Prof Anne-Marie Minihane
| Job Title | Contact | Location |
|---|---|---|
| Professor of Nutrigenomics |
A dot Minihane at uea dot ac dot uk
Tel: +44 (0)1603 59 2389 |
Medical School 1.07A |
Biography
After my PhD, I joined Ashbourne Biosciences in Reading for a short period before moving to a Postdoctoral Fellow position in 1997 in the Hugh Sinclair Human Nutrition Group at the University of Reading. I moved up through the ranks at Reading, being appointed to an academic post in 2001 and to Reader in Integrative Nutrition position in 2005. In 2008-2009 I was co-founder and appointed as Deputy Director of The Institute of Cardiovascular and Metabolic Health in Reading. Following a nine month stay as Associate Professor of Physiology at the University of Auckland, NZ, I was appointed to my current position as Professor of Nutrigenetics at UEA, which is predominately a research focussed role at the University, but also involves a contribution to the Nutrition training of our medical students, a role which I thoroughly enjoy.
Academic Background
Professional Qualifications and professional memberships
BSc in Nutrition and Biochemistry (1992-1996), University College Cork (UCC), Ireland
PhD in Nutrition, Institute of Food Research (IFR) Norwich and UCC (1997-2001)
Member of the British Nutrition Society
Member of the International Society for the Study of Fatty Acids and Lipids (ISSFAL)
Member of the Obesity Society
Member of Australia and Neuroscience Society
Visiting Professor Status at the University of Reading
Key Research Interests
- Nutrigenetics
- Dietary fat composition and the cardiovascular disease (CVD) phenotype, in particular lipoprotein metabolism, vascular function and inflammation
- Long chain n-3 PUFA and CVD and cognitive health
- Diet and cognitive performance
- Aetiology of the association between the APOE4 genotype and chronic disease risk
- Green tea catechins
I am head of the Nutrigenetics group within the Dept of Nutrition with ongoing activities including
- Investigation of genetic determinants the responsiveness to long chain n-3 PUFA intervention in adults, including the FINGEN RCT (in collaboration with Williams and Madden (Reading), Calder and Miles (Southampton), and Lietz and Mathers (Newcastle))
- Dose-response investigation of the impact of flavonoid-rich and flavonoid-poor fruits and vegetables on cardiovascular and cognitive health- the FLAVURS RCT (in collaboration with Lovegrove, Spencer, Kennedy and Gordon (Reading))
- Investigation of the impact of APOE genotype on the responsiveness to dietary fat manipulation- the Satgene RCT (in collaboration with Lovegrove and Jackson (Reading))
- Dairy product composition, adiposity, appetite and satiety (in collaboration with Given, Reynolds and Yaqoob (Reading))
- APOE genotype and inflammation (ongoing collaboration, with Rimbach and his research group at the University of Kiel (Germany))
- Long chain n-3 PUFA and vascular function
- NU-AGE project (EU FP7), in collaboration with Cassidy and Fairweather-Tait at UEA ,and other NU-AGE European Partners. Large Pan-European consortium investigating the impact if dietary change on the inflammatory phenotype in older adults (n=1200)(2010-2016)
- Genetic determinants of dietary flavonoids metabolism
- Diet composition and cognitive performance and age-related cognitive decline
Techniques
A large proportion of our research involves human intervention trials conducted at the Clinical Trials and Research Unit. In addition we employ a variety of molecular techniques, including cell culture, EMSA, Westernblotting, PCR, immunohistochemistry etc to investigate underlying physiological and molecular mechanisms.
Collaborators
|
Name |
Organisation |
|
International
Prof Gerald Rimbach Prof Jose Ordovas A/Prof Sally Poppitt A/Prof Welma Stonehouse Prof José López-Miranda NuGo Consortium 25 partners in 10 European countries |
University of Kiel, Germany Tufts University Boston, US University of Auckland, NZ Massey University, NZ University of Cordova, Spain Italy, France, UK, Germany, Eire, Netherlands, Norway, Poland, Spain, Sweden, |
|
National Prof Christine Williams/Prof Julie Lovegrove/Dr Kim Jackson/Prof Jeremy Spencer Prof Chris Packard/Prof Muriel Caslake Dr Georg Lietz/Prof John Mathers Prof Philip Calder/Dr Graham Burdge Dr Lynda Williams |
Hugh Sinclair Nutrition Group, University of Reading Vascular Biochemistry, University of Glasgow Medical Sciences, University of Newcastle School of Medicine, University of Southampton Rowett Institute, University of Aberdeen |
Article
Jackson, KG, Walden, MW, Murray, P, Smith, AM, Lovegrove, JA, Minihane, A-M and Williams, CM (2012) A sequential two meal challenge reveals abnormalities in postprandial TAG but not glucose in men with increasing numbers of metabolic syndrome components. Atherosclerosis, 220 (1). pp. 237-243.
