Biography

Jonathan Tang BSc. MSc. FIBMS

Over 17 years experience in the field of clinical chemistry and research into metabolic bone disease. Currently a HCPC registered advanced Biomedical Scientist in Biochemistry and a fellow member of the Institute of Biomedical Science (IBMS). Previously held position as a senior Biomedical Scientist of the liquid chromatography tandem mass spectrometry (LC-MS/MS) section at the Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool and Broadgreen University Hospital NHS Trust (2001-2011). Appointed senior research associate, Norwich Medical school, University of East Anglia (UEA) (2011-2016), then promoted to research fellow in metabolic bone disease since 2016.

In 2011, working closely with Prof. William (Bill) Fraser, established Bioanalytical facility (BAF); a multidisciplinary lab facility specialised in fully/semi-automated/manual HPLC-MS/MS, isotopic/non-isotopic immunoassay, and wet chemistry techniques. BAF is accredited by the Central Pathology Accreditation (CPA) and certified for Good Clinical Laboratory Practice (GCLP). I lead a team of research technicians, post-doctoral research associates, biomedical scientists and clinical scientists from UEA and the Norfolk and Norwich University Hospital NHS trust (NNUHFT). I also co-supervise MRes, PhD, BSc. and MBBS students.

I specialise in biochemical analysis of small molecules, proteins and peptides, used in diagnostics and clinical research studies in metabolic bone disease. My research focuses on vitamin D metabolites, bone remodelling/turnover biomarkers, osteoanabolics and homeostatic markers of calcium/phosphate metabolism. Key publications include development of LC-MS/MS assays for vitamin D metabolites (1,25-dihydrox vitamin D, 25-hydroxyvitamin D and 24, 25-dihydroxyvitamin D), and bone turnover markers in the study of their relationships in health and in disease, studies on the effects of vitamin D supplementation/exercise in sport athletes and in general populations. Currently hold grant funding from government, Pharma and research councils for studies in bone stress fracture and treatment using PTH therapeutics.

 

All Publications

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Macdonald, H., Gryka, A., Tang, J., Aucott, L., Fraser, W., Wood, A.

(2017)

Longevity of daily oral Vitamin D3 supplementation: Differences in 25OHD and 24,25(OH)2D observed 2 years after cessation of a 1-year randomized controlled trial (VICtORy RECALL),

in Osteoporosis International

28

(12)

pp. 3361–3372

Full Text UEA Repository

(Article)

(Published)


Papageorgiou, M., Elliott-Sale, K. J., Parsons, A., Tang, J., Greeves, J. P., Fraser, W. D., Sale, C.

(2017)

Effects of reduced energy availability on bone metabolism in women and men,

in Bone

105

pp. 191-199

Full Text UEA Repository

(Article)

(Published)


Al Riyami, S., Tang, J. C. Y., Galitzer, H., Fraser, W.

(2017)

LC-MS/MS measurement of parathyroid hormone PTH (1-34): Use in studying oral PTH (1-34) administration and possible diagnostic application in pseudohypoparathyroidism.,

Full Text

(Poster)

(Published)


Earl, K. E., Sakellariou, G. K., Sinclair, M., Fenech, M., Croden, F., Owens, D. J., Tang, J., Miller, A., Lawton, C., Dye, L., Close, G. L., Fraser, W. D., McArdle, A., Beadsworth, M. B. J.

(2017)

Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England,

in BMJ Open

7

article no. e015296

Full Text UEA Repository

(Article)

(Published)


Saleh, L., Tang, J. C., Gawinecka, J., Boesch, L., Fraser, W. D., von Eckardstein, A., Nowak, A.

(2017)

Impact of a single oral dose of 100,000 IU vitamin D3 on profiles of serum 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in adults with vitamin D insufficiency,

in Clinical Chemistry and Laboratory Medicine

55

(12)

pp. 1912-1921

Full Text UEA Repository

(Article)

(Published)


Hanusch, B., Tuck, S., McNally, R., Wu, J., Prediger, M., Walker, J., Tang, J., Piec, I., Fraser, W., Datta, H., Francis, R.

(2017)

Does regional loss of bone density explain low trauma distal forearm fractures in men (the Mr F study)?,

in Osteoporosis International

28

(10)

pp. 2877–2886

Full Text UEA Repository

(Article)

(Published)


Burstein, G., Tang, J. C. Y., Rothner, A., Galitzer, H., Schwartz, P., Fraser, W.

(2017)

Enhanced bioavailability and reduced pharmacokinetic variability of Oral PTH (1-34) in man,

Full Text

(Poster)

(Published)


Al Riyami, S., Tang, J. C. Y., Dutton, J., Washbourne, C., Galitzer, H., Fraser, W.

