Biography

 

I am Professor of Nutrigenetics and Director of Research and Innovation in Norwich Medical School

 

My research investigates the independent and interactive impact of select dietary components (in particular n-3 fatty acids and flavonoids) and common gene variants on cardio-metabolic health. More recently we have also focussed on age-related cognitive decline and Alzheimer’s disease. APOE represents the maingenotype of interest, focussed on gaining an understanding of the aetiology of genotype-health/disease associations, and the impact of APOE genotype on response to dietary change.

 

Having completed my first degree in Nutrition and Biochemistry at University College Cork (Ireland), I moved to the UK to complete my PhD. I have been based here ever since apart from a one year stay at Auckland Medical School (NZ). I enjoy, the outdoors and sports of all varieties, good food and books, and people and places.

 

 

 

Professional Memberships

 

Member of the British Nutrition Society

 

Member of the American Society of Nutrition

 

Member of the International Society for the Study of Fatty Acids and Lipids (ISSFAL)

 

Academic Advisor to the ILSI Obesity and Diabetes Task Force

 

 

All Publications

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O'Neill, C. M., Minihane, A.

(2017)

The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults

Full Text UEA Repository

(Article)


Vauzour, D., Camprubi Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., Bowman, G. L., Caberlotto, L., Clarke, R., Hogervorst, E., Kiliaan, A. J., Lucca, U., Manach, C., Minihane, A., Mitchell, E. S., Perneczky, R., Perry, H., Roussel, A., Schuermans, J., Sijben, J., Spencer, J. P., Thuret, S., van de Rest, O., Vandewoude, M., Wesnes, K., Williams, R. J., Williams, R. S., Ramirez, M.

(2017)

Nutrition for the ageing brain: towards evidence for an optimal diet

Full Text

(Literature review)


Cassidy, A., Minihane, A.

(2017)

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

Full Text UEA Repository

(Article)


Slim, K. E., Vauzour, D., Tejera, N., Voshol, P. J., Cassidy, A., Minihane, A. M.

(2017)

The effect of dietary fish oil on weight gain and insulin sensitivity is dependent on APOE genotype in humanized targeted replacement mice

Full Text UEA Repository

(Article)


Rodriguez-Ramiro, I., Vauzour, D., Minihane, A.

(2016)

Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms: impact and mechanisms

Full Text

(Conference contribution)


Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M., Kay, C. D., Minihane, A., Cassidy, A.

(2016)

Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial

Full Text UEA Repository

(Article)


Tejera, N., Vauzour, D., Betancor, M. B., Sayanova, O., Usher, S., Cochard, M., Rigby, N., Ruiz-Lopez, N., Menoyo, D., Tocher, D. R., Napier, J. A., Minihane, A. M.

(2016)

A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice

Full Text UEA Repository

(Article)


Minihane, A. M., Armah, C. K., Miles, E. A., Madden, J. M., Clark, A. B., Caslake, M. J., Packard, C. J., Kofler, B. M., Lietz, G., Curtis, P. J., Mathers, J. C., Williams, C. M., Calder, P. C.

(2016)

Consumption of Fish Oil Providing Amounts of Eicosapentaenoic cid and Docosahexaenoic Acid That Can Be Obtained from the Diet Reduces Blood Pressure in Adults with Systolic Hypertension: A Retrospective Analysis

Full Text UEA Repository

(Article)


Minihane, A.

(2016)

Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes

Full Text UEA Repository

(Article)


Shatwan, I. M., Minihane, A., Williams, C. M., Lovegrove, J. A., Jackson, K. G., Vimaleswaran, K. S.

(2016)

Impact of Lipoprotein Lipase Gene Polymorphism, S447X, on Postprandial Triacylglycerol and Glucose Response to Sequential Meal Ingestion

Full Text UEA Repository

(Article)


McManus, S., Tejera, N., Awwad, K., Vauzour, D., Rigby, N., Fleming, I., Cassidy, A., Minihane, A.

(2016)

Differential effects of EPA vs. DHA on postprandial vascular function and the plasma oxylipin profile in men

Full Text UEA Repository

(Article)


Huebbe, P., Dose, J., Schloesser, A., Campbell, G., Gluer, C., Minihane, A., Baines, J. F., Nebel, A., Rimbach, G.

(2015)

Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization—Studies in gene-targeted replacement mice

Full Text UEA Repository

(Article)


Vauzour, D., Tejera, N., O'Neill, C., Booz, V., Jude, B., Wolf, I. M., Rigby, N., Silvan, J. M., Curtis, P. J., Cassidy, A., De Pascual-Teresa, S., Rimbach, G., Minihane, A.

(2015)

Anthocyanins do not influence long-chain n-3 fatty acid status: Studies in cells, rodents and humans

Full Text UEA Repository

(Article)


Chouinard-Watkins, R., Conway, V., Minihane, A., Jackson, K., Lovegrove, J., Plourde, M.

(2015)

Interaction between BMI and APOE genotype is associated with changes in the plasma long chain polyunsaturated fatty acid response to a fish oil supplement in healthy participants: Plasma FA response to DHA in APOE4 carriers

Full Text UEA Repository

(Article)


Minihane, A., Vinoy, S., Russell, W. R., Baka, A., Roche, H. M., Tuohy, K. M., Teeling, J. L., Blaak, E. E., Fenech, M., Vauzour, D., McArdle, H. J., Kremer, B. H. A., Sterkman, L., Vafeiadou, K., Benedetti, M. M., Williams, C. M., Calder, P. C.

