Biography

Geoff Moore obtained a BSc. in Applied Chemistry from the Hatfield Polytechnic (now, University of Hertfordshire), a MSc. in Biochemistry from Imperial College London, and a D.Phil. on structure-function relationships in c-type cytochromes, supervised by Professor R.J.P.Williams F.R.S., from Oxford University. From 1980-1985 he studied in Oxford on a S.E.R.C. Advanced Fellowship and then moved as a Lecturer to UEA in 1986 where he became Professor of Chemistry in 1994.

During his time at Oxford and in the early part of his time at UEA Geoff continued to work on cytochromes and together with Professor Graham Pettigrew (Edinburgh) co-authored two books on cytochromes c. His major research at UEA has been within the Centre of Metalloprotein Spectroscopy and Biology or its off-shoot, the UEA-Wolfson Molecular Structure Centre. In recent years his research has focused on the use of NMR spectroscopy to characterise proteins, and specifically their structure determination, intermolecular interactions and conformational dynamics, and structure-function relationships in protein antibiotics and proteins involved in bacterial iron metabolism.  Geoff joined the UEA Learning, Teaching and Quality Directorate in 2000.

Selected publications

Protein-template-driven formation of polynuclear iron species. Malone, S.A., Lewin, A., Kilic, M.A., Svistunenko, D.A., Cooper, C.E., Wilson, M.T., Le Brun, N.E., Spiro, S. & Moore, G.R. (2004) J Am Chem Soc. 126, 496-504.  DOI:  10.1021/ja036483z

Clusters in an intrinsically disordered protein create a protein binding site: the TolB binding region of colicin E9. Tozawa, K., Macdonald, C.J., Penfold, C.N., James, R., Kleanthous, C., Clayden, N.J. & Moore, G.R. (2005) Biochemistry 44, 11496-11507.  DOI:  10.1021/bi0503596

Characterisation of the conformational properties of urea-unfolded Im7: implications for the early stages of protein folding. Le Duff, C.S, Whittaker, S.B-M., Radford, S.E. & Moore, G.R. (2006) J. Mol. Biol. in press.  DOI:  10.1016/j.jmb.2006.09.037

NMR analysis of the conformational properties of the trapped on-pathway folding intermediate of the bacterial immunity protein Im7. Whittaker, S.B-M., Spence, G.R., Grossmann, J.G., Radford, S.E. & Moore, G.R. (2006) J. Mol. Biol. in press.  DOI:  10.1016/j.jmb.2006.11.012

All Publications

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Johnson, C. L., Solovyova, A. S., Hecht, O., Macdonald, C., Waller, H., Grossmann, J. G., Moore, G. R., Lakey, J. H.

(2017)

The Two-State Prehensile Tail of the Antibacterial Toxin Colicin N,

in Biophysical Journal

113

(8)

pp. 1673-1684

Full Text UEA Repository

(Article)

(Published)


Bradley, J. M., Svistunenko, D., Moore, G. R., Le Brun, N.

(2017)

Tyr25, Tyr58 and Trp133 of Escherichia coli bacterioferritin transfer electrons between iron in the central cavity and the ferroxidase centre,

in Metallomics

9

(10)

pp. 1421-1428

Full Text UEA Repository

(Article)

(Published)


Karsisiotis, A. I., Deacon, O. M., Macdonald, C., Blumenschein, T. M., Moore, G. R., Worrall, J.

(2017)

Near-complete backbone resonance assignments of acid-denatured human cytochrome c in dimethylsulfoxide: a prelude to studying interactions with phospholipids,

in Biomolecular NMR Assignments

11

(2)

pp. 165–168

Full Text UEA Repository

(Article)

(Published)


Karsisiotis, A. I., Deacon, O. M., Wilson, M. T., Macdonald, C., Blumenschein, T. M., Moore, G. R., Worrall, J. R.

(2016)

Increased dynamics in the 40-57 Ω-loop of the G41S variant of human cytochrome c promote its pro-apoptotic conformation,

in Scientific Reports

6

article no. 30447

Full Text UEA Repository

(Article)

(Published)


Bradley, J., Le Brun, N., Moore, G.

(2016)

Ferritins: furnishing proteins with iron,

in JBIC Journal of Biological Inorganic Chemistry

21

(1)

pp. 13-28

Full Text UEA Repository

(Article)

(Published)


Bradley, J. M., Le Brun, N. E., Moore, G. R.

(2016)

Commentary: Ferritins: Furnishing proteins with iron,

in Journal of Rare Diseases Research and Treatment

1

(3)

pp. 22-24

UEA Repository

(Article)

(Published)


Bradley, J. M., Svistunenko, D. A., Lawson, T. L., Hemmings, A. M., Moore, G. R., Le Brun, N. E.

(2015)

Three aromatic residues are required for electron transfer during iron mineralization in Bacterioferritin,

in Angewandte Chemie International Edition

127

(49)

pp. 14976–14980

Full Text UEA Repository

(Article)

(Published)


Pfaffen, S., Bradley, J., Abdulqadir, R., Firme, M. R., Moore, G., Le Brun, N., Murphy, M.

