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Academic

Dr Colin Kay

Colin Kay
Job Title Contact Location
Senior Lecturer  Colin dot Kay at uea dot ac dot uk
Tel: +44 (0)1603 59 1236  
Medical School 2.06A 
  • Personal
  • Research
  • Teaching
  • Publications

Biography

My previous research experience includes 2 year fellowship positions in both the UK and the US and 4 years of research assistantship in Canada. I am trained in nutritional biochemistry (PhD; University of Guelph, Canada) and have also received postdoctoral training in human vascular interventions and controlled dietary feeding trials (Pennsylvania State University, USA). Currently I utilise human and cell-based studies to investigate the effects of diet on disease.

Research interests

  • Cardiovascular bioactivity of dietary phytochemicals
  • Phytochemical metabolism
  • Dietary Flavonoids

Career

  • Senior Lecturer, Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK (Feb 2012 – present).
  • Lecturer, Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK (Feb 2009 – Feb 2012).
  • Research Associate,  Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK (Jan 2007 - Jan 2009).
  • Research Associate - NSERC Postdoctoral Fellow, Co appointment, Departments of Nutritional Sciences and Biobehavioral Health, Penn State University, PA, USA (January 2005 - Dec 2007).
  • Research Associate/Assistant, Pacific Agri-Food Research Center, Department of Agriculture Canada, BC, Canada (January 2003 - January 2005).
  • Graduate Research Assistant, Human Nutrition Laboratory, Department of Human Biology and Nutrition, University of Guelph, ON, Canada (January 2000 - December 2002).

Academic Background

  • Ph.D. 2005,   University of Guelph, Human Biology and Nutritional Science; Industrial Research location, Pacific Agri-Food Research Centre, BC, Canada.
  • M.Sc. 2002, University of Guelph, Human Biology and Nutritional Science.
  • B.Sc. 2000,   University of Guelph, (hons), major in Biological Sciences, minor in Nutrition. 

Key Research Interests

My current research involves the investigation of phytochemical bioactivity following human feeding interventions and in cultured vascular and intestinal cells. This research focuses on the effects of metabolic transformation on the structure and cardiovascular bioactivity of flavonoids.

Selected Publications

 Czank, C., Cassidy, A., Zhang, Q., Morrison, D.J., Preston, T., Kroon, P.A., Botting, N.P., and Kay, C.D. (2013) Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study. Am J Clin Nutr. 97. pp. 995-1003. ISSN 0002-9165

Kay, CD, Hooper, L, Kroon, PA, Rimm, EB and Cassidy, A (2012) Relative impact of flavonoid composition, dose and structure on vascular function: A systematic review of randomised controlled trials of flavonoid-rich food products. Molecular Nutrition & Food Research, 56 (11). pp. 1605-1616. ISSN 16134125

Jennings, A, Welch, A, Fairweather-Tait, SJ, Kay, CD, Minihane, A-M, Chowienczyk, P, Jiang, B, Cecelja, M, Spector, T, Macgregor, A and Cassidy, A (2012) Higher anthocyanin intake is associated with lower arterial stiffness and central pressure in women. The American Journal of Clinical Nutrition. ISSN 0002-9165

Cassidy, A, Rimm, EB, O'Reilly, E, Logroscino, CD, Kay, C, Chiuve, SE and Rexrode, KM (2012) Dietary Flavonoids and Risk of Stroke in Women. Stroke.43(4). Pp. 946-51. ISSN 0039-2499.

Zhang, Q, Raheem, KS, Botting, NP, Slawin, AMZ, Kay, CD and O'Hagan, D (2012) Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids. Tetrahedron, 68 (22). pp. 4194-4201. ISSN 00404020

Hooper, L, Kay, CD, Abdelhamid, A, Kroon, PA, Cohn, JS, Rimm, EB and Cassidy, A (2012) Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. American Journal of Clinical Nutrition, 95 (3). pp. 740-751. ISSN 0002-9165

Woodward, GM, McCarthy, D, Pham-Thanh, D and Kay, CD (2011) Anthocyanins Remain Stable during Commercial Blackcurrant Juice Processing. Journal of Food Science, 76 (6). S408-S414. ISSN 00221147

Cassidy, A., O'Reilly, E. J., Kay, C.D., Sampson, L., Franz, M., Forman, J., Curhan, G. and Rimm, E. B. (2011) Habitual intake of flavonoid subclasses and incident hypertension in adults. American Journal of Clinical Nutrition, 93 (2). pp. 338-347. ISSN 0002-9165

Zhang, Q, Botting, NP and Kay, CD (2011) A gram scale synthesis of a multi-13C-labelled anthocyanin, [6,8,10,3′,5′-13C5]cyanidin-3-glucoside, for use in oral tracer studies in humans. Chemical Communications, 47 (38). pp. 10596-10598. ISSN 1359-7345

Kay, CD (2010) The future of flavonoid research. British Journal of Nutrition, 104 (Suppl 3). S91-S95.

