Dr Angharad Morgan
| Job Title | Contact | Location |
|---|---|---|
| Senior Researcher |
Angharad dot Morgan at uea dot ac dot uk
Tel: +44 (0)1603 59 1949 |
Medical School 2.02 |
Biography
Qualifications
- BSc (Hons) (2:1) Genetics, University of Manchester (2000)
- PhD University of Southampton (2004)
Career
- Senior Researcher in Nutritional Biochemistry/Genetics, University of East Anglia, UK, July 2012 - present.
- Senior Research Scientist, University of Auckland, New Zealand, September 2008 – June 2012.
- Postdoctoral research associate, Cardiff University, UK, February 2005 – August 2008.
- Postdoctoral research associate, University of Toronto, Canada, November 2003 – November 2004.
Academic Background
Key Research Interests
Research interests
Genotyping
Genetic association studies
Nutrigenetics
Gene/diet interactions
Gene/environment interactions
Selected recent publications
- Jostins L, Ripke S, Weersma R, et al. (2012) Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature in press.
- Morgan AR, Han DY, Lam WJ, Triggs CM, Fraser AG, Barclay M, Gearry RB, Meisner S, Stokkers P, Boeckxstaens GW, Ferguson LR. (2011) Genetic variations in matrix metalloproteinases may be associated with increased risk of Ulcerative Colitis. Human Immunology. 2011 72(11), 1117-1127.
- Wang AH, Lam WJ, Han DY, Ding Y, Hu R, Fraser AG, Ferguson LR, Morgan AR (2011) The effect of IL-10 genetic variation and IL-10 serum levels on Crohn's Disease susceptibility in a New Zealand population. Human Immunology. 72(5), 431-435.
- Gerrish A, Russo G, Richards A, et al. (2012) The Role of Variation at AβPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease. J Alzheimers Dis. 28(2), 377-387.
- Jones L, Holmans PA, Hamshere ML, et al. (2010) Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease. PLoS One 5(11), e13950.
- Harold D, Abraham R, Hollingworth P, et al. (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet. 41(10), 1088-1093.
Article
Gentschew, L, Bishop, KS, Han, DY, Morgan, AR, Fraser, AG, Lam, WJ, Karunasinghe, N, Campbell, B and Ferguson, LR (2012) Selenium, Selenoprotein Genes and Crohn’s Disease in a Case-Control Population from Auckland, New Zealand. Nutrients, 4 (9). pp. 1247-1259. ISSN 2072-6643
Gerrish, A, Russo, G, Morgan, AR and et al, (2012) The role of variation at AbPP, PSEN1, PSEN2 and MAPT in late onset Alzheimer's Disease. Journal of Alzheimer's Disease, 28 (2). pp. 377-387.
Jostins, L, Ripke, S, Weersma, R, Morgan, AR and et al, (2012) Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. (In Press)
Morgan, AR (2012) Determining Genetic Risk Factors for Pediatric Type 2 Diabetes. Current Diabetes Reports, 12 (1). pp. 88-92. ISSN 1534-4827
Morgan, AR, Fraser, AG and Ferguson, LR (2012) Metallothionein genes: no association with Crohn's disease in a New Zealand population. Journal of Negative Results in BioMedicine, 11 (1). p. 8. ISSN 1477-5751
Morgan, AR, Lam, W-J, Han, D-Y, Fraser, AG and Ferguson, LR (2012) DNase1: No Association with Crohn's Disease in a New Zealand Population. ISRN Gastroenterology, 2012. pp. 1-4. ISSN 2090-4401
Morgan, AR, Lam, W-J, Han, D-Y, Fraser, AG and Ferguson, LR (2012) Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population. Gastroenterology Research and Practice, 2012. pp. 1-6. ISSN 1687-6121
Morgan, AR, Lam, W-J, Han, D-Y, Fraser, AG and Ferguson, LR (2012) Genetic variation within TLR10 is associated with Crohn's disease in a New Zealand population. Human Immunology, 73 (4). pp. 416-420. ISSN 01988859
Morgan, AR, Thompson, JMD, Waldie, KE, Cornforth, CM, Turic, D, Sonuga-Barke, EJS, Lam, WJ, Ferguson, LR and Mitchell, EA (2012) Initial evidence that polymorphisms in neurotransmitter-regulating genes contribute to being born small for gestational age. Journal of Pediatric Genetics, 2. pp. 105-114.
