Academic Background

Professional Qualifications

BSc in Nutrition and Biochemistry (1992-1996), University College Cork (UCC), Ireland

PhD in Nutrition, Institute of Food Research (IFR) Norwich and UCC (1997-2001)

My current research focus is study the independent and interactive impact of select dietary components (in particular n-3 fatty acids and flavonoids) and common gene variants on cardiometabolic health. More recently, my research has been based upon age-related cognitive decline.

Professional Memberships

Member of the British Nutrition Society

Member of the International Society for the Study of Fatty Acids and Lipids (ISSFAL)

Academic Advisor to ILSI Obesity and Diabetes Task Force

Visiting Professor Status at the University of Reading

 

 

All Publications

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Welch, A., Macgregor, A., Minihane, A., Skinner, J., Valdes, A. A., Spector, T. D., Cassidy, A.

(2014)

Dietary Fat and Fatty Acid Profile Are Associated with Indices of Skeletal Muscle Mass in Women Aged 18-79 Years

in The Journal of nutrition

144.

pp. 327-334

Full Text UEA Repository

(Article)


Kaput, J., van Ommen, B., Kremer, B., Priami, C., Monteiro, J. P., Morine, M., Pepping, F., Diaz, Z., Fenech, M., He, Y., Albers, R., Drevon, C. A., Evelo, C. T., Hancock, R. E. W., Ijsselmuiden, C., Lumey, L. H., Minihane, A., Muller, M., Murgia, C., Radonjic, M., Sobral, B., West, K. P.

(2014)

Consensus statement understanding health and malnutrition through a systems approach : the ENOUGH program for early life

in Genes & Nutrition

9.

pp. 378

Full Text UEA Repository

(Article)


Bhattacharya, B. S., Sweby, P. K., Minihane, A., Jackson, K. G., Tindall, M. J.

(2014)

A mathematical model of the sterol regulatory element binding protein 2 cholesterol biosynthesis pathway

in Journal of Theoretical Biology

349.

pp. 150-62

Full Text UEA Repository

(Article)


Koutsos, A., Jackson, K. G., Lockyer, S., Carvalho-Wells, A., Minihane, A., Lovegrove, J. A.

(2014)

Greater impact of dietary fat manipulation than apolipoprotein E genotype on ex vivo cytokine production - insights from the SATgenε study

in Cytokine

66.

pp. 156-9

Full Text UEA Repository

(Article)


Macready, A. L., George, T. W., Chong, M. F., Alimbetov, D. S., Jin, Y., Vidal, A., Spencer, J. P. E., Kennedy, O. B., Tuohy, K. M., Minihane, A., Gordon, M. H., Lovegrove, J. A., Anti-Inflammatory Agents, Non-Steroidal

(2014)

Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease--FLAVURS : a randomized controlled trial

in The American journal of clinical nutrition

99.

pp. 479-89

Full Text UEA Repository

(Article)


Gammon, C. S., Minihane, A., Kruger, R., Conlon, C. A., von Hurst, P. R., Jones, B., Stonehouse, W., Cholesterol, HDL, Polymorphism, Genetic

(2014)

TaqIB polymorphism in the cholesteryl ester transfer protein (CETP) gene influences lipid responses to the consumption of kiwifruit in hypercholesterolaemic men

in The British Journal of Nutrition

111.

pp. 1077-84

Full Text UEA Repository

(Article)


Borel, P., Lietz, G., Goncalves, A., Szabo de Edelenyi, F., Lecompte, S., Curtis, P., Goumidi, L., Caslake, M., Miles, E., Packard, C., Calder, P., Mathers, J., Minihane, A., Tourniaire, F., Kesse-Guyot, E., Galan, P., Hercberg, S., Breidenassel, C., González Gross, M., Moussa, M., Meirhaeghe, A., Reboul, E.

(2013)

CD36 and SR-BI Are Involved in Cellular Uptake of Provitamin A Carotenoids by Caco-2 and HEK Cells, and Some of Their Genetic Variants Are Associated with Plasma Concentrations of These Micronutrients in Humans.

in The Journal of nutrition

143.

pp. 448-456

UEA Repository

(Article)


Chong, M., George, T., Alimbetov, D., Jin, Y., Weech, M., Macready, A., Spencer, J., Kennedy, O., Minihane, A., Gordon, M., Lovegrove, J.

