Biography

I am Professor of Nutrigenetics and Director of Research and Innovation at Norwich Medical School

 

Our research investigates the impact of select dietary components (in particular n-3 fatty acids and flavonoids) and common gene variants on cardio-metabolic health. A more recent focus is age-related cognitive decline and Alzheimer’s disease. APOE represents the main genotype of interest, investigating the aetiology of genotype-health/disease associations, and the impact of APOE genotype on response to dietary change.

Having completed my first degree in Nutrition and Biochemistry at University College Cork (Ireland), I moved to the UK to complete my PhD. I have been based here ever since, apart from a one-year stay at Auckland Medical School (NZ). I enjoy the outdoors and sports of all varieties, good food and books, and people and places.

 

Professional Memberships

British Nutrition Society

American Society of Nutrition

International Society for the Study of Fatty Acids and Lipids (ISSFAL)

Nutrigenomics Organisation (NuGO)

 

 

 

All Publications

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Vauzour, D., Rodriguez Ramiro, I., Rushbrook, S., Ipharraguerre, I. R., Bevan, D., Davies, S., Tejera, N., Mena, P., de Pascual-Teresa, S., Del Rio, D., Gavrilovic, J., Minihane, A.

(2018)

N-3 fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLD,

in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

1864

(1)

pp. 69-78

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Vauzour, D., Camprubi Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., Bowman, G. L., Caberlotto, L., Clarke, R., Hogervorst, E., Kiliaan, A. J., Lucca, U., Manach, C., Minihane, A., Mitchell, E. S., Perneczky, R., Perry, H., Roussel, A., Schuermans, J., Sijben, J., Spencer, J. P., Thuret, S., van de Rest, O., Vandewoude, M., Wesnes, K., Williams, R. J., Williams, R. S., Ramirez, M.

(2017)

Nutrition for the ageing brain: towards evidence for an optimal diet,

in Ageing Research Reviews

35

pp. 222–240

Full Text

(Literature review)

(Published)


Jackson, K. G., Lockyer, S., Carvalho-Wells, A. L., Williams, C. M., Minihane, A. M., Lovegrove, J. A.

(2017)

Apolipoprotein E (epsilon) genotype has a greater impact on apoB-48 than apoB-100 responses to dietary fat manipulation—insights from the SATgenε study,

in Molecular Nutrition & Food Research

61

(4)

article no. 1600688

Full Text UEA Repository

(Article)

(Published)


Calabuig-Navarro, M. V., Jackson, K. G., Kemp, C. F., Leake, D. S., Walden, C., Lovegrove, J. A., Minihane, A.

(2017)

A randomized trial and novel SPR technique identifies altered lipoprotein-LDL receptor binding as a mechanism underlying elevated LDL-cholesterol in APOE4s,

in Scientific Reports

7

article no. 44119

Full Text UEA Repository

(Article)

(Published)


Slim, K. E., Vauzour, D., Tejera, N., Voshol, P. J., Cassidy, A., Minihane, A. M.

(2017)

The effect of dietary fish oil on weight gain and insulin sensitivity is dependent on APOE genotype in humanized targeted replacement mice,

in The FASEB Journal

31

(3)

pp. 989-997

Full Text UEA Repository

(Article)

(Published)


O'Neill, C. M., Minihane, A.

(2017)

The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults,

in Proceedings of the Nutrition Society

76

pp. 64-75

Full Text UEA Repository

(Article)

(Published)


Cassidy, A., Minihane, A.

(2017)

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids,

in The American Journal of Clinical Nutrition

105

(1)

pp. 10-22

Full Text UEA Repository

(Article)

(Published)


McManus, S., Tejera, N., Awwad, K., Vauzour, D., Rigby, N., Fleming, I., Cassidy, A., Minihane, A.

(2016)

Differential effects of EPA vs. DHA on postprandial vascular function and the plasma oxylipin profile in men,

in The Journal of Lipid Research

57

pp. 1720-1727

Full Text UEA Repository

(Article)

(Published)


Shatwan, I. M., Minihane, A., Williams, C. M., Lovegrove, J. A., Jackson, K. G., Vimaleswaran, K. S.

