| Job Title | Contact | Location |
|---|---|---|
| Clinical Senior Lecturer |
Y dot Loke at uea dot ac dot uk
Tel: +44 (0)1603 59 1234 |
Medical School 2.06A |
Research interests
I am a co-convenor of the Cochrane Adverse Effects Methods Group, and my special interest is in developing methods for evaluating data on adverse effects.
My current teaching activity is aimed at the improving the prescribing skills of medical students. I was awarded a UEA Teaching Fellowship 2004 for work on reducing prescribing errors.
I am a member of the British Pharmacological Society Prescribing Committee, and have recently worked on the society funded project to publish a systematic review on educational interventions to improve prescribing (Br J Clin Pharmacol, in press).
Abdelhamid, AS, Loke, YK, Parekh, S, Chen, YF, Sutton, A, Eastwood, A, Holland, R and Song, F (2012) Use of indirect comparison methods in systematic reviews: a survey of Cochrane review authors. Research Synthesis Methods (Epub ahead of print).
Singh, S, Loke, YK, Spangler, JG and Furberg, CD (2011) Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis. CMAJ, 183 (12). pp. 1359-1366.
Song, F, Xiong, T, Parekh-Bhurke, S, Loke, YK, Sutton, AJ, Eastwood, AJ, Holland, R, Chen, Y-F, Glenny, A-M, Deeks, JJ and Altman, DG (2011) Inconsistency between direct and indirect comparisons of competing interventions: meta-epidemiological study. BMJ (343). d4909-d4909. ISSN 0959-8138
Loke, YK, Cavallazzi, R and Singh, S (2011) Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies. Thorax, 66 (8). pp. 699-708. ISSN 0040-6376
Mulder, RL, van Dalen, EC, Van den Hof, M, Bresters, D, Koot, BG, Castellino, SM, Loke, YK, Leclercq, E, Post, PN, Caron, HN, Postma, A and Kremer, LC (2011) Hepatic late adverse effects after antineoplastic treatment for childhood cancer. Cochrane Database System Review, 6 (7). CD008205.
Pirmohamed, M, Friedmann, PS, Molokhia, M, Loke, YK, Smith, C, Phillips, E, La Grenade, L, Carleton, B, Papaluca-Amati, M, Demoly, P and Shear, NH (2011) Phenotype Standardization for Immune-Mediated Drug-Induced Skin Injury. Clinical Pharmacology and Therapeutics, 11.
Singh, S, Loke, YK and Furberg, CD (2011) Long-term use of thiazolidinediones and the associated risk of pneumonia or lower respiratory tract infection: systematic review and meta-analysis. Thorax, 66 (5). pp. 383-388. ISSN 0040-6376
Alexandre, L, Broughton, T, Loke, Y and Beales, ILP (2011) Meta-analysis: risk of esophageal adenocarcinoma with medications which relax the lower esophageal sphincter. Diseases Of The Esophagus (Epub ahead of print).
Golder, S, Loke, YK and Bland, M (2011) Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview. PLoS Medicine, 8 (5).
Kwok, CS, Loke, YK, Hale, R, Potter, JF and Myint, PK (2011) Atrial fibrillation and incidence of dementia: A systematic review and meta-analysis. Neurology, 76 (10). pp. 914-922. ISSN 0028-3878
Loke, YK, Kwok, CS and Singh, S (2011) Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. British Medical Journal (BMJ), 342. d1309. ISSN 0959-8138
Singh, S, Loke, YK, Enright, PL and Furberg, CD (2011) Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials. BMJ, 342 (jun14 1). d3215-d3215. ISSN 0959-8138
Loke, YK, Kwok, CS, Niruban, A and Myint, PK (2010) Value of severity scales in predicting mortality from community-acquired pneumonia: systematic review and meta-analysis. Thorax, 65 (10). pp. 884-890. ISSN 0040-6376
Loke, YK, Kwok, CS and Singh, S (2010) Risk of myocardial infarction and cardiovascular death associated with inhaled corticosteroids in COPD. European Respiratory Journal, 35 (5). pp. 1003-1021.
