Career History

After initial clinical training in London, I completed my gastrointestinal clinical and research training in Cambridge and Norwich, with a period as a research fellow at the University of Michigan. I came to the UEA as one of the original core team responsible for the planning and set up of the Medical School. Currently, I combine clinical work as a consultant gastroenterologist with both undergraduate and postgraduate teaching and research and at UEA I have built up a portfolio of clinical and laboratory studies examining a wide range of topics in gastroenterology. I have a wide interest and involvement in all aspects of undergraduate and postgraduate education. I was awarded the University’s Excellence in Teaching award in 2008 and elected to the Membership of the Academy of Medical Educators in 2012.
I was previously Head of Specialty Training and Training Programme Director for Gastroenterology in East of England (2006-12) and a member of the National Speciality Advisory Committee in Gastroenterology (2008-12).
I am the principle investigator in multiple clinical and commercial trials currently ongoing in the Norfolk and Suffolk area.

Highlighted Publications

Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells.
Ogunwobi O and Beales ILP
Regul Pep (2006) 134, 105-13

Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways.
Beales ILP and Ogunwobi O 
Mol Cell Endocrinol (2006) 247, 140-9

Leptin stimulates proliferation and inhibits apoptosis in Barrett’s esophageal adenocarcinoma cells by COX-2 dependent, PGE-2 mediated transactivation of the EGF receptor and JNK activation.
Ogunwobi O, Mutungi G and Beales ILP
Endocrinology (2006) 147, 4505-4516

Leptin synergistically enhances the anti-apoptotic and growth-promoting effects of acid in OE33 oesophageal adenocarcinoma cells in culture.
Beales ILP & Ogunwobi OO (2007)
Mol Cell Endocrinol (2007) 274, 60-68
  
Activation of Akt is increased in the dysplasia-carcinoma sequence in Barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a functional and immunohistochemical study.
Beales ILP, Ogunwobi OO, Cameron E, El-Amin K, Mutungi G, Wilkinson M
BMC Cancer (2007) 7, 97

Cyclo-oxygenase-independent inhibition of apoptosis and stimulation of proliferation by leptin in human colon cancer cells.
Ogunwobi OO and Beales ILP
Dig Dis Sci. (2007) 52,1934-45.

Clinical trial: oral prednisolone metasulfobenzoate (predocol) versus oral prednisolone for active ulcerative colitis.
Rhodes JM, Robinson R, Beales I, Pugh S, Dickinson R, Dronfield M, CJ, Wilkinson P, Wilkinson SP.
Aliment Pharm Therap (2008) 27, 228-40

Globular adiponectin, acting via adiponectin receptor-1, inhibits leptin-stimulated oesophageal adenocarcinoma cell proliferation.
Ogunwobi OO and Beales ILP
Mol Cell Endocrinol (2008) 285, 43-59 

Statins inhibit proliferation and induce apoptosis in Barrett’s esophageal adenocarcinoma cells.
Ogunwobi OO and Beales ILP
Am J Gastroenterol (2008) 103, 825-37 
 
Glycine-extended gastrin stimulates proliferation via JAK2- and Akt-
dependent NF-kappaB activation in Barrett's oesophageal adenocarcinoma cells.
Ogunwobi OO and Beales ILP
Mol Cell Endocrinol (2008) 296, 94-102
  
Glycine-extended gastrin inhibits apoptosis in Barrett’s oesophageal and adenocarcinoma cells through JAK2/STAT3 activation
J Mol Endocrinol (2009) doi:10.1677/JME-08-0096

Academic Background

Professional Qualifications and Professional Memberships

  • BSc (Biochemistry) – 1st Class Honours – 1986 
  • MB BS (Distinctions in Medicine, Surgery, Clinical Pharmacology, Pathology) – 1989 
  • MD – 1997 
  • MRCP (UK) – 1992 
  • FRCP – 2007 
  • FHEA – 2001
  • FEBG - 2009
  • MAcadMedEd - 2012
  • Member of the British Society of Gastroenterology, American Physiological Society, British Pharmacological Society

All Publications

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Thomas, T., Loke, Y., Beales, I. L. P.

(2017)

Systematic Review and Meta-analysis: Use of Statins Is Associated with a Reduced Incidence of Oesophageal Adenocarcinoma,

in Journal of Gastrointestinal Cancer

Full Text UEA Repository

(Article)

(Published)


Beales, I., Dearman, L., Vardi, I., Loke, Y.

(2016)

Reduced risk of Barrett’s esophagus in statin users: case–control study and meta-analysis,

in Digestive Diseases and Sciences

61

(1)

pp. 238-246

Full Text UEA Repository

(Article)

(Published)


Alexandre, L., Long, E., Beales, I. L.

