Dr Stephanie Schuller

Job Title	Contact	Location
Lecturer in Infection & Immunity	S dot Schuller at uea dot ac dot uk Tel: 01603 255282	Medical School

Personal
Research
Publications

Biography

Career

Lecturer, University of East Anglia, Oct 2010-present
Research Associate, University College London, 2001–2010
Research Associate, Netherlands Cancer Institute, Amsterdam, 1999-2001
Research Associate, Imperial College London, 1997-1999

Academic Background

PhD, University of Würzburg, Germany, 1997
Diplom, University of Marburg, Germany, 1994

Key Research Interests

Enteropathogenic (EPEC) and enterohaemorrhagic E. coli (EHEC) are major causes of infant diarrhoea. EHEC infection can also lead to the development of potentially fatal haemolytic uraemic syndrome (HUS). Major bacterial virulence factors include a type III secretion system which mediates translocation of bacterial effector proteins into the host cell. These effectors lead to extensive modification of host cell signalling which ultimately results in diarrhoea. EHEC also produce Shiga toxins (Stx) which are associated with HUS and highly cytotoxic to renal microvasculature. Our research aims at understanding EPEC- and EHEC-mediated pathogenesis by using in vitro and ex vivo model systems that closely mimic the environment in the human gut. Particular interests include Stx translocation across the intestinal epithelial barrier and the influence of low oxygen on virulence gene expression.

Jump to: Article

Number of items: 21.

Article

Schuller, Stephanie (2011) Shiga Toxin Interaction with Human Intestinal Epithelium. Toxins, 3 (6). pp. 626-639. ISSN 2072-6651

Schuller, S and Phillips, AD (2010) Microaerobic conditions enhance type 111 secretion and adherence of enterohaemorrhagic Escherichia coli to polarized human intestinal epithelial cells. Environmental Microbiology, 12 (9). pp. 2426-2435.

Crepin, Valérie F., Girard, Francis, Schuller, Stephanie, Phillips, Alan D., Mousnier, Aurelie and Frankel, Gad (2010) Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathwaysin vivo. Molecular Microbiology, 75 (2). pp. 308-323. ISSN 0950382X

Saldana, Z., Erdem, A. L., Schuller, S., Okeke, I. N., Lucas, M., Sivananthan, A., Phillips, A. D., Kaper, J. B., Puente, J. L. and Giron, J. A. (2009) The Escherichia coli Common Pilus and the Bundle-Forming Pilus Act in Concert during the Formation of Localized Adherence by Enteropathogenic E. coli. Journal of Bacteriology, 191 (11). pp. 3451-3461. ISSN 0021-9193

Schuller, Stephanie, Lucas, Mark, Kaper, James B., Girón, Jorge A. and Phillips, Alan D. (2009) The ex vivo response of human intestinal mucosa to enteropathogenic Escherichia coli infection. Cellular Microbiology, 11 (3). pp. 521-530. ISSN 14625814

Bai, L, Schuller, S, Whale, A, Mousnier, A, Marches, O, Wang, L, Ooka, T, Heuschkel, R, Torrente, F, Kaper, JB, Gomes, TA, Xu, J and Phillips, AD (2008) Enteropathogenic Escherichia coli O125:H6 triggers attaching and effacing lesions on human intestinal biopsy specimens independently of Nck and TccP/TccP2. Infect Immun, 76. pp. 361-368.

Mousnier, A., Whale, A. D., Schuller, S., Leong, J. M., Phillips, A. D. and Frankel, G. (2008) Cortactin Recruitment by Enterohemorrhagic Escherichia coli O157:H7 during Infection In Vitro and Ex Vivo. Infection and Immunity, 76 (10). pp. 4669-4676. ISSN 0019-9567

Zilbauer, Matthias, Dorrell, Nick, Elmi, Abdi, Lindley, Keith J., Schuller, Stephanie, Jones, Hannah E., Klein, Nigel J., Núňez, Gabriel, Wren, Brendan W. and Bajaj-Elliott, Mona (2007) A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni. Cellular Microbiology, 9 (10). pp. 2404-2416. ISSN 1462-5814

Whale, A. D., Hernandes, R. T., Ooka, T., Beutin, L., Schuller, S., Garmendia, J., Crowther, L., Vieira, M. A. M., Ogura, Y., Krause, G., Phillips, A. D., Gomes, T. A. T., Hayashi, T. and Frankel, G. (2007) TccP2-mediated subversion of actin dynamics by EPEC 2 - a distinct evolutionary lineage of enteropathogenic Escherichia coli. Microbiology, 153 (6). pp. 1743-1755. ISSN 1350-0872