(2015)

Low-grade inflammation, diet composition and health: Current research evidence and its translation

Full Text UEA Repository

(Article)


Vimaleswaran, K. S., Minihane, A. M., Li, Y., Gill, R., Lovegrove, J. A., Williams, C. M., Jackson, K. G.

(2015)

The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults

Full Text UEA Repository

(Article)


Macready, A. L., George, T. W., Chong, M. F., Alimbetov, D. S., Jin, Y., Vidal, A., Spencer, J. P. E., Kennedy, O. B., Tuohy, K. M., Minihane, A., Gordon, M. H., Lovegrove, J. A., Anti-Inflammatory Agents, Non-Steroidal

(2014)

Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease-FLAVURS: a randomized controlled trial

Full Text UEA Repository

(Article)


Welch, A., Macgregor, A., Minihane, A., Skinner, J., Valdes, A. A., Spector, T. D., Cassidy, A.

(2014)

Dietary Fat and Fatty Acid Profile Are Associated with Indices of Skeletal Muscle Mass in Women Aged 18-79 Years

Full Text UEA Repository

(Article)


Bhattacharya, B. S., Sweby, P. K., Minihane, A., Jackson, K. G., Tindall, M. J.

(2014)

A mathematical model of the sterol regulatory element binding protein 2 cholesterol biosynthesis pathway

Full Text UEA Repository

(Article)


Koutsos, A., Jackson, K. G., Lockyer, S., Carvalho-Wells, A., Minihane, A., Lovegrove, J. A.

(2014)

Greater impact of dietary fat manipulation than apolipoprotein E genotype on ex vivo cytokine production - insights from the SATgenε study

Full Text UEA Repository

(Article)


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Key Research Interests

I am Head of the NUTRIGENETICS group within the Department of Nutrition and Preventive Medicine, with our key research interests being:

  • Nutrigenetics,
  • Dietary n-3 fatty acids and cardio-metabolic health with a focus on lipoprotein metabolism, vascular function and adipose tissue and liver inflammation
  • Diet and cognitive performance
  • Aetiology of the association between the APOE4 genotype and chronic disease risk
  • Determinants of flavonoid metabolism

Research approaches

A large proportion of our research involves human intervention trials (RCTs). In addition, we employ a variety of wild-type and transgenic rodent models and cell and molecular techniques to investigate underlying physiological and molecular mechanisms and to inform the foci of our RCT.

Examples of ongoing RCTs include:

  • COB Study (BBSRC funded, 2012-2018): Investigation of the impact of age, gender, genotype and gut microflora on flavonoid absorption and metabolism (n=210)
  • CANN Study (Centre of Nutrition Memory and Learning, CNLM, University of Illinois funded, 2015-2017): A Randomised Controlled Trial in ‘At Risk’ Humans investigating the Cognitive Benefits of Combined Flavonoid/Fatty Acid and Underlying Mechanisms of Action: The Cognitive Aging Nutrition and Neurogenesis (CANN) trial (n=240)
  • Circles Study (USDA funded, 2014-2016): The effects of blueberry anthocyanins on insulin resistance and vascular, lung and cognitive function in a population with metabolic syndrome (n=120).

 

Collaborators

Name

Organisation

International

Prof Neal Cohen

Dr Sonia de Pascual-Teresa

Prof Gerald Rimbach

Prof José López-Miranda

A/ Prof Mary Jo LaDu

Prof Jose Ordovos

Dr Miriam Ryan & Dr Eileen Gibney

Dr Welma Stonehouse

 

University of Illinois, US

CSIC, Madrid, Spain

University of Kiel, Germany

University of Cordova, Spain

University of Illinois, Chicago

Tufts University Boston, US

University College Dublin, Ireland

CSIRO, Adelaide, Australia

National

Prof Philip Calder

Dr Wendy Hall

  Dr Georg Lietz/ Prof John Mathers

Prof Christine Willimas/ Prof Julie Lovegrove/ Dr Kim Jackson/ Prof Jeremy Spencer

 

University of Southampton

KCL

Newcastle University

University of Reading

External Activities and Indicators of Esteem

  • Deputy Editor of the British Journal of Nutrition (BJN) and Journal of Nutritional Sciences (JNS), and Editorial Advisory Board member for the Nutrition Bulletin,

  • Academic expert on the ILSI Obesity and Diabetes Task Force,

  • Panel member and chair (2016) of the Academy of Finland, Health Panel,

  • Joint National Co-ordinator and Gene Variant Group (GVG) lead for COST- POSITIVe: Interindividual variation in response to consumption of plant food bioactives and determinants involved, an EU Framwork Programme supported by Horizon 2020,
  • Member of the British Nutrition Society, American Nutrition Society, Nutrigebomics Association (NuGo) and the International Society for the  Study of Lipids and Fatty Acids (ISSFAL),

  • Member of HEFCE, UoA6, REF assessment panel 2010-2014,

  • Recipient of the 2008 Nutrition Society Silver Medal Award ‘for scientific excellence in the field of nutrition’.