Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins.
Crack, J. C., Smith, L. J., Stapleton, M. R., Peck, J., Watmough, N. J., Buttner, M. J., Buxton, R. S., Green, J., Oganesyan, V. S., Thomson, A. J., and Le Brun, N. E.
J. Am. Chem. Soc., 2011, 133, 1112-1121.
A new role for heme: facilitating release of iron from the bacterioferritin iron biomineral.
Yasmin, S., Andrews, S. C., Moore, G. R. and Le Brun, N. E.
J. Biol. Chem., 2011, 286, 3473-3483.
Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide sensitive iron-sulphur cluster.
Smith, L. J., Stapleton, M. R., Fullstone, G. J. M., Crack, J. C., Thomson, A. J., Le Brun, N. E., Hunt, D. M., Harvey, E., Adinolfi, S., Buxton, R. S. and Green, J.
Biochem. J., 2010, 432, 417-427.
Iron core mineralisation in prokaryotic ferritins.
Le Brun, N. E., Crow, A., Murphy, M. E. P., Mauk, A. G. and Moore, G. R.
Biochim. Biophys. Acta, 1800, 2010, 732-744.
The dddP gene of Roseovarius nubinhibens encodes a novel lyase that cleaves dimethylsulfoniopropionate into acrylate plus dimethyl sulfide.
Kirkwood, M., Le Brun, N. E., Todd, J. D. and Johnston, A. W. B.
Microbiology, 2010, 156, 1900-1906.
Heme-responsive DNA binding by the global iron regulator Irr from Rhizobium leguminosarum.
Singleton, C., White, G. F., Todd, J. D., Marritt, S. J., Cheesman, M. R., Johnston, A. W. B. and Le Brun, N. E.
J. Biol. Chem.,2010, 285, 16023-16031
There’s NO stopping NsrR, a global regulator of the bacterial NO stress response.
N. P. Tucker, N. E. Le Brun, R. Dixon and M. I. Hutchings
Trends Microbiol., 2010, Accepted
Characterization of [4Fe-4S]-containing and cluster-free forms of Streptomyces WhiD.
J. C. Crack, C. D. den Hengst, P. Jakimowicz, S. Subramanian, M. K. Johnson, M. J. Buttner, A. J. Thomson and N. E. Le Brun
Biochemistry, 2009, 48, 12252-12264
Mechanistic insights into Cu(I) cluster transfer between the chaperone CopZ and its cognate Cu(I)-transporting P-type ATPase CopA.
C. Singleton, S. Hearnshaw, L. Zhou, N. E. Le Brun, and A. M. Hemmings
Biochemical Journal., 2009, 424, 347-356
A tetranuclear Cu(I) cluster in the metallochaperone protein CopZ
S. Hearnshaw, C. West, S. Singleton, L. Zhou, M. A. Kihlken, R. W. Strange, N. E. Le Brun and A. M. Hemmings
Biochemistry (rapid communication), 2009, 48, 9324-9326
Monitoring the iron status of the ferroxidase center of Escherichia coli bacterioferritin using fluorescence spectroscopy
T. L. Lawson, A. Crow, A. Lewin, S. Yasmin, G. R. Moore and N. E. Le Brun
Biochemistry, 2009, 48, 9031-9039
Crystal structure and biophysical properties of Bacillus subtilis BdbD: An oxidizing thiol:disulfide oxidoreductase containing a novel metal site
A. Crow, A. Lewin, O. Hecht, M. Carlsson Möller, G. R. Moore, L. Hederstedt and N. E. Le Brun
Journal of Biological Chemistry, 2009, 284, 23719-23733
The structural basis for iron mineralization by bacterioferritin.
A. Crow, T. L. Lawson, A. Lewin, G. R. Moore and N. E. Le Brun
J. Am. Chem. Soc., 2009, 131, 6808-6813
Structural and mechanistic studies of a stabilized subunit dimer variant of Escherichia coli bacterioferritin identify residues required for core formation
S. G. Wong, A. A. L. Tom-Yew, A. Lewin, N. E. Le Brun, G. R. Moore, M. E. P. Murphy and A. G. Mauk
Journal of Biological Chemistry, 2009, 284, 18873-18881.
