Biography

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Maria is a Lecturer in Analytical Chemistry in the School of Chemistry since October 2017. Maria graduated in Chemistry from the University Jaume I (Spain) in 2007 having spent a year as an Erasmus student at Cork Institute of Technology, Ireland. She then moved to the School of Chemistry at the University of East Anglia (UEA) where she obtained her PhD in Analytical Bionanotechnology (2012) under the supervision of Prof David A. Russell. Her PhD thesis involved interdisciplinary work on intracellular detection and quantification of pH and nitric oxide (NO) using nanoparticles and molecular probes. Her research focused mainly on the synthesis, characterisation, and biological application of functionalised nanoparticles which act as sensors and ratiometric sensors of pH, and on the chemical and biological evaluation of fluorescent molecules which act as markers of NO. Her PhD thesis was complemented with a European Society for Photobiology (ESP) supplement to the PhD Degree awarded in 2015.

From September 2012 to April 2017, Maria was a Postdoctoral Researcher at UEA under the supervision of Prof David A. Russell and Prof Rob A. Field (John Innes Centre). During this period, she worked on several multidisciplinary projects including: 1) the development of simple bioassays based on gold glyconanoparticles for the diagnosis of influenza virus and for the specific detection of Siglecs; 2) the use of double stranded DNA functionalised gold nanoparticles to rapidly determine the crosslinking of DNA duplexes by bisintercator ligands (with Prof M. Searcey, School of Chemistry, UEA); 3) the intracellular evaluation of fluorescent macrocyclic probes as markers of acidic organelles (with Dr F. Galindo, University Jaume I, Spain) and nanosensors for the imaging of compartmentalised NO (with Dr J. Gravilovic and Dr P. Thomas, School of Biological Science, UEA); and 4) the use of nanomaterials (gold, magnetic and upconversion nanoparticles) as drug delivery systems, especially for targeted photodynamic therapy (PDT) of cancer (with Dr Ll. Pérez, University of Barcelona (Spain) and University of Nottingham; and Dr T. Hirsch, University of Regensburg, Germany). Maria has also worked in the field of Forensic Sciences, performing research on the use of antibody functionalised nanoparticles for the detection of drugs and drug metabolites in latent fingerprints.

During her career, Maria has also gained experience in industry. She was an Analyst at Iproma S. L. (Castellón, Spain, from July to September 2006) and I worked as part of the Quality Control and Assurance teams at Johnson Matthey Pharmaceutical Materials (Cork, Ireland, from April to December 2007). During the final year of her PhD, she worked as an Analyst in the Anti-doping Laboratory for the London 2012 Olympic Games under the leadership of GlaxoSmithKline and the Drug Control Centre at King’s College London. From April to October 2017, Maria was a Development Scientist at Iceni Diagnostics (Norwich Research Park Innovation Centre), a company specialised on the development of carbohydrate based diagnostics with who she maintains strong links.

Maria has won several best oral and poster presentation prizes and was awarded the Roscoe Gold Medal for Chemistry and the Westminster Medal for the overall winner during the 2014 SET for Britain.

Selected Publications

Imaging of compartmentalised intracellular nitric oxide, induced during bacterial phagocytosis, using a metalloprotein-gold nanoparticle conjugate
R. Leggett, P. Thomas, M. J. Marín, J. Gavrilovic and D. A. Russell. Analyst (2017)

Water soluble multifunctional antibody-porphyrin-functionalised gold nanoparticles for targeted photodynamic therapy
O. Penon, M. J. Marín,* D. A. Russell and Ll. Pérez-García* (*Corresponding Authors). J. Colloid Interface Sci. 496, 100-110 (2017)

Upconversion nanomaterials for photodynamic therapy
M. J. Marín and D. A. Russell, Invited book chapter for the RSC book: "Near-infrared nanomaterials: Preparation, Bioimaging and Therapy Applications", Edited by Fan Zhang and Dongyuan Zhao. 2016, Chapter 7, Pages 192-231 10.

Glyconanoparticles for colorimetric bioassays
M. J. Marín, C. L. Schofield, R. A. Field and D. A. Russell. Analyst, 140, 1, 59-70 (2015)

Glyconanoparticles for the plasmonic detection and discrimination between human and avian influenza virus
M. J. Marín, A. Rashid, M. Rejzek, S. R. Martin, J. W. McCauley, T. Wileman, R. A. Field and D. A. Russell. Org. Biomol. Chem., 11, 41, 7101-7107 (2013)

A rapid screen for molecules that form duplex to duplex crosslinks in DNA
M. J. Marín, B. D. Rackham, A. N. Round, L. A. Howell, D. A. Russell and M. Searcey. Chem. Commun., 49, 80, 9113-9115 (2013)

Localized intracellular pH measurement using a ratiometric photoinduced electron-transfer-based nanosensor
M. J. Marín, F. Galindo, P. Thomas and D. A. Russell. Angew. Chem., Int. Ed., 51, 38, 96579661 (2012)

All Publications

Leggett, R., Thomas, P., Marín, M. J., Gavrilovic, J., Russell, D. A.

(2017)

Imaging of compartmentalised intracellular nitric oxide, induced during bacterial phagocytosis, using a metalloprotein–gold nanoparticle conjugate,

in Analyst

142

(21)

pp. 4099-4105

Full Text UEA Repository

(Article)

(Published)


Penon, O., Marín, M. J., Russell, D. A., Pérez-García, L.

