Biography

After studying Biology and Chemistry at the University of Marburg, I graduated with a Diploma (1987) which is equivalent to a BSc plus an MSc. I stayed at the University of Marburg to undertake a PhD in Biochemistry entitled “On the Mechanism of Energy Transduction in Biological Membranes – Studies on Isolated and in Liposomes Reconstituted Cytochrome c Oxidase” under the supervision of Professor Bernhard Kadenbach. Part of my PhD work I carried out in the laboratories of Professor Sergio Papa at the Institute of Medical Biochemistry and Chemistry, University of Bari, Italy, and Dr Martin Brand at the Department of Biochemistry, University of Cambridge, United Kingdom. These research visits were sponsored by an EMBO Short Term Fellowship and by the Fonds der Chemischen Industrie, respectively. In 1990 I completed my PhD with distinction.
After my PhD I took up a position as Head of Laboratories at the Faculty of Process Engineering, University of Applied Sciences Furtwangen (1990-1991). This job included planning and designing of laboratories for the new founded course in Bioengineering. In 1992, I returned to science and took up a position as a postdoctoral research assistant at the prestigious Max-Planck-Institute for Biology in Tübingen to work with Professor Peter Overath on the transferrin receptor of Trypanosoma brucei. This allowed me to get a Research Group Leader position at the Department of Parasitology, University of Heidelberg (1995-2001). I continued my work on the transferrin receptor of T. brucei and started screening of natural and synthetic compounds for trypanocidal and leishmanicidal activity. During this time I completed my Habilitation in Biochemistry (2000) and was awarded the venia legendi and the title “Privatdozent”. After a short research stay at the Interdisciplinary Research Center, University of Gießen (2001), I took up a position as Lecturer in Parasitology at the School of Biological Sciences, University of Bristol (2001-2004). Here I continued my work on screening of compounds for trypanocidal activity and was promoted to Senior Lecturer in 2003. In 2004 I joined the Norwich Medical School at the University of East Anglia as Lecturer in Biochemistry and Genetics. Ever since I am carrying forward my research on antimicrobial drug screening. In 2008 I was promoted to Senior Lecturer again.

Career History

Career summary

  • 1987-1990, Graduate Teaching Assistant , Faculty of Chemistry, University of Marburg, Germany
  • 1990-1991, Head of Laboratories, Faculty of Process Engineering, University of Applied Sciences Furtwangen, Germany
  • 1992-1995, Postdoctoral Research Assistant, Department of Membrane Biochemistry, Max-Planck-Institute for Biology Tübingen, Germany
  • 1995-2001, Research Group Leader, Department of Parasitology, University of Heidelberg, Germany
  • 2001, Senior Research Assistant, Interdisciplinary Research Center, University of Gießen, Germany
  • 2001-2004, Lecturer/Senior Lecturer in Parasitology, School of Biological Sciences, University of Bristol, United Kingdom.

Academic Background

  • 1981-1987, University of Marburg, Germany, Diploma in Chemistry and Biology (equivalent to B.Sc. plus M.Sc.)
  • 1987-1990, University of Marburg, Germany, Ph.D. in Biochemistry (Distinction)
  • 1995-2000, University of Heidelberg, Germany, Habilitation in Biochemistry (venia legendi)
  • Since 2005, member of the British Society for Parasitology

All Publications

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Kowalski, K., Szczupk, L., Saloman, S., Steverding, D., Jablonski, A., Vrcek, V., Hildebrandt, A., Lang, H., Rybarczyk-Pirek, A.

(2017)

Cymantrene, Cyrhetrene and Ferrocene Nucleobase Conjugates: Synthesis, Structure, Computational Study, Electrochemistry and Antitrypanosomal Activity,

in ChemPlusChem

82

(2)

pp. 303-314

Full Text UEA Repository

(Article)

(Published)


Steverding, D.

(2017)

The history of leishmaniasis,

in Parasites & Vectors

10

article no. 82

Full Text UEA Repository

(Article)

(Published)


Steverding, D.

(2017)

Neue Methode zur Malariaimpfung erfolgreich getestet,

in Naturwissenschaftliche Rundschau

70

pp. 205-206

UEA Repository

(Article)

(Published)


Steverding, D., Rushworth, S. A.

(2017)

Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine,

in Experimental Parasitology

178

pp. 45–50

Full Text UEA Repository

(Article)

(Published)


Steverding, D., Tyler, K. K., Sexton, D. W.

(2016)

Evaluation of marking of peer-marking in oral presentation,

in Perspectives on Medical Education

5

(2)

pp. 103-107

Full Text UEA Repository

(Article)

(Published)


Steverding, D.

