myint, K.

(2012)

Acute rhabdomyolysis due to combination therapy with atovastatin and warfarin,

in British Journal of Hospital Medicine

73

(2)

pp. 350-351

UEA Repository

(Article)

(Published)


Corander, M., Fenech, M., Coll, A.

(2009)

Science of Self-Preservation: How Melanocortin Action in the Brain Modulates Body Weight, Blood Pressure and Ischemic Damage,

in Circulation

120

pp. 2260-2268

Full Text UEA Repository

(Article)

(Published)


Key Research Interests

My research is focused on exploring the molecular basis of metabolic disease associated with obesity and, by adopting a systems biology-based, integrative approach, on understanding these dysfunctional molecular pathways in the context of whole-body physiology. In particular, I am interested in the relationship between adipose tissue inflammation and restricted adipose expansion and how this translates into changes in lipid distribution at the whole organism level. 

I have secured competitive funding allowing me to undertake a PhD in obesity and metabolic disease research. Following this, I aim to take up an intermediate fellowship that will allow me to complete my scientific and clinical training in parallel. I envisage a career as an academic clinician and look forward to being able to use the novel insights and discoveries provided by my research, and that of my collaborators, in my clinical practice in a university teaching hospital. Ultimately, my long term aim is to make the restricted adipose expandability hypothesis clinically relevant by devising, testing and implementing therapeutic strategies that uncouple obesity from its metabolic complications.