(2017)

Development and Validation of a LC-MS/MS Assay for Quantification of Parathyroid Hormone (PTH 1-34) in human Plasma,

Full Text

(Poster)

(Published)


Al Riyami, S., Tang, J. C. Y., Galitzer, H., Fraser, W.

(2017)

Measurements of Osteoanabolic agents PTH (1-34) and PTHrP (1-36) in therapeutic studies and clinical diagnostics,

Full Text

(Poster)

(Published)


Piec, I., Dutton, J., Al Riyami, S., Washbourne, C., Schoenmakers, I., Galitzer, H., Burshtein, G., Schwartz, P., Tang, J. C. Y., Fraser, W.

(2017)

A LC-MS/MS method for the diagnostic measurement of cAMP in plasma and urine,

(Poster)

(Published)


Tang, J. C. Y., Nicholls, H., Ball, N., Dutton, J., Piec, I., Rudge, J., Washbourne, C., Fraser, W.

(2017)

Assessment of vitamin D status using MitraTM volumetric absorptive microsampling (VAMS) device,

Full Text

(Poster)

(Published)


Tang, J. C. Y., Nicholls, H., Piec, I., Washbourne, C. J., Dutton, J. J., Jackson, S., Greeves, J., Fraser, W. D.

(2017)

Reference intervals for serum 24,25-Dihydroxyvitamin D and the ratio with 25-Hydroxyvitamin established using a newly developed LC-MS/MS method,

in Journal of Nutritional Biochemistry

46

pp. 21–29

Full Text UEA Repository

(Article)

(Published)


Townsend, R., Elliott-Sale, K. J., Currell, K., Tang, J., Fraser, W. D., Sale, C.

(2017)

The Effect of Postexercise Carbohydrate and Protein Ingestion on Bone Metabolism,

in Medicine & Science in Sports & Exercise

49

(6)

pp. 1209-1218

Full Text UEA Repository

(Article)

(Published)


Cleal, J. K., Hargreaves, M. R., Poore, K. R., Tang, J. C. Y., Fraser, W. D., Hanson, M. A., Green, L. R.

(2017)

Reduced fetal vitamin D status by maternal undernutrition during discrete gestational windows in sheep,

in Journal of Developmental Origins of Health and Disease

8

(3)

pp. 370-381

Full Text UEA Repository

(Article)

(Published)


Peel, A. M., Crossman-Barnes, C., Tang, J., Fowler, S., Davies, G., Wilson, A., Loke, Y.

(2017)

Biomarkers in adult asthma: a systematic review of 8-isoprostane in exhaled breath condensate,

in Journal of Breath Research

11

(1)

article no. 016011

Full Text UEA Repository

(Article)

(Published)


Owens, D. J., Tang, J. C. Y., Bradley, W. J., Sparks, S. A., Fraser, W. D., Morton, J. P., Close, G. L.

(2017)

Efficacy of High-Dose Vitamin D Supplements for Elite Athletes,

in Medicine and Science in Sports and Exercise

49

(2)

pp. 349–356

Full Text UEA Repository

(Article)

(Published)


Tang, J. C., Dutton, J. J., Piec, I., Green, D., Fisher, E., Washbourne, C. J., Fraser, W. D.

(2016)

LC–MS/MS application for urine free pyridinoline and free deoxypyridinoline: Urine markers of collagen and bone degradation,

in Clinical Mass Spectrometry

1

pp. 11–18

Full Text UEA Repository

(Article)

(Published)


Piec, I., Chipchase, A., Nicholls, H., Tang, J., Washbourne, C., Fraser, W.

(2016)

FGF23 and Vitamin D Metabolism in Chronic Kidney Disease,

(Poster)

(Published)


Piec, I., Washbourne, C., Tang, J., Fisher, E., Greeves, J., Jackson, S., Fraser, W. D.

(2016)

How accurate is your sclerostin measurement?: Comparison between three commercially available sclerostin ELISA kits,

in Calcified Tissue International

98

(6)

pp. 546-555

Full Text UEA Repository

(Article)

(Published)


He, C., Fraser, W., Tang, J., Brown, K., Renwick, S., Rudland-Thomas, J., Teah, J., Tanqueray, E., Gleeson, M.

(2016)

The effect of 14 weeks of vitamin D3 supplementation on antimicrobial peptides and proteins in athletes,

in Journal of Sports Sciences

34

(1)

pp. 67-74

Full Text UEA Repository

(Article)

(Published)


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Professional Activities

Health and Care Professions Council – Biomedical Scientist  BS43837