(2016)

Sleeping Sickness and Nagana Disease Caused by Trypanosoma brucei,

in Arthropod Borne Diseases.

Springer International Publishing

pp. 277-297

ISBN 978-3-319-13883-1

Full Text UEA Repository

(Chapter)

(Published)


Steverding, D.

(2016)

Kunststoff-abbauendes Bakterium,

in Naturwissenschaftliche Rundschau

69

pp. 198-199

UEA Repository

(Article)

(Published)


de Sousa, D. P., Lima, T. C., Steverding, D.

(2016)

Evaluation of antiparasitic activity of Mentha crispa essential oil, its major constituent rotundifolone and analogues against Trypanosoma brucei,

in Planta Medica

82

(15)

pp. 1346-1350

Full Text UEA Repository

(Article)

(Published)


Steverding, D., Antoszczak, M., Huczyński, A.

(2016)

In vitro activity of salinomycin and monensin derivatives against Trypanosoma brucei,

in Parasites & Vectors

9

article no. 409

Full Text UEA Repository

(Article)

(Published)


Steverding, D., da Nóbrega, F. R., Rushworth, S. A., de Sousa, D. P.

(2016)

Trypanocidal and cysteine protease inhibitory activity of isopentyl caffeate is not linked in Trypanosoma brucei,

in Parasitology Research

115

(11)

pp. 4397–4403

Full Text UEA Repository

(Article)

(Published)


Steverding, D.

(2016)

Neues Antibiotikum in menschlicher Nase entdeckt,

in Naturwissenschaftliche Rundschau

69

pp. 428-429

UEA Repository

(Article)

(Published)


Steverding, D.

(2016)

Neuer Wirkstoff gegen Leishmaniosen und Trypanosomosen,

in Naturwissenschaftliche Rundschau

69

(10)

pp. 535-536

UEA Repository

(Article)

(Published)


Ajoko, C., Steverding, D.

(2015)

The prolyl oligopeptidase inhibitor KYP-2047 is not readily bioavailable to bloodstream form trypanosomes and human myelocytic cells,

in Journal of Pharmaceutical Negative Results

6

(1)

pp. 7-10

Full Text UEA Repository

(Article)

(Published)


Akoyo, C., Steverding, D.

(2015)

A cultivation method for growing bloodstream forms of Trypanosoma brucei to higher cell density and for longer time,

in Parasitology Research

114

(4)

pp. 1611-1612

Full Text UEA Repository

(Article)

(Published)


Ellis, S., Sexton, D., Steverding, D.

(2015)

Trypanotoxic activity of thiosemicarbazone iron chelators,

in Experimental Parasitology

150

pp. 7-12

Full Text UEA Repository

(Article)

(Published)


Steverding, D., Tyler, K.

(2015)

Of mice and men: are billions victim to toxoplasma mid control?,

in Microbiology Today

52

(1)

pp. 10-13

UEA Repository

(Article)

(Published)


Steverding, D.

(2015)

Veränderter Geruchssinn macht Mücken sensibel für menschlichen Körpergeruch,

in Naturwissenschaftliche Rundschau

68

(1)

pp. 38-39

UEA Repository

(Article)

(Published)


Steverding, D.

(2015)

Evaluation of trypanocidal activity of combinations of anti-sleeping sickness drugs with cysteine protease inhibitors,

in Experimental Parasitology

151-152

pp. 28-33

Full Text UEA Repository

(Article)

(Published)


Boncompagni, S., Arthurton, L., Akujuru, E., Pearson, T., Steverding, D., Protasi, F., Mutungi, G.

(2015)

Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres,

in The Journal of Physiology

593

(12)

pp. 2679-2692

Full Text UEA Repository

(Article)

(Published)


Gao, C., Yang, Y., Shi, F., Wang, J., Steverding, D., Wang, X.

(2015)

Development of an immunochromatographic test for diagnosis of visceral leishmaniasis based on detection of a circulating antigen,

in PLoS Neglected Tropical Diseases

9

(6)

article no. e0003902

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

My main research interest in the causative agent of human African trypanosomiasis or sleeping sickness, the protozoan parasite Trypanosoma brucei.

One area of interest is the transferrin receptor of bloodstream forms of T. brucei which structure is completely different from that of the mammalian transferrin receptor. Especially, I am interested in the interaction between host transferrin and the trypanosomal transferrin receptor. In particular, I want to determine the epitope of host transferrin that is involved in binding to the trypanosomal transferrin receptor. This will be done by crystallography of the ligand-receptor-complex in collaboration with Professor Changjiang Dong. Knowledge of this epitope will provide information for designing peptides that are able to interfere with the binding of host transferrin to the trypanosomal transferrin receptor and could be the starting point for the development of peptidomimetic inhibitors and non-peptide inhibitors as trypanocidal agents.