Kofler, BM, Miles, EA, Curtis, P, Armah, CK, Tricon, S, Grew, J, Napper, FL, Farrell, L, Lietz, G, Packard, CJ, Caslake, MJ, Mathers, JC, William, CM, Calder, PC and Minihane, A-M (2012) Apolipoprotein E Genotype and the Cardiovascular Disease Risk Phenotype: Impact of Sex and Adiposity (the FINGEN Study). Atherosclerosis. (In Press)
Lockyer, S, Tzanetou, M, Carvalho-Wells, AL, Jackson, KG, Minihane, A-M and Lovegrove, JA (2012) SATgene dietary model to implement diets of differing fat composition in prospectively genotyped groups (apoE) using commercially available foods. British Journal of Nutrition. (In Press)
Madden, J, Williams, CM, Calder, PC, Lietz, G, Miles, EA, Cordell, H, Mathers, JC and Minihane, AM (2011) The Impact of Common Gene Variants on the Response of Biomarkers of Cardiovascular Disease (CVD) Risk to Increased Fish Oil Fatty Acids Intakes. Annual Review of Nutrition, 31 (1). pp. 203-234. ISSN 1545-4312
Graeser, A-C, Boesch-Saadatmandi, C, Lippmann, J, Wagner, AE, Huebbe, P, Storm, N, Höppner, W, Wiswedel, I, Gardemann, A, Minihane, AM, Döring, F and Rimbach, G (2011) Nrf2-dependent gene expression is affected by the proatherogenic apoE4 genotype-studies in targeted gene replacement mice. Journal of Molecular Medicine (Berlin, Germany), 89 (10). pp. 1027-1035. ISSN 1432-1440
Thompson, A K, Minihane, A.M and Williams, C M (2011) Trans fatty acids, insulin resistance and diabetes. European Journal of Clinical Nutrition, 65 (5). pp. 553-564. ISSN 0954-3007
Miller, Rosalind J., Jackson, Kim G., Dadd, Tony, Mayes, Andrew E., Louise Brown, A. and Minihane, Anne M. (2011) The impact of the catechol- O-methyltransferase genotype on the acute responsiveness of vascular reactivity to a green tea extract. British Journal of Nutrition, 105 (08). pp. 1138-1144. ISSN 0007-1145
Thompson, A K, Minihane, AM and Williams, C M (2011) Trans fatty acids and weight gain. International Journal of Obesity, 35 (3). pp. 315-324. ISSN 0307-0565
Dougkas, A, Minihane, A-M, Givens, DI, Reynolds, CK and Yaqoob, P (2011) The impact of dairy snack composition on appetite and ad libitum food intake. British Journal of Nutrition. (In Press)
Dougkas, Anestis, Reynolds, Christopher K., Givens, Ian D., Elwood, Peter C. and Minihane, Anne M (2011) Associations between dairy consumption and body weight: a review of the evidence and underlying mechanisms. Nutrition Research Reviews, 24 (01). pp. 72-95. ISSN 0954-4224
Miller, Rosalind J., Jackson, Kim G., Dadd, Tony, Nicol, Beate, Dick, Joanne L., Mayes, Andrew E., Brown, A. Louise and Minihane, Anne M (2011) A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins. European Journal of Nutrition. ISSN 1436-6207
Boesch-Saadatmandi, Christine, Rimbach, Gerald, Schrader, Charlotte, Kofler, Bettina M., Armah, Christopher K. and Minihane, Anne M. (2010) Determinants of paraoxonase activity in healthy adults. Molecular Nutrition & Food Research, 54 (12). pp. 1842-1850. ISSN 16134125
Carvalho-Wells, Andrew L., Jackson, Kim G., Gill, Rosalynn, Olano-Martin, Estibaliz, Lovegrove, Julie A., Williams, Christine M. and Minihane, Anne M (2010) Interactions between age and apoE genotype on fasting and postprandial triglycerides levels. Atherosclerosis, 212 (2). pp. 481-487. ISSN 00219150
Boesch-Saadatmandi, Christine, Niering, Julia, Minihane, Anne Marie, Wiswedel, Ingrid, Gardeman, Andreas, Wolffram, Siegfried and Rimbach, Gerald (2010) Impact of apolipoprotein E genotype and dietary quercetin on paraoxonase 1 status in apoE3 and apoE4 transgenic mice. Atherosclerosis, 211 (1). pp. 110-113. ISSN 00219150
Minihane, Anne M (2010) Fatty acid–genotype interactions and cardiovascular risk. Prostaglandins, Leukotrienes and Essential Fatty Acids, 82 (4-6). pp. 259-264. ISSN 09523278
Jackson, Kim G., Clarke, Dave T., Murray, Peter, Lovegrove, Julie A., O’Malley, Brendan, Minihane, Anne M and Williams, Christine M. (2010) Introduction to the DISRUPT postprandial database: subjects, studies and methodologies. Genes & Nutrition, 5 (1). pp. 39-48. ISSN 1555-8932
