Biography

After completing my first degree in Physics (MSci) at Imperial College London, I went on to study for an MRes in Biological Complexity and PhD in Computational Biology at University College London.  My PhD focused on mathematical modelling of the p53 gene regulatory network and in particular integrating models and experiment data. I was employed as a Bioinformatics Officer at the Institute of Cancer Research (ICR) in Sutton for over six years before moving to the University of East Anglia to lead the bioinformatics team within the Cancer Genetics group in September 2013. In June 2016 I was made a senior lecturer.

Highlighted Publications

See All

Gundem, G., Van loo, P., Kremeyer, B., Alexandrov, L., Tubio, J. M. C., Papaemmanuil, E., Brewer, D., Kallio, H., Högnäs, H., Annala, M., Kivinummi, K., Goody, V., Latimer, C., O'Meara, S., Dawson, K., Isaacs, W., Emmert-Buck, M. R., Nykter, M., Foster, C. S., Kote-Jarai, Z., Easton, D. F., Whitaker, H. C., Neal, D. E., Cooper, C., Eeles, R. A., Visakorpi, T., Campbell, P., Mcdermott, U., Wedge, D. C., Bova, G. S.

(2015)

The Evolutionary History of Lethal Metastatic Prostate Cancer,

in Nature

520.

pp. 353–357

Full Text

(Letter)

(Published)


Cooper, C., Eeles, R. A., Wedge, D. C., Van loo, P., Gundem, G., Alexandrov, L., Kreymer, B., Butler, A., Lynch, A., Edwards, S. E., Camacho, N., Massie, C. E., Kote-Jarai, Z., Dennis, N., Merson, S., Leongamornlert, D. A., Zamora, J., Kay, J., Luxton, H. J., Corbishley, C., Thomas, S., Nik-zainal, S., O'Meara, S., Matthews, L., Clark, J., Hurst, R., Mithen (IFR), R., Bristow (Ontario Cancer Inst. CA), R., Boutros, P. C., Fraser, M., Cooke, S., Raine, K., Jones, D., Menzies, A., Stebbings, L., Hinton, J., Teague, J., Mclaren, S., Mudie, L., Hardy, C., Anderson, E., Joseph, O., Goody, V., Robinson, B., Maddison, M., Gamble, S., Greenman, C., Berney, D., Hazell, S., Livni, N., Fisher, C., Ogden, C., Kumar, P., Thompson, A., Woodhouse, C. J., Nicol, D., Mayer, E., Dudderidge, T., Shah, N., Gnanapragasam (Cambridge), V., Voet, T., Campbell, P., Futreal, P. A., Easton, D. F., Warren, A. Y., Foster, C. S., Stratton, M. R., Whitaker, H. C., Mcdermott, U., Brewer, D., Neal, D. E.

(2015)

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue,

in Nature Genetics

47.

pp. 367–372

Full Text

(Letter)

(Published)


Merson, S., Yang, Z. H., Brewer, D., Olmos, D., Eichholz, A., McCarthy, F., Fisher, G., Kovacs, G., Berney, D. M., Foster, C. S., Møller, H., Scardino, P., Cuzick, J., Cooper, C. S., Clark, J.

(2014)

Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer,

in British Journal of Cancer

110.

pp. 1655-62

Full Text UEA Repository

(Article)

(Published)


Olmos, D., Brewer, D., Clark, J., Danila, D. C., Parker, C., Attard, G., Fleisher, M., Reid, A. H., Castro, E., Sandhu, S. K., Barwell, L., Oommen, N. B., Carreira, S., Drake, C. G., Jones, R., Cooper, C. S., Scher, H. I., de Bono, J. S.

(2012)

Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study,

in The Lancet Oncology

13.

pp. 1114-24

Full Text UEA Repository

(Article)

(Published)


Brewer, D., Santarius, T., Shipley, J., Stratton, M., Cooper, C.

