Career History

He has a mathematics degree from Durham University, and a mathematics PhD from the University of Edinburgh, utilizing number theory to study the spacing distributions of quantized harmonic oscillators. He was a lecturer at Bolton University Maths Department for five years, after which two years of mathematical consultancy in industry took place, examining problems varying from satellite positioning algorithms to machine learning approaches to drug discovery. He then spent seven years at the Sanger Institute, developing statistical and mathematical techniques required to analyse cancer genomic data. He then joined the School of Computing Sciences in 2011.

Research Opportunities

Enquiries are welcome (email me) from potential PhD students. He would be keen to recruit anyone interested in stochastic processes, statistical physics, combinatorics and/or their applications to population genetic, genome rearrangement, or evolutionary processes.

 

 

 

All Publications

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Fishwick, C., Higgins, J., Percival-Alwyn, L., Hustler, A., Pearson, J., Bastkowski, S., Moxon, S., Swarbreck, D., Greenman, C. D., Southgate, J.

(2017)

Heterarchy of transcription factors driving basal and luminal cell phenotypes in human urothelium,

in Cell Death and Differentiation

24

pp. 809-818

Full Text UEA Repository

(Article)

(Published)


Greenman, C.

(2017)

A Path Integral Approach to Age Dependent Branching Processes,

in Journal of Statistical Mechanics: Theory and Experiment

2017

(March)

article no. 033101

Full Text UEA Repository

(Article)

(Published)


Behjati, S., Gundem, G., Wedge, D. C., Roberts, N. D., Tarpey, P. S., Cooke, S. L., Van Loo, P., Alexandrov, L. B., Ramakrishna, M., Davies, H., Nik-Zainal, S., Hardy, C., Latimer, C., Raine, K. M., Stebbings, L., Menzies, A., Jones, D., Shepherd, R., Butler, A. P., Teague, J. W., Jorgensen, M., Khatri, B., Pillay, N., Shlien, A., Futreal, P. A., Badie, C., Cooper, C. S., Eeles, R. A., Easton, D., Foster, C., Neal, D. E., Brewer, D. S., Hamdy, F., Lu, Y., Lynch, A. G., Massi, C. E., Ng, A., Whitaker, H. C., Yu, Y., Zhang, H., Bancroft, E., Berney, D., Camacho, N., Corbishley, C., Dadaev, T., Dennis, N., Dudderidge, T., Edwards, S., Fisher, C., Ghori, J., Gnanapragasam, V. J., Greenman, C., Hawkins, S., Hazell, S., Howat, W., Karaszi, K., Kay, J., Kote-Jarai, Z., Kremeyer, B., Kumar, P., Lambert, A., Leongamornlert, D., Livni, N., Luxton, H., Matthews, L., Mayer, E., Merson, S., Nicol, D., Ogden, C., O’Meara, S., Pelvender, G., Shah, N. C., Tavare, S., Thomas, S., Thompson, A., Verrill, C., Warren, A., Zamora, J., McDermott, U., Bova, G. S., Richardson, A. L., Flanagan, A. M., Stratton, M. R., Campbell, P. J.

(2016)

Mutational signatures of ionizing radiation in second malignancies,

in Nature Communications

7

article no. 12605

Full Text UEA Repository

(Article)

(Published)


Chou, T., Greenman, C. D.

(2016)

A hierarchical kinetic theory of birth, death, and fission in age-structured interacting populations,

in Journal of Statistical Physics

164

(1)

pp. 49-76

Full Text UEA Repository

(Article)

(Published)


Beerenwenko, N., Greenman, C., Lagergren, J.

(2016)

Computational Cancer Biology: An Evolutionary Perspective,

in PLoS Computational Biology

12

(2)

article no. e1004717

Full Text UEA Repository

(Article)

(Published)


Greenman, C., Chou, T.

(2016)

Kinetic theory of age-structured stochastic birth-death processes,

in Physical Review E

93

(1)

article no. 012112

Full Text UEA Repository

(Article)

(Published)


Greenman, C., Cooke, S., Marshall, J., Stratton, M., Campbell, P.

(2016)

Modeling the evolution space of breakage fusion bridge cycles with a stochastic folding process,

in Journal of Mathematical Biology

72

(1)

pp. 47-86

Full Text UEA Repository

(Article)

(Published)


Chedom, D. F., Murcia, P. R., Greenman, C. D.

