Article

Springer, J, Tschirner, A, Hartman, K, Palus, S, Wirth, EK, Busquets Ruis, S, Möller, N, von Haehling, S, Argiles, JM, Köhrle, J, Adams, V, Anker, SD and Doehner, W (2012) Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia. International Journal of Cancer (Epub ahead of print). ISSN 00207136

von Haehling, S, Schefold, JC, Jankowska, EA, Springer, J, Vazir, A, Kalra, PR, Sandek, A, Fauler, G, Stojakovic, T, Trauner, M, Ponikowski, P, Volk, H-D, Doehner, W, Coats, AJ, Poole-Wilson, PA and Anker, SD (2012) Ursodeoxycholic Acid in Patients With Chronic Heart Failure: A Double-Blind, Randomized, Placebo-Controlled, Crossover Trial. Journal of the American College of Cardiology, 59 (6). pp. 585-592. ISSN 07351097

Stadler, K, Palus, S, Schur, R, Akashi, YJ, Bockmeyer, B, Datta, R, Halem, H, Dong, J, Culler, MD, Adams, V, Anker, SD and Springer, JJ (2011) Ghrelin and Its Analogues, BIM-28131 and BIM-28125, Improve Body Weight and Regulate the Expression of MuRF-1 and MAFbx in a Rat Heart Failure Model. PLoS ONE, 6 (11). e26865. ISSN 1932-6203

Rokutan, Hirofumi, Suckow, Christian, von Haehling, Stephan, Strassburg, Sabine, Bockmeyer, Barbara, Doehner, Wolfram, Waller, Christiane, Bauersachs, Johann, von Websky, Karoline, Hocher, Berthold, Anker, Stefan D and Springer, Jochen (2011) Furosemide induces mortality in a rat model of chronic heart failure. International journal of cardiology, Epub ahead of print. ISSN 1874-1754

Kung, Thomas, Szabó, Tibor, Springer, Jochen, Doehner, Wolfram, Anker, Stefan D and von Haehling, Stephan (2011) Cachexia in heart disease: highlights from the ESC 2010. Journal of cachexia, sarcopenia and muscle, 2 (1). pp. 63-69. ISSN 2190-6009

Schmidt, K, Von Haehling, S, Doehner, W, Palus, S, Anker, SD and Springer, J (2011) IGF-1 treatment reduces weight loss and improves outcome in a rat model of cancer cachexia. J Cachex Sarcopenia Muscle. (In Press)

Sandek, Anja, Bjarnason, Ingvar, Volk, Hans-Dieter, Crane, Roger, Meddings, Jonathan B, Niebauer, Josef, Kalra, Paul R, Buhner, Sabine, Herrmann, Ralph, Springer, Jochen, Doehner, Wolfram, von Haehling, Stephan, Anker, Stefan D and Rauchhaus, Mathias (2010) Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure. International journal of cardiology, Epub ahead of print. ISSN 1874-1754

Groneberg, David A, Scutaru, Cristian, Lauks, Mathias, Takemura, Masaya, Fischer, Tanja C, Kölzow, Silvana, van Mark, Anke, Uibel, Stefanie, Wagner, Ulrich, Vitzthum, Karin, Beck, Fabian, Mache, Stefanie, Kreiter, Carolin, Kusma, Bianca, Friedebold, Annika, Zell, Hanna, Gerber, Alexander, Bock, Johanna, Al-Mutawakl, Khaled, Donat, Johannes, Geier, Maria, Pilzner, Carolin, Welker, Pia, Joachim, Ricarda, Bias, Harald, Götting, Michael, Sakr, Mohannad, Addicks, Johann P, Börger, Julia-Annik, Jensen, Anna-Maria, Grajewski, Sonja, Shami, Awfa, Neye, Niko, Kröger, Stefan, Hoffmann, Sarah, Kloss, Lisa, Mayer, Sebastian, Puk, Clemens, Henkel, Ulrich, Rospino, Robert, Schilling, Ute, Krieger, Evelyn, Westphal, Gesa, Meyer-Falcke, Andreas, Hupperts, Hagen, de Roux, Andrés, Tropp, Salome, Weiland, Marco, Mühlbach, Janette, Steinberg, Johannes, Szerwinski, Anne, Falahkohan, Sepiede, Sudik, Claudia, Bircks, Anna, Noga, Oliver, Dickgreber, Nicolas, Dinh, Q Thai, Golpon, Heiko, Kloft, Beatrix, Groneberg, Rafael, Witt, Christian, Wicker, Sabine, Zhang, Li, Springer, Jochen, Kütting, Birgitta, Mingomataj, Ervin C, Fischer, Axel, Schöffel, Norman, Unger, Volker and Quarcoo, David (2010) Mobile Air Quality Studies (MAQS)-an international project. Journal of Occupational Medicine and Toxicology, 5 (1). p. 8. ISSN 1745-6673