(2010)

A census of amplified and overexpressed human cancer genes,

in Nature Reviews

10.

pp. 59-64

Full Text UEA Repository

(Article)

(Published)


Jhavar, S., Reid, A., Clark, J., Kote-Jarai, Z., Christmas, T., Thompson, A., Woodhouse, C., Ogden, C., Fisher, C., Corbishley, C., De-Bono, J., Eeles, R., Brewer, D., Cooper, C.

(2008)

Detection of TMPRSS2-ERG translocations in human prostate cancer by expression profiling using GeneChip Human Exon 1.0 ST arrays,

in Journal of Molecular Diagnostics

10.

pp. 50-7

Full Text UEA Repository

(Article)

(Published)


All Publications

See Highlights
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Camacho, N., Van Loo, P., Edwards, S., Kay, J., Matthews, L., Haase, K., Clark, J., Dennis, N., Thomas, S., Kremeyer, B., Zamora, J., Butler, A., Gundem, G., Merson, S., Luxton, H., Hawkins, S., Ghori, M., Marsden, L., Lambert, A., Karaszi, K., Pelvender, G., Massie, C., Kote-Jarai, Z., Raine, K., Jones, D., Howat, W., Hazell, S., Livni, N., Fisher, C., Ogden, C., Kumar, P., Thompson, A., Nicol, D., Mayer, E., Dudderidge, T., Yu, Y., Zhang, H., Shah, N., Gnanapragasam, V., Isaacs, W., Visakorpi, T., Hamdy, F., Berney, D., Verrill, C., Warren, A., Wedge, D., Lynch, A., Foster, C., Lu, Y. J., Bova, G. S., Whitaker, H., McDermott, U., Neal, D., Eeles, R., Cooper, C., Brewer, D.

(2017)

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data,

in PLoS Genetics

13

(9)

article no. e1007001

Full Text UEA Repository

(Article)

(Published)


Luca, B., Brewer, D. S., Edwards, D. R., Edward, S., Whitaker, H. C., Merson, S., Denis, N., Cooper, R. A., Hazell, S., Warren, A. Y., Eeles, R., Lynch, A. G., Ross-Adams, H., Lamb, A. D., Neal, D. E., Sethia, K., Mills, R. D., Ball, R. Y., Curley, H., Clark, J., Moulton, V., Cooper, C. S.

(2017)

DESNT: a poor prognosis category of human prostate cancer,

in European Urology Focus

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Behjati, S., Gundem, G., Wedge, D. C., Roberts, N. D., Tarpey, P. S., Cooke, S. L., Van Loo, P., Alexandrov, L. B., Ramakrishna, M., Davies, H., Nik-Zainal, S., Hardy, C., Latimer, C., Raine, K. M., Stebbings, L., Menzies, A., Jones, D., Shepherd, R., Butler, A. P., Teague, J. W., Jorgensen, M., Khatri, B., Pillay, N., Shlien, A., Futreal, P. A., Badie, C., Cooper, C. S., Eeles, R. A., Easton, D., Foster, C., Neal, D. E., Brewer, D. S., Hamdy, F., Lu, Y., Lynch, A. G., Massi, C. E., Ng, A., Whitaker, H. C., Yu, Y., Zhang, H., Bancroft, E., Berney, D., Camacho, N., Corbishley, C., Dadaev, T., Dennis, N., Dudderidge, T., Edwards, S., Fisher, C., Ghori, J., Gnanapragasam, V. J., Greenman, C., Hawkins, S., Hazell, S., Howat, W., Karaszi, K., Kay, J., Kote-Jarai, Z., Kremeyer, B., Kumar, P., Lambert, A., Leongamornlert, D., Livni, N., Luxton, H., Matthews, L., Mayer, E., Merson, S., Nicol, D., Ogden, C., O’Meara, S., Pelvender, G., Shah, N. C., Tavare, S., Thomas, S., Thompson, A., Verrill, C., Warren, A., Zamora, J., McDermott, U., Bova, G. S., Richardson, A. L., Flanagan, A. M., Stratton, M. R., Campbell, P. J.

