Biography

Professional Qualifications and professional memberships

  • PhD in Chemical and Biological Sciences for Health, Faculty of Pharmacy, University Montpellier 1, France
  • MSc in Biological and Medical Sciences, Faculty of Pharmacy, University Bordeaux 2, France
  • BSc in Molecular and Cellular Biochemistry/Pharmacology, Faculty of Medicine, University Bordeaux 2, France
  • Member of The Groupe Polyphenols
  • Member of the Biochemical Society

Career History

Research Fellow, University of East Anglia, UK (2011-present) Post-Doctoral Research Fellow, University of Reading, UK (2008-2011) (BBSRC Fellowship)Post-Doctoral Research Fellow, University of Reading, UK (2005-2008) (MRC Fellowship)

All Publications

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Vauzour, D., Rodriguez Ramiro, I., Rushbrook, S., Ipharraguerre, I. R., Bevan, D., Davies, S., Tejera, N., Mena, P., de Pascual-Teresa, S., Del Rio, D., Gavrilovic, J., Minihane, A.

(2018)

N-3 fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLD,

in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

1864

(1)

pp. 69-78

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Vauzour, D., Camprubi Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., Bowman, G. L., Caberlotto, L., Clarke, R., Hogervorst, E., Kiliaan, A. J., Lucca, U., Manach, C., Minihane, A., Mitchell, E. S., Perneczky, R., Perry, H., Roussel, A., Schuermans, J., Sijben, J., Spencer, J. P., Thuret, S., van de Rest, O., Vandewoude, M., Wesnes, K., Williams, R. J., Williams, R. S., Ramirez, M.

(2017)

Nutrition for the ageing brain: towards evidence for an optimal diet,

in Ageing Research Reviews

35

pp. 222–240

Full Text

(Literature review)

(Published)


Slim, K. E., Vauzour, D., Tejera, N., Voshol, P. J., Cassidy, A., Minihane, A. M.

(2017)

The effect of dietary fish oil on weight gain and insulin sensitivity is dependent on APOE genotype in humanized targeted replacement mice,

in The FASEB Journal

31

(3)

pp. 989-997

Full Text UEA Repository

(Article)

(Published)


Vauzour, D.

(2017)

Polyphenols and brain health,

in OCL

24

(2)

article no. A202

Full Text UEA Repository

(Article)

(Published)


Corona, G., Vauzour, D.

(2017)

Neuroprotective Effects of Polyphenols in Aging and Age-Related Neurological Disorders,

in Neuroprotective Effects of Phytochemicals in Neurological Disorders.

Wiley

pp. 65-78

ISBN 978-1-119-15514-0

(Chapter (peer-reviewed))

(Published)


Neshatdoust, S., Saunders, C., Castle, S. M., Vauzour, D., Williams, C., Butler, L., Lovegrove, J. A., Spencer, J. P. E.

(2016)

High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: Two randomised, controlled trials,

in Nutrition and Healthy Aging

4

(1)

pp. 81-93

Full Text UEA Repository

(Article)

(Published)


McManus, S., Tejera, N., Awwad, K., Vauzour, D., Rigby, N., Fleming, I., Cassidy, A., Minihane, A.

(2016)

Differential effects of EPA vs. DHA on postprandial vascular function and the plasma oxylipin profile in men,

in The Journal of Lipid Research

57

pp. 1720-1727

Full Text UEA Repository

(Article)

(Published)


Esteban-Fernández, A., Corona, G., Vauzour, D., Spencer, J. P. E.

(2016)

Neuroprotective Effects Associated with Wine and Its Phenolic Constituents,

in Wine Safety, Consumer Preference, and Human Health.

Springer International Publishing

pp. 279-292

ISBN 978-3-319-24512-6

Full Text UEA Repository

(Chapter)

(Published)


Rodriguez-Ramiro, I., Vauzour, D., Minihane, A.

(2016)

Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms: impact and mechanisms,

in Proceedings of the Nutrition Society.

Cambridge

pp. 47-60

ISBN 0029-6651

Full Text

(Conference contribution)

(Published)


Tejera, N., Vauzour, D., Betancor, M. B., Sayanova, O., Usher, S., Cochard, M., Rigby, N., Ruiz-Lopez, N., Menoyo, D., Tocher, D. R., Napier, J. A., Minihane, A. M.

(2016)

A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice,

in Journal of Nutrition

146

(2)

pp. 227-235

Full Text UEA Repository

(Article)

(Published)


Minihane, A., Vinoy, S., Russell, W. R., Baka, A., Roche, H. M., Tuohy, K. M., Teeling, J. L., Blaak, E. E., Fenech, M., Vauzour, D., McArdle, H. J., Kremer, B. H. A., Sterkman, L., Vafeiadou, K., Benedetti, M. M., Williams, C. M., Calder, P. C.