Woodward, Gary, Needs, Paul W. and Kay, Colin D (2010) Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation. Molecular Nutrition & Food Research, 55 (3). pp. 378-386. ISSN 16134125

 


Research Group Overview:

Flavonoids are a family of over 5000 different naturally occurring compounds found within common foodstuffs.  There is mounting evidence that supports the notion that dietary flavonoids act to slow the onset of chronic disease, particularly cardiovascular disease. However, the specific structural characteristics that confer these protective effects and whether these effects are brought about by compounds acting in isolation, in combination or as metabolites, still remains unknown. We are investigating the structural characteristics that allow this class of compounds to provide health benefits using in vivo and in vitro models of metabolism and cardiovascular disease.   
 

Lab Group Profile:

Dr. Jason Kerr (Postdoctoral fellow): Research project focuses on understanding the collective bioactivity of dietary flavonoids, with particular interest placed on defining the specific structural characteristics, and the molecular mechanisms, by which flavonoids have a beneficial effect on cardiovascular health. Jason has extensive experience in the establishment and culture of primary and stably engineered mammalian cells, the development of in vitro pharmacological assay systems, and biochemical and molecular biology techniques related to the cloning of genetic material and expression and characterisation of recombinant protein.

Rachel de Ferrars (PhD candidate): Research project focuses on investigating the bioavailability of anthocyanins and the distribution and elimination of their metabolites in humans.

Hiren Amin (PhD candidate): Research project focuses on screening novel anthocyanin metabolites for potential biological activities using in vitro vascular cell models.

Michael Edwards (PhD candidate): Research project focuses on investigating the bioactivity of flavonoids and their common phenolic degradation products using in vitro vascular cell models.

Jessica di Gesso (PhD candidate): Research project focuses on discovering and targeting the inflammatory signalling pathways responsible for the cardioprotective effects of dietary flavonoids using in vitro inflammatory cell models.

Michael Smith (PhD Candidate): Research project focuses on establishing human metabolites of anthocyanins as potential therapeutic targets using chromatographic and mass spectrometry techniques.

Emily Warner (PhD Candidate): Research project focuses on targeting the underlying signalling pathways responsible for the cardioprotective effects of dietary flavonoids using in vitro vascular cell models.
 

Previous Lab Members:

Dr. Charles Czank (Postdoctoral Fellow): Research project focused on the impact of processing and human metabolism on anthocyanin structure and bioactivity as it relates to cardiovascular health. Charles presently holds a Principal Scientist position at Leatherhead Foods Research, UK.



Dr. Gary Woodward (PhD): Gary's thesis work title was 'Anthocyanin stability, metabolic conjugation and in vitro modulation of endothelial superoxide production'.  Gary is presently a Research Associate at the University of Oxford in the Pre-Reg Clinical Scientist track at Oxford University Hospitals.

 


 


Teaching Interests

My current teaching activity is focused mainly on Problem Based Learning tutorials and Nutrition and Research Practice lectures, seminars, tutorials and workshops to MB/BS medical degree students. Current lecturers, seminars, workshops include: Health Effects of Obesity, Diet and Respiratory Disease, Diet in Children and Research Protocol and Project Modules. In addition I am a Director of Learning Teaching and Quality for Post Graduate Research in the Faculty of Health.


Number of items: 40.

Article

De Ferrars, R M, Czank, C, Zhang, Q, Botting, N P, Kroon, P A, Cassidy, A and Kay, C D (2014) The pharmacokinetics of anthocyanins and their metabolites in humans. British Journal of Pharmacology, 171 (13). pp. 3268-3282. ISSN 00071188

de Ferrars, Rachel M, Czank, Charles, Saha, Shikha, Needs, Paul W, Zhang, Qingzhi, Raheem, K Saki, Kroon, Paul A and Kay, Colin D (2014) Methods for isolating, identifying and quantifying anthocyanin metabolites in clinical samples. Analytical Chemistry. ISSN 0003-2700

de Ferrars, Rachel M, Cassidy, Aedín, Curtis, Peter and Kay, Colin D (2014) Phenolic metabolites of anthocyanins following a dietary intervention study in post-menopausal women. Molecular Nutrition & Food Research, 58 (3). pp. 490-502. ISSN 1613-4133

