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Office: CAP 3.09 Email: s.bew@uea.ac.uk Tel: +44(0) 1603-593142 School Position: Lecturer in Chemistry; Organic Safety Adviser; Library representative for chemistry Staff – student committee |
Dr Bew graduated with a BSc in Chemistry from the University of Leicester. Moving to the University of Bristol, he undertook his PhD under the supervision of Dr J. B. Sweeney, which was concerned with the synthesis of organotin derived 3-sulpholenes and their reactions. Upon completing his studies he undertook postdoctoral research at the University of Bath - working on BNCT agents, then at the University of Nottingham and subsequently the University of Wales (Cardiff) - on the synthesis of the boron containing antibiotic Aplasmomycin and finally at Oxford University - working for Professor S. G. Davies on developing chiral auxilaries their chemistry and immobilisation onto solid support. He took up his current position at the School of Chemical Sciences & Pharmacy in October 2000.
Our research interests lie at the interface of synthetic chemistry, natural product synthesis and biology. It is our aim to develop interesting, useful synthetic chemistry for the development of innovative chemical entities and or natural products. To facilitate and enable this process we utilise state-of-the-art chemical techniques, equipment and protocols.
Our research group has collaborations with chemical engineers at the Universities of Bath, Edinburgh and Sheffield, as well as being part of a consortium of eight universities that are funded via the EPSRC to investigate the as well as having numerous collaborations with colleagues in the School of Biological Sciences at UEA. We have focused our attention on investigating the synthesis and applications of novel chemical entities for probing the molecular recognition of cell surfaces, exploring cell-cell interactions and examining cell-surface receptors. We are particularly interested in developing structures that have potential applications in diagnosing and / or treating a wide variety of cancers.
Our research continues to be supported from a wide variety of sources for example: EPSRC, MRC, BBSRC, GlaxoSmithKline (CASE award), Pfizer, the Bryan Gunn Leukaemia Trust, EEDA and Millennium Pharmaceuticals (CASE award), NRP and UEA, Wellcome Trust, Biofocus plc (CASE award) and the Big C.
Selected publications
Stereoselective synthesis of N-alkylaziridines from N-chloroamines.
Sean P. Bew, D. L. Hughes, Nicholas J. Palmer, Vladimir Savic, Katy M. Soapi, Martin A. Wilson,
Chemical Communications, 2006, 33, advanced article
DOI: 10.1039/b608504k
Expedient synthesis of substituted (S)-N-(α)-methylbenzylaziridines.
Sean P. Bew, D. L. Hughes, Nicholas J. Palmer, Vladimir Savic, Katy M. Soapi, Martin A. Wilson,
Chemical Communications, 2006, 33, 3513 - 3515
DOI: 10.1039/b606033a
Acid-catalyzed synthesis of methylene-bridged (S)-tyrosine-phenol dimers.
Sean P. Bew, D. L. Hughes, Sunil V. Sharma,
Journal of Organic Chemistry, 2006, 71, 7881 - 7884.
DOI: 10.1021/jo0610863