Springer, J., Anker, S. D. and Doehner, W. (2010) Adiponectin Resistance in Heart Failure and the Emerging Pattern of Metabolic Failure in Chronic Heart Failure. Circulation: Heart Failure, 3 (2). pp. 181-182. ISSN 1941-3289

Springer, Jochen, Adams, Volker and Anker, Stefan D (2010) Myostatin: Regulator of muscle wasting in heart failure and treatment target for cardiac cachexia. Circulation, 121 (3). pp. 354-356. ISSN 1524-4539

Kung, Thomas, Springer, Jochen, Doehner, Wolfram, Anker, Stefan D and von Haehling, Stephan (2010) Novel treatment approaches to cachexia and sarcopenia: highlights from the 5th Cachexia Conference. Expert opinion on investigational drugs, 19 (4). pp. 579-585. ISSN 1744-7658

Akashi, Yoshihiro J., Palus, Sandra, Datta, Rakesh, Halem, Heather, Taylor, John E., Thoene-Reineke, Christa, Dong, Jesse, Thum, Thomas, Culler, Michael D., Anker, Stefan D. and Springer, Jochen (2009) No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure. International Journal of Cardiology, 137 (3). pp. 267-275. ISSN 01675273

Gratze, Petra, Boschmann, Michael, Dechend, Ralf, Qadri, Fatimunnisa, Malchow, Jeanette, Graeske, Sabine, Engeli, Stefan, Janke, Jürgen, Springer, Jochen, Contrepas, Aurelie, Plehm, Ralph, Klaus, Susanne, Nguyen, Genevieve, Luft, Friedrich C and Muller, Dominik N (2009) Energy metabolism in human renin-gene transgenic rats: does renin contribute to obesity? Hypertension, 53 (3). pp. 516-523. ISSN 1524-4563

Palus, Sandra, Akashi, Yoshihiro, von Haehling, Stephan, Anker, Stefan D. and Springer, Jochen (2009) The influence of age and sex on disease development in a novel animal model of cardiac cachexia. International Journal of Cardiology, 133 (3). pp. 388-393. ISSN 01675273

Spintzik, Jessica, Springer, Jochen and Westermann, Bettina (2009) Morphological and histological organization of the pyriform appendage of the tetrabranchiate Nautilus pompilius (Cephalopoda, Mollusca). Journal of morphology, 270 (4). pp. 459-468. ISSN 1097-4687

Wright, James M., von Haehling, Stephan, Schefold, Joerg C., Jankowska, Ewa, Doehner, Wolfram, Springer, Jochen, Strohschein, Kristin, Genth-Zotz, Sabine, Volk, Hans-Dieter, Poole-Wilson, Philip and Anker, Stefan D. (2009) Leukocyte Redistribution: Effects of Beta Blockers in Patients with Chronic Heart Failure. PLoS ONE, 4 (7). e6411. ISSN 1932-6203

von Haehling, Stephan, Lainscak, Mitja, Springer, Jochen and Anker, Stefan D. (2009) Cardiac cachexia: A systematic overview. Pharmacology & Therapeutics, 121 (3). pp. 227-252. ISSN 01637258

DOEHNER, W, Springer, J, LANDMESSER, U, STRUTHERS, A and ANKER, S (2008) Uric acid in chronic heart failure — current pathophysiological concepts☆. European Journal of Heart Failure, 10 (12). pp. 1269-1270. ISSN 13889842

VONHAEHLING, S, SCHEFOLD, J, Springer, J and ANKER, S (2008) The Cholesterol Paradox Revisited: Heart Failure, Systemic Inflammation, and Beyond. Heart Failure Clinics, 4 (2). pp. 141-151. ISSN 15517136

Springer, J, Groneberg, D. A., Dinh, Q. T., Quarcoo, D., Hamelmann, E., Braun-Dullaeus, R. C., Geppetti, P., Anker, S. D. and Fischer, A. (2007) Neurokinin-1 receptor activation induces reactive oxygen species and epithelial damage in allergic airway inflammation. Clinical & Experimental Allergy, 37 (12). pp. 1788-1797. ISSN 0954-7894

Akashi, Yoshihiro J., Springer, Jochen, Lainscak, Mitja and Anker, Stefan D. (2007) Atrial natriuretic peptide and related peptides. Clinical Chemistry and Laboratory Medicine, 45 (10). pp. 1259-1267. ISSN 1434-6621