Optimizing the sensitivity to O2 of the transcription factor FNR: Ser24 modulates the kinetics of the [4Fe-4S] to [2Fe-2S] conversion
A. J. Jervis, J. C. Crack, G. F. White, P. J. Artymiuk, M. R. Cheesman, A. J. Thomson, N. E. Le Brun and J. Green
Proc. Natl. Acad. Sci. USA, 2009, 106, 4659-4664.
Bacterial direct oxygen sensors.
J. Green, J. C. Crack, A. J. Thomson and N. E. Le Brun
Current Opinions in Microbiology, 2009, Accepted.
Structure and functional properties of Bacillus subtilis endospore-biogenesis factor StoA.
A. Crow, Y. Liu, M. Carlsson Möller, N. E. Le Brun and L. Hederstedt.
Journal of Biological Chemistry, 2009, Accepted [DOI:10.1074/jbc.M809566200].
The N-terminal soluble domains of Bacillus subtilis CopA exhibit a high affinity and capacity for Cu(I) ions.
C. Singleton and N. E. Le Brun.
Dalton Transactions, 2009, 688 - 696 [DOI: 10.1039/B810412C].
The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster.
N. P. Tucker, M. G. Hicks, T. A. Clarke, J. C. Crack, G. C. Chandra, N. E. Le Brun, R. Dixon and M. I. Hutchings.
PLoS One 2008, 3, e3623.
Signal perception by FNR: the role of the iron-sulfur cluster.
J. C. Crack, A. J. Jervis, A. A. Gaskell, G. F. White, J. Green, A. J. Thomson and N. E. Le Brun
Biochemical Society Transactions 2008, 36, 1144-1148.
Distinct characteristics of Ag+- and Cd2+-binding to CopZ from Bacillus subtilis.
M. A. Kihlken, C. Singleton and N. E. Le Brun
Journal of Biological Inorganic Biochemistry 2008, 13, 1011-1023.
The active site cysteinyls and hydrophobic cavity residues of ResA are important for cytochrome c maturation in Bacillus subtilis.
C. T. C. Hodson, A. Lewin, L. Hederstedt and N. E. Le Brun
Journal of Bacteriology 2008, 190, 4697-4705.
Effects of Substitutions in the CXXC Active Site Motif of the Extra-Cytoplasmic Thioredoxin ResA.
A. Lewin, A. Crow, C. T. C. Hodson, L. Hederstedt and N. E. Le Brun
Biochemical Journal 2008, 414, 81-91.
High Cu(I) and low proton affinities of the CXXC motif of Bacillus subtilis CopZ.
L. Zhou, C. Singleton and N. E. Le Brun
Biochemical Journal 2008, 413, 459-465.
Structure and Cu(I)-binding properties of the N-terminal soluble domains of Bacillus subtilis CopA
C. Singleton, L. Banci, S. Ciofi-Baffoni, L. Tenori, M. A. Kihlken, R. Boetzel and N. E. Le Brun
Biochemical Journal 2008, 411, 571-579.
Influence of the environment on the [4Fe-4S]2+ to [2Fe-2S]2+ cluster switch in the transcriptional regulator FNR
J. C. Crack, A. A. Gaskell, J. Green, M. R. Cheesman, N. E. Le Brun and A. J. Thomson
Journal of the American Chemical Society 2008, 130, 1749 - 1758.
Reactions of nitric oxide and oxygen with the regulator of fumarate and nitrate reduction, a global transcriptional regulator, during anaerobic growth of E. coli
J. C. Crack, N. E. Le Brun, J. Green and A. J. Jervis
Methods in Enzymology, 2008, 437, 189 – 207. DOI: 10.1016/S0076-6879(07)37011-0
RsmA is an anti-sigma factor that modulates its activity through a [2Fe-2S] cluster cofactor.
A. A. Gaskell, J. C. Crack, G. H. Kelemen, M. I. Hutchings and N. E. Le Brun
Journal of Biological Chemistry, 2007, 282, 31812-31820
Superoxide-mediated amplification of the oxygen-induced switch from [4Fe-4S] to [2Fe-2S] clusters in the transcriptional regulator FNR
J. C. Crack, J. Green, M. R. Cheesman, N. E. Le Brun and A. J. Thomson
Proceedings of the National Academy of Sciences of the USA 2007, 104, 2092-2097.
