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Academic

Dr Dietmar Steverding

Senior Lecturer in Biochemistry and Genetics

Job Title Contact Location
Senior Lecturer 
in Biochemistry and Genetics		 D dot Steverding at uea dot ac dot uk
Tel: +44 (0)1603 59 1291   		 
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Career

Professional Qualifications and professional memberships

  • Master’s degree in Biology, Chemistry and Education; University of Marburg 1987
  • PhD in Biochemistry; University of Marburg 1990
  • Habilitation in Biochemistry; University of Heidelberg 2000
  • Member of the German Society for Parasitology (since January 1996)
  • Member of the German Society for Biochemistry and Molecular Biology (since June 1999)
  • Member of the British Society for Parasitology (since April 2005)

Research interests

  • Kinetoplastid parasites
  • Drug development against neglected tropical diseases
  • PCR diagnosis of sleeping sickness

 

Career summary

After my PhD, I took up a postdoctoral position at the prestigious Max-Planck-Institute for Biology Tübingen.  In 1995 I was appointed as Research Group Leader in Infection Biology in the Department of Parasitolgy at the University of Heidelberg.  During that time I completed my Habilitation in Biochemistry in the Faculty of Medicine and was awarded the venia legendi in Biochemistry and the title “Privatdozent”, which is equivalent to assistant/associate professor.  In 2001 I took up a Lectureship in Parasitology in the School of Biological Sciences at the University of Bristol.  Since 2004 I am Senior Lecturer in Biochemistry and Genetics in the School of Medicine, Health Policy and Practice at the University of East Anglia.

Key Research Interests

My main research interest is the causative agent of human African trypanosomiasis or sleeping sickness, Trypanosoma brucei.  Especially, I am interested in the iron metabolism of bloodstream forms of T. brucei, in the anti-trypanosomal activities of cysteine proteinase, proteasome and topoisomerase inhibitors, and in the diagnosis of the sleeping sickness by PCR tests.

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Selected publication

  • Caffrey, C.R. & Steverding, D. (2008) Recent initiatives and strategies to developing new drugs for tropical parasitic diseases. Expert Opin. Drug Discov., 3, 173-186
  • Caffrey, C.R., Steverding, D., Swenerton, R.K., Kelly, B., Walshe, D., Debnath, A., Zhou, Y.-M., Doyle, P.S., Fafarman, A.T., Zorn, J.A., Land, K.M., Beauchene, J., Schreiber, K., Moll, H., Ponte-Sucre, A., Schirmeister, T., Saravanamuthu, A., Fairlamb, A.H., Cohen, F.E., McKerrow, J.H., Weisman, J.L. & May, B.C.H. (2007) Bis-acridines as lead anti-parasitic agents: structure activity analysis of a discrete compound library in vitro. Antimicrob. Agents Chemother. 51, 2164-2172
  • Steverding, D. (2006) On the significance of host antibody response to the Trypanosoma brucei transferrin receptor during chronic infection. Microbes Infect. 8, 2777-2782
  • Ginger, M.L., Ngazoa, E., Pereira, C.A., Pullen, T.J., Kabiri, M., Becker, K., Gull, K., & Steverding, D. (2005) Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei. J. Biol. Chem. 280, 11781-11789
  • Deterding, A., Dungey, F.A., Thompson, K.-A. & Steverding, D. (2005) Anti-trypanosomal activities of DNA topoisomerase inhibitors. Acta Trop. 93, 311-316
  • Becker, S., Franco, J.R., Simarro, P.P., Stich, A., Abel, P.M. & Steverding, D. (2004) Real-time PCR for detection of Trypanosoma brucei in human blood samples. Diagn. Microbiol. Infect. Dis. 50, 193-199
  • Genn, R.J., Pemberton, A.J., Royle, H.J., Spackman, R.W., Smith, E., Rivett, A.J. & Steverding, D. (2004) Trypanocidal effect of α’,β’-epoxyketones indicates that trypanosomes are particularly sensitive to inhibitors of proteasome trypsin-like activity. Int. J. Antimicrob. Agents 24, 286-289
  • Nkemgu-Njinkeng, J., Rosenkranz, V., Wink, M. & Steverding, D. (2002) Antitrypanosomal activities of proteasome inhibitors. Antimicrob. Agents Chemother. 46, 2038-2040
  • Kabiri, M., & Steverding, D. (2001) Identification of a developmentally regulated iron superoxide dismutase in Trypanosoma brucei. Biochem. J. 360, 173-177
  • Hofer, A., Steverding, D., Chabes, A., Brun, R. & Thelander, L. (2001) Trypanosoma brucei CTP synthetase: a new target for the treatment of African sleeping sickness Proc. Natl. Acad. Sci. USA 98, 6412-6416

Teaching Interests

My current teaching is focussed on the MB/BS medical degree course.