(2016)

Mutational signatures of ionizing radiation in second malignancies,

in Nature Communications

7

article no. 12605

Full Text UEA Repository

(Article)

(Published)


Cooper, C. S., Clark, J., Brewer, D. S., Edwards, D. R.

(2016)

Prostate Single Nucleotide Polymorphism Provides a Crucial Clue to Cancer Aggression in Active Surveillance Patients,

in European Urology

69

(2)

pp. 229-30

Full Text

(Editorial)

(Published)


Gundem, G., Van loo, P., Kremeyer, B., Alexandrov, L., Tubio, J. M. C., Papaemmanuil, E., Brewer, D., Kallio, H., Högnäs, H., Annala, M., Kivinummi, K., Goody, V., Latimer, C., O'Meara, S., Dawson, K., Isaacs, W., Emmert-Buck, M. R., Nykter, M., Foster, C. S., Kote-Jarai, Z., Easton, D. F., Whitaker, H. C., Neal, D. E., Cooper, C., Eeles, R. A., Visakorpi, T., Campbell, P., Mcdermott, U., Wedge, D. C., Bova, G. S.

(2015)

The Evolutionary History of Lethal Metastatic Prostate Cancer,

in Nature

520

(7547)

pp. 353–357

Full Text

(Letter)

(Published)


Massie, C. E., Spiteri, I., Ross-Adams, H., Luxton, H. J., Kay, J., Whitaker, H. C., Dunning, M. J., Lamb, A. D., Ramos-Montoya, A., Brewer, D., Cooper, C., Eeles, R. A., Warren, A. Y., Tavaré, S., Neal, D. E., Lynch, A. G.

(2015)

HES5 silencing is an early and recurrent change in prostate tumourigenesis,

in Endocrine-Related Cancer (ERC)

22

(2)

pp. 131-144

Full Text UEA Repository

(Article)

(Published)


Cooper, C., Eeles, R. A., Wedge, D. C., Van loo, P., Gundem, G., Alexandrov, L., Kreymer, B., Butler, A., Lynch, A., Edwards, S. E., Camacho, N., Massie, C. E., Kote-Jarai, Z., Dennis, N., Merson, S., Leongamornlert, D. A., Zamora, J., Kay, J., Luxton, H. J., Corbishley, C., Thomas, S., Nik-zainal, S., O'Meara, S., Matthews, L., Clark, J., Hurst, R., Mithen (IFR), R., Bristow (Ontario Cancer Inst. CA), R., Boutros, P. C., Fraser, M., Cooke, S., Raine, K., Jones, D., Menzies, A., Stebbings, L., Hinton, J., Teague, J., Mclaren, S., Mudie, L., Hardy, C., Anderson, E., Joseph, O., Goody, V., Robinson, B., Maddison, M., Gamble, S., Greenman, C., Berney, D., Hazell, S., Livni, N., Fisher, C., Ogden, C., Kumar, P., Thompson, A., Woodhouse, C. J., Nicol, D., Mayer, E., Dudderidge, T., Shah, N., Gnanapragasam (Cambridge), V., Voet, T., Campbell, P., Futreal, P. A., Easton, D. F., Warren, A. Y., Foster, C. S., Stratton, M. R., Whitaker, H. C., Mcdermott, U., Brewer, D., Neal, D. E.

(2015)

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue,

in Nature Genetics

47

pp. 367–372

Full Text

(Letter)

(Published)


Wu, P., Walker, B. A., Broyl, A., Kaiser, M., Johnson, D. C., Kuiper, R., van Duin, M., Gregory, W. M., Davies, F. E., Brewer, D., Hose, D., Sonneveld, P., Morgan, G. J.

(2015)

A gene expression based predictor for high risk myeloma treated with intensive therapy and autologous stem cell rescue,

in Leukemia & Lymphoma

56

(3)

pp. 594-601

Full Text UEA Repository

(Article)

(Published)


Manson-Bahr, D., Ball, R., Gundem, G., Mills, R., Rochester, M., Goody, V., O'Meara, S., Flather, M., Keeling, M., Yazbek Hanna, M., Hurst, R., Curley, H., Clark, J., Brewer, D., Mcdermott, U., Cooper, C.

