Career History

Professional Qualifications and Professional Memberships

  • BSc (Hons), University of Ulster (1987) 
  • MSc, University of Aberdeen (1988)
  • PhD, University of Cambridge (1991)
  • Royal Society Wolfson Research Merit Award Holder (2013-18)
  • Member, UK Nutrition Society 
  • Member, American Heart Association 
  • Member, American Nutrition Society
  • Fellow, Society of Biology
  • Fellow, Royal Society of Chemistry

Research Interests

  • Phytochemicals and human health 
  • Flavonoids and cardiometabolic health
  • Biomarkers of ageing and cardiovascular disease risk 
  • Diet-gene interactions   

Career Summary

Aedin Cassidy was appointed to a personal Chair in Nutrition in 2004. Her research focuses on understanding the impact of plant bioactives on cardiometabolic health. She completed her PhD and post-doctoral work at Cambridge University. Prior to joining UEA, she was Head of Molecular Nutrition in the Biosciences Division of Unilever Research, UK. She has been awarded the Nutrition Society Medal (1999), ‘Outstanding Contribution to Research’ in Tokyo, Japan for contribution to isoflavone research (2008), Finalist, Times Higher Education Awards for ‘International Collaboration of the Year’ 2013, awarded ‘Outstanding Contribution to Clinical research on Flavonoids’ at the International Conference on Polyphenols, Buenos Aires, Argentina (2013). She was awarded the Royal Society Wolfson Research Merit Award in 2013 and is listed on Thomson Reuters 2014 Highly Cited Researchers. She has served on various committees and expert panels including RAE2008 and REF2014. She is a visiting Professor at the Harvard T. H. Chan School of Public Health. She is a Fellow of the Society for Biology and the Royal Society of Chemistry.

 

All Publications

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Cassidy, A., Minihane, A.

(2017)

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

Full Text UEA Repository

(Article)


Slim, K. E., Vauzour, D., Tejera, N., Voshol, P. J., Cassidy, A., Minihane, A. M.

(2017)

The effect of dietary fish oil on weight gain and insulin sensitivity is dependent on APOE genotype in humanized targeted replacement mice

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(Article)


Jennings, A., MacGregor, A., Spector, T., Cassidy, A.

(2016)

Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: evidence from discordant monozygotic twins

Full Text UEA Repository

(Article)


Nimptsch, K., Zhang, X., Cassidy, A., Song, M., O'Reilly, E. J., Lin, J. H., Pischon, T., Rimm, E. B., Willett, W. C., Fuchs, C. S., Ogino, S., Chan, A. T., Giovannucci, E. L., Wu, K.

(2016)

Habitual intake of flavonoid subclasses and risk of colorectal cancer in two large prospective cohorts

Full Text UEA Repository

(Article)


Cassidy, A., Franz, M., Rimm, E. B.

(2016)

Dietary flavonoid intake and incidence of erectile dysfunction

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(Article)


Mehta, A. J., Cassidy, A., Litonjua, A. A., Sparrow, D., Vokonas, P., Schwartz, J.

(2016)

Dietary anthocyanin intake and age-related decline in lung function: longitudinal findings from the VA Normative Aging Study

Full Text UEA Repository

(Article)


Bertoia, M. L., Rimm, E. B., Mukamal, K. J., Hu, F. B., Willett, W. C., Cassidy, A.

(2016)

Dietary flavonoid intake and weight maintenance: three prospective cohorts of 124,086 US men and women followed for up to 24 years

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(Article)


Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M., Kay, C. D., Minihane, A., Cassidy, A.

(2016)

Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial

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(Article)


van Sluijs, E. M. F., Sharp, S. J., Ambrosini, G. L., Cassidy, A., Griffin, S. J., Ekelund, U.

(2016)

The independent prospective associations of activity intensity and dietary energy density with adiposity in young adolescents

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(Article)


Davidson, R., Jupp, O., Bao, Y., Macgregor, A., Donell, S., Cassidy, A., Clark, I.

(2016)

Can sulforaphane prevent the onset or slow the progression of osteoarthritis?

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(Article)


McManus, S., Tejera, N., Awwad, K., Vauzour, D., Rigby, N., Fleming, I., Cassidy, A., Minihane, A.

(2016)

Differential effects of EPA vs. DHA on postprandial vascular function and the plasma oxylipin profile in men

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(Article)


Chang, S., Cassidy, A., Willett, W. C., Rimm, E. B., O'Reilly, E. J., Okereke, O. I.