Olano-Martin, Estibaliz, Anil, Eliz, Caslake, Muriel J., Packard, Chris J., Bedford, Dorothy, Stewart, Grace, Peiris, Dammika, Williams, Christine M. and Minihane, Anne M (2010) Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil. Atherosclerosis, 209 (1). pp. 104-110. ISSN 00219150
Jackson, Kim G., Abraham, Elizheeba C., Smith, Adrian M., Murray, Peter, O’Malley, Brendan, Williams, Christine M. and Minihane, Anne M (2010) Impact of age and menopausal status on the postprandial triacylglycerol response in healthy women. Atherosclerosis, 208 (1). pp. 246-252. ISSN 00219150
Kuhlmann, Inga, Minihane, Anne, Huebbe, Patricia, Nebel, Almut and Rimbach, Gerald (2010) Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review. Lipids in Health and Disease, 9 (1). p. 8. ISSN 1476-511X
Jackson, KG and Minihane, AM (2010) Postprandial lipaemia and cardiovascular disease: Impact of age and gender on non-fasting triacylglycerol levels. Future Medicine-Clinical Lipdiology, 5. pp. 1-4.
Jackson, KJ, Poppitt, SD and Minihane, AM (2010) Postprandial lipaemia and cardiovascular disease risk: interrelationships between dietary, physiological and genetic determinants. Atherosclerosis. (In Press)
Moore, RJ, Jackson, KG and Minihane, AM (2009) Green tea (Camellia sinensis) catechins and vascular function. British Journal of Nutrition, 102 (12). pp. 1790-1802. ISSN 0007-1145
Jackson, Kim G., Armah, Christopher K., Doman, Izzy, James, Lewis, Cheghani, Farah and Minihane, Anne M (2009) The impact of age on the postprandial vascular response to a fish oil-enriched meal. British Journal of Nutrition, 102 (10). pp. 1414-1419. ISSN 0007-1145
Garcia-Alonso, Maria, Minihane, Anne Marie, Rimbach, Gerald, Rivas-Gonzalo, Julian C. and de Pascual-Teresa, Sonia (2009) Red wine anthocyanins are rapidly absorbed in humans and affect monocyte chemoattractant protein 1 levels and antioxidant capacity of plasma. The Journal of Nutritional Biochemistry, 20 (7). pp. 521-529. ISSN 09552863
Minihane, AM (2009) Nutrient gene interactions in lipid metabolism. Current Opinion in Clinical Nutrition and Metabolic Care, 12 (4). pp. 357-363. ISSN 1363-1950
Boesch-Saadatmandi, Christine, Wolffram, Siegfried, Minihane, Anne Marie and Rimbach, Gerald (2009) Effect of apoE genotype and dietary quercetin on blood lipids and TNF-α levels in apoE3 and apoE4 targeted gene replacement mice. British Journal of Nutrition, 101 (10). pp. 1440-1443. ISSN 0007-1145
Rimbach, Gerald and Minihane, Anne M (2009) Nutrigenetics and personalised nutrition: how far have we progressed and are we likely to get there? Proceedings of the Nutrition Society, 68 (02). pp. 162-172. ISSN 0029-6651
Thompson, Abby K., Shaw, Danielle I., Minihane, Anne M. and Williams, Christine M. (2008) Trans-fatty acids and cancer: the evidence reviewed. Nutrition Research Reviews, 21 (02). pp. 174-188. ISSN 0954-4224
Caslake, MJ, Miles, EA, Kofler, BM, Lietz, G, Curtis, P, Armah, CK, Kimber, AC, Grew, JP, Farrell, L, Stannard, J, Napper, FL, Sala-Vila, A, West, AL, Mathers, JC, Packard, C, Williams, CM, Calder, PC and Minihane, AM (2008) Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study. The American Journal of Clinical Nutrition, 88 (3). pp. 618-629. ISSN 0002-9165
Jofre-Monseny, Laia, Huebbe, Patricia, Stange, Inken, Boesch-Saadatmandi, Christine, Frank, Jan, Jackson, Kim, Minihane, Anne Marie and Rimbach, Gerald (2008) Influence of apolipoprotein E genotype and dietary α-tocopherol on redox status and C-reactive protein levels in apolipoprotein E3 and E4 targeted replacement mice. British Journal of Nutrition, 100 (01). pp. 44-53. ISSN 0007-1145
Armah, Christopher K., Jackson, Kim G., Doman, Izzy, James, Lewis, Cheghani, Farah and Minihane, Anne M (2008) Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clinical Science, 114 (11). pp. 679-686. ISSN 0143-5221