Gazzieri, David, Trevisani, Marcello, Springer, Jochen, Harrison, Selena, Cottrell, Graeme S., Andre, Eunice, Nicoletti, Paola, Massi, Daniela, Zecchi, Sandra and Nosi, Daniele (2007) Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury. Free Radical Biology and Medicine, 43 (4). pp. 581-589. ISSN 08915849

Lainscak, Mitja, von Haehling, Stephan, Springer, Jochen and Anker, Stefan D (2007) Biomarkers for chronic heart failure. Heart failure monitor, 5 (3). pp. 77-82. ISSN 1470-8590

Springer, Jochen, von Haehling, Stephan and Anker, Stefan D (2006) The need for a standardized definition for cachexia in chronic illness. Nature Clinical Practice Endocrinology & Metabolism, 2 (8). pp. 416-417. ISSN 1745-8366

Springer, Jochen, Filippatos, Gerasimos, Akashi, Yoshihiro J and Anker, Stefan D (2006) Prognosis and therapy approaches of cardiac cachexia. Current Opinion in Cardiology, 21 (3). pp. 229-233. ISSN 0268-4705

Dinh, Q. T., Cryer, A., Dinh, S., Peiser, C., Wu, S., Springer, J., Hamelmann, E., Klapp, B. F., Heppt, W. and Fischer, A. (2005) Transcriptional up-regulation of histamine receptor-1 in epithelial, mucus and inflammatory cells in perennial allergic rhinitis. Clinical <html_ent glyph="@amp;" ascii="&amp;"/> Experimental Allergy, 35 (11). pp. 1443-1448. ISSN 0954-7894

STRASSBURG, S, Springer, J and ANKER, S (2005) Muscle wasting in cardiac cachexia. The International Journal of Biochemistry & Cell Biology, 37 (10). pp. 1938-1947. ISSN 13572725

Springer, Jochen, Ruth, Peter, Beuerlein, Knut, Palus, Sandra, Schipp, Rudolf and Westermann, Bettina (2005) Distribution and function of biogenic amines in the heart of Nautilus pompilius L. (Cephalopoda, Tetrabranchiata). Journal of Molecular Histology, 36 (5). pp. 345-353. ISSN 1567-2379

Springer, J, GRONEBERG, D, PREGLA, R and FISCHER, A (2005) Inflammatory cells as source of tachykinin-induced mucus secretion in chronic bronchitis. Regulatory Peptides, 124 (1-3). pp. 195-201. ISSN 01670115

Springer, J, PLEIMES, D, SCHOLZ, F and FISCHER, A (2005) Substance P mediates AP-1 induction in A549 cells via reactive oxygen species. Regulatory Peptides, 124 (1-3). pp. 99-103. ISSN 01670115

Akashi, Yoshihiro J., Springer, Jochen and Anker, Stefan D. (2005) Cachexia in chronic heart failure: Prognostic implications and novel therapeutic approaches. Current Heart Failure Reports, 2 (4). pp. 198-203. ISSN 1546-9530

Dinh, Q. T., Groneberg, D. A., Peiser, C., Springer, J., Joachim, R. A., Arck, P. C., Klapp, B. F. and Fischer, A. (2004) Nerve growth factor-induced substance P in capsaicin-insensitive vagal neurons innervating the lower mouse airway. Clinical <html_ent glyph="@amp;" ascii="&amp;"/> Experimental Allergy, 34 (9). pp. 1474-1479. ISSN 0954-7894

Springer, J, Okonko, DO and Anker, SD (2004) Vagal Nerve Stimulation in Chronic Heart Failure: An Antiinflammatory Intervention? * Response. Circulation, 110 (4). e34-e34. ISSN 0009-7322

Springer, J., Scholz, F.R., Peiser, C., Groneberg, D.A. and Fischer, A. (2004) SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke. Biological Chemistry, 385 (7). pp. 649-653. ISSN 1431-6730

SANDEK, A, Springer, J, HABEDANK, D, BRUNKHORST, F and ANKER, S (2004) Procalcitonin-guided antibiotic treatment in heart failure. The Lancet, 363 (9420). p. 1555. ISSN 01406736

Springer, Jochen, Wagner, Sabine, Subramamiam, Arun, McGregor, Gerald P, Groneberg, David A and Fischer, Axel (2004) BDNF-overexpression regulates the reactivity of small pulmonary arteries to neurokinin A. Regulatory Peptides, 118 (1-2). pp. 19-23. ISSN 01670115

Groneberg, David A., Witt, Heiko, Adcock, Ian M., Hansen, Gesine and Springer, Jochen (2004) SMADS AS INTRACELLULAR MEDIATORS OF AIRWAY INFLAMMATION. Experimental Lung Research, 30 (3). pp. 223-250. ISSN 0190-2148