  • PBL tutor for Foundation Year and Year 1
  • Lectures and Seminars for Foundation Year and Year 1
  • Year 4 SSS in Biochemistry
  • Research Seminars for MRes in Health Research
  • Lectures for the BIO course Host-Parasite-Interactions

Jump to: Article | Book Section | Monograph | Conference or Workshop Item
Number of items: 71.

Article

Wilke, A and Steverding, DJ (2019) Ochronosis as an unusual cause of a valvular defect: a case report. J Med Case Reports, 3 (1). p. 9302.

Steverding, DJ, Wang, X and Sexton, DW (2019) The trypanocidal effect of NO-releasing agents is not due to inhibition of the major cysteine proteinase in Trypanosoma brucei. Parasitology Research, 105 (5). pp. 1333-1338.

Steverding, D, Wang, X, Potts, B and Palladino, MA (2011) Trypanocidal Activity of β-Lactone-γ-Lactam Proteasome Inhibitors. Planta Medica (Epub ahead of print). ISSN 1439-0221

Steverding, D, Evans, P, Msika, L, Riley, B, Wallington, J and Schelenz, S (2011) In vitro antifungal activity of DNA topoisomerase inhibitors. Medical mycology : official publication of the International Society for Human and Animal Mycology (Epub ahead of print). pp. 1-4. ISSN 1460-2709

Steverding, D, Baldisserotto, A, Wang, X and Marastoni, M (2011) Trypanocidal activity of peptidyl vinyl ester derivatives selective for inhibition of mammalian proteasome trypsin-like activity. Experimental Parasitology, 128 (4). pp. 444-447. ISSN 00144894

Diepholz, D, Wilke, A, Maisch, B and Steverding, D (2011) Demonstration of TGF-beta and XIII-alpha in Endocardial Biopsies of Carcinoid Heart Disease Patients: an Immunofluorescence Study. Cardiology Research, 2 (3). pp. 119-122. ISSN 19232829

Steverding, D (2011) The Cathepsin B-Selective Inhibitors CA-074 and CA-074Me Inactivate Cathepsin L Under Reducing Conditions. The Open Enzyme Inhibition Journal, 4 (1). pp. 11-16. ISSN 18749402

Steverding, Dietmar, Sexton, Darren, Wang, Xia, Gehrke, Sebastian, Wagner, Gerd K and Caffrey, Conor R (2011) Trypanosoma brucei: chemical evidence that cathepsin L rather thab cathepsin B is essential for survival and the relevant drug target. The Journal of Biological Chemistry. (Submitted)

Wilke, A and Steverding, D (2011) Does the Cardiologist Have a Key Role in Long-Term Management of Hypertension? Cardiology Research, 2 (2). pp. 79-81. ISSN 19232829

Steverding, DJ (2010) Fermentation Biotechnology Microbial production of 1,3-propanediol. Fermentation Biotechnology Microbial production of 1,3-propanediol, 44 (6). pp. 384-389. ISSN 0009-2851

Kwok, SC, Schelenz, S, Wang, X and Steverding, DJ (2010) In vitro effect of DNA topoisomerase inhibitors on Candida albicans. Med Mycol, 48 (1). pp. 155-160.

Meader, Emma, Mayer, Melinda J, Gasson, Michael J, Steverding, Dietmar, Carding, Simon R and Narbad, Arjan (2010) Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system. Anaerobe, 16 (6). pp. 549-54. ISSN 1095-8274

Steverding, DJ (2010) Die Geschichte der Kolibakterien. Biologie in unserer Zeit (40). pp. 194-201. ISSN 0045-205X

Steverding, DJ (2010) Horziontaler Gentransfer. Naturwiss Rundsch. pp. 221-222.

Steverding, DJ (2010) The development of drugs for treatment of lseeping sickness: a historical review. Parasites and Vectors, 3 (1). p. 15.

Wilke, A, Dapunt, O and Steverding, DJ (2010) Bluish pigmentation of the slera and the aortic valve in a patient with alkaptonuric ochronosis. Herz, 35. p. 41.

Caffrey, CR and Steverding, DJ (2009) Kinoplastid papain-like cystein peptidases. Mol Biochem Parasitol, 167 (1). pp. 12-19.