Song, F, Parekh, S, Hooper, L, Loke, YK, Ryder, JJ, Sutton, AJ, Hing, C, Shing, C, Pang, C and Harvey, IM (2010) Dissemination and publication of research findings: an updated review of related biases. Health Technol Assess, 14 (8). pp. 1-220.
Kwok, CS and Loke, YK (2010) Meta-analysis: effects of proton pump inhibitors on cardiovascular events and mortality in patients receiving clopidogrel. Ailment Pharmacol Ther.
Khandanpour, N, Loke, YK, Meyer, F, Jennings, BA and Armon, MP (2009) Homocysteine and peripheral arterial disease: systematic review and meta-analysis. European Journal of Vascular and Endovascular Surgery, 38 (3). pp. 316-322.
Herxheimer, A., Clarke, M., Edwards, R., Jefferson, T. and Loke, Y. (2009) Time for case-control studies of NSAIDs and oseltamivir. BMJ, 339 (3). b3048-b3048. ISSN 0959-8138
Song, F, Loke, YK, Walsh, T, Glenny, AM, Eastwood, AJ and Altman, DG (2009) Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews. BMJ, 338 (3). b1147-b1147. ISSN 0959-8138
Golder, S and Loke, YK (2009) Search strategies to identify information on adverse effects: a systematic review. J Med Libr Assoc, 97 (2). pp. 84-92.
Khandanpour, N, Willis, G, Meyer, F, Armon, MP, Loke, YK, Wright, A, Finglas, P and Jennings, BA (2009) Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHRFR) C677T mutations: A case-control study and meta-analysis. Journal of Vascular Surgery, 49 (3). pp. 711-718.
Loke, YK, Jeevanantham, V and Singh, S (2009) Bisphosphonates and atrial fibrillation: systematic review and meta-analysis. Drug Safety, 32 (3). pp. 219-228.
Loke, YK, Singh, S and Furberg, CD (2009) Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ, 180 (1). pp. 32-39.
Ross, S and Loke, YK (2009) Do educational interventions improve prescribing by medical students and junior doctors? A systematic review. British Journal of Clinical Pharmacology, 67 (6). pp. 662-670.
Singh, S, Amin, AV and Loke, YK (2009) Long-term Use of Inhaled Corticosteroids and the Risk of Pneumonia in Chronic Obstructive Pulmonary Disease - A Meta-analysis. Archives of Internal Medicine, 169 (3). pp. 219-229.
Song, F, Loke, YK, Walsh, T, Glenny, AM, Eastwood, AJ and Altman, DG (2009) Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews. BMJ, 338 (b1147).
Song, F, Parekh-Bhurke, S, Hooper, L, Loke, YK, Sutton, AJ, Hing, CB and Harvey, IM (2009) Extent of publication bias in different categories of research cohorts: a meta-analysis of empirical studies. BMC Medical Research Methodology, 9. p. 79.
Holland, R, Loke, YK, Desborough, J, Wright, David, Hall, S and Goodyer, L (2008) Pharmacist-led medication review: response to Silcock & Petty. British Journal of Clinical Pharmacology, 66 (4). p. 576. ISSN 03065251
Golder, S, Loke, YK and McIntosh, HM (2008) Poor reporting and inadequate searches were apparent in systematic reviews of adverse effects. Journal of Clinical Epidemiology, 61 (5). pp. 440-448.
Ryder, J J, Garrison, K, Song, F, Hooper, L, Skinner, J, Loke, Y, Loughlin, J, Higgins, J P T and Macgregor, AJ (2008) Genetic associations in peripheral joint osteoarthritis and spinal degenerative disease: a systematic review. Annals of the Rheumatic Diseases, 67 (5). pp. 584-591. ISSN 0003-4967
Holland, RC, Desborough, J, Goodyer, L, Hall, S, Wright, David and Loke, YK (2008) Does pharmacist-led medication review help to reduce hospital admissions and deaths in older people? A systematic review and meta-analysis. British Journal of Clinical Pharmacology, 65 (3). pp. 303-316.
