Career History

  • Reader in Structural Biology, University of East Anglia (2002-present)
  • Senior Lecturer, University of East Anglia (2000-2002)
  • Lecturer, University of East Anglia (1994-2000)
  • STA Research Fellow, Tsukuba, Japan (1993-1994)
  • Lecturer, Birkbeck College, London (1989-1993)
  • Cray Research Fellow, Birkbeck College, London (1988-1989)
  • Royal Society Research Fellow, Beijing, China (1987-1988)
  • Ph.D. University of London (1987)
  • B.Sc. Chemistry, University College London (1982)

All Publications

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Salmon, M., Thimmappa, R. B., Minto, R. E., Melton, R. E., Hughes, R. K., O'Maille, P. E., Hemmings, A. M., Osbourn, A.

(2016)

A conserved amino acid residue critical for product and substrate specificity in plant triterpene synthases,

in Proceedings of the National Academy of Sciences of the United States of America (PNAS)

113

(30)

pp. E4407–E4414

Full Text UEA Repository

(Article)

(Published)


Bradley, J. M., Svistunenko, D. A., Lawson, T. L., Hemmings, A. M., Moore, G. R., Le Brun, N. E.

(2015)

Three aromatic residues are required for electron transfer during iron mineralization in Bacterioferritin,

in Angewandte Chemie International Edition

127

(49)

pp. 14976–14980

Full Text UEA Repository

(Article)

(Published)


Etzold, S., Mackenzie, D. A., Jeffers, F., Walshaw, J., Roos, S., Hemmings, A. M., Juge, N.

(2014)

Structural and molecular insights into novel surface-exposed mucus adhesins from Lactobacillus reuteri human strains: A novel mucus adhesin from Lactobacillus reuteri,

in Molecular Microbiology

92

(3)

pp. 543-556

Full Text UEA Repository

(Article)

(Published)


Etzold, S., Kober, O. I., Mackenzie, D. A., Tailford, L. E., Gunning, A. P., Walshaw, J., Hemmings, A. M., Juge, N.

(2014)

Structural basis for adaptation of lactobacilli to gastrointestinal mucus,

in Environmental Microbiology

16

(3)

pp. 888-903

Full Text UEA Repository

(Article)

(Published)


Stentz, R., Osborne, S., Horn, N., Li, A., Hautefort, I., Bongaerts, R., Rouyer, M., Bailey, P., Shears, S., Hemmings, A., Brearley, C. A., Carding, S.

(2014)

A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut,

in Cell Reports

6

(4)

pp. 646-656

Full Text UEA Repository

(Article)

(Published)


Soond, S. M., Smith, P. G., Wahl, L., Swingler, T. E., Clark, I. M., Hemmings, A. M., Chantry, A.

(2013)

Novel WWP2 ubiquitin ligase isoforms as potential prognostic markers and molecular targets in cancer,

in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

1832

(12)

pp. 2127-2135

Full Text UEA Repository

(Article)

(Published)


Geisler, K., Hughes, R. K., Sainsbury, F., Lomonossoff, G. P., Rejzek, M., Fairhurst, S., Olsen, C., Motawia, M. S., Melton, R. E., Hemmings, A. M., Bak, S., Osbourn, A.

(2013)

Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants,

in Proceedings of the National Academy of Sciences of the United States of America (PNAS)

110

(35)

pp. E3360-E3367

Full Text UEA Repository

(Article)

(Published)


Holmes, N., Walshaw, J., Leggett, R., Thibessard, A., Dalton, K., Gillespie, M., Hemmings, A., Gust, B., Kelemen, G.

(2013)

Coiled-coil protein Scy is a key component of a multiprotein assembly contrlling polarized growth in Streptomyces,

in Proceedings of the National Academy of Sciences of the United States of America (PNAS)

110

(5)

pp. 397-406

UEA Repository

(Article)

(Published)


Bradley, J., Marritt, S., Kihlken, M., Haynes, K., Hemmings, A., Berks, B., Cheesman, M., Butt, J.

(2012)

Redox and Chemical Activities of the Hemes in the Sulfur Oxidation Pathway Enzyme SoxAX,

in Journal of Biological Chemistry

287

(48)

pp. 40350-40359

Full Text UEA Repository

(Article)

(Published)


Lockwood, C., Clarke, T., Butt, J., Hemmings, A., Richardson, D.

(2011)

Characterization of the active site and calcium binding in cytochromecnitrite reductases,

in Biochemical Society Transactions

39

(6)

pp. 1871-1875

Full Text UEA Repository

(Article)

(Published)


Kemp, G., Clarke, T., Marritt, S., Lockwood, C., Poock, S., Hemmings, A., Richardson, D., Cheesman, M., Butt, J.

(2010)

Kinetic and thermodynamic resolution of the interactions between sulfite and the pentahaem cytochrome NrfA fromEscherichia coli,

in Biochemical Journal

431

(1)

pp. 73-80

Full Text UEA Repository

(Article)

(Published)


Hearnshaw, S., West, C., Singleton, C., Zhou, L., Kihlken, M., Strange, R., Le Brun, N., Hemmings, A.

(2009)

A Tetranuclear Cu(I) Cluster in the Metallochaperone Protein CopZ,

in Biochemistry

48

(40)

pp. 9324-9326

Full Text UEA Repository

(Article)

(Published)


MacKenzie, D., Tailford, L., Hemmings, A., Juge, N.