Davidson, Rose K, Jupp, Orla, de Ferrars, Rachel, Kay, Colin D, Culley, Kirsty L, Norton, Rosemary, Driscoll, Clare, Vincent, Tonia L, Donell, Simon T, Bao, Yongping and Clark, Ian M (2013) Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo : Sulforaphane is Protective in the Articular Joint. Arthritis and rheumatism, 65 (12). pp. 3130-3140. ISSN 1529-0131

Czank, Charles, Cassidy, Aedin, Zhang, Q., Morrison, Derek, Preston, T., Kroon, Paul, Botting, N. P. and Kay, Colin (2013) Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study. American Journal of Clinical Nutrition, 97 (5). pp. 995-1003. ISSN 0002-9165

Jennings, Amy, Welch, Ailsa A, Fairweather-Tait, Sue J, Kay, Colin, Minihane, Anne-Marie, Chowienczyk, Phil, Jiang, Benyu, Cecelja, Marina, Spector, Tim, Macgregor, Alex, Cassidy, Aedín and Fairweather-Tait, Susan (2012) Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women. The American journal of clinical nutrition, 96 (4). pp. 781-788. ISSN 1938-3207

Kay, CD, Hooper, L, Kroon, PA, Rimm, EB and Cassidy, A (2012) Relative impact of flavonoid composition, dose and structure on vascular function: A systematic review of randomised controlled trials of flavonoid-rich food products. Molecular Nutrition & Food Research, 56 (11). pp. 1605-1616.

West, SG, Gebauer, SK, Kay, C, Bagshaw, DM, Savastano, DM, Diefenbach, C and Kris-Etherton, PM (2012) Diets Containing Pistachios Reduce Systolic Blood Pressure and Peripheral Vascular Responses to Stress in Adults With Dyslipidemia. Hypertension, 60 (1). pp. 58-63. ISSN 0194-911X

Cassidy, A, Rimm, EB, O'Reilly, E, Logroscino, C, Kay, C, Chiuve, SE and Rexrode, KM (2012) Dietary Flavonoids and Risk of Stroke in Women. Stroke, 43. pp. 946-951. ISSN 0039-2499

Zhang, Q, Raheem, KS, Botting, NP, Slawin, AMZ, Kay, C and O'Hagan, D (2012) Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids. Tetrahedron, 68 (22). pp. 4194-4201.

Hooper, L, Kay, CD, Abdelhamid, A, Kroon, PA, Cohn, JS, Rimm, EB and Cassidy, A (2012) Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. American Journal of Clinical Nutrition, 95 (3). pp. 740-751. ISSN 0002-9165

Zhang, Qingzhi, Botting, Nigel P and Kay, Colin (2011) A gram scale synthesis of a multi-13C-labelled anthocyanin, [6,8,10,3',5'-13C5]cyanidin-3-glucoside, for use in oral tracer studies in humans. Chemical communications (Cambridge, England), 47 (38). pp. 10596-10598. ISSN 1359-7345

Woodward, GM, McCarthy, D, Pham-Thanh, D and Kay, CD (2011) Anthocyanins Remain Stable during Commercial Blackcurrant Juice Processing. Journal of Food Science, 76 (6). S408-S414.

Njike, Valentine Yanchou, Faridi, Zubaida, Shuval, Kerem, Dutta, Suparna, Kay, Colin D, West, Sheila G, Kris-Etherton, Penny M and Katz, David L (2011) Effects of sugar-sweetened and sugar-free cocoa on endothelial function in overweight adults. International journal of cardiology, 149 (1). pp. 83-88.

Cassidy, A., O'Reilly, E. J., Kay, C., Sampson, L., Franz, M., Forman, J., Curhan, G. and Rimm, E. B. (2011) Habitual intake of flavonoid subclasses and incident hypertension in adults. American Journal of Clinical Nutrition, 93 (2). pp. 338-347. ISSN 0002-9165

Kay, CD (2010) The future of flavonoid research. British Journal of Nutrition, 104 (Suppl 3). S91-S95.

Kay, Colin D, Gebauer, Sarah K, West, Sheila G and Kris-Etherton, Penny M (2010) Pistachios increase serum antioxidants and lower serum oxidized-LDL in hypercholesterolemic adults. The Journal of nutrition, 140 (6). pp. 1093-1098. ISSN 1541-6100

Woodward, Gary, Needs, Paul W. and Kay, Colin D (2010) Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation. Molecular Nutrition & Food Research, 55 (3). pp. 378-386.