Golder, S and Loke, YK (2008) Is there evidence for biased reporting of published adverse effects data in pharmaceutical industry-dunded studies? British Journal of Clinical Pharmacology, 66 (6). pp. 767-773.
Loke, YK, Trivedi, A and Singh, S (2008) Meta-analysis: Gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Alimentary Pharmacology and Therapeutics, 27 (1). pp. 31-40.
Singh, S and Loke, YK (2008) The safety of rosiglitazone in the treatment of type 2 diabetes. Expert Opin Drug Saf, 7 (5). pp. 579-585.
Singh, S, Loke, YK and Furberg, CD (2008) Inhaled anticholonergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA, 300 (12). pp. 1439-1450.
Gray, E, Ullah, S, Lwin, A, Javed, S, Farrow, C, Southgate, J, Jenkins, P and Loke, YK (2007) Prescription Errors in Patients on an Acute Medical Assessment Unit. Royal College of Physicians of Edinburgh, 37. pp. 305-308.
Loke, YK, Price, D and Herxheimer, A (2007) Systematic reviews of adverse effects: framework for a structures approach. BMC Medical Research Methodology, 7 (1). p. 32.
Singh, S, Loke, YK and Furberg, C (2007) Long-term Risk of Cardiovascular Events with Rosiglitazone - A Systematic review and Meta-analysis. JAMA, 298 (10). pp. 1189-1195.
Singh, S, Loke, YK and Furberg, CD (2007) Thiazolidinediones and Heart Failure: A Teleo-Anaylsis. Diabetes Care, 30 (8). pp. 2148-2153.
Vivancos, R, Schelenz, S and Loke, YK (2007) Internet treatment of sexually transmitted infections - a public health hazard? BMC Public Health, 7 (147). p. 333.
Golder, S, Loke, YK and McIntosh, HM (2006) Room for improvement? A survey of the methods used in systematic reviews of adverse effects. BMC Medical Research Methodology, 6 (1). p. 3.
Golder, SP, McIntosh, HM and Loke, YK (2006) Identifying systematic reviews of the adverse effects of health care interventions. BMC Medical Research Methodology, 6 (1). p. 22.
Loke, YK, Price, D, Derry, S and Aronson, JK (2006) Case reports of suspected adverse drug reactions--systematic literature survey of follow-up. British Medical Journal, 332 (7537). pp. 335-339.
Singh, S and Loke, YK (2006) Statins and pancreatitis: a systematic review of observational studies and spontaneous case reports. Drug Safety, 29 (12). pp. 1123-1132.
Loke, YK, Derry, S and Aronson, JK (2004) A comparison of three different sources of data in assessing the frequencies of adverse reactions to amiodarone. British Journal of Clinical Pharmacology, 57 (5). pp. 616-621.
Mills, E, Loke, YK, Wu, P, Montori, VM, Perri, D, Moher, D and Guyatt, G (2004) Determining the reporting quality of RCTs in clinical pharmacology. British Journal of Clinical Pharmacology, 58 (1). pp. 61-65.
Loke, YK, Bell, A and Derry, S (2003) Aspirin for the prevention of cardiovascular disease: calculating benefit and harm in the individual patient. British Journal of Clinical Pharmacology, 55 (3). pp. 282-287.
Loke, YK and Derry, S (2003) Does anybody read evidence-based articles? BMC Medical Research Methodology, 3 (1). p. 14.
Loke, YK and Derry, S (2002) Air travel and venous thrombosis: how much help might aspirin be? MedGenMed, 4. p. 3.
Loke, YK, Derry, S and Pritchard-Copley, A (2002) Appetite suppressants and valvular heart disease - a systematic review. BMC Clin Pharmacol, 2 (1). p. 6.