Steverding, DJ and Wang, X (2009) Typanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib. Parasites and Vectors, 2 (1). p. 29.

Steverding, DJ and Wang, X (2009) Evaluation of anti-sleeping sickness drugs and topoisomerase inhibitors in combination on Trypanosoma brucei. Journal of Antimicrobial Chemotherapy, 63 (6). pp. 1293-1295.

Subramanya, P, Hardin, FC, Steverding, DJ and Mensa-Wilmot, K (2009) Glycosylphosphatidylinositol-phospholipase C regulates transferrin endocytosis in the Africaqn trypanosome. Biochem Journal, 417. pp. 685-694.

Bouzid, M, Steverding, DJ and Tyler, KM (2008) Detection and surveillance of waterborne protozoan parasites. Current Opinion in Biotechnology, 19 (3). pp. 302-306.

Caffrey, CR and Steverding, DJ (2008) Recent initiatives and strategies to developing new drugs for tropical parasitic diseases. Expert Opin Drug Discov, 3 (2). pp. 173-186.

Maier, A and Steverding, DJ (2008) Expression and purification of non-glycosylated Trypanosoma brucei transferrin receptor in insect cells. Exp Parasitol, 120 (2). pp. 205-207.

Merschjohann, K and Steverding, DJ (2008) In vitro trypanocidal activity of the anti-helminthic drug nichlosamide. Exp Parasitol, 118 (4). pp. 637-640.

Steverding, DJ (2008) The history of African trypanosomiasis. Parasites and Vectors, 1 (1). p. 3.

Wang, X, Jobe, M, Tyler, KM and Steverding, DJ (2008) Efficacy of common laboratory disinfectants and heat on killing trypanosomatid parasites. Parasites and Vectors, 1 (1). p. 35.

Caffrey, CR, Steverding, DJ, Swenerton, RK, Kelly, B, Walshe, D, Debnath, A, Zhou, Y-M, Doyle, PS, Fafarman, AT, Zorn, JA, Land, KM, Bauchene, J, Schreiber, K, Moll, H, Pontre-Sucre, A, Schirmeister, T, Saravanamuthu, A and Fairlamb, AH (2007) Bisacridines as lead anti-parasitic agents: structure activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother. Antimicrob Agents Chemother, 51. pp. 2164-2172.

Caffrey, CR, Steverding, DJ, Swenerton, RK, Kelly, B, Walshe, D, Debnath, A, Zhou, Y-M, Doyle, PS, Fafarman, AT, Zorn, JA, Land, KM, Beauchene, J, Schreiber, K, Moll, H, Ponte-Sucre, A, Schirmeister, T, Saravanamuthu, A, Fairlamb, AH, Cohen, FE, McKerrow, JH, Weisman, JL and May, BCH (2007) Bis-acridines as lead anti-parasitic agents: structure activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother, 51 (6). pp. 2164-2172.

Scory, S, Stierhof, Y-D, Caffrey, CR and Steverding, DJ (2007) The cysteine proteinase inhibitor Z-Phe-Ala-CHN2 alters cell morphology and cell division activity of Trypanosoma brucei bloodstream forms in vivo. Kinetoplastid Biology and Disease, 6 (2).

Steverding, DJ (2007) Antigenic variation in pathogenic micro-organisms: similarities and differences. African Journal Microbiol Research, 1 (7). pp. 104-112.

Steverding, DJ (2007) Deforestation and parasitic insect-borne diseases. Biological Sciences Review, 20 (1). pp. 21-25.

Steverding, DJ (2007) The proteasome as a potential target for chemotherapy of African trypanosomiasis. Drug Development Research, 68 (5). pp. 205-212.

Merschjohann, K and Steverding, DJ (2006) In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolense by iron chelators. Kinetoplastid Biology and Disease, 5 (3).

Steverding, DJ (2006) A new initiative for the development of new diagnostic tests for human African trypanosomiasis. Kinetoplastid Biology and Disease, 5 (1).

Steverding, DJ (2006) On the significance of host antibody response to the Trypanosoma brucei transferrin receptor during chronic infection. Microbes and Infection, 8 (12-13). pp. 2777-2782.

Steverding, DJ (2006) Cysteine proteinase inhibitors as therapy for parasitic diseases: advances in inhibitor design. Mini Rev Med Chem, 6 (9). pp. 1025-1032.

Steverding, DJ (2006) Ubiquitination of plasma membrane ectophosphatase in bloodstream forms of Trypanosoma brucei. Parasitology Research, 98 (2). pp. 157-161.