Another area of interest is the screening of compounds for antimicrobial activity. Especially, I have an interest in the antitrypanosomal activity of cysteine protease, proteasome and topoisomerase inhibitors. Primarily, I am testing natural and synthetic compounds for their trypanocidal and cytotoxic activities using cell culture based assays. These investigations are carried out in collaboration with different partners from all over the world. In addition, I have also an interest in screening compounds for activity against fungal infections (e.g. Candida ssp.).

A third area of interest in the diagnosis of neglected tropical diseases. I am particular interested in the development of PCR based methods for diagnosis of trypanosomatid infections (Trypanosoma ssp. andLeishmania ssp.). I am also interested in the diagnosis of helminth infections (Echinococcus ssp.) using immunological methods.

Research Keywords

Screening of compounds for antitrypanosomal activity

Iron metabolism of trypanosomes

Diagnosis of neglected tropical diseases

Screening of compounds for antifungal activity

Trypanosomal transferrin receptor

Postgraduate Research Student Supervision

Antimicrobial drug screening

Studies into the trypanosomal LDL receptor

 

Highlighted Publications

  • Steverding, D., Sexton, D.W., Wang, X., Gehrke, S.S., Wagner, G.K. & Caffrey, C.R. (2012) Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target. Int. J. Parasitol. 42, 481-488   
  • Steverding, D., Wang, X., Potts, B.C.M. & Palladino, M.A. (2012) Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors. Planta Med. 78, 131-134
  •  Steverding, D. & Wang, X. (2009) Evaluation of anti-sleeping sickness drugs and topoisomerase inhibitors in combination on Trypanosoma brucei. J. Antimicrob. Chemother. 63, 1293-1295
  • Deterding, A., Dungey, F.A., Thompson, K.-A. & Steverding, D. (2005) Anti-trypanosomal activities of DNA topoisomerase inhibitors. Acta Trop. 93, 311-316
  • Becker, S., Franco, J.R., Simarro, P.P., Stich, A., Abel, P.M. & Steverding, D. (2004). Real-time PCR for detection of Trypanosoma brucei in human blood samples. Diagn. Microbiol. Infect. Dis. 50, 193-199
  • Genn, R.J., Pemberton, A.J., Royle, H.J., Spackman, R.W., Smith, E., Rivett, A.J. & Steverding, D. (2004) Trypanocidal effect of α’,β’-epoxyketones indicates that trypanosomes are particularly sensitive to inhibitors of proteasome trypsin-like activity. Int. J. Antimicrob. Agents 24, 286-289
  • Nkemgu-Njinkeng, J., Rosenkranz, V., Wink, M. & Steverding, D. (2002) Antitrypanosomal activities of proteasome inhibitors. Antimicrob. Agents Chemother. 46, 2038-2040
  • Kabiri, M. & Steverding, D. (2000) Studies on the recycling of the transferrin receptor in Trypanosoma brucei using an inducible gene expression system. Eur. J. Biochem. 267, 3309-3314
  • Fast, B., Kremp, K., Boshart, M. & Steverding, D. (1999) Iron-dependent regulation of transferrin-receptor expression in Trypanosoma brucei. Biochem. J. 342, 691-696
  • Steverding, D., Stierhof, Y.-D., Fuchs, H., Tauber, R. & Overath P. (1995) Transferrin  binding protein complex is the receptor for transferrin uptake in Trypanosoma  brucei. J. Cell Biol. 131, 1173-1182

 