Schuller, Stephanie, Chong, Yuwen, Lewin, Jackie, Kenny, Brendan, Frankel, Gad and Phillips, Alan D. (2007) Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture models. Cellular Microbiology, 9 (5). pp. 1352-1364. ISSN 1462-5814

Mundy, R., Schuller, S., Girard, F., Fairbrother, J. M., Phillips, A. D. and Frankel, G. (2007) Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropism. Microbiology, 153 (4). pp. 959-967. ISSN 1350-0872

Schuller, Stephanie, Heuschkel, Robert, Torrente, Franco, Kaper, James B. and Phillips, Alan D. (2007) Shiga toxin binding in normal and inflamed human intestinal mucosa. Microbes and Infection, 9 (1). pp. 35-39. ISSN 12864579

Dean, P., Maresca, M, Schuller, S, Phillips, AD and Kenny, B (2006) Potent diarrheagenic mechanism mediated by the cooperative action of three enteropathogenic Escherichia coli-injected effector proteins. Proceedings of the National Academy of Sciences, 103 (6). pp. 1876-1881. ISSN 0027-8424

Marches, O., Wiles, S., Dziva, F., La Ragione, R. M., Schuller, S., Best, A., Phillips, A. D., Hartland, E. L., Woodward, M. J., Stevens, M. P. and Frankel, G. (2005) Characterization of Two Non-Locus of Enterocyte Effacement-Encoded Type III-Translocated Effectors, NleC and NleD, in Attaching and Effacing Pathogens. Infection and Immunity, 73 (12). pp. 8411-8417. ISSN 0019-9567

Garmendia, Junkal, Phillips, Alan D., Carlier, Marie-France, Chong, Yuwen, Schuller, Stephanie, Marches, Olivier, Dahan, Sivan, Oswald, Eric, Shaw, Rob K., Knutton, Stuart and Frankel, Gad (2004) TccP is an enterohaemorrhagic Escherichia coli O157:H7 type III effector protein that couples Tir to the actin-cytoskeleton. Cellular Microbiology, 6 (12). pp. 1167-1183. ISSN 1462-5814

Phillips, AD, Brown, A, Swallow, DM, Hicks, S, Schuller, S, Murch, SH and Walker-Smith, JA (2004) Acetylated sialic acid residues and blood group antigens localise within the epithelium in microvillous atrophy indicating internal accumulation of the glycocalyx. Gut, 53 (12). pp. 1764-1771. ISSN 0017-5749

Schuller, Stephanie, Frankel, Gad and Phillips, Alan D. (2004) Interaction of Shiga toxin from Escherichia coli with human intestinal epithelial cell lines and explants: Stx2 induces epithelial damage in organ culture. Cellular Microbiology, 6 (3). pp. 289-301. ISSN 1462-5814

Schuller, Stephanie, Neefjes, Jacques, Ottenhoff, Tom, Thole, Jelle and Young, Douglas (2001) Coronin is involved in uptake of Mycobacterium bovis BCG in human macrophages but not in phagosome maintenance. Cellular Microbiology, 3 (12). pp. 785-793. ISSN 1462-5814

Kügler, S, Schuller, S and Goebel, W (1997) Involvement of MAP-kinases and -phosphatases in uptake and intracellular replication of Listeria monocytogenes in J774 macrophage cells. FEMS Microbiology Letters, 157 (1). pp. 131-136. ISSN 03781097

Sokolovic, Z, Schuller, S, Bohne, J, Baur, A, Rdest, U, Dickneite, C, Nichterlein, T and Goebel, W (1996) Differences in virulence and in expression of PrfA and PrfA-regulated virulence genes of Listeria monocytogenes strains belonging to serogroup 4. Infection and immunity, 64 (10). pp. 4008-4019. ISSN 0019-9567

Schwan, W R, Kügler, S, Schuller, S, Kopecko, D J and Goebel, W (1996) Detection and characterization by differential PCR of host eukaryotic cell genes differentially transcribed following uptake of intracellular bacteria. Infection and immunity, 64 (1). pp. 91-99. ISSN 0019-9567

This list was generated on Thu Apr 4 23:37:19 2013 BST.

UEA

Academic

Norwich Medical School