Olano-Martin, E., Abraham, E. C., Gill-Garrison, R., Valdes, A. M., Grimaldi, K., Tang, F., Jackson, K. G., Williams, C. M. and Minihane, A. M. (2008) Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender. The Journal of Lipid Research, 49 (5). pp. 945-953. ISSN 0022-2275
Frank, J., George, T. W., Lodge, J. K., Rodriguez-Mateos, A. M., Spencer, J. P. E., Minihane, A. M. and Rimbach, G. (2008) Daily Consumption of an Aqueous Green Tea Extract Supplement Does Not Impair Liver Function or Alter Cardiovascular Disease Risk Biomarkers in Healthy Men. Journal of Nutrition, 139 (1). pp. 58-62. ISSN 0022-3166
Jofre-Monseny, Laia, Minihane, Anne Marie and Rimbach, Gerald (2008) Impact of apoE genotype on oxidative stress, inflammation and disease risk. Molecular Nutrition & Food Research, 52 (1). pp. 131-145. ISSN 16134125
Spencer, Jeremy P. E., Abd El Mohsen, Manal M., Minihane, Anne Marie and Mathers, John C. (2008) Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. British Journal of Nutrition, 99 (01). pp. 12-22. ISSN 0007-1145
Jofre-Monseny, L, Minihane, AM and Rimbach, G (2008) The associations and potential means of modifying the impact of an apoE genotype on oxidative stress, inflammation and disease risk. Molecular Nutrition and Food Research, 52. pp. 131-145. ISSN 1613-4125
Rimbach, G, Pallauf, J, Moehring, J, Kraemer, K and Minihane, AM (2008) Effect of Dietary Phytate and microbial phytase on mieral and trace element bioavailability - a literature review. Current Topics in Nutraceutical Research, 6. pp. 131-144.
Thompson, AK, Shaw, DI, Minihane, A-M and Williams, CM (2008) Trans fatty acids and cancer: the evidence reviewed. Nutrition Research Reviews, 21. pp. 174-188.
Huebbe, P, Jofre-Monseny, L, Boesch-Saadatmandi, Ch, Minihane, AM and Rimbach, G (2007) Effect of apoE genotype and vitamin E on biomarkers of oxidative stress in cultured neuronal cells and the brain of targeted replacement mice. Journal of Physiology and Pharmacology : an official journal of the Polish Physiological Society, 58 (4). pp. 683-698. ISSN 1899-1505
Huebbe, Patricia, Schaffer, Sebastian, Jofre-Monseny, Laia, Boesch-Saadatmandi, Christine, Minihane, Anne Marie, Müller, Walter E., Eckert, Gunter P. and Rimbach, Gerald (2007) Apolipoprotein E genotype and alpha-tocopherol modulate amyloid precursor protein metabolism and cell cycle regulation. Molecular Nutrition & Food Research, 51 (12). pp. 1510-1517. ISSN 16134125
Minihane, A.M., Jofre-Monseny, L., Olano-Martin, E. and Rimbach, G. (2007) ApoE genotype, cardiovascular risk and responsiveness to dietary fat manipulation. Proceedings of the Nutrition Society, 66 (02). pp. 183-197. ISSN 0029-6651
Jackson, K G, Armah, C K and Minihane, A M (2007) Meal fatty acids and postprandial vascular reactivity. Biochemical Society transactions, 35 (Pt 3). pp. 451-453. ISSN 0300-5127
Jofre-Monseny, Laia, Loboda, Agnieszka, Wagner, Anika E., Huebbe, Patricia, Boesch-Saadatmandi, Christine, Jozkowicz, Alicja, Minihane, Anne Marie, Dulak, Jozef and Rimbach, Gerald (2007) Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression. Biochemical and Biophysical Research Communications, 357 (1). pp. 319-324. ISSN 0006291X
Jofre-Monseny, Laia, de Pascual-Teresa, Sonia, Plonka, Eva, Huebbe, Patricia, Boesch-Saadatmandi, Christine, Minihane, Anne Marie and Rimbach, Gerald (2007) Differential effects of apolipoprotein E3 and E4 on markers of oxidative status in macrophages. British Journal of Nutrition, 97 (05). pp. 864-871. ISSN 0007-1145
Minihane, AM and Harland, JI (2007) Impact of oil used by the frying industry on population fat intake. Critical Reviews in Food Science and Nutrition, 47 (3). pp. 287-297. ISSN 1040-8398
Minihane, AM, Jofre-Monseny, L, Olano-Martin, E and Rimbach, GH (2007) Apolipoprotein E genotype, cardiovascular risk and responsiveness to dietary fat manipulation. Proceedings of the Nutrition Society, 66. pp. 183-187.
