Biography

Prof Dylan Edwards is Pro-Vice Chancellor for the Faculty of Medicine and Health Sciences at UEA, with oversight of the university's role in the Norwich Research Park (NRP).  He also has responsibility for UEA's Continuing Professional Development activities. 

From 1998-2016 he was Chair of Cancer Studies in the School of Biological Sciences (BIO), before moving to the Norwich Medical School to take over the role of Executrive Dean of the Faculty of Medicine and Health Sciences.  From 2008-13 he was Head of BIO, and from 2015-16 was Interim Director of The Genome Analysis Centre on the NRP, now known as the Earlham Institute.

He did his PhD at UCL working with Dr. Irving Johnston on yeast cell cycle mutants and postdoctoral research on growth factor regulation of gene expression in mammalian cells at the University of Western Ontario with Dr. David Denhardt (of Denhardt’s solution). This led on to work with Dr. John Heath at Oxford University on the regulation of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), which has been a theme of his subsequent work as a principal investigator. He was an Assistant and Associate Professor at the University of Calgary, Canada from 1989-98, before returning to the UK to become Big C Chair of Cancer Studies.

Dylan Edwards is a molecular biologist principally interested in the functions of the human “degradome” – the repertoire of proteases and their inhibitors that cells and tissues use during tissue remodelling processes in development, tissue repair and disease states. A major focus of the work of the laboratory is on cancer, where we are studying proteases to identify novel diagnostic markers and therapeutic targets, and to identify the cellular and molecular mechanisms of extracellular proteases. From 2004-9 he was Coordinator of the European Union Framework Programme 6 “Cancerdegradome” Project, which involved 41 Partner laboratories in 13 countries, and from 2011-15 was a partner in the FP7 “SaveMe” project on pancreatic cancer imaging and therapy using nanoparticles. 

Website: http://www.edwardslab.co.uk/

 

Career History

  • Pro-Vice Chancellor, Faculty of Medicine and Health Sciences 2017-present
  • Executive Dean, Faculty of Medicine and Health Sciences 2016-17
  • Interim Director, The Genome Analysis Centre (TGAC), Norwich Research Park 2015-16
  • Head of School of Biological Sciences, UEA (2008-2013)
  • Professor, Chair of Cancer Studies, School of Biological Sciences 1998-2016 and Norwich Medical School 2016-present
  • Associate Professor, Departments of Medical Biochemistry, and Pharmacology & Therapeutics, University of Calgary, Canada 1994-1998.
  • Assistant Professor, Departments of Pharmacology & Therapeutics, and Medical Biochemistry, University of Calgary, Calgary, Alberta, Canada. 1989-1994
  • Research Associate, Department of Biochemistry, Oxford University, Oxford 1986-1989.
  • Research Associate, Cancer Research Laboratory, University of Western Ontario, London, Ontario, Canada. 1980-1985
  • PhD Department of Biochemistry, University College, London. 1980
  • M.A. (Cantab) 1979
  • BA Natural Sciences Jesus College, Cambridge University, 1975

ResearcherID

http://www.researcherid.com/rid/B-4734-2009

 

All Publications

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Marlein, C. R., Zaitseva, L., Piddock, R. E., Robinson, S., Edwards, D., Shafat, M. S., Zhou, Z., Lawes, M., Bowles, K. M., Rushworth, S. A.

(2017)

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts,

in Blood

130

(14)

pp. 1649-1660

Full Text UEA Repository

(Article)

(Published)


Sarper, M., Allen, M. D., Gomm, J., Haywood, L., Decock, J., Thirkettle, S., Ustaoglu, A., Sarker, S., Marshall, J., Edwards, D. R., Jones, J. L.

(2017)

Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function,

in Breast Cancer Research

19

article no. 33

Full Text UEA Repository

(Article)

(Published)


Piddock, R. E., Loughran, N., Marlein, C. R., Robinson, S. D., Edwards, D. R., Yu, S., Pillinger, G. E., Zhou, Z., Zaitseva, L., Auger, M. J., Rushworth, S. A., Bowles, K. M.

(2017)

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment,

in Blood Cancer Journal

7

(3)

article no. e539

Full Text UEA Repository

(Article)

(Published)


Shafat, M. S., Oellerich, T., Mohr, S., Robinson, S. D., Edwards, D. R., Marlein, C. R., Piddock, R. E., Fenech, M., Zaitseva, L., Abdul-Aziz, A., Turner, J., Watkins, J. A., Lawes, M., Bowles, K. M., Rushworth, S. A.