Curtis, Peter J, Kroon, Paul A, Hollands, Wendy J, Walls, Rebecca, Jenkins, Gail, Kay, Colin D and Cassidy, Aedín (2009) Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeks. The Journal of nutrition, 139 (12). pp. 2266-2271. ISSN 1541-6100

Hanwell, Heather E C, Kay, Colin D, Lampe, Johanna W, Holub, Bruce J and Duncan, Alison M (2009) Acute fish oil and soy isoflavone supplementation increase postprandial serum (n-3) polyunsaturated fatty acids and isoflavones but do not affect triacylglycerols or biomarkers of oxidative stress in overweight and obese hypertriglyceridemic men. The Journal of nutrition, 139 (6). pp. 1128-34. ISSN 1541-6100

Hanwell, C, Kay, CD, Holub, BJ and Duncan, A (2009) Soy protein isoflavones, serum lipids and markers of oxidation and inflammation. Journal of Nutrition, 139. pp. 1-7.

Kay, CD, Kroon, PA and Cassidy, A (2009) The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products. Molecular Nutrition & Food Research, 53 (Suppl 1). S92-101.

Woodward, G, Kroon, PA, Cassidy, A and Kay, CD (2009) Anthocyanin stability and recovery: implications for the analysis of clinical and experimental samples. Journal of Agricultural and Food Chemistry, 57 (12). pp. 5271-5278.

Gebauer, Sarah K, West, Sheila G, Kay, Colin D, Alaupovic, Petar, Bagshaw, Deborah and Kris-Etherton, Penny M (2008) Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action : a dose-response study. The American journal of clinical nutrition, 88 (3). pp. 651-9. ISSN 1938-3207

Gebauer, SK, West, SG, Kay, CD, Alaupovic, P, Bagshaw, DM and Kris-Etherton, PM (2008) Effects of pistachios on cardiovascular risk factors and potential mechanisms of action: a dose-response study. American Journal of Clinical Nutrition, 88 (3). pp. 651-659.

Kay, CD (2006) Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans. Nutrition Research Reviews, 19 (1). pp. 137-146.

Kay, CD and Kris-Etherton, PM (2006) Effects of antioxidant-rich foods on vascular reactivity: review of the clinical evidence. Atherosclerosis, 8. pp. 510-522.

Kay, CD, Mazza, G and Holub, BJ (2005) Anthocyanins exist in the circulation primarily as metabolites in adult men. Journal of Nutrition, 135 (11). pp. 2582-2588.

Kay, CD, Mazza, G, Holub, BJ and Wang, J (2004) Anthocyanin Metabolites in Human urine and Serum. British Journal of Nutrition, 91 (6). pp. 933-942.

Mazza, G, Cacace, JE and Kay, CD (2004) Methods of Analysis for Anthocynanins in Plants and Biological Fluids. Journal of AOAC International, 87 (1). pp. 129-145.

Kay, CD and Holub, BJ (2003) The Postprandial Effects of Dietary Antioxidants in Humans. Atherosclerosis, 5. pp. 452-458.

Mazza, G, Kay, Colin D, Cottrell, Tony and Holub, Bruce J (2002) Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. Journal of Agricultural and Food Chemistry, 50 (26). pp. 7731-7. ISSN 0021-8561

Kay, CD and Holub, BJ (2002) The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects. British Journal of Nutrition, 88 (4). pp. 389-397.

Mazza, G, Kay, CD, Cotrell, T and Holub, BJ (2002) Absorption of Anthocyanins from Blueberries and Serum Antioxidant Status in Humans. Journal of Agricultural and Food Chemistry, 50 (26). pp. 7731-7737.

Book Section

Kay, Colin and Cassidy, Aedin (2013) Encyclopedia of Human Nutrition : Phytochemicals: Classification and Occurrence. In: University of East Anglia. Academic Press, pp. 490-497. ISBN 978-0-12-375083-9

Cassidy, A and Kay, CD (2010) Phytochemicals. In: Nutrition and Metabolism - Vol. 2. Wiley-Blackwell. ISBN 978-1-4051-6808-3

Mazza, G and Kay, CD (2008) Bioactivity, Absorption, and Metabolism of Anthocyanins. In: Recent Advances in Polyphenol Research. Blackwell Publishing Ltd, pp. 228-254. ISBN 1405158379

Kay, CD, Kris-Etherton, PM, Psota, PM, Bagshaw, DM and West, SG (2007) Clinical nutrition studies: Maximising opportunities and managing the challenges. In: Handbook of Nutrition and Food. 3rd Edition. Taylor & Francis, pp. 693-714. ISBN 0849392187

Kay, CD and Holub, BJ (2005) Anthocyanins and cancer prevention. In: Nutrition and Cancer Prevention. CRC Press, pp. 411-434. ISBN 0849339456

Book

Kay, Colin (2013) Bioactives in Fruit : Health Benefits and Functional Foods. John Wiley & Sons, Ltd, Oxford, UK. ISBN 9780470674970

This list was generated on Sat Oct 25 11:44:26 2014 BST.
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