(2016)

Impact of lipoprotein lipase gene polymorphism, S447X, on postprandial triacylglycerol and glucose response to sequential meal ingestion,

in International Journal of Molecular Sciences

17

(3)

article no. 397

Full Text UEA Repository

(Article)

(Published)


Minihane, A.

(2016)

Impact of genotype on EPA and DHA status and responsiveness to increased intakes,

in Nutrients

8

(3)

article no. 123

Full Text UEA Repository

(Article)

(Published)


Minihane, A. M., Armah, C. K., Miles, E. A., Madden, J. M., Clark, A. B., Caslake, M. J., Packard, C. J., Kofler, B. M., Lietz, G., Curtis, P. J., Mathers, J. C., Williams, C. M., Calder, P. C.

(2016)

Consumption of fish oil providing amounts of eicosapentaenoic acid and docosahexaenoic acid that can be obtained from the diet reduces blood pressure in adults with systolic hypertension: A Retrospective Analysis,

in Journal of Nutrition

146

(3)

pp. 516-523

Full Text UEA Repository

(Article)

(Published)


Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M., Kay, C. D., Minihane, A., Cassidy, A.

(2016)

Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial,

in The American Journal of Clinical Nutrition

103

(3)

pp. 694-702

Full Text UEA Repository

(Article)

(Published)


Rodriguez-Ramiro, I., Vauzour, D., Minihane, A.

(2016)

Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms: impact and mechanisms,

in Proceedings of the Nutrition Society.

Cambridge

pp. 47-60

ISBN 0029-6651

Full Text

(Conference contribution)

(Published)


Tejera, N., Vauzour, D., Betancor, M. B., Sayanova, O., Usher, S., Cochard, M., Rigby, N., Ruiz-Lopez, N., Menoyo, D., Tocher, D. R., Napier, J. A., Minihane, A. M.

(2016)

A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice,

in Journal of Nutrition

146

(2)

pp. 227-235

Full Text UEA Repository

(Article)

(Published)


Minihane, A., Vinoy, S., Russell, W. R., Baka, A., Roche, H. M., Tuohy, K. M., Teeling, J. L., Blaak, E. E., Fenech, M., Vauzour, D., McArdle, H. J., Kremer, B. H. A., Sterkman, L., Vafeiadou, K., Benedetti, M. M., Williams, C. M., Calder, P. C.

(2015)

Low-grade inflammation, diet composition and health: Current research evidence and its translation,

in British Journal of Nutrition

114

(7)

pp. 999-1012

Full Text UEA Repository

(Article)

(Published)


Chouinard-Watkins, R., Conway, V., Minihane, A., Jackson, K., Lovegrove, J., Plourde, M.

(2015)

Interaction between BMI and APOE genotype is associated with changes in the plasma long chain polyunsaturated fatty acid response to a fish oil supplement in healthy participants: Plasma FA response to DHA in APOE4 carriers,

in American Journal of Clinical Nutrition

102

(2)

pp. 505-513

Full Text UEA Repository

(Article)

(Published)


Vauzour, D., Tejera, N., O'Neill, C., Booz, V., Jude, B., Wolf, I. M., Rigby, N., Silvan, J. M., Curtis, P. J., Cassidy, A., De Pascual-Teresa, S., Rimbach, G., Minihane, A.

(2015)

Anthocyanins do not influence long-chain n-3 fatty acid status: Studies in cells, rodents and humans,

in Journal of Nutritional Biochemistry

26

(3)

pp. 211-218

Full Text UEA Repository

(Article)

(Published)


Huebbe, P., Dose, J., Schloesser, A., Campbell, G., Gluer, C., Minihane, A., Baines, J. F., Nebel, A., Rimbach, G.

(2015)

Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization—Studies in gene-targeted replacement mice,

in Molecular Nutrition & Food Research

59

(2)

pp. 334-343

Full Text UEA Repository

(Article)

(Published)


Vimaleswaran, K. S., Minihane, A. M., Li, Y., Gill, R., Lovegrove, J. A., Williams, C. M., Jackson, K. G.