(2015)

Low-grade inflammation, diet composition and health: Current research evidence and its translation,

in British Journal of Nutrition

114

(7)

pp. 999-1012

Full Text UEA Repository

(Article)

(Published)


Vauzour, D., Martinsen, A., Layé, S.

(2015)

Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects?,

in Neurochemistry International

89

pp. 63-74

Full Text UEA Repository

(Article)

(Published)


Vauzour, D., Tejera, N., O'Neill, C., Booz, V., Jude, B., Wolf, I. M., Rigby, N., Silvan, J. M., Curtis, P. J., Cassidy, A., De Pascual-Teresa, S., Rimbach, G., Minihane, A.

(2015)

Anthocyanins do not influence long-chain n-3 fatty acid status: Studies in cells, rodents and humans,

in Journal of Nutritional Biochemistry

26

(3)

pp. 211-218

Full Text UEA Repository

(Article)

(Published)


Achterfeldt, S., Traka, M., Martin, C., Vauzour, D., Kroon, P. A.

(2015)

Do anthocyanins in purple tomatoes reduce the risk of cardiovascular disease?,

in Proceedings of the Nutrition Society

74

(OCE1)

pp. E85

Full Text UEA Repository

(Article)

(Published)


Angeloni, C., Maraldi, T., Milenkovic, D., Vauzour, D.

(2015)

Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2014,

in Oxidative Medicine and Cellular Longevity

2015

article no. 782424

Full Text

(Editorial)

(Published)


Vauzour, D., Pinto, J. T., Cooper, A. J. L., Spencer, J. P. E.

(2014)

The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK-1/JNK1/2 pro-apoptotic signalling,

in Biochemical Journal

463

(1)

pp. 41-52

Full Text UEA Repository

(Article)

(Published)


Rodriguez-Mateos, A., Vauzour, D., Krueger, C. G., Shanmuganayagam, D., Reed, J., Calani, L., Mena, P., Del Rio, D., Crozier, A.

(2014)

Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update,

in Archives of Toxicology

88

(10)

pp. 1803-1853

Full Text UEA Repository

(Article)

(Published)


Vauzour, D.

(2014)

Polyphénols et neuroprotection : où en sommes-nous aujourd'hui ?,

in Cahiers de Nutrition et de Dietetique

49

(4)

pp. 181–187

Full Text UEA Repository

(Article)

(Published)


Angeloni, C., Maraldi, T., Vauzour, D.

(2014)

Redox signaling in degenerative diseases: from molecular mechanisms to health implications,

in BioMed Research International

2014

pp. 245761

Full Text UEA Repository

(Article)

(Published)


Vauzour, D., Buonfiglio, M., Corona, G., Chirafisi, J., Vafeiadou, K., Angeloni, C., Hrelia, S., Hrelia, P., Spencer, J.

(2014)

Sulforaphane protects cortical neurons against endogenous neurotoxins in a model of Parkinson's disease,

in Acta Horticulturae.

pp. 341-348

ISBN 9789462610286

UEA Repository

(Chapter)

(Published)


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Key Research Interests

  • Neurodegenerative disorders
  • Phytochemicals
  • Neuroinflammation
  • Memory, learning and neuro-cognitive performances
  • Molecular mechanisms
  • Association between the APOE4 genotype and chronic disease risk

My research interest is to develop novel dietary or therapeutic strategies to delay brain ageing, cognitive decline and cardiovascular disease, including stroke and vascular dementia and involves the fields of oxidative stress, free radical biochemistry, neurodegeneration and the health effects of dietary polyphenols, such as flavonoids. Concurrently, my major research interests centre on two functionally associated fields of biomedical sciences: 1) The elucidation of cellular and molecular mechanisms underlying the toxicity exerted by endogenously formed compounds, as well as exogenous agents, believed to be involved in various degenerative diseases; 2) The cellular and molecular principles involved in the protective effects evoked by potentially beneficial natural compounds.

Using a variety of experimental models including primary brain cell culture, age-related cognitive decline rodents and human intervention trials, my initial work has provided further insights into the potential for phytochemicals and their in vivo metabolites to promote human vascular function, decrease (neuro)inflammation, enhance memory, learning and neuro-cognitive performances and to slow the progression of Alzheimer’s and Parkinson’s disease pathophysiology. This work has led to substantial knowledge of potential mechanisms of action of phytochemicals based on their modulation of intracellular signalling pathways. In particular, my major contribution has been to show that phytochemicals exert such diverse biological effects through their modulation of intracellular signalling pathways (MAP kinases, PI3 kinase/Akt and Keap-1/Nrf2). My recent interests concern the investigation of the aetiological basis of APOEgenotype-disease associations, and the impact of this common genotype on responsiveness to dietary changes. This work is very much at the translational end of the research spectrum and aligned with the current move towards a more personalised approach to disease prevention and therapeutics.