(2013)

Impact of the quantity and flavonoid content of fruits and vegetables on markers of intake in adults with an increased risk of cardiovascular disease: the FLAVURS trial

in European Journal of Nutrition

52.

pp. 361-378

Full Text UEA Repository

(Article)


Minihane, A., Diabetes Mellitus, Type 2

(2013)

Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins

in European Journal of Clinical Nutrition

67.

pp. 536-40

Full Text UEA Repository

(Article)


Minihane, A.

(2013)

The genetic contribution to disease risk and variability in response to diet : where is the hidden heritability?

in Proceedings of the Nutrition Society

72.

pp. 40-7

Full Text UEA Repository

(Article)


Huebbe, P., Dose, J., Schloesser, A., Rimbach, G., Nebel, A., Rausch, P., Baines, J. F., Campbell, G., Gluer, C., Minihane, A.

(2013)

APOE ε3 is an energy-thrifty allele : Studies on fat storage, energy expenditure and physical activity in targeted replacement mice.

in Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490

UEA Repository

(Article)


Macready, A., George, T., Chong, M., Alimbetov, D., Jin, Y., Vidal, A., Spencer, J., Kennedy, O., Tuohy, K., Gordon, M., Lovegrove, J., Minihane, A.

(2013)

Flavonoid-rich fruits and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease. : FLAVURS: a randomized controlled trial

in American Journal of Clinical Nutrition

UEA Repository

(Article)


Jackson, K. G., Walden, C. M., Murray, P., Smith, A. M., Minihane, A., Lovegrove, J. A., Williams, C. M., Cholesterol, HDL, Cholesterol, LDL, Fatty Acids, Nonesterified

(2013)

Greater impairment of postprandial triacylglycerol than glucose response in metabolic syndrome subjects with fasting hyperglycaemia

in Metabolism: clinical and experimental

62.

pp. 1065-1069

Full Text UEA Repository

(Article)


Gammon, C. S., Kruger, R., Minihane, A., Conlon, C. A., von Hurst, P. R., Stonehouse, W.

(2013)

Kiwifruit consumption favourably affects plasma lipids in a randomised controlled trial in hypercholesterolaemic men

in The British Journal of Nutrition

109.

pp. 2208-2218

Full Text UEA Repository

(Article)


Stonehouse, W., Conlon, C. A., Podd, J., Hill, S. R., Minihane, A., Haskell, C., Kennedy, D., Memory, Short-Term

(2013)

DHA supplementation improved both memory and reaction time in healthy young adults : a randomized controlled trial

in The American journal of clinical nutrition

97.

pp. 1134-1143

Full Text UEA Repository

(Article)


Dougkas, A., Minihane, A., Givens, D., Reynolds, C., Yaqoob, P.

(2012)

Differential effects of dairy snacks on appetite, but not overall energy intake

in British Journal of Nutrition

2.

pp. 1-12

UEA Repository

(Article)


Jackson, K., Walden, M., Murray, P., Smith, A., Lovegrove, J., Minihane, A., Williams, C.

(2012)

A sequential two meal challenge reveals abnormalities in postprandial TAG but not glucose in men with increasing numbers of metabolic syndrome components

in Atherosclerosis

220.

pp. 237-243

Full Text UEA Repository

(Article)


Kofler, B., Miles, E., Curtis, P., Armah, C., Tricon, S., Grew, J., Napper, F., Farrell, L., Lietz, G., Packard, C., Caslake, M., Mathers, J., Williams, C., Calder, P., Minihane, A.

(2012)

Apolipoprotein E genotype and the cardiovascular disease risk phenotype: Impact of sex and adiposity (the FINGEN study)

in Atherosclerosis

221.

pp. 467-470

Full Text UEA Repository

(Article)


Lockyer, S., Tzanetou, M., Carvalho-Wells, A., Jackson, K., Minihane, A., Lovegrove, J.

(2012)

SATgene dietary model to implement diets of differing fat composition in prospectively genotyped groups (apoE) using commercially available foods

in British Journal of Nutrition

108.

pp. 1705-1713

Full Text UEA Repository

(Article)


Miller, R., Jackson, K., Dadd, T., Mayes, A., Brown, A., Lovegrove, J., Minihane, A.

(2012)

The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion

in Molecular Nutrition & Food Research

56.

pp. 966-975

Full Text UEA Repository

(Article)


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Key Research Interests

I am Head of the Nutrigenetics group within the Dept of Nutrition with our key research interests being:

  • Nutrigenetics
  • Dietary n-3 fatty acids and cardio-metabolic health with a focus on lipoprotein metabolism, vascular function and adipose tissue and liver inflammation
  • Diet and cognitive performance
  • Aetiology of the association between the APOE4 genotype and chronic disease risk
  • Determinants of flavonoid metabolism

Research approaches

A large proportion of our research involves human intervention trials (RCTs) conducted at the Clinical Trials Unit. In addition, we employ a variety of wild-type and transgenic rodent models and cell and molecular techniques to investigate underlying physiological and molecular mechanisms and to inform the foci of our RCT.