Steverding, DJ, Pemberton, AJ, Royle, H, Spackman, RW and Rivett, AJ (2006) Evaluation of the anti-trypanosomal activity of tyropeptin A. Planta Medica, 72 (8). pp. 761-763.

Deterding, A, Dungey, FA, Thompson, KA and Steverding, DJ (2005) Anti-trypanosomal activities of DNA topoisomerase inhibitors. Acta Tropica, 93 (3). pp. 311-316.

Ginger, ML, Ngazoa, ES, Pereira, CA, Pullen, TJ, Kabiri, M, Becker, K, Gull, K and Steverding, DJ (2005) Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei. Journal of Biological Chemistry, 280 (12). pp. 11781-11789.

Steverding, D and Tyler, KM (2005) Novel antitrypanosomal agents. Expert Opin Investig Drugs, 14 (8). pp. 939-955.

Steverding, DJ, Morgan, E, Tkaczynski, P, Walder, F and Tinsley, R (2005) Effect of Australian tea tree oil on Gyrodactylus spp. infection of the three-spined stickleback Gasterosteus aculeatus. Dis Aquat Organ, 66 (1). pp. 29-32.

Becker, S, Franco, JR, Simarro, PP, Stich, A, Abel, PM and Steverding, DJ (2004) Real-time PCR for detection of Trypanosoma brucei in human blood samples. Diagnostic Microbiology and Infectious Diseases, 50 (3). pp. 193-199.

Glenn, RJ, Harvey, IM, Pemberton, AJ, Royle, HJ, Spackman, RW, Smith, E, Jennifer Rivett, A and Steverding, DJ (2004) Trypanocidal effect of alpha',beta'-epoxyketones indicates that trypanosomes are particularly sensitive to inhibitors of proteasome trypsin-like activity. International Journal of Antimicrobial Agents, 24 (3). pp. 286-289.

Steverding, DJ and Scory, S (2004) Trypanosoma brucei: unexpected azide sensitivity of bloodstream forms. Journal of Parasitology, 90 (5). pp. 1188-1190.

Steverding, DJ and Troscianko, T (2004) On the role of blue shadows in the visual behaviour of tsetse flies. Proceedings of the Biol Sci, 271 (Suppl 3).

Biebinger, S, Helfert, S, Steverding, DJ, Ansorge, I and Clayton, C (2003) Impaired dimerization and trafficking of ESAG6 lacking a glycosyl-phosphatidylinositol anchor. Mol Biochem Parasitol, 132 (2). pp. 93-96.

Nkemgu, NJ, Grande, R, Hansell, E, McKerrow, JH, Caffrey, CR and Steverding, DJ (2003) Improved trypanocidal activities of cathepsin L inhibitors. International Journal of Antimicrobial Agents, 22 (2). pp. 155-159.

Steverding, DJ (2003) The significance of transferrin receptor variation in Trypanosoma brucei. Trends Parasitol, 19 (3). pp. 125-127.

Breidbach, T, Ngazoa, E and Steverding, DJ (2002) Trypanosoma brucei: in vitro slender-to-stumpy differentiation of culture-adapted, monomorphic bloodstream forms. Exp Parasitol, 101 (4). pp. 223-230.

Breidbach, T, Scory, S, Krauth-Siegel, RL and Steverding, DJ (2002) Growth inhibition of bloodstream forms of Trypanosoma brucei by the iron chelator deferoxamine. International Journal of Parasitology, 32 (4). pp. 473-479.

Caffrey, CR, Schanz, M, Nkemngu, NJ, Brush, M, Hansell, E, Cohen, FE, Flaherty, TM, McKerrow, JH and Steverding, DJ (2002) Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. International Journal of Antimicrobial Agents, 19 (3). pp. 227-231.

Nkemngu - Njinkeng, J, Rosenkranz, V, Wink, M and Steverding, DJ (2002) Antitrypanosomal activities of proteasome inhibitors. Antimicrob Agents Chemother, 46 (6). pp. 2038-2040.

Stich, A and Steverding, DJ (2002) Die Rückkehr einer Seuche: Trypanosomen. Biologie in unserer Zeit, 32 (5). pp. 294-302.

Stich, A and Steverding, DJ (2002) Wiederauferstanden: Die Schlafkrankheit. Chem unserer Zeit, 36 (5). pp. 332-333.

