Academic Background

I am Professor of Nutrigenetics and Director of Research and Innovation in Norwich Medical School

My research investigates the independent and interactive impact of select dietary components (in particular n-3 fatty acids and flavonoids) and common gene variants on cardio-metabolic health. More recently we have also focussed on age-related cognitive decline and dementia.

 

Professional Qualifications

BSc in Nutrition and Biochemistry (1992-1996), University College Cork (UCC), Ireland

PhD in Nutrition, Institute of Food Research (IFR) Norwich and UCC (1997-2001)

Leading Departments, Leadership Foundation Training (2015-2016)

 

Professional Memberships

Member of the British Nutrition Society

Member of the American Society of Nutrition

Member of the International Society for the Study of Fatty Acids and Lipids (ISSFAL)

Academic Advisor to the ILSI Obesity and Diabetes Task Force

All Publications

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Rodriguez-Ramiro, I., Vauzour, D., Minihane, A.

(2016)

Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms: impact and mechanisms

Cambridge

pp. 47-60

ISBN 0029-6651

Full Text

(Conference contribution)


Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M., Kay, C. D., Minihane, A., Cassidy, A.

(2016)

Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial

in The American Journal of Clinical Nutrition

103.

pp. 694-702

Full Text UEA Repository

(Article)


Tejera, N., Vauzour, D., Betancor, M. B., Sayanova, O., Usher, S., Cochard, M., Rigby, N., Ruiz-Lopez, N., Menoyo, D., Tocher, D. R., Napier, J. A., Minihane, A. M.

(2016)

A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice

in Journal of Nutrition

146.

pp. 227-235

Full Text UEA Repository

(Article)


Minihane, A. M., Armah, C. K., Miles, E. A., Madden, J. M., Clark, A. B., Caslake, M. J., Packard, C. J., Kofler, B. M., Lietz, G., Curtis, P. J., Mathers, J. C., Williams, C. M., Calder, P. C.

(2016)

Consumption of Fish Oil Providing Amounts of Eicosapentaenoic cid and Docosahexaenoic Acid That Can Be Obtained from the Diet Reduces Blood Pressure in Adults with Systolic Hypertension: A Retrospective Analysis

in Journal of Nutrition

146.

pp. 516-523

Full Text UEA Repository

(Article)


Minihane, A.

(2016)

Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes

in Nutrients

8.

Full Text UEA Repository

(Article)


Shatwan, I. M., Minihane, A., Williams, C. M., Lovegrove, J. A., Jackson, K. G., Vimaleswaran, K. S.

(2016)

Impact of Lipoprotein Lipase Gene Polymorphism, S447X, on Postprandial Triacylglycerol and Glucose Response to Sequential Meal Ingestion

in International Journal of Molecular Sciences

17.

Full Text UEA Repository

(Article)


McManus, S., Tejera, N., Awwad, K., Vauzour, D., Rigby, N., Fleming, I., Cassidy, A., Minihane, A.

(2016)

Differential effects of EPA vs. DHA on postprandial vascular function and the plasma oxylipin profile in men

in The Journal of Lipid Research

57.

pp. 1720-1727

Full Text UEA Repository

(Article)


Huebbe, P., Dose, J., Schloesser, A., Campbell, G., Gluer, C., Minihane, A., Baines, J. F., Nebel, A., Rimbach, G.

(2015)

Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization—Studies in gene-targeted replacement mice

in Molecular Nutrition & Food Research

59.

pp. 334-343

Full Text UEA Repository

(Article)


Vauzour, D., Tejera, N., O'Neill, C., Booz, V., Jude, B., Wolf, I. M., Rigby, N., Silvan, J. M., Curtis, P. J., Cassidy, A., De Pascual-Teresa, S., Rimbach, G., Minihane, A.