Examples of ongoing RCTs include:

  • COB Study (BBSRC funded): Investigation of the impact of age, gender, genotype and gut microflora on flavonoid absorption and metabolism (n=240)
  • CANN Study (Centre of Nutrition Memory and Learning, CNLM, University of Illinois funded): A Randomised Controlled Trial in ‘At Risk’ Humans investigating the Cognitive Benefits of Combined Flavonoid/Fatty Acid and Underlying Mechanisms of Action: The Cognitive Aging Nutrition and Neurogenesis (CANN) trial (n=220)
  • FOFA Study (UEA funded): Investigation of the vascular impact of EPA and DHA in adult males (n=50)
  • NU-AGE project (EU FP7 funded), in collaboration with Cassidy and Fairweather-Tait (PI at UEA), and other NU-AGE European Partners. Large Pan-European consortium investigating the impact if dietary change on the inflammatory phenotype in older adults (n=1200)(2010-2016)

Collaborators

Name

Organisation

International

Prof Neal Cohen

Dr Sonia de Pascual-Teresa

Prof Gerald Rimbach

Prof José López-Miranda

A/ Prof Mary Jo LaDu

Prof Jose Ordovos

Dr Miriam Ryan & Dr Eileen Gibney

Dr Welma Stonehouse

 

University of Illinois, US

CSIC, Madrid, Spain

University of Kiel, Germany

University of Cordova, Spain

University of Illinois, Chicago

Tofts University Boston, US

University College Dublin, Ireland

CSIRO, Adelaide, Australia

National

Prof Philip Calder

Dr Wendy Hall

Dr Georg Lietz/ Prof John Mathers

Prof Christine Willimas/ Prof Julie Lovegrove/ Dr Kim Jackson/ Prof Jeremy Spencer

 

School of Medicine, Uni of Southampton

Diabetes & Institutional Sciences, London

Medical Sciences, University of Newcastle

Hugh Sinclair Nutrition Group, University of Reading

 

Selected publications

1.       Macready AL, George TW, Chong MF, Alimbetov DS, Jin Y, Vidal A, Spencer JPE, Kennedy OB, Tuohy K, Minihane AM, Gordon MH,. Lovegrove JA for the FLAVURS study group. Flavonoid-rich fruits and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease – FLAVURS: a randomized controlled trial. American Journal of Clinical Nutrition, in press.

2.       Minihane AM. The genetic contribution to disease risk and variability in response to diet: Where is the hidden heritability? Proc Nutr Soc 2013;72:40-47.

3.       Welma Stonehouse, Cathryn A Conlon, John Podd, Stephen Hill, Anne M Minihane, Chrystal Haskell, David Kennedy. Docosahexaenoic acid supplementation improves memory and speed of memory in healthy young adults. American Journal of Clinical Nutrition 2013;97:1134-43.

 4.       Carvalho-WellsAL,  JacksonKG, LockyerS, LovegroveJA, Minihane AM. APOE genotype influences the triglyceride and C-reactive protein response to altered dietary fat intake in UK adults. American Journal of Clinical Nutrition 2012;96:1447-1453.

5.       GraeserA-C, Bösch-SaadatmandiC, LippmannJ, Storm N, WiswedelI, GardemanA, EgertS, MüllerMJ, MinihaneAM, DöringF, RimbachG. Nrf2 dependent gene expression is affected by the apoE genotype– Studies in transgenic mice and in humans. Journal of Molecular Medicine 2011;89:1027-35.

 6.       Madden J, Williams CM, Calder PC, Lietz G, Miles EA, Cordell H, Mathers JC, Minihane AM. The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes. Annual Review of Nutrition 2011;31:203-34.

7.       Olano-Martin E, Anil E, Caslake MJ, Packard CJ, Bedford D, Stewart G, Peiris D,  Williams CM, Minihane AM. Contribution of apolipoproteins E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil. Atherosclerosis 2010;209:104-110.

8.        Caslake MJ, Miles EA, Kofler BM, Lietz G, Curtis P, Armah CK, Kimber AC, Grew JP, Farrell L, Stannard J, Napper FL, Sala-Vila A, West AL, Mathers JC, Packard C, Williams CM, Calder PC, Minihane AM. Impact of gender and genotype on cardiovascular biomarker response to fish oils (FINGEN Study). American      Journal of Clinical Nutrition, 2008;88:618-629.