(2014)

Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma,

in World Journal of Gastrointestinal Pathophysiology

5

(4)

pp. 534-549

Full Text UEA Repository

(Article)

(Published)


Beales, I. L. P., Garcia-Morales, C., Ogunwobi, O. O., Mutungi, G.

(2014)

Adiponectin inhibits leptin-induced oncogenic signalling in oesophageal cancer cells by activation of PTP1B,

in Molecular and Cellular Endocrinology

382

(1)

pp. 150-8

Full Text UEA Repository

(Article)

(Published)


Brooks, J., Warburton, R., Beales, I. L. P.

(2013)

Prevention of upper gastrointestinal haemorrhage: current controversies and clinical guidance,

in Therapeutic Advances in Chronic Disease

4

(5)

pp. 206-22

Full Text UEA Repository

(Article)

(Published)


Beales, I. L. P., Hensley, A., Loke, Y.

(2013)

Reduced esophageal cancer incidence in statin users, particularly with cyclo-oxygenase inhibition,

in World Journal of Gastrointestinal Pharmacology and Therapeutics

4

(3)

pp. 69-79

Full Text UEA Repository

(Article)

(Published)


Beales, I. L. P.

(2013)

Management of ulcerative colitis shows the failings in chronic disease management in the current NHS,

in BMJ

346

pp. f1189

UEA Repository

(Article)

(Published)


Alexandre, L., Broughton, T., Loke, Y., Beales, I. L. P.

(2012)

Meta-analysis: risk of esophageal adenocarcinoma with medications which relax the lower esophageal sphincter,

in Diseases of the Esophagus

25

(6)

pp. 535-44

Full Text UEA Repository

(Article)

(Published)


Beales, I. L. P., Vardi, I., Dearman, L.

(2012)

Regular statin and aspirin use in patients with Barrett's oesophagus is associated with a reduced incidence of oesophageal adenocarcinoma,

in European Journal of Gastroenterology & Hepatology

24

(8)

pp. 917-23

Full Text UEA Repository

(Article)

(Published)


Broughton, T., Sington, J., Beales, I. L. P.

(2012)

Statin use is associated with a reduced incidence of colorectal cancer: a colonoscopy-controlled case-control study,

in BMC Gastroenterology

12

article no. 36

Full Text UEA Repository

(Article)

(Published)


Fang, D., Das, K. M., Cao, W., Malhotra, U., Triadafilopoulos, G., Najarian, R. M., Hardie, L. J., Lightdale, C. J., Beales, I. L. P., Felix, V. N., Schneider, P. M., Bellizzi, A. M.

(2011)

Barrett's esophagus: progression to adenocarcinoma and markers,

in Annals of the New York Academy of Sciences

1232

pp. 210-29

Full Text UEA Repository

(Article)

(Published)


Beales, I., Broughton, T., Sington, J.

(2011)

Statins use is associated with a reduced incidence of colorectal adenomatous polyps: a case-control study,

in Gut

60

(Suppl 1)

pp. A5-A5

Full Text UEA Repository

(Article)

(Published)


Beales, I. L. P., Ogunwobi, O. O.

(2010)

Microsomal prostaglandin E synthase-1 inhibition blocks proliferation and enhances apoptosis in oesophageal adenocarcinoma cells without affecting endothelial prostacyclin production,

in International Journal of Cancer

126

(9)

pp. 2247-2255

Full Text UEA Repository

(Article)

(Published)


Alexandre, L., Broughton, T., Loke, Y., Beales, I.

(2010)

Risk of oesophageal adenocarcinoma with medications which relax the lower oesophageal sphincter: a meta-analysis. Gut 2010;59(Suppl 111),

UEA Repository

(Paper)

(Published)


Scobioala-Laker, N., Reynolds, A., Parris, A., Mitchell, E., Lewis, M., Kennedy, H., Stebbings, W., Prior, A., Phillips, M., Beales, I., Williams, M.

(2009)

A Novel 3D Ex Vivo Model of Native Human Barrett's Oesophagus,

UEA Repository

(Paper)

(Published)


Beales, I.

(2009)

Clopidogrel in patients with peptic ulcer.,

in British Medical Journal

338

(3)

pp. 1932

Full Text UEA Repository

(Article)

(Published)


Beales, I.

(2009)

Recent advances in peptic ulcer bleeding,

in F1000 Medicine Reports

1

pp. 44

Full Text UEA Repository

(Article)

(Published)


Beales, I., Ogunwobi, O.

(2009)

Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation,

in Molecular Endocrinol

42

pp. 305-318

Full Text UEA Repository

(Article)

(Published)


Ogunwobi, O., Beales, I.

