Biography

 

Dr Barbara Jennings (PhD) joined Norwich Medical School (NMS) as part of the inaugural team when it was established in 2002, and is a Senior Lecturer in the Medical Education department. She is the academic lead for the genetics curriculum at NMS and for faculty continuous-professional-development (CPD).

 

Barbara is a scientist: her PhD was about cancer genetics, and she has a background in clinical molecular diagnostics for the NHS. Her published research spans cancer genetics, genetic epidemiology, pharmacogenetics, and technology-enhanced-learning.

 

Barbara is passionate about widening access to higher education and the importance of open access publications, which she discusses on twitter @GeneticsMBBS. She is the course director of a free online course about personalised medicine and pharmacogenetics:

 

https://www.futurelearn.com/courses/personalized-medicine?lr=55

 

Collaborative educational responsibilities include external examining and membership of the Editorial Board of the journal AMEE MedEdPublish. Barbara is a Senior Fellow of the Higher Education Academy.

 



  

Career History

  • UEA: Senior Lecturer in Molecular Medicine (from 2002)
  • Norfolk and Norwich University Hospital: Principal Clinical Scientist (1990 to 2002)
  • Bath University: Postgraduate Research Associate (1989 to 1990)
  • UEA: Postgraduate Research Associate (1988 to 1989)

Academic Background

University of East Anglia

  • Post Graduate Certificate in Higher Education Practice (2004)
  • Ph.D. in Cancer Genetics (1994)
  • B.Sc. (hons) Biological Sciences (1988)

Medical Education Training:

Higher Education Academy

  • Senior Fellow (2016)

ASME/Harvard-Macy Institute 

  • Educational Leadership Course (2004)
  • Advanced Module Developing Leaders in Healthcare Education (2008)

All Publications

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Jennings, B. A., Prinsley, P., Philpott, C., Willis, G., Bhutta, M. F.

(2017)

The genetics of cholesteatoma. A systematic review using narrative synthesis,

in Clinical Otolaryngology

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Jennings, B. A., Keenan, I.

(2017)

Life Sciences in an Integrated Curriculum: Starting the Conversation,

in MedEdPublish

6

(2)

pp. 1

Full Text

(Editorial)

(Published)


Killeen, T., Skinner, J., Loke, Y., Jennings, B.

(2016)

Student Selected Components - a modern curriculum to complement a systems-based medical degree,

in MedEdPublish

5

(1)

article no. 13

Full Text UEA Repository

(Article)

(Published)


Prinsley, P., Jennings, B., Philpott, C., Bhutta, M.

(2016)

The Genetics of Cholesteatoma,

Full Text

(Abstract)

(Published)


Meulendijks, D., Henricks, L. M., Sonke, G. S., Deenen, M. J., Froehlich, T. K., Amstutz, U., Largiadèr, C. R., Jennings, B. A., Marinaki, A. M., Sanderson, J. D., Kleibl, Z., Kleiblova, P., Schwab, M., Zanger, U. M., Palles, C., Tomlinson, I., Gross, E., van Kuilenburg, A. B., Punt, C. J., Koopman, M., Beijnen, J. H., Cats, A.

(2015)

Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: A systematic review and meta-analysis of individual patient data,

in The Lancet Oncology

16

(16)

pp. 1639-1650

Full Text UEA Repository

(Article)

(Published)


Jennings, B. A., Shakespeare, T., Loke, Y. K.

(2015)

Scanning the human genome and the horizon: the potential and pitfalls of pharmacogenetics and stratified medicine,

in British Journal of General Practice

65

(653)

pp. 284 -285

Full Text

(Editorial)

(Published)


Jennings, B., Willis, G.

(2015)

How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy,

in Cancer Letters

356

(2 Part A)

pp. 224-230

Full Text

(Special issue)

(Published)


Jennings, B.

(2014)

A vision of personalised medicine revealed through modern genomics and open science,

in European Journal of Human Genetics

22

article no. 1420

Full Text

(Book/Film/Article review)

(Published)


Jennings, B. A., Loke, Y. K., Skinner, J., Keane, M., Chu, G. S., Turner, R., Epurescu, D., Barrett, A., Willis, G.

(2013)

Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines,

in PLoS ONE

8

(10)

article no. e78053

Full Text UEA Repository

(Article)

(Published)


Jennings, B. A., Kwok, C. S., Willis, G., Matthews, V., Wawruch, P., Loke, Y. K.

(2012)

Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis,

in Pharmacogenetics and Genomics

22

(4)

pp. 290-304

Full Text UEA Repository

(Article)

(Published)


Jennings, B., Papageorgiou, A.

(2011)

The holistic curriculum: balancing basic and social sciences with clinical practice.,

in The Changing Face of Medical Education.

Radcliffe Publishing

UEA Repository

(Chapter)

(Published)


Khandanpour, N., Jennings, B., Armon, M. P., Wright, A., Willis, G., Clark, A., Meyer, F.