(2017)

Water soluble, multifunctional antibody-porphyrin gold nanoparticles for targeted photodynamic therapy,

in Journal of Colloid and Interface Science

496

pp. 100–110

Full Text UEA Repository

(Article)

(Published)


Schofield, C. L., Marin, M. J., Rejzek, M., Crocker, P. R., Field, R. A., Russell, D. A.

(2016)

Detection of mSiglec-E, in solution and expressed on the surface of Chinese hamster ovary cells, using sialic acid functionalised gold nanoparticles,

in The Analyst

141

(20)

pp. 5799-5809

Full Text UEA Repository

(Article)

(Published)


Marin Altaba, M., Russell, D.

(2016)

Upconversion nanomaterials for photodynamic therapy,

in Near-infrared Nanomaterials: Preparation, Bioimaging and Therapy Applications.

Royal Society of Chemistry

pp. 192-231

ISBN 978-1-78262-319-9

Full Text

(Chapter (peer-reviewed))

(Published)


Camerin, M., Moreno, M., Marin, M. J., Schofield, C. L., Chambrier, I., Cook, M. J., Coppellotti, O., Jori, G., Russell, D. A.

(2016)

Delivery of a hydrophobic phthalocyanine photosensitizer using PEGylated gold nanoparticle conjugates for the in vivo photodynamic therapy of amelanotic melanoma,

in Photochemical & Photobiological Sciences

15

(5)

pp. 618-625

Full Text UEA Repository

(Article)

(Published)


Penon, O., Marin Altaba, M., Amabilino, D., Russell, D., Pérez-García, L.

(2016)

Iron oxide nanoparticles functionalized with novel hydrophobic and hydrophilic porphyrins as potential agents for photodynamic therapy,

in Journal of Colloid and Interface Science

462

pp. 154-165

Full Text UEA Repository

(Article)

(Published)


Saura, V., Marin Altaba, M., Burguete, M. I., Russell, D., Galindo, F., Luis, S. V.

(2015)

Synthesis of new fluorescent bichromophoric compounds as ratiometric pH probes for intracellular measurements,

in Organic & Biomolecular Chemistry

13

(28)

pp. 7736-7749

Full Text UEA Repository

(Article)

(Published)


Marin, M., Schofield, C., Field, R., Russell, D.

(2015)

Glyconanoparticles for colorimetric bioassays,

in Analyst

140

pp. 59-70

Full Text UEA Repository

(Article)

(Published)


Wadhavane, P. D., Izquierdo, M. Á., Lutters, D., Burguete, M. I., Marin, M., Russell, D. A., Galindo, F., Luis, S. V.

(2014)

Fluorescent macrocyclic probes with pendant functional groups as markers of acidic organelles within live cells,

in Organic & Biomolecular Chemistry

12

pp. 823-831

Full Text UEA Repository

(Article)

(Published)


Marin, M., Rashid, A., Rejzek, M., Fairhurst, S. A., Wharton, S. A., Martin, S. R., Mccauley, J. W., Wileman, T., Field, R. A., Russell, D. A.

(2013)

Glyconanoparticles for the plasmonic detection and discrimination between human and avian influenza virus,

in Organic & Biomolecular Chemistry

11

(41)

pp. 7101-7107

Full Text UEA Repository

(Article)

(Published)


Marin, M., Galindo, F., Thomas, P., Wileman, T., Russell, D.

(2013)

A photoinduced electron transfer-based nanoprobe as a marker of acidic organelles in mammalian cells,

in Analytical and Bioanalytical Chemistry

405

(19)

pp. 6197-6207

Full Text UEA Repository

(Article)

(Published)


Marin, M., Rackham, B. D., Round, A. N., Howell, L. A., Russell, D. A., Searcey, M.

(2013)

A rapid screen for molecules that form duplex to duplex crosslinks in DNA,

in Chemical Communications

49

(80)

pp. 9113

Full Text UEA Repository

(Article)

(Published)


Marin, M., Galindo, F., Thomas, P., Russell, D.

(2012)

Localized Intracellular pH Measurement Using a Ratiometric Photoinduced Electron-Transfer-Based Nanosensor,

in Angewandte Chemie International Edition

51

(38)

pp. 9657-9661

Full Text UEA Repository

(Article)

(Published)


Marin, M., Thomas, P., Fabregat, V., Luis, S. V., Russell, D. A., Galindo, F.

(2011)

Fluorescence of 1,2-diaminoanthraquinone and its nitric oxide reaction product within macrophage cells,

in ChemBioChem

12

(16)

pp. 2471-2477

Full Text UEA Repository

(Article)

(Published)


Bru, M., Burguete, M. I., Galindo, F., Luis, S. V., Marin, M., Vigara, L.

(2006)

Cross-linked poly(2-hydroxyethylmethacrylate) films doped with 1,2-diaminoanthraquinone (DAQ) as efficient materials for the colorimetric sensing of nitric oxide and nitrite anion,

in Tetrahedron Letters

47

(11)

pp. 1787-1791

Full Text UEA Repository

(Article)

(Published)


Key Research Interests

Research in the Marín group focuses on the application of nanoscience to address biological challenges. The main interests are in the synthesis and the use of nanomaterials as colorimetric sensors, intracellular sensors and as drug delivery systems for cancer treatment.