Prof Marcus Flather
| Job Title | Contact | Location |
|---|---|---|
| Clinical Professor in Medicine |
M dot Flather at uea dot ac dot uk
Tel: +44 (0)1603 59 1420 |
(43) Floor 1 |
Biography
In 1993 he moved to McMaster University in Hamilton, Canada, to work with Salim Yusuf as a Clinical Research Scholar on international trials in acute coronary syndromes including the OASIS programme, and undertook formal training in clinical trials and epidemiology. In 1996 he took up the post of Director of the new Clinical Trials and Evaluation Unit (CTEU) at the Royal Brompton and Harefield Hospitals where the Unit developed an international reputation in the design and management of randomised trials in cardiovascular and respiratory diseases.
In September 2011 he took up the post of Professor of Medicine and Clinical Trials at the University of East Anglia and Director of Research at the Norfolk and Norwich University Hospitals NHS Foundation Trust in Norwich. Marcus Flather is a Fellow of the Royal College of Physicians (UK) and holds a certificate of higher specialist training in Cardiology and General (Internal) Medicine in the UK (CCST). He has about 200 peer reviewed publications, is a recognised expert in clinical trials and has more than 20 years experience of collaborating with industry partners in drug and device development.
Article
Kotecha, D, New, G, Collins, P, Eccleston, D, Krum, H, Pepper, J and Flather, MD (2012) Radial artery pulse wave analysis for non-invasive assessment of coronary artery disease. International journal of cardiology. ISSN 1874-1754
Flather, MD, Babalis, D, Booth, J, Bardaji, A, Machecourt, J, Opolski, G, Ottani, F, Bueno, H, Banya, W, Brady, AR, Bojestig, M and Lindahl, B (2011) Cluster-randomized trial to evaluate the effects of a quality improvement program on management of non–ST-elevation acute coronary syndromes: The European Quality Improvement Programme for Acute Coronary Syndromes (EQUIP-ACS). American Heart Journal, 162 (4). 700-707.e1. ISSN 00028703
von Haehling, S, van Veldhuisen, DJ, Roughton, M, Babalis, D, de Boer, RA, Coats, AJ, Manzano, L, Flather, MD and Anker, SD (2011) Anaemia among patients with heart failure and preserved or reduced ejection fraction: results from the SENIORS study. European Journal of Heart Failure, 13 (6). pp. 656-663. ISSN 1388-9842
O'Donoghue, ML, Bhatt, DL, Wiviott, SD, Goodman, SG, Fitzgerald, DJ, Angiolillo, DJ, Goto, S, Montalescot, G, Zeymer, U, Aylward, PE, Guetta, V, Dudek, D, Ziecina, R, Contant, CF and Flather, MD (2011) Safety and Tolerability of Atopaxar in the Treatment of Patients With Acute Coronary Syndromes: The Lessons From Antagonizing the Cellular Effects of Thrombin-Acute Coronary Syndromes Trial. Circulation, 123 (17). pp. 1843-1853. ISSN 0009-7322
Manzano, L, Babalis, D, Roughton, M, Shibata, M, Anker, SD, Ghio, S, van Veldhuisen, DJ, Cohen-Solal, A, Coats, AJ, Poole-Wilson, PPA and Flather, MD (2011) Predictors of clinical outcomes in elderly patients with heart failure. European Journal of Heart Failure, 13 (5). pp. 528-536. ISSN 1388-9842
Ambrosio, G, Flather, MD, Bohm, M, Cohen-Solal, A, Murrone, A, Mascagni, F, Spinucci, G, Conti, MG, van Veldhuisen, DJ, Tavazzi, L and Coats, AJ (2011) B-blockade with nebivolol for prevention of acute ischaemic events in elderly patients with heart failure. Heart, 97 (3). pp. 209-214. ISSN 1355-6037
Yusuf, S, Healey, JS, Pogue, J, Chrolavicius, S, Flather, M, Hart, RG, Hohnloser, SH, Joyner, CD, Pfeffer, MA and Connolly, SJ (2011) Irbesartan in patients with atrial fibrillation. The New England journal of medicine, 364 (10). pp. 928-938. ISSN 1533-4406
Wallentin, L, Yusuf, S, Ezekowitz, MD, Alings, M, Flather, M, Franzosi, MG, Pais, P, Dans, A, Eikelboom, J, Oldgren, J, Pogue, J, Reilly, PA, Yang, S and Connolly, SJ (2010) Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. The Lancet, 376 (9745). pp. 975-983. ISSN 01406736
Taggart, DP, Altman, DG, Gray, AM, Lees, B, Nugara, F, Yu, L-M., Campbell, H and Flather, M (2010) Randomized trial to compare bilateral vs. single internal mammary coronary artery bypass grafting: 1-year results of the Arterial Revascularisation Trial (ART). European Heart Journal, 31 (20). pp. 2470-2481. ISSN 0195-668X
van Veldhuisen, DJ, Cohen-Solal, A, Bohm, M, Anker, SD, Babalis, D, Roughton, M, Coats, AJ, Poole-Wilson, PA, Flather, MD and SENIORS, Investigators (2009) Beta blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: Data From SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure). J Am Coll Cardiol, 53 (23). pp. 2150-2158.