(2015)

Anthocyanins do not influence long-chain n-3 fatty acid status: Studies in cells, rodents and humans

in Journal of Nutritional Biochemistry

26.

pp. 211-218

Full Text UEA Repository

(Article)


Chouinard-Watkins, R., Conway, V., Minihane, A., Jackson, K., Lovegrove, J., Plourde, M.

(2015)

Interaction between BMI and APOE genotype is associated with changes in the plasma long chain polyunsaturated fatty acid response to a fish oil supplement in healthy participants: Plasma FA response to DHA in APOE4 carriers

in American Journal of Clinical Nutrition

102.

pp. 505-513

Full Text UEA Repository

(Article)


Minihane, A., Vinoy, S., Russell, W. R., Baka, A., Roche, H. M., Tuohy, K. M., Teeling, J. L., Blaak, E. E., Fenech, M., Vauzour, D., McArdle, H. J., Kremer, B. H. A., Sterkman, L., Vafeiadou, K., Benedetti, M. M., Williams, C. M., Calder, P. C.

(2015)

Low-grade inflammation, diet composition and health: Current research evidence and its translation

in British Journal of Nutrition

114.

pp. 999-1012

Full Text UEA Repository

(Article)


Vimaleswaran, K. S., Minihane, A. M., Li, Y., Gill, R., Lovegrove, J. A., Williams, C. M., Jackson, K. G.

(2015)

The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults

in Nutrition & Metabolism

12.

pp. 7

Full Text UEA Repository

(Article)


Macready, A. L., George, T. W., Chong, M. F., Alimbetov, D. S., Jin, Y., Vidal, A., Spencer, J. P. E., Kennedy, O. B., Tuohy, K. M., Minihane, A., Gordon, M. H., Lovegrove, J. A., Anti-Inflammatory Agents, Non-Steroidal

(2014)

Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease-FLAVURS: a randomized controlled trial

in American Journal of Clinical Nutrition

99.

pp. 479-489

Full Text UEA Repository

(Article)


Welch, A., Macgregor, A., Minihane, A., Skinner, J., Valdes, A. A., Spector, T. D., Cassidy, A.

(2014)

Dietary Fat and Fatty Acid Profile Are Associated with Indices of Skeletal Muscle Mass in Women Aged 18-79 Years

in The Journal of Nutrition

144.

pp. 327-334

Full Text UEA Repository

(Article)


Bhattacharya, B. S., Sweby, P. K., Minihane, A., Jackson, K. G., Tindall, M. J.

(2014)

A mathematical model of the sterol regulatory element binding protein 2 cholesterol biosynthesis pathway

in Journal of Theoretical Biology

349.

pp. 150-62

Full Text UEA Repository

(Article)


Koutsos, A., Jackson, K. G., Lockyer, S., Carvalho-Wells, A., Minihane, A., Lovegrove, J. A.

(2014)

Greater impact of dietary fat manipulation than apolipoprotein E genotype on ex vivo cytokine production - insights from the SATgenε study

in Cytokine

66.

pp. 156-9

Full Text UEA Repository

(Article)


Gammon, C. S., Minihane, A., Kruger, R., Conlon, C. A., von Hurst, P. R., Jones, B., Stonehouse, W., Cholesterol, HDL, Polymorphism, Genetic

(2014)

TaqIB polymorphism in the cholesteryl ester transfer protein (CETP) gene influences lipid responses to the consumption of kiwifruit in hypercholesterolaemic men

in British Journal of Nutrition

111.

pp. 1077-84

Full Text UEA Repository

(Article)


Conway, V., Allard, M., Minihane, A., Jackson, K. G., Lovegrove, J. A., Plourde, M.

(2014)

Postprandial enrichment of triacylglycerol-rich lipoproteins with omega-3 fatty acids: lack of an interaction with apolipoprotein E genotype?

in Lipids in Health and Disease

13.

pp. 148

Full Text UEA Repository

(Article)


Minihane, A.