(This paper was featured as an Editors’ choice in Science, 2007, 315, 914)
Atx1-like chaperones and their cognate P-type ATPases: copper-binding and transfer.
C. Singleton and N. E. Le Brun
Biometals 2007, 20, 275-289
Molecular basis for specificity of the extra-cytoplasmic thioredoxin ResA
A. Lewin, A. Crow, A. Oubrie and NE Le Brun
Journal of Biological Chemistry, 2006, 281, 35467-35477
Detection of sulphide-release from the oxygen-sensing [4Fe-4S] cluster of FNR
J. C. Crack, J. Green, N. E. Le Brun and A. J. Thomson
Journal of Biological Chemistry, 2006, 281, 18909-18913
Formation of protein-coated iron minerals
A. Lewin, G. R. Moore and N. E. Le Brun
Dalton Transactions, 2005, 3597-3610
Iron proteins for storage and transport and their synthetic analogs
A. Lewin, N. E. Le Brun and G. R. Moore
In Encyclopedia of Inorganic Chemistry, 2005, 2nd Ed., Edited by R. B. King, Wiley.
The role of ResA in type II cytochrome c maturation
A. Crow, N. E. Le Brun and A. Oubrie
Biochemical Society Transactions, 2005, 33, 149-151
Protein-template-driven formation of polynuclear iron species
S. A. Malone, A. Lewin, M. A. Kilic, D. A. Svistunenko, C. E. Cooper, M. T. Wilson, N. E. Le Brun, S. Spiro and G. R. Moore
Journal of the American Chemical Society, 2004, 126, 496-504
Structural basis of redox-coupled protein substrate selection by the cytochrome c biosynthesis protein ResA.
C. Allister, R. M. Acheson, N. E. Le Brun and A. Oubrie
Journal of Biological Chemistry, 2004, 279, 23654-23660
Effect of phosphate on bacterioferritin-catalysed iron(II) oxidation
H. Aitken-Rogers, C. Singleton, A. Lewin, A. Taylor-Gee, G. R. Moore and N. E. Le Brun
Journal of Biological Inorganic Chemistry, 2004, 9, 161-170
CopZ from Bacillus subtilis interacts in vivo with a copper exporting CPx-type ATPase CopA.
D. S. Radford, M. A. Kihlken, G. P. M. Borrelly, C. R. Harwood, N. E. Le Brun and J. S. Cavet
Fems Microbiology Letters, 2003, 220, 105-112
Bacillus subtilis ResA is a thiol-disulfide oxidoreductase involved in cytochrome c synthesis
L. S. Erlendsson, R. M. Acheson, L. Hederstedt and N. E. Le Brun
Journal of Biological Chemistry, 2003, 278, 17852-17858
Core formation in Escherichia coli bacterioferritin requires a functional ferroxidase center
S. Baaghil, A. Lewin, G. R. Moore and N. E. Le Brun
Biochemistry, 2003, 42, 14047-14056
Copper-mediated dimerization of CopZ, a predicted copper chaperone from Bacillus subtilis
M. A. Kihlken, A. P. Leech and N. E. Le Brun
Biochemical Journal, 2002, 368, 729-739
Iron detoxification properties of Escherichia coli bacterioferritin - Attenuation of oxyradical chemistry
F. Bou-Abdallah, A. C. Lewin, N. E. Le Brun, G. R. Moore and N. D. Chasteen
Journal of Biological Chemistry, 2002, 277, 37064-37069
Studies of copper(II)-binding to bacterioferritin and its effect on iron(II) oxidation
S. Baaghil, A. J. Thomson, G. R. Moore and N. E. Le Brun
Journal of the Chemical Society-Dalton Transactions, 2002, 811-818
Investigating protein sensitised lanthanide ion luminescence in complexes formed between terbium and the iron binding proteins; human serum transferrin, neisserial ferric iron binding protein and Escherichia coli bacterioferritin.
G. F. White, I. Harvey, N. E. Le Brun, J. A. Farrar and A. J. Thomson
Journal of Inorganic Biochemistry, 2001, 86, 479