(2011)

Do novel risk biomarkers reflect the severity of peripheral arterial disease?,

in Angiology

62

(2)

pp. 126-33

UEA Repository

(Article)

(Published)


Winney, B., Abdelhamid, B., Day, T., Davison, D., Echeta, C., Evseeva, I., Hutnik, K., Leslie, S., Nicodemus, K., Royrvik, E. C., Tonks, S., Yang, X., Cheshire, J., Longley, P., Mateos, P., Groom, A., Relton, C., Bishop, D. T., Black, K., Northwood, E., Parkinson, L., Frayling, T. M., Steele, A., Sampson, J. R., King, T., Dixon, R., Middleton, D., Jennings, B., Bowden, R., Donnelly, P., Bodmer, W.

(2011)

People of the British Isles: preliminary analysis of genotypes and surnames in a UK control population,

in European Journal of Human Genetics

20

pp. 203–210

Full Text UEA Repository

(Article)

(Published)


Jennings, B., Willis, G., Skinner, J., Relton, C.

(2010)

Genetic selection? A study of individual variation in the enzymes of folate metabolism.,

in BMC Medical Genetics

11

article no. 18

Full Text UEA Repository

(Article)

(Published)


Khandanpour, N., Armon, M. P., Jennings, B., Clark, A., Meyer, F.

(2010)

The association between ankle brachial pressure index and pulse wave velocity: clinical implication of pulse wave velocity.,

in Angiology

60

(6)

pp. 732-738

UEA Repository

(Article)

(Published)


Khandanpour, N., Loke, Y., Meyer, F., Jennings, B., Armon, M.

(2009)

Homocysteine and peripheral arterial disease: systematic review and meta-analysis.,

in European Journal of Vascular and Endovascular Surgery

38

(3)

pp. 316-322

Full Text UEA Repository

(Article)

(Published)


Khandanpour, N., Armon, M., Jennings, B., Clark, A., Meyer, F.

(2009)

Photoplethysmography, an easy and accurate method for measuring ankle brachial pressure index: Can photoplethysmography replace doppler.,

in European Journal of Vascular and Endovascular Surgery

43

(6)

pp. 578-582

Full Text UEA Repository

(Article)

(Published)


Khandanpour, N., Armon, M., Jennings, B., Clark, A., Willis, G., Meyer, F.

(2009)

Folate Supplementation Improves Arterial Function in Patients with Peripheral Arterial Disease. A Randomised Double Blind, Placebo Controlled Clinical Trial.,

in British Journal of Surgery

96

pp. 990-998

Full Text UEA Repository

(Article)

(Published)


Khandanpour, N., Armon, M., Jennings, B., Finglas, P., Willis, G., Clark, A., Meyer, F.

(2009)

Randomised clinical trial of folate supplementation in patients with peripheral arterial disease.,

in British Journal of Surgery

96

(9)

pp. 990-998

Full Text UEA Repository

(Article)

(Published)


Khandanpour, N., Willis, G., Meyer, F., Armon, M., Loke, Y., Wright, A., Finglas, P., Jennings, B.

(2009)

Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHRFR) C677T mutations: A case-control study and meta-analysis.,

in Journal of Vascular Surgery

49

(3)

pp. 711-718

Full Text UEA Repository

(Article)

(Published)


<- Page 1 of 3 ->

Key Research Interests

My current research is in the field of molecular genetic medicine and the identification of predictive markers for cancer patients.

I collaborate with colleagues in Newcastle and Oxford universities and within the Norwich Research Park. Recent research has included genetic disease association studies, intervention studies, systematic reviews and pharmacogenetic studies. My epidemiological research has focused on folate metabolism.

  • We have shown that the enzymes of intracellular folate metabolism are remarkably polymorphic and some genotypes may affect survival in utero. A common variant (MTHFR 677C>T mutation) is associated with raised homocysteine, peripheral artery disease and colorectal cancer.
  • As East Anglian leads for the People of the British Isles (POBI) study, which is led by the University of Oxford, we have contributed to an investigation of the population structure in Britain and the development of resources for the 1000 genomes project.
  • In a primary pharmacogenetic study and through meta-analysis, we have measured the clinical validity of markers that predict adverse events for patients with colorectal cancer treated with fluoropyrimidines.
     

Highlighted publications

Barbara A Jennings, Yoon K Loke, Jane Skinner, Melanie Keane, Gavin S Chu, Richard Turner, Daniel Epurescu, Ann Barrett, Gavin Willis. Evaluating Predictive Pharmacogenetic Signatures of Adverse Events in Colorectal Cancer Patients Treated with Fluoropyrimidines. Plos One 2013 (in press).

Jennings BA, Kwok CS, Willis G, Matthews V, Wawruch P, Loke YK. Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer; a systematic review and meta-analysis. Pharmacogenet Genomics 2012; 4:290-304.