(2015)

Inferring the clonal structure of viral populations from time series sequencing,

in PLoS Computational Biology

11

(11)

article no. e1004344

Full Text UEA Repository

(Article)

(Published)


Penso-Dolfin, L., Wu, T., Greenman, C.

(2015)

The Combinatorics of Tandem Duplication,

in Discrete Applied Mathematics

194

pp. 1–22

Full Text UEA Repository

(Article)

(Published)


Kelly, S., Greenman, C., Cook, P. R., Papantonis, A.

(2015)

Exon skipping is correlated with exon circularization,

in Journal of Molecular Biology

427

(15)

pp. 2414-2417

Full Text UEA Repository

(Article)

(Published)


Cooper, C., Eeles, R. A., Wedge, D. C., Van loo, P., Gundem, G., Alexandrov, L., Kreymer, B., Butler, A., Lynch, A., Edwards, S. E., Camacho, N., Massie, C. E., Kote-Jarai, Z., Dennis, N., Merson, S., Leongamornlert, D. A., Zamora, J., Kay, J., Luxton, H. J., Corbishley, C., Thomas, S., Nik-zainal, S., O'Meara, S., Matthews, L., Clark, J., Hurst, R., Mithen (IFR), R., Bristow (Ontario Cancer Inst. CA), R., Boutros, P. C., Fraser, M., Cooke, S., Raine, K., Jones, D., Menzies, A., Stebbings, L., Hinton, J., Teague, J., Mclaren, S., Mudie, L., Hardy, C., Anderson, E., Joseph, O., Goody, V., Robinson, B., Maddison, M., Gamble, S., Greenman, C., Berney, D., Hazell, S., Livni, N., Fisher, C., Ogden, C., Kumar, P., Thompson, A., Woodhouse, C. J., Nicol, D., Mayer, E., Dudderidge, T., Shah, N., Gnanapragasam (Cambridge), V., Voet, T., Campbell, P., Futreal, P. A., Easton, D. F., Warren, A. Y., Foster, C. S., Stratton, M. R., Whitaker, H. C., Mcdermott, U., Brewer, D., Neal, D. E.

(2015)

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue,

in Nature Genetics

47

pp. 367–372

Full Text

(Letter)

(Published)


Roshan, A., Jones, P., Greenman, C.

(2014)

Exact, time-independent estimation of clone size distributions in normal and mutated cells,

in Journal of The Royal Society Interface

11

(99)

article no. 20140654

Full Text UEA Repository

(Article)

(Published)


Newman, S., Howarth, K. D., Greenman, C., Bignell, G. R., Tavaré, S., Edwards, P. A. W.

(2013)

The Relative Timing of Mutations in a Breast Cancer Genome,

in PLoS ONE

8

(6)

article no. e64991

Full Text UEA Repository

(Article)

(Published)


McBride, D. J., Etemadmoghadam, D., Cooke, S. L., Alsop, K., George, J., Butler, A., Cho, J., Galappaththige, D., Greenman, C., Howarth, K. D., Lau, K. W., Ng, C. K., Raine, K., Teague, J., Wedge, D. C., Caubit, X., Stratton, M. R., Brenton, J. D., Campbell, P. J., Futreal, P. A., Bowtell, D. D.

(2012)

Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes,

in The Journal of Pathology

227

(4)

pp. 446-455

Full Text UEA Repository

(Article)

(Published)


Greenman, C. D.

(2012)

Haploinsufficient Gene Selection in Cancer,

in Science

337

(6090)

pp. 47-48

Full Text UEA Repository

(Article)

(Published)


Stephens, P. J., Tarpey, P. S., Davies, H., Van Loo, P., Greenman, C., Wedge, D. C., Zainal, S. N., Martin, S., Varela, I., Bignell, G. R., Yates, L. R., Papaemmanuil, E., Beare, D., Butler, A., Cheverton, A., Gamble, J., Hinton, J., Jia, M., Jayakumar, A., Jones, D., Latimer, C., Lau, K. W., Mclaren, S., Mcbride, D. J., Menzies, A., Mudie, L., Raine, K., Rad, R., Spencer Chapman, M., Teague, J., Easton, D., Langerød, A., Lee, M. T. M., Shen, C., Tee, B. T. K., Huimin, B. W., Broeks, A., Vargas, A. C., Turashvili, G., Martens, J., Fatima, A., Miron, P., Chin, S., Thomas, G., Boyault, S., Mariani, O., Lakhani, S. R., Van De Vijver, M., Van ‘t Veer, L., Foekens, J., Desmedt, C., Sotiriou, C., Tutt, A., Caldas, C., Reis-Filho, J. S., Aparicio, S. A. J. R., Salomon, A. V., Børresen-Dale, A., Richardson, A., Campbell, P. J., Futreal, P. A., Stratton, M. R.