Derry, S, Loke, YK and Aronson, JK (2001) Incomplete evidence: the inadequacy of databases in tracing published adverse drug reactions in clinical trials. BMC Medical Research Methodology, 1. p. 7.
Loke, YK and Derry, S (2001) Reporting of adverse drug reactions in randomised controlled trials - a systematic survey. BMC Clin Pharmacol, 1 (1). p. 3.
Derry, S, Edwards, JE, Loke, YK, Moore, RA and McQuay, HJ (2000) Risk of gastrointestinal haemorrhage with long term use of aspirin: met-analysis. BMJ, 321 (7270). pp. 1183-1187.
Loke, YK, Das, D and Tan, MH (1998) An unusual case of oesophagopleural fistula. Med J Mal, 54. pp. 183-185.
Loke, YK, Murugesan, E, Suryati, A and Tan, MH (1998) An outbreak of rabies in dogs in the state of Terengganu 1995-1996. Med J Mal, 54. pp. 97-99.
Loke, YK and Tan, MH (1998) A case of Munchausen syndrome. Med J Mal, 54. pp. 181-183.
Loke, YK and Tan, MH (1998) An unusual case of Wegener's Granulomatosis. Med J Mal, 54. pp. 107-109.
Loke, YK, Tee, MH and Tan, MH (1998) Decompression illness associated with underwater logging: 6 case reports from Kenyor Lake, Malaysia. Med J Mal, 54. pp. 100-1003.
Loke, YK, Gunn, A and Tan, MH (1997) Endoscopic findings in pateinst with suspected upper gastintestinal haemorrhage in Terengganu, Malaysia. Med J Mal, 4. pp. 20-22.
Loke, YK, Hwang, SL and Tan, MH (1997) Delays in thrombolytic therapy in acute myocardial infarction: an audit from the east coast of peninsular Malaysia. Ann Acad Med Singapore, 3. pp. 285-289.
Loke, YK, Lai, VM, Tan, MH and Gunn, A (1997) Bizarre ECG in head injury mimicking ventricular tachycardia. Singapore Med J, 4. pp. 166-168.
Loke, YK and Tan, MH (1997) A unique case of tetrodotoxin poisoning. Med J Mal, 2. pp. 172-174.
Loke, YK Single dose piroxicam in acute postoperative pain: a quantitative systematic review (Cochrane Review). In: The Cochrame Library, Issue 4. Oxford: Update Software.
Joshi, N, Loke, Y and Macgregor, A (2010) The Reproductive Safety of Disease Modifying Anti-Rheumatic Drugs and Biologic Agents in Men: A Systematic Review. In: Annual Meeting of the British-Society-Rheumatology/Spring Meeting of British-Health-Professional-in-Rheumatology, 21-23 April 2010, Birmingham, England.
Alexandre, L, Broughton, T, Loke, Y and Beales, I (2010) Risk of oesophageal adenocarcinoma with medications which relax the lower oesophageal sphincter: a meta-analysis. Gut 2010;59(Suppl 111). In: United European Gastroenterology Week, October 2010, Barcelona.
Jeevanantham, V, Loke, Y and Singh, S (2008) Bisphosphonates and the risk of atrial fibrillation: A systematic review and meta-analysis. In: 31st Annual Meeting of the Society-of-General-Internal-Medicine, 09-12 April 2008, Pittsburgh, PA.
Singh, S, Loke, Y and Furberg, CD (2008) Long-term use of thiazolidinediones and fractures in type 2 diabetes: a systematic review and meta-analysis. In: 31st Annual Meeting of the Society-of-General-Internal-Medicine, 09-12 April 2008, Pittsburgh, PA.
Duvendack, M, Palmer-Jones, R, Copestake, JG, Hooper, L, Loke, Y and Rao, N (2011) What is the evidence of the impact of microfinance on the well-being of poor people? EPPI-Centre, Social Science Research Unit, Institute of Education, University of London, London.
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