Spencer, JPE, Abd El Mohsen, MM and Minihane, AM (2007) Metabolism of dietary phytochemicals: a review of the metabolic forms identified in humans. Current Topics in Nutraceutical Research, 4. pp. 175-186.
Ewins, BA, Vassiliadou, M, Minihane, AM, Rimbach, GH and Weinberg, PD (2006) Techniques for quantifying effects of dietary antioxidants on transcription factor translocation and nitric oxide production in cultured cells. Genes & Nutrition, 1 (2). pp. 125-131. ISSN 1555-8932
Page, Nigel M, Olano-Martin, Estibaliz, Lanaway, Christopher, Turner, Rufus and Minihane, Anne Marie (2006) Polymorphisms in the Apolipoprotein L1 gene and their effects on blood lipid and glucose levels in middle age males. Genes & nutrition, 1 (2). pp. 133-135. ISSN 1555-8932
Proteggente, A, Rota, C, Majewicz, J, Rimbach, G, Minihane, A, Kraemer, K and Lodge, J (2006) Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) α-tocopherol: A biokinetic study in apoE4 male subjects. Free Radical Biology and Medicine, 40 (12). pp. 2080-2091. ISSN 08915849
Hall, WL, Vafeiadou, K, Hallund, J, Bugel, S, Reimann, M, Koebnick, C, Zunft, HJ, Ferrari, M, Branca, F, Dadd, T, Talbot, D, Powell, J, Minihane, AM, Cassidy, A, Nilsson, M, Dahlman-Wright, K, Gustafsson, JA and Williams, CM (2006) Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production. American Journal of Clinical Nutrition, 83 (3). pp. 592-600.
Spencer, JPE, Abd El Mohsen, M and Minihane, AM (2006) Metabolism of dietary phytochemicals: A review of the metabolic forms identified in humans. Topics in Nutraceutical Research, 4. pp. 187-203.
Majewicz, Jonathan, Rimbach, Gerald, Proteggente, Anna R., Lodge, John K., Kraemer, Klaus and Minihane, Anne M (2005) Dietary vitamin C down-regulates inflammatory gene expression in apoE4 smokers. Biochemical and Biophysical Research Communications, 338 (2). pp. 951-955. ISSN 0006291X
Hall, Wendy L, Vafeiadou, Katerina, Hallund, Jesper, Bügel, Susanne, Koebnick, Corinna, Reimann, Manja, Ferrari, Marika, Branca, Francesco, Talbot, Duncan, Dadd, Tony, Nilsson, Maria, Dahlman-Wright, Karin, Gustafsson, Jan-Ake, Minihane, Anne Marie and Williams, Christine M (2005) Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production. The American journal of clinical nutrition, 82 (6). pp. 1260-1268. ISSN 0002-9165
Proteggente, AR, Turner, R, Majewicz, J, Rimbach, G, Minihane, AM, Krämer, K and Lodge, JK (2005) Noncompetitive plasma biokinetics of deuterium-labeled natural and synthetic alpha-tocopherol in healthy men with an apoE4 genotype. The Journal of Nutrition, 135 (5). pp. 1063-1069. ISSN 0022-3166
Dietrich, Marion, Hu, Youqing, Block, Gladys, Olano, Estibaliz, Packer, Lester, Morrow, Jason D, Hudes, Mark, Abdukeyum, Gulbahar, Rimbach, Gerald and Minihane, Anne M (2005) Associations between apolipoprotein E genotype and circulating F2-isoprostane levels in humans. Lipids, 40 (4). pp. 329-334. ISSN 0024-4201
Minihane, A. M., Brady, L. M., Lovegrove, S. S., Lesauvage, S. V., Williams, C. M. and Lovegrove, J. A. (2005) Lack of effect of dietary n-6:n-3 PUFA ratio on plasma lipids and markers of insulin responses in Indian Asians living in the UK. European Journal of Nutrition, 44 (1). pp. 26-32. ISSN 1436-6207
Rota, Cristina, Rimbach, Gerald, Minihane, Anne Marie, Stoecklin, Elisabeth and Barella, Luca (2005) Dietary vitamin E modulates differential gene expression in the rat hippocampus: Potential implications for its neuroprotective properties. Nutritional Neuroscience, 8 (1). pp. 21-29. ISSN 1028-415X
Turner, R, Etienne, N, Alonso, MG, de Pascual-Teresa, S, Minihane, AM, Weinberg, PD and Rimbach, G (2005) Antioxidant and anti-atherogenic activities of olive oil phenolics. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition, 75 (1). pp. 61-70. ISSN 0300-9831
Buckley, Richard, Shewring, Bethan, Turner, Rufus, Yaqoob, Parveen and Minihane, Anne M (2004) Circulating triacylglycerol and apoE levels in response to EPA and docosahexaenoic acid supplementation in adult human subjects. British Journal of Nutrition, 92 (03). pp. 477-483. ISSN 0007-1145