(2015)

Mutation detection in formalin-fixed prostate cancer biopsies taken at the time of diagnosis using next generation DNA sequencing,

in Journal of Clinical Pathology

68

pp. 212-217

Full Text UEA Repository

(Article)

(Published)


Zuo, J., Brewer, D., Arlt, V. M., Cooper, C., Phillips, D. H.

(2014)

Benzo[a]pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice,

in BMC Genomics

15

article no. 880

Full Text UEA Repository

(Article)

(Published)


Ju, Y. S., Alexandrov, L. B., Gerstung, M., Martincorena, I., Nik-Zainal, S., Ramakrishna, M., Davies, H. R., Papaemmanuil, E., Gundem, G., Shlien, A., Bolli, N., Behjati, S., Tarpey, P. S., Nangalia, J., Massie, C. E., Butler, A. P., Teague, J. W., Vassiliou, G. S., Green, A. R., Du, M., Unnikrishnan, A., Pimanda, J. E., Teh, B. T., Munshi, N., Greaves, M., Vyas, P., El-Naggar, A. K., Santarius, T., Collins, V. P., Grundy, R., Taylor, J. A., Hayes, D. N., Malkin, D., Foster, C. S., Warren, A. Y., Whitaker, H. C., Brewer, D., Eeles, R., Cooper, C., Neal, D., Visakorpi, T., Isaacs, W. B., Bova, G. S., Flanagan, A. M., Futreal, P. A., Lynch, A. G., Chinnery, P. F., McDermott, U., Stratton, M. R., Campbell, P. J.

(2014)

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer,

in eLife

3

article no. e02935

pp. 1-28

Full Text UEA Repository

(Article)

(Published)


Tubio, J. M. C., Li, Y., Ju, Y. S., Martincorena, I., Cooke, S. L., Tojo, M., Gundem, G., Pipinikas, C. P., Zamora, J., Raine, K., Menzies, A., Roman-Garcia, P., Fullam, A., Gerstung, M., Shlien, A., Tarpey, P. S., Papaemmanuil, E., Knappskog, S., Van Loo, P., Ramakrishna, M., Davies, H. R., Marshall, J., Wedge, D. C., Teague, J. W., Butler, A. P., Nik-Zainal, S., Alexandrov, L., Behjati, S., Yates, L. R., Bolli, N., Mudie, L., Hardy, C., Martin, S., McLaren, S., O'Meara, S., Anderson, E., Maddison, M., Gamble, S., Foster, C., Warren, A. Y., Whitaker, H., Brewer, D., Eeles, R., Cooper, C., Neal, D., Lynch, A. G., Visakorpi, T., Isaacs, W. B., van't Veer, L., Caldas, C., Desmedt, C., Sotiriou, C., Aparicio, S., Foekens, J. A., Eyfjörd, J. E., Lakhani, S. R., Thomas, G., Myklebost, O., Span, P. N., Børresen-Dale, A., Richardson, A. L., Van de Vijver, M., Vincent-Salomon, A., Van den Eynden, G. G., Flanagan, A. M., Futreal, P. A., Janes, S. M., Bova, G. S., Stratton, M. R., McDermott, U., Campbell, P. J.

(2014)

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes,

in Science

345

(6196)

pp. 1251343

Full Text UEA Repository

(Article)

(Published)


Merson, S., Yang, Z. H., Brewer, D., Olmos, D., Eichholz, A., McCarthy, F., Fisher, G., Kovacs, G., Berney, D. M., Foster, C. S., Møller, H., Scardino, P., Cuzick, J., Cooper, C. S., Clark, J.

(2014)

Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer,

in British Journal of Cancer

110

(6)

pp. 1655-62

Full Text UEA Repository

(Article)

(Published)


Wu, P., Agnelli, L., Walker, B. A., Todoerti, K., Lionetti, M., Johnson, D. C., Kaiser, M., Mirabella, F., Wardell, C., Gregory, W. M., Davies, F. E., Brewer, D., Neri, A., Morgan, G. J.