Selected recent publications

Vauzour, D. (2012) Dietary Polyphenols as Modulators of Brain Functions: Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects. Oxid Med Cell Longev. doi:10.1155/2012/914273

Rendeiro, C, Vauzour, D, Kean, RJ, Butler, LT, Rattray, M, Spencer, JPE and Williams, CM (2012) Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Psychopharmacology. 223(3). Pp 319-330

Spencer, JPE, Vafeiadou, K, Williams, RJ and Vauzour, D (2012) Neuroinflammation: Modulation by flavonoids and mechanisms of action. Molecular Aspects of Medicine, 33 (1). pp. 83-97.

Spilsbury, A, Vauzour, D, Spencer, JPE and Rattray, M (2012) Regulation of NF-κB activity in astrocytes: Effects of flavonoids at dietary-relevant concentrations. Biochemical and Biophysical Research Communications. 418(3). pp. 578-583

Vauzour, D and Minihane, A-M (2012) Neuroinflammation and the APOε genotype: Implications for Alzheimer's disease and modulation by dietary flavonoids and n-3 polyunsaturated fatty acids. Nutrition and Aging, 1 (1). pp. 41-53.

Vauzour, D, Buonfiglio, M, Corona, G, Chirafisi, J, Vafeiadou, K, Angeloni, C, Hrelia, S, Hrelia, P and Spencer, JPE (2010) Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes. Molecular Nutrition & Food Research, 54 (4). pp. 532-42.

Vauzour, D, Corona, G and Spencer, JPE (2010) Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity. Archives of Biochemistry and Biophysics, 501 (1). pp. 106-11.

Vauzour, D, Houseman, ej, George, TW, Corona, G, Garnotel, R, Jackson, KG, Sellier, C, Gillery, P, Kennedy, OB, Lovegrove, JA and Spencer, JPE (2010) Moderate Champagne consumption promotes an acute improvement in acute endothelIal-independent vascular function in healthy human volunteers. The British Journal of Nutrition, 103 (8). pp. 1168-78.

Vauzour, D, Ravaioli, G, Vafeiadou, K, Rodriguez-Mateos, A, Angeloni, C and Spencer, JPE (2008) Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. Archives of Biochemistry and Biophysics, 476 (2). pp. 145-51.

Vauzour, D, Vafeiadou, K, Rodriguez-Mateos, A, Rendeiro, C and Spencer, JPE (2008) The neuroprotective potential of flavonoids: a multiplicity of effects. Genes & Nutrition, 3 (3-4). pp. 115-26.

Williams, CM, El Mohsen, MA, Vauzour, D, Rendeiro, C, Butler, LT, Ellis, JA, Whiteman, M and Spencer, JPE (2008) Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radical Biology & Medicine, 45 (3). pp. 295-305.

Vauzour, D, Vafeiadou, K, Rice-Evans, C, Williams, RJ and Spencer, JPE (2007) Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons. Journal of Neurochemistry, 103 (4). pp. 1355-67. 

External Activities and Indicators of Esteem

  • Invited and current member of the editorial board of: Nutrition and Aging; Neuroscience & Medicine; Journal of Food Science and Engineering
  • Member of the “Groupe Polyphenols” Board Committee (http://www.groupepolyphenols.com/)
  • Member of the Alcohol in Moderation’s Social, Scientific and Medical Council (http://www.aim-digest.com/)
  • Invited and chartered member of the IFSAR (International Scientific Forum on Alcohol Research) (http://www.bu.edu/alcohol-forum/)
  • Referee for research proposals submitted to the Alzheimer’s Association and the French National Research Agency (ANR).
  • I regularly review manuscripts for the Journal of Cellular and Molecular Medicine, Free Radicals in Biology and Medicine; European Journal of Nutrition; Journal of neurochemistry, Food and chemical Toxicology, Food & Function; British Journal of Pharmacology; Neuropharmacology; Brain Research, Genes & Nutrition; Journal of Wine Research; Cell Biology and Toxicology; British Journal of Nutrition; Nutrition and Cancer, Cellular & Molecular Biology Letters and Archives of Biochemistry and Biophysics.
  • Invited speaker Nov 2011: 6th International Wine and Heart Health Summit, Newberg, Oregon
  • Outreach July 2010: “Antioxidants and brain health benefits” (Decision News Media, Brussels); http://www.nutraingredients.com/Research/Antioxidants-demonstrate-brain-health-benefits
  • Invited speaker June 2010: Antioxidants 2010: Science, testing and regulation, Brussels, Belgium
  • Invited speaker Jan 2009: National Institute of Human Nutrition (IRNHA), Bordeaux, France
  • Invited speaker Sept 2009: 5th Probiotics, Prebiotics & New Foods Meeting, Rome, Italy
  • Invited speaker Dec 2006: International Networking for Young Scientists (INYS), Lund, Sweden