(2015)

The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults,

in Nutrition & Metabolism

12

pp. 7

Full Text UEA Repository

(Article)

(Published)


Childs, C. E., Kew, S., Finnegan, Y. E., Minihane, A. M., Leigh-Firbank, E. C., Williams, C. M., Calder, P. C.

(2014)

Increased dietary α-linolenic acid has sex-specific effects upon eicosapentaenoic acid status in humans: re-examination of data from a randomised, placebo-controlled, parallel study,

in Nutrition Journal

13

article no. 113

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

I am Head of the NUTRIGENETICS group within the Department of Nutrition and Preventive Medicine, with our key research interests being:

  • Nutrigenetics,
  • n-3 fatty acids and cardio-metabolic health, with a focus on plasma lipids, and vascular and hepatic function,
  • Cognition and Alzheimer’s disease,
  • Aetiology of APOE4 genotype-chronic disease associations,
  • Determinants of flavonoid metabolism.

 

Research approaches

A large proportion of our research involves human intervention trials (RCTs). In addition, we employ a variety of wild-type and transgenic rodent models and cell and molecular techniques to investigate underlying mechanisms, and to inform the foci of our RCTs.

 

Examples of ongoing RCTs include:

  • MedEx (Alzheimer’s Research UK funded, 2018-2020): Diet, physical activity and dementia risk in UK adults: Epidemiology and MedEx feasibility study, Norwich, Newcastle, Birmingham and Aberdeen.
  • COB (BBSRC funded, 2012-2018): Investigation of the impact of age, gender, genotype and gut microflora on flavonoid absorption and metabolism (n=210)
  • CANN (Centre of Nutrition Memory and Learning, CNLM, University of Illinois funded, 2015-2018): A Randomised Controlled Trial in ‘At Risk’ Humans investigating the Cognitive Benefits of Combined Flavonoid/Fatty Acid and Underlying Mechanisms of Action: The Cognitive Aging Nutrition and Neurogenesis (CANN) trial (n=240)
  • Circles (USDA funded, 2014-2017): The effects of blueberry anthocyanin’s on insulin resistance and vascular, lung and cognitive function in a population with metabolic syndrome (n=120).

 

Current Collaborators

Prof Neal Cohen/Dr Ryan Larsen: University of Illinois, US

Prof Andrew Scholey: Swinburne University, Melbourne, Australia

Prof Trevor Mori: University of Western Australia, Perth, Australia

Prof Gerald Rimbach: Christian-Albrechts-Universität zu Kiel, Germany

Prof Dr Matthias Schulze: DIFE, Potsdam, Germany

Dr Sonia de Pascual-Teresa: CSIC, Madrid, Spain

Prof Jose Lopez Miranda:  University of Cordoba, Spain

Prof Miguel Martinez Gonzalez, Dr Cristina Razquin Burillo, Universidad de Navarra, Spain

Prof Marienne Geleijnse, Wageningen University, The Netherlands

Prof Julie Lovegrove, Dr Kim Jackson: University of Reading, UK

Dr Mario Servo, Prof John Mathers, Dr Blossom Stephan, Dr Stella Paddick: Newcastle University, UK

Dr Sarah Aldred, University of Birmingham, UK

 

External Activities and Indicators of Esteem

  • Deputy Editor of the British Journal of Nutrition (BJN) and the Journal of Nutritional Sciences (JNS), and Editorial Advisory Board member for the Nutrition Bulletin,
  • Academic Expert and Scientific Advisory Committee member of ILSI Europe,
  • Panel member and chair of the Academy of Finland, Health Panel, 2014-2016,
  • Joint National Co-ordinator and Gene Variant Group (GVG) lead for COST- POSITIVe: Inter-individual variation in response to consumption of plant food bioactives and determinants involved, an EU Framework Programme supported by Horizon 2020,
  • Member of HEFCE, UoA6, REF assessment panel 2010-2014,
  • Recipient of the 2008 Nutrition Society Silver Medal Award ‘for scientific excellence in the field of nutrition’.