Beuerlein, K, Ruth, P, Scholz, FR, Springer, J, Lieb, B, Gebauer, W, Westermann, B, Schmidtberg, H, von Boletzky, S, Markl, J and Schipp, R (2004) Blood cells and the biosynthesis of hemocyanin in Sepia embryos. Micron, 35 (1-2). pp. 115-116. ISSN 09684328

Grosse-Siestrup, Christian, Unger, Volker, Pfeffer, Jeanette, Dinh, Q. Thai, Nagel, Stefan, Springer, Jochen, Witt, Christian, Wussow, Anke and Groneberg, David A. (2004) Hepatotoxic effects of polidocanol in a model of autologously perfused porcine livers. Archives of Toxicology, 78 (12). pp. 697-705. ISSN 0340-5761

Springer, Jochen, Amadesi , Silvia, Trevisani , Marcello, Harrison, Selena, Din, Q. Thai, McGregor , Gerald P, Fischer , Axel, Fischer , Pierangelo and Groneberg, David A (2004) Effects of alpha calcitonin gene-related peptide in human bronchial smooth muscle and pulmonary artery. Regulatory Peptides, 118 (3). pp. 127-134. ISSN 01670115

Springer, J. and Fischer, A. (2003) Substance P-induced pulmonary vascular remodelling in precision cut lung slices. European Respiratory Journal, 22 (4). pp. 596-601. ISSN 0903-1936

Springer, J, Geppetti, P, Fischer, A and Groneberg, DA (2003) Calcitonin gene-related peptide as inflammatory mediator. Pulmonary Pharmacology & Therapeutics, 16 (3). pp. 121-130. ISSN 10945539

Springer, Jochen, McGregor, Gerard P., Fink, Ludger and Fischer, Axel (2003) Alternative splicing in single cells dissected from complex tissues: separate expression of prepro-tachykinin A mRNA splice variants in sensory neurones. Journal of Neurochemistry, 85 (4). pp. 882-888. ISSN 00223042

Springer, J., Ruth, P., Beuerlein, K., Westermann, B. and Schipp, R. (2003) Immunohistochemical Localization of Cardio-Active Neuropeptides in the Heart of a Living Fossil, Nautilus pompilius L. (Cephalopoda, Tetrabranchiata). Journal of Molecular Histology, 35 (1). pp. 21-28. ISSN 1567-2379

Peiser, Christian, Springer, Jochen, Groneberg, David A, McGregor, Gerard P, Fischer, Axel and Lang, Rudolf E (2002) Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus. Neuroscience Letters, 320 (1-2). pp. 41-44. ISSN 03043940

Groneberg, D.A., Peiser, C., Dinh, Q.T., Springer, J. and Fischer, A. (2002) Abundant Expression of c-Jun in Guinea Pig Sympathetic Ganglia Under Basal Conditions and Allergen Challenge. Lung, 180 (4). pp. 221-228. ISSN 03412040

Groneberg, D, Springer, J and Fischer, A (2001) Vasoactive Intestinal Polypeptide as Mediator of Asthma. Pulmonary Pharmacology & Therapeutics, 14 (5). pp. 391-401. ISSN 10945539

Amadesi, S, Moreau, J, Tognetto, M, Springer, J, Trevisani, M, Naline, E, Advenier, C, Fisher, A, Vinci, D, Mapp, C, Miotto, D, Cavallesco, G and Geppetti, P (2001) NK1 receptor stimulation causes contraction and inositol phosphate increase in medium-size human isolated bronchi. American journal of respiratory and critical care medicine, 163 (5). pp. 1206-1211. ISSN 1073-449X

Groneberg, David A., Nickolaus, Monika, Springer, Jochen, Döring, Frank, Daniel, Hannelore and Fischer, Axel (2001) Localization of the Peptide Transporter PEPT2 in the Lung. The American Journal of Pathology, 158 (2). pp. 707-714. ISSN 00029440

Hagner, S, Haberberger, R, Kummer, W, Springer, J, Fischer, A, Böhm, S, Göke, B and McGregor, GP (2001) Immunohistochemical detection of calcitonin gene-related peptide receptor (CGRPR)–1 in the endothelium of human coronary artery and bronchial blood vessels. Neuropeptides, 35 (1). pp. 58-64. ISSN 01434179

Fischer, Tanja C, Hartmann, Petra, Löser, Christoph, Springer, Jochen, Peiser, Christian, Dinh, Q Thai, Fischer, Axel and Groneberg, David A (2001) Abundant Expression of Vasoactive Intestinal Polypeptide Receptor VPAC2 mRNA in Human Skin. Journal of Investigative Dermatology, 117 (3). pp. 754-756. ISSN 0022-202X

Groneberg, David A., Wiegand, Silke, Dinh, Q. Thai, Peiser, Christian, Springer, Jochen and Fischer, Axel (2001) Expression of immediate early genes in sensory ganglia. Neurochemical Research, 26 (10). pp. 1113-1117. ISSN 03643190

Book Section

Akashi, YJ, Springer, J and Anker, SD (2007) Cardiac Cachexia. In: Geriatric Nutrition. Taylor & Francis Group, LLC.