MESA, Maria Dolores, Buckley, Richard, Minihane, Anne Marie and Yaqoob, Parveen (2004) Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on the oxidizability and thrombogenicity of low-density lipoprotein. Atherosclerosis, 175 (2). pp. 333-343. ISSN 00219150
Brady, LM, Lovegrove, SS, Lesauvage, SVM, Gower, BA, Minihane, AM, Williams, CM and Lovegrove, JA (2004) Increased n-6 polyunsaturated fatty acids do not attenuate the effects of long-chain n-3 polyunsaturated fatty acids on insulin sensitivity or triacylglycerol reduction in Indian Asians. The American Journal of Clinical Nutrition, 79 (6). pp. 983-991. ISSN 0002-9165
Lovegrove, JA, Lovegrove, SS, Lesauvage, SVM, Brady, LM, Saini, N, Minihane, AM and Williams, CM (2004) Moderate fish-oil supplementation reverses low-platelet, long-chain n-3 polyunsaturated fatty acid status and reduces plasma triacylglycerol concentrations in British Indo-Asians. The American Journal of Clinical Nutrition, 79 (6). pp. 974-982. ISSN 0002-9165
Barella, Luca, Muller, Patrick Y, Schlachter, Manfred, Hunziker, Willi, Stöcklin, Elisabeth, Spitzer, Volker, Meier, Nina, de Pascual-Teresa, Sonia, Minihane, Anne Marie and Rimbach, Gerald (2004) Identification of hepatic molecular mechanisms of action of alpha-tocopherol using global gene expression profile analysis in rats. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1689 (1). pp. 66-74. ISSN 09254439
Rota, Cristina, Barella, Luca, Minihane, Anne Marie, Stocklin, Elisabeth and Rimbach, Gerald (2004) Dietary Alpha-Tocopherol Affects Differential Gene Expression in Rat Testes. IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 56 (5). pp. 277-280. ISSN 1521-6543
Kew, S, Mesa, MD, Tricon, S, Buckley, R, Minihane, AM and Yaqoob, P (2004) Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humans. The American Journal of Clinical Nutrition, 79 (4). pp. 674-681. ISSN 0002-9165
Rimbach, G, Weinberg, PD, De Pascual-Teresa, S, Alonso, MG, Ewins, BA, Turner, R, Minihane, AM, Botting, NP, Fairley, B, Matsugo, S, Uchida, Y and Cassidy, A (2004) Sulfation of genistein alters its antioxidant properties and its effect on platelet aggregation and monocyte and endothelial function. Biochimica et Biophysica Acta, 1670 (3). pp. 229-237.
Turner, R, Baron, T, Wolffram, S, Minihane, AM, Cassidy, A, Rimbach, G and Weinberg, PD (2004) Effect of circulating forms of soy isoflavones on the oxidation of low density lipoprotein. Free Radical Research, 38 (2). pp. 209-216.
Lovegrove, JA, Brady, LM, Lesauvage, SVM, Lovegrove, SS, Minihane, AM and Williams, CM (2003) Lack of association between central adiposity and lipaemia in UK Sikh men. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, 27 (11). pp. 1373-1382. ISSN 0307-0565
Rimbach, G., De Pascual-Teresa, S., Ewins, B. A., Matsugo, S., Uchida, Y., Minihane, A. M., Turner, R., Vafei Adou, K. and Weinberg, P. D. (2003) Antioxidant and free radical scavenging activity of isoflavone metabolites. Xenobiotica, 33 (9). pp. 913-925. ISSN 0049-8254
Burdge, Graham C., Finnegan, Yvonne E., Minihane, Anne M., Williams, Christine M. and Wootton, Stephen A. (2003) Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [C]α-linolenic acid to longer-chain fatty acids and partitioning towards β-oxidation in older men. British Journal of Nutrition, 90 (02). pp. 311-321. ISSN 0007-1145
Finnegan, YE, Howarth, D, Minihane, AM, Kew, S, Miller, GJ, Calder, PC and Williams, CM (2003) Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans. The Journal of Nutrition, 133 (7). pp. 2210-2213. ISSN 0022-3166
Gottstein, Nicole, Ewins, Benjamin A., Eccleston, Clair, Hubbard, Gary P., Kavanagh, Ian C., Minihane, Anne Marie, Weinberg, Peter D. and Rimbach, Gerald (2003) Effect of genistein and daidzein on platelet aggregation and monocyte and endothelial function. British Journal of Nutrition, 89 (05). pp. 607-615. ISSN 0007-1145