Morgan, AR, Han, D-Y, Lam, W-J, Triggs, CM, Fraser, AG, Barclay, M, Gearry, RB, Meisner, S, Stokkers, P, Boeckxstaens, GE and Ferguson, LR (2011) Genetic variations in matrix metalloproteinases may be associated with increased risk of ulcerative colitis. Human Immunology, 72 (11). pp. 1117-1127. ISSN 01988859
Thompson, JMD, Sonuga-Barke, EJ, Morgan, AR, Cornforth, CM, Turic, D, Ferguson, LR, Mitchell, EA and Waldie, KE (2011) The catechol-O-methyltransferase (COMT) Val158Met polymorphism moderates the effect of antenatal stress on childhood behavioural problems: longitudinal evidence across multiple ages. Developmental Medicine & Child Neurology, 54 (2). pp. 148-154. ISSN 00121622
Wang, AH, Lam, W-J, Han, D-Y, Ding, Y, Hu, R, Fraser, AG, Ferguson, LR and Morgan, AR (2011) The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population. Human Immunology, 72 (5). pp. 431-435. ISSN 01988859
El Khoury, J, Jones, L, Holmans, PA, Hamshere, ML, Harold, D, Moskvina, V, Ivanov, D, Pocklington, A, Abraham, R, Hollingworth, P, Sims, R, Gerrish, A, Pahwa, JS, Jones, N, Stretton, A, Morgan, AR, Lovestone, S, Powell, J, Proitsi, P, Lupton, MK, Brayne, C, Rubinsztein, DC, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, KS, Passmore, PA, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, AD, Love, S, Kehoe, PG, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Schürmann, B, van den Bussche, H, Heuser, I, Peters, O, Kornhuber, J, Wiltfang, J, Dichgans, M, Frölich, L, Hampel, H, Hüll, M, Rujescu, D, Goate, AM., Kauwe, JSK., Cruchaga, C, Nowotny, P, Morris, JC, Mayo, K, Livingston, G, Bass, NJ, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, CE, Singleton, AB, Guerreiro, R, Mühleisen, TW, Nöthen, MM, Moebus, S, Jöckel, KH, Klopp, N, Wichmann, HE, Rüther, E, Carrasquillo, MM, Pankratz, VS, Younkin, SG, Hardy, J, O'Donovan, MC, Owen, MJ and Williams, J (2010) Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease. PLoS ONE, 5 (11). e13950. ISSN 1932-6203
Ferguson, LR, Han, DY, Fraser, AG, Huebner, C, Lam, WJ and Morgan, AR (2010) IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population. Gastroenterology Research and Practice, 2010. pp. 1-12. ISSN 1687-6121
Ferguson, LR, Han, DY, Fraser, AG, Huebner, C, Lam, WJ, Morgan, AR, Duan, H and Karunasinghe, N (2010) Genetic factors in chronic inflammation: Single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 690 (1-2). pp. 108-115. ISSN 00275107
Morgan, AR, Han, D-Y, Lam, W-J, Fraser, AG and Ferguson, LR (2010) Association analysis of 3p21 with Crohn's disease in a New Zealand population. Human Immunology, 71 (6). pp. 602-609. ISSN 01988859
Morgan, AR, Han, DY, Huebner, C, Lam, WJ, Fraser, AG and Ferguson, LR (2010) PTPN2but notPTPN22is associated with Crohn's disease in a New Zealand population. Tissue Antigens, 76 (2). pp. 119-125. ISSN 00012815
Morgan, AR, Thompson, JMD, Murphy, R, Black, PN, Lam, W-J, Ferguson, LR and Mitchell, EA (2010) Obesity and diabetes genes are associated with being born small for gestational age: Results from the Auckland Birthweight Collaborative study. BMC Medical Genetics, 11 (1). p. 125. ISSN 1471-2350
Nolan, DJ, Han, D, Lam, W, Morgan, AR, Fraser, AG, Tapsell, LC and Ferguson, LR (2010) Genetic adult lactase persistence is associated with risk of Crohn's Disease in a New Zealand population. BMC Research Notes, 3 (1). p. 339. ISSN 1756-0500
Harold, Denise, Abraham, Richard, Hollingworth, Paul, Sims, Rebecca, Gerrish, Amy, Hamshere, Marian L, Pahwa, Jaspreet Singh, Moskvina, Valentina, Dowzell, Kimberley, Williams, Amy, Jones, Nicola, Thomas, Charlene, Stretton, Alexandra, Morgan, AR, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K, Brayne, Carol, Rubinsztein, David C, Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S, Passmore, Peter A, Craig, David, McGuinness, Bernadette, Todd, Stephen, Holmes, Clive, Mann, David, Smith, A David, Love, Seth, Kehoe, Patrick G, Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Schürmann, Britta, van den Bussche, Hendrik, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Hüll, Michael, Rujescu, Dan, Goate, Alison M, Kauwe, John S K, Cruchaga, Carlos, Nowotny, Petra, Morris, John C, Mayo, Kevin, Sleegers, Kristel, Bettens, Karolien, Engelborghs, Sebastiaan, De Deyn, Peter P, Van Broeckhoven, Christine, Livingston, Gill, Bass, Nicholas J, Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panagiotis, Al-Chalabi, Ammar, Shaw, Christopher E, Tsolaki, Magda, Singleton, Andrew B, Guerreiro, Rita, Mühleisen, Thomas W, Nöthen, Markus M, Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H-Erich, Carrasquillo, Minerva M, Pankratz, V Shane, Younkin, Steven G, Holmans, Peter A, O'Donovan, Michael, Owen, Michael J and Williams, Julie (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature Genetics, 41 (10). pp. 1088-1093. ISSN 1061-4036
Morgan, AR, Hollingworth, P, Abraham, R, Lovestone, S, Brayne, C, Rubinsztein, DC, Lynch, A, Lawlor, B, Gill, M, O'Donovan, MC, Owen, MJ and Williams, J (2009) Association analysis of dynamin-bindin protein (DNMBP) on chromosme 10q with late onset Alzheimer's disease in a large caucasian UK sample. American Journal of Medical Genetics Part B - Neuropsychiatric Genetics, 150B (1). pp. 61-64.
