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Office: CAP 3.50 Email: r.goss@uea.ac.uk Tel: +44(0) 1603-593766 School Position: Senior lecturer in Organic Chemistry |
PhD Studentships available:
Elucidating the biosynthesis of an unusual marine metabolite
Genochemetics: a new approach to natural product analogue generation
Background Information
- Lecturer in Organic Chemistry, University of East Anglia
- Lecturer in Organic Chemistry, University of Exeter, 2003-2005
- Lecturer in Organic Chemistry, University of Nottingham, 2002-2003.
- Post doctoral research associate for Prof. P.F.Leadlay FRS, Prof J. Staunton FRS, Department of Biochemistry, University of Cambridge, 2000-2002
- Ph.D. for Professor David O’Hagan, Department of Chemistry, Durham University, 1997-2000
- B.Sc. Chemistry, University of Durham, 1994-1997
Significant Awards
- Royal Society Dorothy Hodgkin Fellow, 2003-2007
- 2007 RSC Meldola Medal (awarded to the most promising UK chemist under the age of 32) “distinguished for excellent contributions at the interface of organic chemistry and molecular biology”
Research Interests
The Goss group is interested in the biosynthesis of natural products and in how these biosynthetic pathways may be harnessed to generate natural products of our own design. Many natural products are of medicinal importance. We are also interested in determining the molecular mode of action of drug molecules. It is our aim to couple these two interests, manipulating biosynthetic pathways to expediently access series of otherwise synthetically intractable natural product analogues, which can be utilised in structure activity determination.
Committees/Posts
- RSC Bioorganic Group committee member and secretary
- RSC Member of Organic division executive
Selected publications
Pacidamycin Biosynthesis: Identification and Heterologous Expression of the First Uridyl Peptide Antibiotic Gene Cluster
Emma J. Rackham, Sabine Grüschow, Amany E. Ragab, Shilo Dickens, and Rebecca J. M. Goss*
ChemBioChem., 2010, 11, 1700-1709
Biogenesis of the unique 4’, 5’-dehydronucleoside of the uridyl peptide antibiotic pacidamycin
A. E. Ragab, S. Grüschow, R. J. M. Goss*
J. Am. Chem. Soc., 2011
DOI: http://dx.doi.org/10.1021/ja206163j
Diversity in natural product families is governed by more than enzyme promiscuity alone: establishing control of the pacidamycin portfolio
S. Grüschow, E. Rackham, R. J. M. Goss*
Chemical Science, 2011
DOI: 10.1039/C1SC00378J
Highlighted in Chemistry World
Highlight in C&EN News 89(34), August 22, 2011
Gene expression enabling synthetic diversification of unnatural products:chemogenetic generation pacidamycin analogs
Abhijeet Deb Roy, Sabine Grüschow, Nickiwe Cairns, Rebecca J. M. Goss*
J. Am. Chem. Soc., 2010, Article ASAP.
DOI: 10.1021/ja1060406. Highlighted in C.&EN. News, August 23rd, 2010
Revealing the first uridyl peptide antibiotic biosynthetic gene cluster and probing pacidamycin biosynthesis
E. Rackham, S. Gruschow, R. J. M. Goss*
Bioengineered Bugs, 2011 In press
Bioeng Bugs. 2011 Jul 1;2(4). [Epub ahead of print]
An expeditious route to fluorinated rapamycin analogues by utilising mutasynthesis.
Goss RJ*, Lanceron S, Deb Roy A, Sprague S, Nur-E-Alam M, Hughes DL, Wilkinson B, Moss S
J.Chembiochem. 2010 Mar 22;11(5):698-702.
PMID: 20186904
Engineering Biofilms for Biocatalysis
Andreas N. Tsoligkas, Michael Winn, James Bowen, Tim W. Overton, Mark J. H. Simmons*, Rebecca J. M. Goss*
ChemBioChem, 2011, 12, 1391-1395
DOI: 10.1002/cbic.201100200
A single Streptomyces mutualist makes multiple antifungals: a weedkiller cocktail used by the fungus farming ant Acromyrmex octospinosus
R. F. Seipke, J. Barke, C. Brearley, L. Hill, D. W. Yu, R. J. M. Goss, M. I. Hutchings*
PLoS ONE, 2011, 8, e22028
PMID: 21857911