Kew, S, Banerjee, T, Minihane, AM, Finnegan, YE, Muggli, R, Albers, R, Williams, CM and Calder, PC (2003) Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. The American Journal of Clinical Nutrition, 77 (5). pp. 1287-1295. ISSN 0002-9165
Kew, S, Banerjee, T, Minihane, AM, Finnegan, YE, Williams, CM and Calder, PC (2003) Relation between the fatty acid composition of peripheral blood mononuclear cells and measures of immune cell function in healthy, free-living subjects aged 25-72 y. The American Journal of Clinical Nutrition, 77 (5). pp. 1278-1286. ISSN 0002-9165
Finnegan, YE, Minihane, AM, Leigh-Firbank, EC, Kew, S, Meijer, GW, Muggli, R, Calder, PC and Williams, CM (2003) Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. The American Journal of Clinical Nutrition, 77 (4). pp. 783-795. ISSN 0002-9165
Virgili, Fabio, Ambra, Roberto, Muratori, Flaminia, Natella, Fausta, Majewicz, Jonathan, Minihane, Anne Marie and Rimbach, Gerald (2003) Effect of Oxidized Low-Density Lipoprotein on Differential Gene Expression in Primary Human Endothelial Cells. Antioxidants & Redox Signaling, 5 (2). pp. 237-247. ISSN 1523-0864
Bingham, M, Gibson, G, Gottstein, N, de Pascual-Teresa, S, Minihane, AM and Rimbach, G (2003) Gut metabolism and carioprotective effects of dietary isoflavones. Current Topics in Nutraceutical Research, 1. pp. 31-48.
Rimbach, Gerald, Minihane, Anne Marie, Majewicz, Jonathan, Fischer, Alexandra, Pallauf, Josef, Virgli, Fabio and Weinberg, Peter D. (2002) Regulation of cell signalling by vitamin E. Proceedings of the Nutrition Society, 61 (04). pp. 415-425. ISSN 0029-6651
Minihane, Anne (2002) Influence of the APOC3 −2854T>G polymorphism on plasma lipid levels: effect of age and gender. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1583 (3). pp. 311-314. ISSN 13881981
Eccleston, Clair, Baoru, Yang, Tahvonen, Raija, Kallio, Heikki, Rimbach, Gerald H and Minihane, Anne M (2002) Effects of an antioxidant-rich juice (sea buckthorn) on risk factors for coronary heart disease in humans. The Journal of Nutritional Biochemistry, 13 (6). pp. 346-354. ISSN 09552863
Khan, S, Minihane, AM, Talmud, PJ, Wright, JW, Murphy, MC, Williams, CM and Griffin, BA (2002) Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype. Journal of Lipid Research, 43 (6). pp. 979-985.
Leigh-Firbank, Elizabeth C., Minihane, Anne M, Leake, David S., Wright, John W., Murphy, Margaret C., Griffin, Bruce A. and Williams, Christine M. (2002) Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. British Journal of Nutrition, 87 (05). pp. 435-445. ISSN 0007-1145
Minihane, AM and Rimbach, G (2002) Iron absorption and the iron-binding and anti-oxidant properties of phytic acid. International Journal Of Food Science & Technology, 37. pp. 741-748.
Minihane, AM (2001) The postgenome era: opportunities for the food industry to meet the nutritional needs of the future. Nutrition Bulletin, 26. pp. 341-344.
Book Section
Minihane, A-M (2009) Human nutrigenetic research: the strengths and limitations of various study designs. In: Design on Human Nutrigenomics Studies. Wageningen Academic Publishers, Wageningen.
Minihane, A-M, Givens, DI and Gibbs, RA (2008) The health benefits of n-3 fatty acids and their concentration in organic and conventional animal derived foods. In: Health Benefits of Organic Food: Effect of the Environment. CABI, Wallingford.
Minihane, A-M and Lovegrove, JA (2006) Health benefits of polyunsaturated fatty acids. In: Improving the Fat Content of Foods. Woodhead Publishing Ltd, Abingdon.
Minihane, A-M (2005) Fatty acid gene expression and coronary heart disease. In: Nutrigenomics: The Role of Oxidant and Antioxidants in Gene Expression. Marcel Decker, New York.
Rota, C, Minihane, AM, Weinberg, P, Weber, S, Packer, L and Rimbach, G (2005) Cell regulatory activity of tocopherols and tocotrienols. In: Nutrigenomics. Marcel Decker, New York.
Yaqoob, P, Minihane, A-M and Williams, CM (2005) Fat metabolism. In: Human Nutrition. Elsevier Publishers, Oxford.