Springer, J and Fischer, A (2001) Immunocytochemistry and Immunohistochemistry. In: Methods in Molecular Medicine, Human Airway Inflammation. Humana Press.

Monograph

Rokutan, Hirofumi, Anker, Stefan D and Springer, Jochen (2010) In vivo models of cardiac diseases: application to drug development and screening. Review. INFORMA HEALTHCARE, TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND , EXPERT OPINION ON DRUG DISCOVERY Volume 5, Issue 1, Pages 65-78.

Springer, Jochen and Anker, Stefan D (2010) The underestimated impact of cachexia. Editorial. INFORMA HEALTHCARE, TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND , EXPERT OPINION ON DRUG DISCOVERY Volume 5, Issue 1, Pages 1-3.

Conference or Workshop Item

Springer, J, Hartmann, A, Palus, S, Adams, V, von Harsdorf, R, Anker, SD and Doehner, W (2009) The Xanthine Oxidase Inhibitors Oxypurinol and Allopurinol Reduce Wasting and Improve Cardiac Function in Experimental Cancer Cachexia. In: 13th Annual Scientific Meeting of the Heart-Failure-Society-of-America, SEP 13-16, 2009, Boston, MA.

Springer, J, Hartmann, A, Palus, S, Grzesiak, A, Aaschia, E and Anker, SD (2009) Development of Severe Progressive Heart Failure in Experimental Cancer Cachexia. In: 13th Annual Scientific Meeting of the Heart-Failure-Society-of-America, SEP 13-16, 2009, Boston, MA.

Springer, J, Palus, S, von Haehling, S and Anker, SD (2009) The Aldosterone Antagonist Spironolactone Improves Cardiac Function in Experimental Cancer Cachexia. In: 13th Annual Scientific Meeting of the Heart-Failure-Society-of-America, SEP 13-16, 2009, Boston, MA.

Springer, J, Akashi, Y, Palus, S, Strassburg, S and Anker, SD (2008) Frusemide and mortality in a rat model of chronic heart failure. In: 12th Annual Scientific Meeting of the Heart-Failure-Society-of-America, SEP 21-24, 2008, Toronto, CANADA.

Springer, J, Palus, S, Rauchhaus, M and Anker, SD (2008) Experimental cancer cachexia severely impairs heart function. In: 12th Annual Scientific Meeting of the Heart-Failure-Society-of-America, SEP 21-24, 2008, Toronto, CANADA.

Kramer, S, Binder, E, Wang-Rosenke, Y, Springer, J, Anker, SD, Neumayer, HH and Peters, H (2008) Predominant wasting of body fat characterizes experimental uremic cachexia. In: 18th Scientific Meeting of the European-Society-of-Hypertension/22nd Scientific Meeting of the International-Society-of-Hypertension, JUN 14-19, 2008, Berlin, GERMANY.

Dinh, Q, Quarcoo, D, Scholze, A, Groneberg, D, Peiser, C, Springer, J, Klapp, B, Braun, A and Fischer, A (2008) Alteration of sensory airway nerves in transgenic mice overexpressing NGF in clara cells of the airways. In: 27th Congress of the European-Academy-of-Allergology-and-Clinical-Immunology, JUN 07-11, 2008, Barcelona, SPAIN.

Dinh, Q, Scholze, A, Joachim, R, Springer, J, Groneberg, D, Peiser, C, Fischer, A and Klapp, B (2008) The TRPV1 knockout mice show less allergic airway inflammation in a mouse model of allergic airway inflammation. In: 27th Congress of the European-Academy-of-Allergology-and-Clinical-Immunology, JUN 07-11, 2008, Barcelona, SPAIN.

Grosz, B, Kramer, S, Mika, A, Loof, T, Khadzhynov, D, Akashi, Y, Springer, J, Anker, S and Peters, H (2007) Gender effects on cardiovascular and renal outcome in mild uremia. In: 44th ERA-EDTA Congress, JUN 22-24, 2007, Barcelona, SPAIN.