(2012)

The landscape of cancer genes and mutational processes in breast cancer,

in Nature

486

(7403)

Full Text UEA Repository

(Article)

(Published)


Nik-Zainal, S., Alexandrov, L., Wedge, D., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L., Menzies, A., Martin, S., Leung, K., Chen, L., Leroy, C., Ramakrishna, M., Rance, R., Lau, K., Mudie, L., Varela, I., McBride, D., Bignell, G., Cooke, S., Shlien, A., Gamble, J., Whitmore, I., Maddison, M., Tarpey, P., Davies, H., Papaemmanuil, E., Stephens, P., McLaren, S., Butler, A., Teague, J., Jönsson, G., Garber, J., Silver, D., Miron, P., Fatima, A., Boyault, S., Langerød, A., Tutt, A., Martens, J., Aparicio, S., Borg, Å., Salomon, A., Thomas, G., Børresen-Dale, A., Richardson, A., Neuberger, M., Futreal, P., Campbell, P., Stratton, M.

(2012)

Mutational Processes Molding the Genomes of 21 Breast Cancers,

in Cell

149

(5)

pp. 979-993

Full Text UEA Repository

(Article)

(Published)


Greenman, C. D., Pleasance, E. D., Newman, S., Yang, F., Fu, B., Nik-zainal, S., Jones, D., Lau, K. W., Carter, N., Edwards, P. A. W., Futreal, P. A., Stratton, M. R., Campbell, P. J.

(2012)

Estimation of rearrangement phylogeny for cancer genomes,

in Genome Research

22

(2)

pp. 346-361

Full Text UEA Repository

(Article)

(Published)


Greenman, C.

(2012)

Estimation of Rearrangement Phylogeny in Cancer,

in Genome Research

22

pp. 346-361

UEA Repository

(Article)

(Published)


Garnett, M. J., Edelman, E. J., Heidorn, S. J., Dastur, A., Lau, K. W., Greninger, P., Thompson, I. R., Luo, X., Soares, J., Liu, Q., Iorio, F., Surdez, D., Chen, L., Milano, R. J., Bignell, G. R., Tam, A. T., Davies, H., Stevenson, J. A., Barthorpe, S., Lutz, S. R., Kogera, F., Lawrence, K., Mclaren-douglas, A., Mitropoulos, X., Mironenko, T., Thi, H., Richardson, L., Zhou, W., Jewitt, F., Zhang, T., O’brien, P., Boisvert, J. L., Price, S., Hur, W., Yang, W., Deng, X., Butler, A., Choi, H. G., Chang, J. W., Baselga, J., Stamenkovic, I., Engelman, J. A., Sharma, S. V., Delattre, O., Saez-rodriguez, J., Gray, N. S., Settleman, J., Futreal, P. A., Haber, D. A., Stratton, M. R., Ramaswamy, S., Mcdermott, U., Benes, C. H., Greenman, C.

(2012)

Systematic identification of genomic markers of drug sensitivity in cancer cells,

in Nature

483

(7391)

pp. 570-575

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

Chris Greenman is part of the Computational Biology and the Machine Learning and Statistics research groups. Recent areas of interest include; the development of techniques from statistical physics applied to age-dependent branching processes, including (quantum) field theoretic methods, applications to cell populations and mutation processes, combinatorial approaches to counting and representing genomic rearrangement processes, cancer and viral evolutionary processes.  

Selected Recent Papers:

  • Greenman C D, Second quantization approaches for stochastic age-structured birth-death processes, http://arxiv.org/abs/1512.05431, 2016.

  • Greenman C D and Chou T, Kinetic theory of age-structured stochastic birth-death processes, Phys. Rev. E 93, 012112, 2016.

  • Penso-Dolfin L, Wu T, Greenman C D, The Combinatorics of Tandem Duplication, Discrete Applied Mathematics, 194, pp. 1–22, 2015.

  • Chedom D F, Murcia P R, Greenman C D, Inferring the Clonal Structure of Viral Populations from Time Series Sequencing, PLoS Computational Biology, 11, 2015.

 

Teaching Interests

Advanced Statistics, Computing Principles, Natural Science Project Coordinator.