Winney, Bruce, Abdelhamid, Boumertit, Day, Tammy, Davison, Dan, Echeta, Chikodi, Evseeva, Irina, Hutnik, Katarzyna, Leslie, Stephen, Nicodemus, Kristin, Royrvik, Ellen C, Tonks, Susan, Yang, Xiaofeng, Cheshire, James, Longley, Paul, Mateos, Pablo, Groom, Alexandra, Relton, Caroline, Bishop, D. Tim, Black, Kathryn, Northwood, Emma, Parkinson, Louise, Frayling, Timothy M, Steele, Anna, Sampson, Julian R, King, Turi, Dixon, Ron, Middleton, Derek, Jennings, Barbara, Bowden, Rory, Donnelly, Peter and Bodmer, Walter People of the British Isles: preliminary analysis of genotypes and surnames in a UK control population. Eur JHum Genet 2012; 2;203-10.

Khandanpour, Nader, Jennings, Barbara, Armon, Matthew P, Wright, Anthony, Willis, Gavin, Clark, Allan and Meyer, F .Do novel risk biomarkers reflect the severity of peripheral arterial disease? Angiology 2011:62; 126-33. ISSN 1940-1574.

Jennings BA, Willis G, Skinner J, Relton C. Genetic selection? A study of individual variation in the enzymes of folate metabolism. BMC Medical Genetics 2010;11(1):18.

Khandanpour N, Armon MP, Jennings BA, Clark A, Willis G, Finglas P, Meyer F. Randomized clinical trial of folate supplementation in patients with peripheral arterial disease. British Journal of Surgery 2009;96:990-998.

Willis G, Bardsley V, Fellows IW, Lonsdale R, Wimperis JZ, Jennings BA. Hepatocellular carcinoma and the penetrance of HFE C282Y mutations: a cross sectional study. BMC Gastroenterol. 2005 Jun 1;5(1):17.

Willis G., Wimperis J.Z., Fellows I., Smith K., Jennings. HFE mutations in the elderly. B.A. Blood Cells, Molecules and Diseases 2003:31/32; 240-246.

Lee JH, Han SU, Cho H, Jennings BA, Dean M, Schmidt L, Zbar B, Vande Woude GF. 2000. A novel germ line juxtamembrane Met mutation in human gastric cancer. Oncogene 19:4947-4953.

Willis G, Wimperis JZ, Smith K, Fellows I, Jennings BA. HFE (haemochromatosis gene) C282Y homozygotes in an elderly male population. Lancet 1999;354:221-222.

Research Keywords

Genetic Epidemiology
Cancer Genetics
Pharmacogenetics
Folate Metabolism

Postgraduate Research Student Supervision

Genetic Epidemiology
Cancer Genetics
Pharmacogenetics
Folate Metabolism

Enterprise and Engagement activities

I contributed to Photo-ID, an exhibition funded by the Wellcome Trust that was produced by scientists, photographers and artists. The curator, Professor Keith Roberts, edited a book to accompany the project. In this chapter I present my research in its social context; Genetics and Identity; exploring our history, defining our futures? - 2009
Faculty Member for Future Medicine Summer School at UEA – July 2013
Faculty member for DNA Day for European Society of Human Genetics – April 2013

Teaching Interests

I have particular interests in

  • Online learning and E-teaching. For example, through the production of a microsite linking useful resources for teaching and learning human genetics; GENIE https://www.uea.ac.uk/medicine-health-sciences/continuing-professional-development/genie-genetic-information-and-education/research-resources.
  • Curriculum design for medical education, and have reflected on the development of the MB BS curriculum at UEA in a recent book chapter (Jennings BA and Papageorgiou A. The holistic curriculum: balancing basic and social sciences with clinical practice. The Changing Face of Medical Education. Radcliffe Publishing 2011).
  • Small group teaching; I have been a problem based learning and genetics tutor since 2002.
  • Student selected components of the MB BS curriculum as a vehicle to allow in depth study of complex fields of research.
  • Widening access to medical education so that the medical profession is representative of the community that it serves.

External Activities and Indicators of Esteem

  • Expert Reviewer for Medical Research Council (RCUK) grant application - April 2013
  • East Anglian lead for the People of the British Isles Study (www.peopleofthebritishisles.org) - 2006 to 2012
  • Contributor to the national list of genetics learning outcomes for UK undergraduate medical students defined by the National Genetics and Education Centre - 2005
  • External Examiner for Manchester University - From 2013
  • Book reviewer for European Journal of Human Genetics - 2006 and 2012
  • "Jennings BA Black Swans and Bell Curves. Eur J Hum Genet 2012; 20:1202."
  • "A balanced perspective of psychiatric genetics: Psychiatric Genetics and Genomics. Jennings BA. Eur J Hum Genet 2006; 14:1145-6."

Key Responsibilities

Genetics Theme Lead and Academic Lead for Student Selected Studies for the MB BS Degree.