BSc in Nutrition and Biochemistry (1992-1996), University College Cork (UCC), Ireland
PhD in Nutrition, Institute of Food Research (IFR) Norwich and UCC (1997-2001)
My current research focus is investigating the independent and interactive impact of select dietary components (in particular n-3 fatty acids and flavonoids) and common gene variants on cardiometabolic health. More recently, my research has also focussed on age-related cognitive decline and dementia.
Member of the British Nutrition Society
Member of the International Society for the Study of Fatty Acids and Lipids (ISSFAL)
Academic Advisor to the ILSI Obesity and Diabetes Task Force
Visiting Professor Status at the University of Reading
Key Research Interests
I am Head of the Nutrigenetics group within the Dept of Nutrition with our key research interests being:
- Dietary n-3 fatty acids and cardio-metabolic health with a focus on lipoprotein metabolism, vascular function and adipose tissue and liver inflammation
- Diet and cognitive performance
- Aetiology of the association between the APOE4 genotype and chronic disease risk
- Determinants of flavonoid metabolism
A large proportion of our research involves human intervention trials (RCTs) conducted at the Clinical Trials Unit. In addition, we employ a variety of wild-type and transgenic rodent models and cell and molecular techniques to investigate underlying physiological and molecular mechanisms and to inform the foci of our RCT.
Examples of ongoing RCTs include:
- COB Study (BBSRC funded): Investigation of the impact of age, gender, genotype and gut microflora on flavonoid absorption and metabolism (n=210)
- CANN Study (Centre of Nutrition Memory and Learning, CNLM, University of Illinois funded): A Randomised Controlled Trial in ‘At Risk’ Humans investigating the Cognitive Benefits of Combined Flavonoid/Fatty Acid and Underlying Mechanisms of Action: The Cognitive Aging Nutrition and Neurogenesis (CANN) trial (n=240)
- FOFA Study (UEA funded): Investigation of the vascular impact of EPA and DHA in adult males (n=50)
- NU-AGE project (EU FP7 funded), in collaboration with Cassidy and Fairweather-Tait (PI at UEA), and other NU-AGE European Partners. Large Pan-European consortium investigating the impact if dietary change on the inflammatory phenotype in older adults (n=1200)(2010-2016)
Prof Neal Cohen
Dr Sonia de Pascual-Teresa
Prof Gerald Rimbach
Prof José López-Miranda
A/ Prof Mary Jo LaDu
Prof Jose Ordovos
Dr Miriam Ryan & Dr Eileen Gibney
Dr Welma Stonehouse
University of Illinois, US
CSIC, Madrid, Spain
University of Kiel, Germany
University of Cordova, Spain
University of Illinois, Chicago
Tufts University Boston, US
University College Dublin, Ireland
CSIRO, Adelaide, Australia
Prof Philip Calder
Dr Wendy Hall
Dr Georg Lietz/ Prof John Mathers
Prof Christine Willimas/ Prof Julie Lovegrove/ Dr Kim Jackson/ Prof Jeremy Spencer
School of Medicine, Uni of Southampton
Diabetes & Institutional Sciences, London
Medical Sciences, University of Newcastle
Hugh Sinclair Nutrition Group, University of Reading
1. Macready AL, George TW, Chong MF, Alimbetov DS, Jin Y, Vidal A, Spencer JPE, Kennedy OB, Tuohy K, Minihane AM, Gordon MH,. Lovegrove JA for the FLAVURS study group. Flavonoid-rich fruits and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease – FLAVURS: a randomized controlled trial. American Journal of Clinical Nutrition, in press.
2. Minihane AM. The genetic contribution to disease risk and variability in response to diet: Where is the hidden heritability? Proc Nutr Soc 2013;72:40-47.
3. Welma Stonehouse, Cathryn A Conlon, John Podd, Stephen Hill, Anne M Minihane, Chrystal Haskell, David Kennedy. Docosahexaenoic acid supplementation improves memory and speed of memory in healthy young adults. American Journal of Clinical Nutrition 2013;97:1134-43.
4. Carvalho-WellsAL, JacksonKG, LockyerS, LovegroveJA, Minihane AM. APOE genotype influences the triglyceride and C-reactive protein response to altered dietary fat intake in UK adults. American Journal of Clinical Nutrition 2012;96:1447-1453.
5. GraeserA-C, Bösch-SaadatmandiC, LippmannJ, Storm N, WiswedelI, GardemanA, EgertS, MüllerMJ, MinihaneAM, DöringF, RimbachG. Nrf2 dependent gene expression is affected by the apoE genotype– Studies in transgenic mice and in humans. Journal of Molecular Medicine 2011;89:1027-35.
6. Madden J, Williams CM, Calder PC, Lietz G, Miles EA, Cordell H, Mathers JC, Minihane AM. The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes. Annual Review of Nutrition 2011;31:203-34.
7. Olano-Martin E, Anil E, Caslake MJ, Packard CJ, Bedford D, Stewart G, Peiris D, Williams CM, Minihane AM. Contribution of apolipoproteins E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil. Atherosclerosis 2010;209:104-110.
8. Caslake MJ, Miles EA, Kofler BM, Lietz G, Curtis P, Armah CK, Kimber AC, Grew JP, Farrell L, Stannard J, Napper FL, Sala-Vila A, West AL, Mathers JC, Packard C, Williams CM, Calder PC, Minihane AM. Impact of gender and genotype on cardiovascular biomarker response to fish oils (FINGEN Study). American Journal of Clinical Nutrition, 2008;88:618-629.
9. Olano-MartinE, Abraham EC, Gill-Garrison R , Valdes AM, GrimaldiK, TangF, JacksonKG, WilliamsCM and MinihaneAM. Influence of ApoA5 gene variants on postprandial triglyceride metabolism: Impact of gender. Journal of Lipid Research, 2008;49:945-953.
10. Armah, CK, Jackson KG, Doman I, James L, Cheghani F and Minihane AM. Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clinical Science, 2008:114:679-686.
External Activities and Indicators of Esteem
- Deputy Editor of the British Journal of Nutrition (BJN) and Journal of Nutritional Sciences (JNS), and Section Editor of the European Journal of Clinical Nutrition (EJCN).
- Current academic expert on the ILSI Obesity and Diabetes Task Force.
- Member of HEFCE, UoA6, REF assessment panel 2010-2014.
- Member of the British Nutrition Society and the International Society for the Study of Lipids and Fatty Acids (ISSFAL).
- Recipient of the 2008 Nutrition Society Silver Medal Award ‘for scientific excellence in the field of nutrition’.
- External Examiner for Newcastle University, University of Singapore and University of Aberdeen UG and PG nutrition related courses.