(2008)

Globular adiponectin, acting via adiponectin receptor-1, inhibits leptin-stimulated oesophageal adenocarcinoma cell proliferation,

in Molecular and Cellular Endocrinology

285

(1-2)

pp. 43-50

Full Text UEA Repository

(Article)

(Published)


Ogunwobi, O., Mutungi, G., Beales, I.

(2008)

Isothiocyanates inhibits proliferation of barrett's oesophagus and oesophageal adenocarcinoma cells.,

in Gut

57

pp. A127-A127

UEA Repository

(Article)

(Published)


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Key Research Interests

Research Interests

  • Biology of gastrointestinal peptide hormones
  • Barrett’s oesophagus and oesophageal adenocarcinoma
  • Regulation of gastrointestinal mucosal inflammation and the relationship to cancer
  • Peptic ulcer disease and Helicobacter pylori infection
  • Signal transduction in the gastrointestinal epithelium
  • Gastrointestinal pharmacology, including the clinical trials of novel agents for inflammatory bowel diseases, anaemia and dyspepsia
  • Aetiology and management of acute and chronic gastrointestinal bleeding
  • Aetiology and treatment of Microscopic colitis
  • Management of anaemia of gastrointestinal origin
  • Management of Clostridium difficile infection
  • Management of systemic diseases affecting the gastrointestinal tract

Research Keywords

  • Receptor biology
  • Hormones
  • Therapeutics
  • JAK/STAT pathway
  • Cancer biology
  • Aetiology and prognosis of disease

Postgraduate Research Student Supervision

  • Clinical gastroenterology
  • Signal transduction
  • Therapeutics
  • Education and training
  • Endoscopy
  • Inflammation
  • Cell Biology 

Enterprise and Engagement Activities

  • Medical Advisor to Norfolk and Suffolk Crohns and Colitis group (2009)
  • Member of National Advisory group for Crohn’s and Colitis UK (2009)
  • Member of the Organising Committee for the World Organization for Specialized Studies on Diseases of the Oesophagus (2012)
  • Advisory board member and consultant to several pharmaceutical and research organisations, including AstraZeneca, Proctor and Gamble, Shire, Ferring, Amgen, Pfizer, Almirall (2005)

Teaching Interests

Current teaching activity is encompasses a wide range of under- and post-graduate teaching. This includes undergraduate teaching for the MB BS medical degree, postgraduate teaching for gastroenterology and endoscopy and post-qualification nursing courses.

I teach in all 5 years of the MB BS programme, in lecture, seminar, workshop and ward-based teaching situations. In addition to clinical gastroenterology/medicine, I teach physiology, pharmacology, cell biology and pathology.

I am very involved in teaching gastrointestinal endoscopy nationally and nationally. I chair the JAG quality assurance for endoscopy training working group and I am co-director the Norwich endoscopy training centre. I am member of both the British Society of Gastroenterology Training Committee and the National Endoscopy Training Centres Committee.

I am a member of the National Gastroenterology Specialty Examination Question writing group.

I have designed and provided the Integration and Revision courses for both the 3rd,4th and 5th year MB BS students.

I supervise 3rd, 4th and 5th year student undertaking clinical and laboratory-based research projects.

I examine in the MB BS course in the written papers, OSCEs, SSS presentations, Research Project review committees and Research Project marking.

I teach on the Endoscopy for Nurses, Nutrition for Nurses and Critical Care Nursing courses.

External Activities and Indicators of Esteem

  • Associate Editor, Therapeutic Advances in chronic disease (2011)
  • Associate Editor Anti-inflammatory Agents in Medicinal Chemistry (2013)
  • Associate Editor, Frontiers in Internal Medicine (2013)
  • Member of British Society of Gastroenterology Research Committee (2013)
  • Member of the NIHR Gastroenterology Research Network Committee (2008)
  • Member of the editorial boards of American Journal of Digestive Diseases, Edorium Journal of Gastroenterology, Clinical Anti-Inflammatory and Anti-Allergy Drugs, Universal Journal of Clinical Medicine, www.gastrotraining.com, f1000 Research, World Journal of Gastrointestinal Pharmacology and Therapeutics, Webmedcentral Research (2010)
  • Manuscript reviewer for over 50 peer-reviewed journals (2001)
  • Grant submission reviewer for MRC, Wellcome, NIHR, Cancer Research UK (2003)

Administrative Posts

  • Deputy Director of MB BS course - Head of MB BS curriculum
  • Module 8 Lead (Digestion and Nutrition)
  • Head of Timetabling for MB BS course
  • Member of MB BS assessment group
  • Member of Year 3 examination board
  • Member of the Curriculum Design and Implementation Committee (CDD) in the MB BS
  • Lead for integrative teaching in MB BS years 3, 4 and 5.
  • Co-director of the Norwich Endoscopy Training Centre
  • Chair of Norfolk and Suffolk Gastroenterology Research Network