(2017)

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment,

in Blood

129

(10)

pp. 1320-1332

Full Text UEA Repository

(Article)

(Published)


Luca, B., Brewer, D. S., Edwards, D. R., Edward, S., Whitaker, H. C., Merson, S., Denis, N., Cooper, R. A., Hazell, S., Warren, A. Y., Eeles, R., Lynch, A. G., Ross-Adams, H., Lamb, A. D., Neal, D. E., Sethia, K., Mills, R. D., Ball, R. Y., Curley, H., Clark, J., Moulton, V., Cooper, C. S.

(2017)

DESNT: a poor prognosis category of human prostate cancer,

in European Urology Focus

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Jenkinson, S., Brown, L., Ombor, J., Milburn, J., Smulders-Srinivasan, T., Veuger, S., Edwards, D., Bass, R.

(2017)

Identification of novel peptide motifs in the serpin maspin that affect vascular smooth muscle cell function,

in Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

1864

(2)

pp. 336-344

Full Text UEA Repository

(Article)

(Published)


Grunwald, B., Vandooren, J., Gerg, M., Ahomaa, K., Hunger, A., Berchtold, S., Akbareian, S., Schaten, S., Knolle, P., Edwards, D. R., Opdenakker, G., Kruger, A.

(2016)

Systemic Ablation of MMP9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL-6 Expression in the Bone Marrow,

in Molecular Cancer Research

14

(11)

pp. 1147-1158

Full Text UEA Repository

(Article)

(Published)


Vandooren, J., Opdenakker, G., Loadmann, P. M., Edwards, D. R.

(2016)

Proteases in cancer drug delivery,

in Advanced Drug Delivery Reviews

97

pp. 144-155

Full Text UEA Repository

(Article)

(Published)


Cooper, C. S., Clark, J., Brewer, D. S., Edwards, D. R.

(2016)

Prostate Single Nucleotide Polymorphism Provides a Crucial Clue to Cancer Aggression in Active Surveillance Patients,

in European Urology

69

(2)

pp. 229-30

Full Text

(Editorial)

(Published)


Kelwick, R., Desanlis, I., Wheeler, G. N., Edwards, D. R.

(2015)

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family,

in Genome Biology

16

article no. 113

Full Text UEA Repository

(Article)

(Published)


Decock, J., Hendrickx, W., Thirkettle, S., Gutiérrez-Fernández, A., Robinson, S. D., Edwards, D. R.

(2015)

Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice,

in Breast Cancer Research

17

(1)

article no. 38

Full Text UEA Repository

(Article)

(Published)


Kelwick, R., Wagstaff, L., Decock, J., Roghi, C., Cooley, L. S., Robinson, S. D., Arnold, H., Gavrilovic, J., Jaworski, D. M., Yamamoto, K., Nagase, H., Seubert, B., Krüger, A., Edwards, D. R.

(2015)

Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15: ADAMTS-15 Inhibits Breast Cancer Cell Migration,

in International Journal of Cancer

136

(4)

pp. E14–E26

Full Text UEA Repository

(Article)

(Published)


Ellison, T. S., Atkinson, S. J., Steri, V., Kirkup, B. M., Preedy, M. E. J., Johnson, R. T., Ruhrberg, C., Edwards, D. R., Schneider, J. G., Weilbaecher, K., Robinson, S. D.

(2015)

Suppression of β3-integrin in mice triggers a neuropilin-1- dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis,

in Disease Models & Mechanisms

8

pp. 1105-1119

Full Text UEA Repository

(Article)

(Published)


Allen, M. D., Thomas, G. J., Clark, S., Dawoud, M. M., Vallath, S., Payne, S. J., Gomm, J. J., Dreger, S. A., Dickinson, S., Edwards, D., Pennington, C. J., Sestak, I., Cuzick, J., Marshall, J. F., Hart, I. R., Jones, J. L.

(2014)

Altered Microenvironment Promotes Progression of Preinvasive Breast Cancer: Myoepithelial Expression of  v 6 Integrin in DCIS Identifies High-risk Patients and Predicts Recurrence,

in Clinical Cancer Research

20

(2)

pp. 344-357

Full Text UEA Repository

(Article)

(Published)


Steri, V., Ellison, T. S., Gontarczyk, A. M., Weilbaecher, K., Schneider, J. G., Edwards, D., Fruttiger, M., Hodivala-Dilke, K. M., Robinson, S. D.

(2014)

Acute depletion of endothelial β3-integrin transiently inhibits tumor growth and angiogenesis in mice,

in Circulation Research

114

(1)

pp. 79-91

Full Text UEA Repository

(Article)

(Published)


Vandooren, J., Berghmans, N., Dillen, C., Van Aelst, I., Ronsse, I., Israel, L. L., Rosenberger, I., Kreuter, J., Lellouche, J., Michaeli, S., Locatelli, E., Franchini, M. C., Aiertza, M. K., Sánchez-abella, L., Loinaz, I., Edwards, D. R., Shenkman, L., Opdenakker, G.