(2016)

Dietary flavonoid intake and risk of incident depression in midlife and older women

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(Article)


Kelaiditi, E., Jennings, A., Steves, C. J., Skinner, J., Cassidy, A., MacGregor, A. J., Welch, A. A.

(2016)

Measurements of skeletal muscle mass and power are positively related to a Mediterranean dietary pattern in women

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(Article)


Pallister, T., Jennings, A., Mohney, R. P., Yarand, D., Mangino, M., Cassidy, A., MacGregor, A., Spector, T. D., Menni, C.

(2016)

Characterizing blood metabolomics profiles associated with self-reported food intakes in female twins

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(Article)


Cassidy, A., Bertoia, M., Chiuve, S., Flint, A., Forman, J., Rimm, E. B.

(2016)

Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men

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(Article)


Pallister, T., Haller, T., Thorand, B., Altmaier, E., Cassidy, A., Martin, T., Jennings, A., Mohney, R. P., Gieger, C., MacGregor, A., Kastenmüller, G., Metspalu, A., Spector, T. D., Menni, C.

(2016)

Metabolites of milk intake: a metabolomic approach in UK twins with findings replicated in two European cohorts

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(Article)


Jennings, A., MacGregor, A., Pallister, T., Spector, T., Cassidy, A.

(2016)

Associations between branched chain amino acid intake and biomarkers of adiposity and cardiometabolic health independent of genetic factors: a twin study

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(Article)


Edwards, M., Czank, C., Woodward, G., Cassidy, A., Kay, C.

(2015)

Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function

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(Article)


Vauzour, D., Tejera, N., O'Neill, C., Booz, V., Jude, B., Wolf, I. M., Rigby, N., Silvan, J. M., Curtis, P. J., Cassidy, A., De Pascual-Teresa, S., Rimbach, G., Minihane, A.

(2015)

Anthocyanins do not influence long-chain n-3 fatty acid status: Studies in cells, rodents and humans

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(Article)


Amin, H. P., Czank, C., Raheem, S., Zhang, Q., Botting, N. P., Cassidy, A., Kay, C.

(2015)

Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelialcells

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(Article)


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Key Research Interests

My research programme is focused on bioactive compounds present in plants, with interest in their metabolism, bioavailability and health effects, using a combination of cell/in vitro models and human studies, and working in collaboration with colleagues both nationally and internationally. On-going projects include research on:

  • Cardiometabolic effects of flavonoids and other bioactives [trials and prospective studies with the Harvard T.H. Chan School of Public Health (Rimm)]
  • Factors affecting the in vivo bioavailability of flavonoids 
  • Molecular mechanisms of flavonoids 
  • Effects of genotype on flavonoid metabolism

Selected recent publications

Cassidy A, Mukamal KJ, Liu L, Franz M, Eliassen AH, Rimm EB (2013).  High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women.  Circulation, 15;127(2):188-96.

Curtis PJ, Potter J, Kroon PA, Wilson P, Dhatariya K Sampson M, Cassidy A (2013).  Vascular function and atherosclerosis progression following 1 year flavonoid intake in statin treated postmenopausal women with type 2 diabetes: a double-blind randomized controlled trial.  Am J Clin Nutr, May;97(5):936-42.

Cassidy A, Rimm EB, O'Reilly E, Logroscino C, Kay C, Chiuve SE, Rexrode KM (2012) Dietary Flavonoids and Risk of Stroke in Women. Stroke, 43, 946-51.

Curtis P, Potter JF, Sampson M and Cassidy A (2012) Chronic ingestion of flavan-3-ols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated 10-year CVD risk in medicated postmenopausal women with type 2 diabetes: a one year double-blind randomized controlled trial. Diabetes Care, 35, 226-32.

Gao X, Cassidy A, Schwarzchild M, Rimm EB, Ascherio A (2012) Habitual intake of dietary flavonoids and risk of Parkinson's disease. Neurology,78, 1138-45.

External Activities and Indicators of Esteem

  • Royal Society Wolfson Research Merit Award Holder (2013-18)
  • Flavonoid Research Award (2013) for 'Scientific Contribution to Clinical Research in Polyphenols', International Conference in Polyphenols, Buenos Aires, Argentina 
  • ‘Outstanding Contribution to Research’ Award (2008), Tokyo, Japan - for contribution to isoflavone research field
  • REF 2014 - member of sub-panel 3 (2011-2014)