Crossman, DC, Morton, AC, Gunn, JP, Greenwood, JP, Hall, AS, Fox, KAA, Lucking, AJ, Flather, MD, Lees, B and Foley, CE (2008) Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA-HEART Study). Trials, 9 (1). p. 8. ISSN 1745-6215
Di Mario, C, Dudek, D, Piscione, F, Mielecki, W, Savonitto, S, Murena, E, Dimopoulos, K, Manari, A, Gaspardone, A, Ochala, A, Zmudka, K, Bolognese, L, Steg, PG and Flather, MD (2008) Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the Combined Abciximab REteplase Stent Study in Acute Myocardial Infarction (CARESS-in-AMI): an open, prospective, randomised, multicentre trial. The Lancet, 371 (9612). pp. 559-568. ISSN 01406736
Elkeles, RS, Godsland, IF, Feher, MD, Rubens, MB, Roughton, M, Nugara, F, Humphries, SE, Richmond, W and Flather, MD (2008) Coronary calcium measurement improves prediction of cardiovascular events in asymptomatic patients with type 2 diabetes: the PREDICT study. European Heart Journal, 29 (18). pp. 2244-2251. ISSN 0195-668X
Yao, G, Freemantle, N, Flather, M, Tharmanathan, P, Coats, AJ, Poole-Wilson, PA and SENIORS, Investigators (2008) Long-term cost-effectiveness analysis of nebivolol compared with standard care in elderly patients with heart failure: an individual patient-based simulation model. Pharmacoeconomics, 26 (10). pp. 879-889.
Faris, R, Flather, MD, Purcell, H, Poole-Wilson, PA and Coats, AJ (2006) Diuretics for heart failure. Cochrane Database of Systematic Reviews 2006, 1. CD003838.
Flather, MD, Poole-Wilson, PA and Coats, AJ (2006) Beta blockers and heart failure in older people. European Heart Journal, 27. p. 888.
Flather, MD, Shibata, MC, Coats, AJ, van Veldhuisen, DJ, Parkhomenko, A, Borbola, J, Cohen-Solal, A, Dumitrascu, D, Ferrari, R, Lechat, P, Soler-Soler, J, Tavazzi, L, Spinarova, L, Toman, J, Bohm, M, Anker, SD, Thompson, SG and Poole-Wilson, PA (2005) Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). European Heart Journal, 26 (3). pp. 215-225.
Collinson, J, Flather, M, Coats, AJ, Pepper, JR and Heneim, M (2004) Influence of valve prosthesis type on the recovery of ventricular dysfunction and subendocardial ischaemia folloeing valve replacement for aortic stenosis. International Journal of Cardiology, 97 (3). pp. 535-641.
Faris, R, Flather, M, Purcell, H, Henein, M, Poole-Wilson, P and Coats, A (2002) Current evidence supporting the role of diuretics in heart failure: a meta analysis of randomised controlled trials. International Journal of Cardiology, 82 (2). pp. 149-158. ISSN 01675273
Shamim, W, Yousufuddin, M, Xiao, HB, Flather, M, Henein, M, Gibson, D and Coats, AJ (2002) Septal q waves as an indicator of risk of mortality in elderly patients with chronic heart failure. Am Heart J, 144 (4). pp. 740-744.
Shibata, MC, Flather, MD, Bohm, M, Borbola, J, Cohen-Solal, A, Dumitrascu, D, Ferrari, R, Lechat, P, Parkhomenko, A, Soler-Soler, J, Tavazzi, L, Toman, J, van Veldhuisen, DJ, Coats, AJ and Poole-Wilson, PA (2002) Study of the Effects of Nebivolol Intervention on Outcomes and Rehospitalisation in Seniors with heart Failure. (SENIORS). Rationale and design. International Journal of Cardiology, 86 (1). pp. 77-85.
Yousufuddin, M, Henein, My, Flather, M, Wang, D, Shamim, W, O'Sullivan, C, Kemp, M, Kazzam, E, Banner, NR, Amrani, M and Coats, AJ (2001) Incremental importance of peak-exercise plasma levels of endothelin-1 and natriuretic peptides in chronic heart failure. J Cardiovasc Pharmacol, 38 (3). pp. 468-473.