9.        Olano-MartinE, Abraham EC,      Gill-Garrison R , Valdes AM, GrimaldiK, TangF,  JacksonKG, WilliamsCM and MinihaneAM. Influence of ApoA5 gene variants on postprandial triglyceride metabolism: Impact of gender. Journal of Lipid Research, 2008;49:945-953.

10.        Armah, CK, Jackson KG, Doman I, James L, Cheghani F and Minihane AM. Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clinical Science, 2008:114:679-686.

 

External Activities and Indicators of Esteem

  • Deputy Editor of the British Journal of Nutrition (BJN) and Journal of Nutritional Sciences (JNS), and editorial board member of the European Journal of Clinical Nutrition (EJCN) and Nutrition & Aging.
  • Current academic expert of the ILSI Obesity and Diabetes Task Force.
  • Member of HEFCE, UoA6, REF assessment panel 2010-2014.
  • Member of the British Nutrition Society and the International Society for the Study of Lipids and Fatty Acids (ISSFAL).
  • Recipient of the 2008 Nutrition Society Silver Medal Award ‘for scientific excellence in the field of nutrition’.
  • External Examiner for Newcastle University, University of Singapore and University of Aberdeen UG and PG nutrition related courses.

 

Professional Activities

National and International Presentations

  • July 2014: ‘Impact of long chain n-3 PUFA and flavanols in a rodent model of non-alcoholic fatty liver disease’. International Society for the Study of Fatty Acids and Lipids (ISSFAL) 2014 Biennial Conference, Stockholm, Sweden

  • July 2014: ‘Role of Obesity/Diabetes/Impaired Glucose Tolerance/Metabolic Disease in Brain Ageing, Including Metabolic Factors. ILSI, Nutrition for the Ageing Brain: Towards Evidence for an Optimal Diet, 2-day Symposium, Milan, Italy

  • Apr 2014: ‘Nutrigenetics and personalised/stratified approaches to the provision of dietary advice’. Belgian Nutrition Society Annual Conference, Brussels, Belgium

  • Mar 2014, LOW GRADE INFLAMMATION, ILSI Annual Conference, Brussels, Belgium

  • October 2013: ANTHOCYANINS AND HEALTH: 'From populations to cells, parent compounds to key metabolites'. Organised and chaired the session at the VI International Conference on Polyphenols & Health, Buenos Aires, Argentina

  • September 2013: 'INFLAMMATION: FRIEND OR FOE?' and also chair of organising committee. ILSI Workshop on ‘Low grade inflammation: a high grade challenge’. Granada, Spain

  • April 2013: 'Nutrigenetics and Cognitive Health' - 114th Abbott Nutrition Research Conference in Colombus, Ohio, US

  • February 2013: 'Polyunsaturated fatty acids (PUFA) and health'. UK-Thailand Food Matrix Microstructure and Gut Health workshop in Bangkok, Thailand

  • February 2013: 'The fishy tale of omega-3 fatty acids and cardiovascular and cognitive health'. UK-Vietnam Food Matrix Microstructure and Gut Health workshop in Hanoi, Vietnam

  • Mar 2012: ‘Diet*genotype interactions: implications for health and future dietary recommendations’, Nutrition Society Future Food and Health conference, Aberdeen, UK

  • October 2011: ‘Nutrigenetics and personalised/stratified approaches to the provision of dietary advice’, ILSI Europe Symposium on Health Benefits of Foods, Prague, Czech Republic

  • May 2011: ‘Nutrigenetics and personalised/stratified approaches to the provision of dietary advice’, Nutrition for Medicine Conference, Sydney, Australia

  • May 2011: The impact of fish oils on cardiovascular health: ‘What dose does what and in who’ Nutrition for Medicine Conference, Sydney, Australia

  • October 2010: ‘Personalised advice base on genetic information’, ILSI conference, Copenhagen, Denmark

  • Sept 2010: The future of personalised nutrition, NuGo annual conference, Glasgow, UK

  • Dec 2009: Is the efficacy of n-3 fatty acids influenced by genetic polymorphisms, Australia/NZ Nutrition Society Conference, Newcastle, Australia

  • July 2009, Fatty acid-genotype interactions and cardiovascular risk Fatty acids in cell signalling (FACS), Oxford, UK

  • June 2009, ‘Nutrigenomics (Nutrigenetics) and cardiovascular disease (CVD), NutrEvent 2009, Lille, France