(2009)

Crystal Structure of a Mucus-binding Protein Repeat Reveals an Unexpected Functional Immunoglobulin Binding Activity,

in Journal of Biological Chemistry

284

(47)

pp. 32444-32453

Full Text UEA Repository

(Article)

(Published)


Singleton, C., Hearnshaw, S., Zhou, L., Le Brun, N., Hemmings, A.

(2009)

Mechanistic insights into Cu(I) cluster transfer between the chaperone CopZ and its cognate Cu(I)-transporting P-type ATPase, CopA,

in Biochemical Journal

424

(3)

pp. 347-356

Full Text UEA Repository

(Article)

(Published)


Caddick, S., Harrison, C., Stavridou, I., Mitchell, J., Hemmings, A., Brearley, C.

(2008)

Solanum tuberosum inositol phosphate kinase (StlTPK1) displaying inositol phosphate-inositol phosphate and inositol phosphate-ADP phosphotransferase activities,

in FEBS Letters

582

(12)

pp. 1731-1737

Full Text UEA Repository

(Article)

(Published)


Clarke, T., Kemp, G., Van Wonderen, J., Doyle, R., Cole, J., Tovell, N., Cheesman, M., Butt, J., Richardson, D., Hemmings, A.

(2008)

Role of a conserved gluatmine residue in tuning the catalytic activity of Escherichia coli cytochrome c nitrite reductase,

in Biochemistry

47

(12)

pp. 3789-3799

Full Text UEA Repository

(Article)

(Published)


Clarke, T., Mills, P., Poock, S., Butt, J., Cheesman, M., Cole, J., Hinton, J., Hemmings, A., Kemp, G., Soderberg, C., Spiro, S., Van Wonderen, J., Richardson, D.

(2008)

Escherichia coli cytochrome c nitrite reductase NrfA,

in Methods in Enzymology

437

pp. 63-77

Full Text UEA Repository

(Article)

(Published)


Clarke, T., Cole, J., Richardson, D., Hemmings, A.

(2007)

The crystal structure of the pentahaem c-type cytochrome NrfB and characterization of its solution-state interaction with the pentahaem nitrite reductase NrfA,

in Biochemical Journal

406

(1)

pp. 19-30

Full Text UEA Repository

(Article)

(Published)


Jepson, B., Mohan, S., Clarke, T., Gates, A., Cole, J., Butler, C., Butt, J., Hemmings, A., Richardson, D.

(2007)

Spectropotentiometric and structural analysis of the periplasmic nitrate reductase from Escherichia coli,

in Journal of Biological Chemistry

282

pp. 6425-6437

Full Text UEA Repository

(Article)

(Published)


Sauve, V., Bruno, S., Berks, B., Hemmings, A.

(2007)

The SoxYZ complex carries sulfur cycle intermediates on a peptide swinging arm,

in Journal of Biological Chemistry

282

pp. 23194-23204

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

I am interested in the structural basis for the molecular interactions which underpin biological processes. My group employs techniques in structural, molecular and computational biology to study fundamental problems in mechanistic enzymology and molecular recognition. I am particularly interested in the question of bacterial survival (life – respiration and uptake of nutrients, particularly metals; and death – production of cytotoxic proteins). The aim of this research is to provide insights into how the structures of bacterial proteins and their complexes with ligands and substrates (e.g. RNA/DNA, metal ions and sugars) determine the likelihood of survival of the bacterium. The group forms part of the UEA Centre for Molecular and Structural Biochemistry (CMSB) and has particular expertise in studies of metal and cofactor-rich proteins.

Current Research Projects

  • Interactions of commensal bacteria with the gut
  • Multiheme proteins involved in bacterial anaerobic respiration
  • The mechanisms of metal trafficking in bacteria
  • Structural enzymology of plant biosynthetic enzymes
  • Bioinformatics and protein structure prediction, particularly of cofactor-rich proteins

Life in our research group

We are based on the second floor of the School of Biological Sciences and form a part of the larger grouping of biological chemists and biochemists working within the Centre for Molecular and Structural Biochemistry. The research environment is excellent and we have access to a wide range of facilities either within the School, nearby in the University or elsewhere on the Norwich Research Park. We collect X-ray scattering and diffraction data at synchrotrons in the UK and elsewhere in Europe and beyond on a regular basis. We also collaborate widely and our work is multidisciplinary. This means that we have a wide range of literature to screen and we keep up to date with scientific developments by attending research seminars and international meetings.

Research Studentships

Click here for current PhD opportunities in the School of Biological Sciences.

Click here for current PhD opportunities in the School of Chemistry.

But feel free to email me to discuss PhD, MPhil and MRes opportunities and and alternative sources of funding.

Teaching Interests

  • Protein Structure and Chemistry (CHE-3H81) [Organiser]
  • Protein Engineering (CHE-3H84) [Organiser]
  • Biophysical Chemistry (CHE-2F7Y)
  • Forensic Analysis and Interpretation II (CHE-2H57)
  • Introductory Chemistry for the Life Sciences (BIO-1A61)
  • Molecular Enzymology (BIO-3C01) [Organiser]
  • Fundamentals of Molecular Biology and Genetics (BIO-1A13)
  • Seminars in Biochemistry (BIO-1A3Y)
  • Modelling and Statistics for Biologists (BIO-1A7Y)
  • Genomes, Genes and Genomics (BIO-3C41)

External Activities and Indicators of Esteem

  • Member of Working Group 1 of the Collaborative Computational Project No.4 (CCP4, Protein Crystallography)

Administrative Posts

  • Chair of BIO PGT Exam Boards
  • BIO Safety Officer