(2014)

Nutrigenetics and personalised/stratified approaches to the provision of dietary advice

in Archives of Public Health

72.

Full Text UEA Repository

(Article)


Rudkowska, I., Guenard, F., Julien, P., Couture, P., Lemieux, S., Barbier, O., Calder, P., Minihane, A., Vohl, M.

(2014)

Genome-wide association study of the plasma triglyceride response to an n-3 polyunsaturated fatty acid supplementation

in The Journal of Lipid Research

55.

pp. 1245-1253

Full Text UEA Repository

(Article)


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Key Research Interests

I am Head of the NUTRIGENETICS group within the Department of Nutrition and Preventive Medicine, with our key research interests being:

  • Nutrigenetics,
  • Dietary n-3 fatty acids and cardio-metabolic health with a focus on lipoprotein metabolism, vascular function and adipose tissue and liver inflammation
  • Diet and cognitive performance
  • Aetiology of the association between the APOE4 genotype and chronic disease risk
  • Determinants of flavonoid metabolism

Research approaches

A large proportion of our research involves human intervention trials (RCTs) conducted at the Clinical Trials Unit and in collaboration with colleagues at the Norwich and Norfolk University Hospital (NNUH). In addition, we employ a variety of wild-type and transgenic rodent models and cell and molecular techniques to investigate underlying physiological and molecular mechanisms and to inform the foci of our RCT.

Examples of ongoing RCTs include:

  • COB Study (BBSRC funded, 2012-2018): Investigation of the impact of age, gender, genotype and gut microflora on flavonoid absorption and metabolism (n=210)
  • CANN Study (Centre of Nutrition Memory and Learning, CNLM, University of Illinois funded, 2015-2017): A Randomised Controlled Trial in ‘At Risk’ Humans investigating the Cognitive Benefits of Combined Flavonoid/Fatty Acid and Underlying Mechanisms of Action: The Cognitive Aging Nutrition and Neurogenesis (CANN) trial (n=240)
  • Circles Study (USDA funded, 2014-2016): The effects of blueberry anthocyanins on insulin resistance and vascular, lung and cognitive function in a population with metabolic syndrome (n=120).

 

Collaborators

Name

Organisation

International

Prof Neal Cohen

Dr Sonia de Pascual-Teresa

Prof Gerald Rimbach

Prof José López-Miranda

A/ Prof Mary Jo LaDu

Prof Jose Ordovos

Dr Miriam Ryan & Dr Eileen Gibney

Dr Welma Stonehouse

 

University of Illinois, US

CSIC, Madrid, Spain

University of Kiel, Germany

University of Cordova, Spain

University of Illinois, Chicago

Tufts University Boston, US

University College Dublin, Ireland

CSIRO, Adelaide, Australia

National

Prof Philip Calder

Dr Wendy Hall

  Dr Georg Lietz/ Prof John Mathers

Prof Christine Willimas/ Prof Julie Lovegrove/ Dr Kim Jackson/ Prof Jeremy Spencer

 

University of Southampton

KCL

Newcastle University

University of Reading

External Activities and Indicators of Esteem

  • Deputy Editor of the British Journal of Nutrition (BJN) and Journal of Nutritional Sciences (JNS),

  • Academic expert on the ILSI Obesity and Diabetes Task Force,

  • Panel member and chair (2016) of the Academy of Finland, Health Panel,

  • Joint National Co-ordinator for COST- POSITIVe : Interindividual variation in response to consumption of plant food bioactives and determinants involved, an EU Framwork Programme supported by Horizon 2020,
  • Member of the British Nutrition Society, American Nutrition Society, Nutrigebomics Association (NuGo) and the International Society for the  Study of Lipids and Fatty Acids (ISSFAL),

  • Member of HEFCE, UoA6, REF assessment panel 2010-2014,

  • Recipient of the 2008 Nutrition Society Silver Medal Award ‘for scientific excellence in the field of nutrition’.