Hall, WL, Vafeiadou, AM, Minihane, A-M, Rimbach, GH and Williams, CM (2004) Isoflavones and coronary heart disease. In: Functional Foods, Cardiovascular Disease and Diabetes. Woodhead Publishing, Abingdon.
Minihane, A-M (2004) Milk, blood lipids and coronary heart disease (CHD) - The myth and the evidence. In: Dairying, Using Science to Meet Consumers Needs. Nottingham University Press, Nottingham.
Fischer, A, Pallauf, J, Majewicz, J, Minihane, A-M and Rimbach, G (2003) Selenium and vitamin E. In: Molecular Nutrition. CABI Publishing, Wallingford.
Minihane, A-M (1999) Dietary properties of edible vegetable oils. In: Oils and Fats Handbook. Leatherhead Food RA, Leatherhead.
Monograph
Shaw, DI, Thompson, AK, Minihane, A-M and Williams, CM (2007) Update on trans fatty acids and health: Position statement by the Scientific Advisory Committee on Nutrition (SACN). Other. TSO, Government Report, London.
External Activities and Indicators of Esteem
- Invited current editorial board member of the British Journal of Nutrition (BJN), Journal of Nutritional Sciences (JNS), European Journal of Clinical Nutrition (EJCN) and Nutrition & Aging.
- Current academic expert on the ILSI Diabetes Metabolic Syndrome subpanel
- Invited member of HEFCE, REF assessment panel 2010-2014
- Invited current member of the Biosciences for Business (Knowledge Transfer Network funded by Government, Regional Development Agencies, Devolved Administrations & Research Councils) sub-committee on ‘Nutrition for Optimum health and Well-Being’,
- Invited member of the Scientific Advisory Committee on Nutrition (SACN) Trans Fatty acid risk assessment drafting team, with the report entitled Update on trans fatty acids and health: Position Statement published in December 2007,
- Elected member of the Nutrition Society Programmes Committee between 2002 and 2005
- Human nutrition advisor to the FSA ‘Advisory Committee on Animal Foodstuffs’
- Regular reviewer of grant applications and final reports for the FSA, BBSRC, Welcome and Programme de Recherche en Alimentation et Nutrition Humaine (PNRA, France),
- External reviewer of the Dutch, Nutrition and chronic diseases: the role of genetic predisposition research programme (1997-2005),
- Co-editor of a book entitled ‘Effect of the environment on the health benefits of organic food’ published in Aug 2008
- Member of the British Nutrition Society, the International Society for the Study of Lipids and Fatty Acids (ISSFAL), the Obesity Society, the NZ Physiology Society, and the Australian Neuroscience Society.
- Recipient of the 2008 Nutrition Society Silver Medal Award ‘for scientific excellence in the field of nutrition’,
- External Examiner for Newcastle University, University of Singapore and University of Aberdeen UG and PG nutrition related courses
Professional Activities
- Invited presentation at National & International conferences (2008-present)
- Mar 2012, Diet‐genotype interactions: implications for health and future dietary recommendations, Nutrition Society Future Food and Health conference, Aberdeen, UK
- October 2011, Nutrigenetics and personalised/stratified approaches to the provision of dietary advice, ILSI Europe Symposium on Health Benefits of Foods, Prague, Czech Republic
- May 2011, Nutrigenetics and personalised/stratified approaches to the provision of dietary advice, Nutrition for Medicine Conference, Sydney, Australia
- May 2011, The impact of fish oils on cardiovascular health: ‘What dose does what and in who’ Nutrition for Medicine Conference, Sydney, Australia
- October 2010, Personalised advice base on genetic information, ILSI conference, Copenhagen, Denmark
- Sept 2010, The future of personalised nutrition, NuGo annual conference, Glasgow, UK
- Dec 2009, Is the efficacy of n-3 fatty acids influenced by genetic polymorphisms, Australia/NZ Nutrition Society Conference, Newcastle, Australia
- July 2009, Fatty acid-genotype interactions and cardiovascular risk Fatty acids in cell signalling (FACS), Oxford, UK
- June 2009, Nutrigenomics (Nutrigenetics) and cardiovascular disease (CVD), NutrEvent 2009, Lille, France
- Sept 2008, Influence of a leptin receptor gene variant on postprandial triglyceride metabolism Keystone Metabolism and Cardiovascular Risk Conference, Breckenridge, Colorado, US
- Sept 2008, Nutrigenetic research: the strengths and limitations of various models and study designs
- Nutrgenomic Network of Excellence Conference, Postsdam, Germany
- July 2008, ‘Silver Medal Lecture’ Nutrigenetics: A valuable public health tool or simply an expensive research exercise, Nutrition Society, Nottingham, UK
- Apr 2008, Fatty acid composition health and disease
- SCI Conference, Abu Dhabi, UAE.