Selected publication

  • Caffrey, C.R. & Steverding, D. (2008) Recent initiatives and strategies to developing new drugs for tropical parasitic diseases. Expert Opin. Drug Discov., 3, 173-186
  • Caffrey, C.R., Steverding, D., Swenerton, R.K., Kelly, B., Walshe, D., Debnath, A., Zhou, Y.-M., Doyle, P.S., Fafarman, A.T., Zorn, J.A., Land, K.M., Beauchene, J., Schreiber, K., Moll, H., Ponte-Sucre, A., Schirmeister, T., Saravanamuthu, A., Fairlamb, A.H., Cohen, F.E., McKerrow, J.H., Weisman, J.L. & May, B.C.H. (2007) Bis-acridines as lead anti-parasitic agents: structure activity analysis of a discrete compound library in vitro. Antimicrob. Agents Chemother. 51, 2164-2172
  • Steverding, D. (2006) On the significance of host antibody response to the Trypanosoma bruceitransferrin receptor during chronic infection. Microbes Infect. 8, 2777-2782
  • Ginger, M.L., Ngazoa, E., Pereira, C.A., Pullen, T.J., Kabiri, M., Becker, K., Gull, K., & Steverding, D. (2005) Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei. J. Biol. Chem. 280, 11781-11789
  • Deterding, A., Dungey, F.A., Thompson, K.-A. & Steverding, D. (2005) Anti-trypanosomal activities of DNA topoisomerase inhibitors. Acta Trop. 93, 311-316
  • Becker, S., Franco, J.R., Simarro, P.P., Stich, A., Abel, P.M. & Steverding, D. (2004) Real-time PCR for detection of Trypanosoma brucei in human blood samples. Diagn. Microbiol. Infect. Dis. 50, 193-199
  • Genn, R.J., Pemberton, A.J., Royle, H.J., Spackman, R.W., Smith, E., Rivett, A.J. & Steverding, D. (2004) Trypanocidal effect of α’,β’-epoxyketones indicates that trypanosomes are particularly sensitive to inhibitors of proteasome trypsin-like activity. Int. J. Antimicrob. Agents 24, 286-289
  • Nkemgu-Njinkeng, J., Rosenkranz, V., Wink, M. & Steverding, D. (2002) Antitrypanosomal activities of proteasome inhibitors. Antimicrob. Agents Chemother. 46, 2038-2040
  • Kabiri, M., & Steverding, D. (2001) Identification of a developmentally regulated iron superoxide dismutase in Trypanosoma brucei. Biochem. J. 360, 173-177
  • Hofer, A., Steverding, D., Chabes, A., Brun, R. & Thelander, L. (2001) Trypanosoma brucei CTP synthetase: a new target for the treatment of African sleeping sickness Proc. Natl. Acad. Sci. USA 98, 6412-6416

Teaching Interests

My teaching is mainly focussed on the MB/BS medical degree course. My teaching interests are in providing medical students with an understanding of the basic sciences, especially in Biochemistry. Another interest is the method of problem-based learning which I practise in my role as PBL tutor. In addition, I am interested in teaching presentation skills to undergraduates and postgraduates. Another area of teaching interests is to give lessons in Parasitology to Biology students.

External Activities and Indicators of Esteem

Activity / Indicator of Esteem

Date / Year

Additional Info

Invited membership of the editorial board of the journal “Parasites & Vectors”

since 2008

 

Invited membership of the editorial board of the journal “The Open Parasitology Journal”

since 2007

 

Invited membership of the editorial board of the journal “Current Drug Target”

1999-2001

 

Regular reviewer for high-impact journals

since 2000

e.g. PLoS Pathog, Drug Discov Today, Mol Microbiol, J Med Chem, Antimicrob Agents Chemother

Regular reviewer for national and international funding agencies

since 2000

e.g. MRC, BBSRC, The Wellcome Trust, WHO/TDR, DFG, MRC South Africa, Swiss National Science Foundation, Fondation pour la Recherche Médicale, Research Foundation Flanders

Invitation to give a talk at the “BA Festival of Science”, University of East Anglia, Norwich Research Park and the City of Norwich, Norwich, UK

25/09/2006

 

Invitation to give an inaugural address at the opening ceremony for the new degree courses „Biomedizinische Technik” and “Industrielle Biotechnologie”, University of Ansbach, Germany

21/10/2009

 

Invitations to presents talks on the trypanosomal transferrin receptor and on antitrypanosomal drug screening and target evaluation

since 1996

e.g. University of Heidelberg, University of Würzburg, University of Glasgow, University of Manchester, University of Umeå, University of California San Francisco

Invitations to write review articles for journals and books

Since 2000

e.g. Curr Drug Target, Biol unserer Zeit, Expert Opin Investig Drugs, Mini Rev Med Chem, Expert Opin Drug Discov, Adv Exp Med Biol

Enterprise and Engagement activities

  

Consultancy service for the Department of Tropical Medicine, Medical Mission Hospital, Würzburg, Germany, on screening of compounds for trypanocidal activity

since 2000

 

Scientific Advisor for the "Foundation for Innovative New Diagnostics (FIND) and the World Health Organization (WHO) for a project to develop new diagnostic tools to support the control of human African trypanosomiasis

2006

 

Key Responsibilities

I am deputy lead for year 5, co-ordinator for the postgraduate module on presentation skills and responsible for year 1 Biochemistry SSS. In addition, I am member of exam boards and several committees. I am a student advisor, elective tutor and MB/BS interviewer.