(2015)

A diatom ferritin optimized for iron oxidation but not iron storage,

in The Journal of Biological Chemistry

290

pp. 28416-28427

Full Text UEA Repository

(Article)

(Published)


Karsisiotis, A. I., Deacon, O. M., Rajagopal, B., Macdonald, C., Blumenschein, T. M. A., Moore, G., Worrall, J. R.

(2015)

Backbone resonance assignments of ferric human cytochrome c and the pro-apoptotic G41S mutant in the ferric and ferrous states,

in Biomolecular NMR Assignments

9

(2)

pp. 415-419

Full Text UEA Repository

(Article)

(Published)


Wong, S., Grigg, J., Le Brun, N., Moore, G., Murphy, M., Mauk, G.

(2015)

The B-type Channel is a Major Route for Iron Entry into the Ferroxidase Center and Central Cavity of Bacterioferritin,

in The Journal of Biological Chemistry

290

(6)

pp. 3732-3739

Full Text UEA Repository

(Article)

(Published)


Bradley, J. M., Moore, G. R., Le Brun, N. E.

(2014)

Mechanisms of iron mineralization in ferritins: one size does not fit all,

in JBIC Journal of Biological Inorganic Chemistry

19

(6)

pp. 775-785

Full Text UEA Repository

(Article)

(Published)


Wong, S., Abdulqadir, R., Le Brun, N., Moore, G., Mauk, A.

(2012)

Fe-haem bound to Escherichia colibacterioferritin accelerates iron core formation by an electron transfer mechanism,

in Biochemical Journal

444

(3)

pp. 553-560

Full Text UEA Repository

(Article)

(Published)


Zhou, L., Singleton, C., Hecht, O., Moore, G., Le Brun, N.

(2012)

Cu(l)- and proton-binding properties of the first N-terminal soluble domain of Bacillus subtilis CopA,

in FEBS Journal

279

pp. 285-298

UEA Repository

(Article)

(Published)


Whittaker, S., Clayden, N., Moore, G.

(2011)

NMR characterisation of the relationship between frustration and the excited state of Im7.,

in Journal of Molecular Biology

414

(4)

pp. 511-29

Full Text UEA Repository

(Article)

(Published)


Yasmin, S., Andrews, S. C., Moore, G., Le Brun, N.

(2011)

A New Role for Heme, Facilitating Release of Iron from the Bacterioferritin Iron Biomineral,

in The Journal of Biological Chemistry

286

(5)

pp. 3473-3483

Full Text UEA Repository

(Article)

(Published)


Zhou, L., Singleton, C., Hecht, O., Moore, G., Le Brun, N.

(2011)

Cu(I)- and proton-binding properties of the first N-terminal soluble domain of Bacillus subtilis CopA,

in FEBS Journal

279

(2)

pp. 285-298

Full Text UEA Repository

(Article)

(Published)


Yasmin, S., Andrews, S., Moore, G., Le Brun, N.

(2011)

A new role for heme: facilitating release of iron from the bacterioferritin iron biomineral,

in The Journal of Biological Chemistry

286

pp. 3473-3483

UEA Repository

(Article)

(Published)


Le Brun, N., Crow, A., Murphy, M., Mauk, A., Moore, G.

(2010)

Iron core mineralisation in prokaryotic ferritins.,

in Biochimica et Biophysica Acta

1800

(8)

pp. 732-44

Full Text UEA Repository

(Article)

(Published)


Hecht, O., Zhang, Y., Li, C., Penfold, C., James, R., Moore, G.

(2010)

Characterisation of the interaction of colicin A with its co-receptor TolA.,

in FEBS Letters

584

(11)

pp. 2249-52

UEA Repository

(Article)

(Published)


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Key Research Interests

The UEA-Wolfson Molecular Structure Centre

The UEA Molecular Structure Centre was founded in 1996 by researchers from the Schools of Biological and Chemical Sciences to ‘promote the determination and analysis of molecular structures at atomic resolution within the Norwich Research Park’ using solution-state NMR, solid-state NMR and X-ray crystallographic methods. Changes in research programmes at UEA together with changes in experimental methodologies, particularly the increased use of synchrotron X-ray sources in crystallography, led to a change in emphasis of the UEA Molecular Structure Centre, which is now focussed on solution-state NMR. Its name too has changed, to the UEA-Wolfson Molecular Structure Centre in recognition of the generous support of the Wolfson Foundation for the Centre. The aim of the Centre remains the same, however.

The Centre is equipped with Varian 300, 400, 500 and 600 MHz NMR spectrometers. These are equipped between them for inverse-detect 13C/15N NMR, deuterium decoupling for 2H/13C/15N samples, an inverse triple-resonance 8 mm probe for low-solubility samples, and direct-detect probes for 1H and 15N-31P studies. In 2007 an 800 MHz Bruker Avance IIa NMR spectrometer will be installed in the Centre.

Both internal UEA users and external researchers wishing to use the facilities of the Centre should contact either its Director, Prof. Geoff Moore, or the NMR manager, Mr Colin MacDonald.