Caffrey, CR, Hansell, E, Lucas, KD, Brinen, LS, Alvarez Hernandez, A, Cheng, J, Gwaltney 2nd, SL, Roush, WR, Stierhof, YD, Bogyo, M, Steverding, DJ and McKerrow, JH (2001) Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Mol Biochem Parasitol, 118 (1). pp. 61-73.

Fischer, A, Simarro, PP, Franco, JR, Becher, H and Steverding, DJ (2001) Increased trypanolytic activity in sera of sleeping sickness patients after chemotherapy. Trop Med Int Health, 6 (12). pp. 1070-1074.

Hofer, A, Steverding, DJ, Chabes, A, Brun, R and Thelander, L (2001) Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness. Proceedings of the Natl Acad Sci U S A, 98 (11). pp. 6412-6416.

Kabiri, M and Steverding, DJ (2001) Identification of a developmentally regulated iron superoxide dismutase of Trypanosoma brucei. Biochem Journal, 360 (1). pp. 173-177.

Kabiri, M and Steverding, DJ (2001) Trypanosoma evansi: demonstration of a transferrin receptor derived from expression site-associated genes 6 and 7. Journal of Parasitology, 87 (5). pp. 1189-1191.

Merschjohann, K, Sporer, F, Steverding, DJ and Wink, M (2001) In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense. Planta Medica, 67 (7). pp. 623-627.

Steverding, DJ (2001) Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase. Redox Report, 6 (4). pp. 209-210.

Book Section

Steverding, D, Tyler, KM and Grisard, EC (2012) Delivering on promise? The Impact of Kinetoplastid Genomics on Sleeping Sickness, Chagas Disease and Leishmaniasis. In: Genomics Applications and the Developing World. UNSPECIFIED. (In Press)

Steverding, DJ (2008) Parasites' receptors for human transferrin and lactoferrin. In: Iron Metabolism and Disease Pt 2 Cellular Iron Metabolism. Research Signpost, Kerala, pp. 421-434.

Monograph

Steverding, D (2011) Neue Malariamucke entdeckt. Other. Rundsch, Naturwiss 64, 149-150.

Steverding, D (2011) Dinosaurier als erste Wirte fur Lause. Other. Rundsch, Naturwiss 64, 305-306.

Steverding, D (2011) Theodor Escherich (1857-1911). Review. Rundsch, Naturwiss 64,14-19.

Steverding, D (2011) Die Auswirkung der weltweiten Abholzung auf die Verbreitung Vektor-ubertragener Krankheiten. Review. Rundsch, Naturwiss 64, 341-346.

Steverding, D (2010) Malariaparasit Plasmodium falciparum stammt vom Gorilla. Other. Rundsch, Naturwiss 63, 592-593.

Conference or Workshop Item

Steverding, DJ, Deterding, A, Dungey, FA and Thompson, K (2004) DNA topoisomerase inhibitors as anti-trypanosomal drugs. In: 21st Annual Meeting of the German Society foir Parasitology (DGP), Wurzberg Germany, Int J Med Micro.

Ngazoa, ES, Kabiri, M, Becker, K and Steverding, DJ (2002) Trypanosoma brucei tranferrin receptor mRNA contains iron elements in the 5'-UTR. In: 21st Annual Meeting of the German Society for Parasitology (DGP), Würzberg, Germany, Int J Med Micro.

This list was generated on Sat May 26 10:37:47 2012 BST.

External Activities and Indicators of Esteem

  • Grant reviewer for The Wellcome Trust, The German Research Council, The Medical Research Council, The Swiss National Science Foundation, World Health Organization/TDR and The International Foundation for Science
  • Regular reviewer for scientific journals
  • Invited memberships to the editorial boards of the journals "The Open Parasitology Journal" (since 2007) and "Parasites & Vectors" (since 2008)
  • Scientific Advisor for the "Foundation for Innovative New Diagnostics (FIND) and the World Health Organization (WHO) for a project to develop new diagnostic tools to support the control of human African trypanosomiasis (2006).

Administrative Posts/Responsibilities

  • Academic Lead of Module 13 (Emergency Care)
  • Academic Lead of the MRes Module 5 (Research Seminars)
  • Domain Leader for the Year 4 SSS in Biochemistry
  • Member of CDD
  • Member of the MRes course committee
  • Member of the Foundation Year committee
  • Personal advisor for MB/BS and Foundation Year students
  • Member of the Timetabling Group
  • Interviewing applicants for the Foundation Year Course
  • Member of the Year 5 MB/BS Exam Board
  • Member of the MRes Exam Board
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