Abraham, R, Moskvina, V, Sims, R, Hollingworth, P, Morgan, AR, Georgieva, L, Dowzell, K, Cichon, S, Hillmer, AM, O'Donovan, MC, Williams, J, Owen, MJ and Kirov, G (2008) A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. BMC Medical Genomics, 1 (1). p. 44. ISSN 1755-8794
Morgan, AR, Turic, D, Jehu, L, Hamilton, G, Hollingworth, P, Moskvina, V, Jones, L, Lovestone, S, Brayne, C, Rubinsztein, DC, Lawlor, B, Gill, M, O'Donovan, MC, Owen, MJ and Williams, J (2008) Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. American Journal of Medican Genetics Part B - Neuropsychiatric Genetics, 144B (6). pp. 762-770.
Grupe, A., Abraham, R., Li, Y., Rowland, C., Hollingworth, P., Morgan, AR, Jehu, L., Segurado, R., Stone, D., Schadt, E., Karnoub, M., Nowotny, P., Tacey, K., Catanese, J., Sninsky, J., Brayne, C., Rubinsztein, D., Gill, M., Lawlor, B., Lovestone, S., Holmans, P., O'Donovan, M., Morris, J. C., Thal, L., Goate, A., Owen, M. J. and Williams, J. (2007) Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Human Molecular Genetics, 16 (8). pp. 865-873. ISSN 0964-6906
Hamilton, G, Proitsi, P, Jehu, L, Morgan, AR, Williams, J, O'Donovan, MC, Owen, MJ, Powell, JF and Lovestone, S (2007) Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence forSOS2,PCK1, andPPARγas susceptibility loci. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B (4). pp. 508-516. ISSN 15524841
Morgan, AR, Hamilton, G., Turic, D., Jehu, L., Harold, D., Abraham, R., Hollingworth, P., Moskvina, V., Brayne, C., Rubinsztein, D.C., Lynch, A., Lawlor, B., Gill, M., O'Donovan, M., Powell, J., Lovestone, S., Williams, J. and Owen, M.J. (2007) Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B (6). pp. 727-731. ISSN 15524841
Edwards-Lee, T., Ringman, J. M., Chung, J., Werner, J., Morgan, AR, Hyslop, P. St. G., Thompson, P., Dutton, R., Mlikotic, A., Rogaeva, E. and Hardy, J. (2005) An African American family with early-onset Alzheimer disease and an APP (T714I) mutation. Neurology, 64 (2). pp. 377-379. ISSN 0028-3878
Pearce, E, Tregouet, DA, Samnegard, A, Morgan, AR, Cox, C, Hamsten, A, Eriksson, P and Ye, S (2005) Haplotype Effect of the Matrix Metalloproteinase-1 Gene on Risk of Myocardial Infarction. Circulation Research, 97 (10). pp. 1070-1076. ISSN 0009-7330
Sato, C, Morgan, AR, Lang, AE, Salehi-Rad, S, Kawarai, T, Meng, Y, Ray, PN, Farrer, LA, St George-Hyslop, P and Rogaeva, E (2005) Analysis of the glucocerebrosidase gene in Parkinson's disease. Movement Disorders, 20 (3). pp. 367-370. ISSN 0885-3185
Groen, JL, Kawarai, T, Toulina, A, Rivoiro, C, Salehi-Rad, S, Sato, C, Morgan, AR, Liang, Y, Postuma, RB, St George-Hyslop, P, Lang, AE and Rogaeva, E (2004) Genetic association study of PINK1 coding polymorphisms in Parkinson's disease. Neuroscience Letters, 372 (3). pp. 226-229. ISSN 03043940
Morgan, AR, Rerkasem, K, Gallagher, PJ, Zhang, B, Morris, GE, Calder, PC, Grimble, RF, Eriksson, P, McPheat, WL, Shearman, CP and Ye, S (2004) Differences in Matrix Metalloproteinase-1 and Matrix Metalloproteinase-12 Transcript Levels Among Carotid Atherosclerotic Plaques With Different Histopathological Characteristics. Stroke, 35 (6). pp. 1310-1315. ISSN 0039-2499
Rogaeva, E, Morgan, AR and et al, (2004) Analysis of the PINK1 Gene in a Large Cohort of Cases With Parkinson Disease. Archives of Neurology, 61 (12). pp. 1898-1904. ISSN 0003-9942
Morgan, AR, Zhang, B, Tapper, W, Collins, A and Ye, S (2003) Haplotypic analysis of the MMP-9 gene in relation to coronary aartery disease. Journal of Molecular Medicine, 81. pp. 321-326.