(2013)

Improved risk stratification in myeloma using a microRNA-based classifier,

in British Journal of Haematology

162

(3)

pp. 348-59

Full Text UEA Repository

(Article)

(Published)


Cuzick, J., Yang, Z. H., Fisher, G., Tikishvili, E., Stone, S., Lanchbury, J. S., Camacho, N., Merson, S., Brewer, D., Cooper, C. S., Clark, J., Berney, D. M., Møller, H., Scardino, P., Sangale, Z.

(2013)

Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer,

in British Journal of Cancer

108

(12)

pp. 2582-9

Full Text UEA Repository

(Article)

(Published)


Olmos, D., Brewer, D., Clark, J., Danila, D. C., Parker, C., Attard, G., Fleisher, M., Reid, A. H., Castro, E., Sandhu, S. K., Barwell, L., Oommen, N. B., Carreira, S., Drake, C. G., Jones, R., Cooper, C. S., Scher, H. I., de Bono, J. S.

(2012)

Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study,

in The Lancet Oncology

13

(11)

pp. 1114-24

Full Text UEA Repository

(Article)

(Published)


Reid, A. H. M., Attard, G., Brewer, D., Miranda, S., Riisnaes, R., Clark, J., Hylands, L., Merson, S., Vergis, R., Jameson, C., Høyer, S., Sørenson, K. D., Borre, M., Jones, C., de Bono, J. S., Cooper, C. S.

(2012)

Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer,

in Modern Pathology

25

(6)

pp. 902-10

Full Text UEA Repository

(Article)

(Published)


Wu, P., Walker, B. A., Brewer, D., Gregory, W. M., Ashcroft, J., Ross, F. M., Jackson, G. H., Child, A. J., Davies, F. E., Morgan, G. J.

(2011)

A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment,

in Clinical Cancer Research

17

(19)

pp. 6347-55

Full Text UEA Repository

(Article)

(Published)


Bee, A., Brewer, D., Beesley, C., Dodson, A., Forootan, S., Dickinson, T., Gerard, P., Lane, B., Yao, S., Cooper, C. S., Djamgoz, M. B. A., Gosden, C. M., Ke, Y., Foster, C. S.

(2011)

siRNA knockdown of ribosomal protein gene RPL19 abrogates the aggressive phenotype of human prostate cancer,

in PLoS ONE

6

(7)

article no. e22672

Full Text UEA Repository

(Article)

(Published)


Suwaki, N., Vanhecke, E., Atkins, K. M., Graf, M., Swabey, K., Huang, P., Schraml, P., Moch, H., Cassidy, A. M., Brewer, D., Al-Lazikani, B., Workman, P., De-Bono, J., Kaye, S. B., Larkin, J., Gore, M. E., Sawyers, C. L., Nelson, P., Beer, T. M., Geng, H., Gao, L., Qian, D. Z., Alumkal, J. J., Thomas, G., Thomas, G. V.

(2011)

A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma,

in Science Translational Medicine

3

(85)

pp. 85ra47

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

 

My main research interests lie in applying and developing novel analytic techniques to large-scale ‘omic datasets from human tumour samples to answer clinically relevant questions in translational cancer research.  I am currently working as a leading bioinformatician on the The ICGC UK prostate project, a multi-centre collaboration that aims to collect and analyse the whole genome sequence, transcriptome and methylome of 250 prostatectomy prostate cancer samples and their matched blood and the ICGC PanProstate project. I am also involved in the Movember GAP1 Urine Biomarker Project  and detecting sub-types of cancer using novel Bayesian clustering methods. I have a growing interest in the role that bacteria plays in cancer and have developed an analytic pipeline (SEPATH) that identifies infectious agents in whole genome sequencing data. This pipeline will be applied to the whole genome sequence data of 40,000 cancer genomes from Genomics England’s 100,000 Genome project, 1000 prostate cancer genomes from the ICGC PanProstate project and 2500 geneomes from the ICGC PanCancer project.