(2013)

Intradermal air pouch leukocytosis as an in vivo test for nanoparticles,

in International Journal of Nanomedicine

8

(1)

pp. 4745—4756

Full Text UEA Repository

(Article)

(Published)


Eccles, S. A., Aboagye, E., Ali, S., Anderson, A. S., Armes, J., Berditchevski, F., Blaydes, J. P., Brennan, K., Brown, N., Bryant, H. E., Bundred, N. J., Burchell, J. M., Campbell, A., Carroll, J., Clarke, R., Coles, C. E., Cook, G. J., Cox, A., Curtin, N. J., Dekker, L. V., Dos Santos Silva, I., Duffy, S., Easton, D., Eccles, D. M., Edwards, D., Edwards, J., Evans, D., Fenlon, D. F., Flanagan, J. M., Foster, C., Gallagher, W. M., Garcia-Closas, M., Gee, J., Gescher, A. J., Goh, V., Groves, A. M., Harvey, A. J., Harvie, M., Hennessy, B. T., Hiscox, S., Holen, I., Howell, S. J., Howell, A., Hubbard, G. P., Hulbert-Williams, N., Hunter, M. S., Jasani, B., Jones, L., Key, T., Kirwan, C. C., Kong, A., Kunkler, I. H., Langdon, S. P., Leach, M. O., Mann, D., Marshall, J., Martin, L., Martin, S. G., Macdougall, J. E., Miles, D., Miller, W. R., Morris, J. R., Moss, S. M., Mullan, P., Natrajan, R., O'Connor, J. P., Palmieri, C., Pharoah, P. D., Rakha, E. A., Reed, E., Robinson, S. P., Sahai, E., Saxton, J., Schmid, P., Smalley, M. J., Speirs, V., Stein, R., Stingl, J., Streuli, C., Tutt, A. N., Velikova, G., Walker, R., Watson, C. J., Williams, K., Young, L., Thompson, A.

(2013)

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer,

in Breast Cancer Research

15

(5)

pp. R92

UEA Repository

(Article)

(Published)


Decock, J., Roghi, C., Edwards, D. R.

(2013)

Matrix metalloproteinases: a dual role in breast cancer?,

in Breast Cancer Management

2

(5)

pp. 353-356

Full Text UEA Repository

(Article)

(Published)


Gerrard, D., Fricke, C., Edward, D., Edwards, D., Chapman, T.

(2013)

Genome-Wide Responses of Female Fruit Flies Subjected to Divergent Mating Regimes,

in PLoS ONE

8

(6)

article no. e68136

Full Text UEA Repository

(Article)

(Published)


Thirkettle, S., Decock, J., Arnold, H., Pennington, C. J., Jaworski, D. M., Edwards, D. R.

(2013)

Matrix Metalloproteinase 8 (Collagenase 2) Induces the Expression of Interleukins 6 and 8 in Breast Cancer Cells,

in Journal of Biological Chemistry

288

(23)

pp. 16282-16294

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

Video

Main Research Interests include:

  • Extracellular matrix adhesion, signalling and proteolytic remodelling in angiogenesis
  • Investigation of the roles of ADAM proteases in cell signalling
  • Studies of degradome genes in multiple sclerosis.
  • Molecular mechanisms of transcriptional and post-transcriptional control of degradome gene expression
  • The hepatocyte growth factor signalling pathway in angiogenesis and wound healing
  • Novel cancer therapies or chemopreventive agents, focussing on dietary phytonutrients
  • MicroRNAs in cancer

PhD Positions 

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Teaching Interests

  • 1A13 (Fundamentals of Molecular Biology and Genetics)
  • 1A4Y (Skills for Biologists)
  • 1A5Y (Introduction to Biomedicine)
  • 3C27 (Cancer Biology)

Professional Activities

  • Editorial Board Member - International Journal of Cancer

Administrative Posts

  • Pro-Vice Chancellor for Medicine and Health Sciences (2017-present)
  • Executive Dean, Faculty of Medeicine and Health Sciences (2016-2017)
  • BIO Research Staff Coordinator (2014-15)
  • Member, Senate Student Disciplinary Committee (2013-16)
  • Athena SWAN Co-Chair for BIO (2014-16)
  • Head of School of Biological Sciences(2008-13)
  • Chair of BIO Executive (2008-13)
  • Chair of Finance Committee (2008-13)
  • Chair of UEA Biological Hazards and Genetic Manipulation Committee (2008-13)