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Office: CAP 1.28 Email: d.russell@uea.ac.uk Tel/Fax: +44(0)1603 593012 School Position: Professor of Chemistry, Head of School |
David Russell joined the School as a lecturer in 1991. He was promoted to Senior Lecturer (1997), Reader (1999) and then to a Chair in 2002. David’s research focuses on bioanalytical chemistry at the nanoscale. Using biological receptors, monolayer structures are created on gold nanoparticle, magnetic particle or planar surfaces for the development of optically based molecular recognition systems. Biological receptors include proteins, enzymes, carbohydrates and antibodies. In order to measure and quantify the molecular recognition process, the surface bound biomolecules are probed using fluorescence, UV-visible absorption or surface plasmon resonance spectroscopies.
Current research involves the stabilisation of metal nanoparticles: with carbohydrates for the detection of toxins and viruses; with antibodies and proteins for the detection of drugs and/or drug metabolites within fingerprints; with proteins for the fluorescence detection of intracellular targets; and to deliver light activated photosensitiser agents to initiate cytotoxic apoptosis of cancer cells via photodynamic therapy.
David’s research is currently supported by: EPSRC; EPSRC Basic Technology programme (Glycoarrays consortium involving 7 academic groups); Big C cancer charity and industry. His research has been recognized through the award of the RSC SAC Silver Medal and a Stichting Research Prize from Schlumberger. In 2009 David founded a spin-out company Intelligent Fingerprinting Ltd. based on his research on the detection of drugs and drug metabolites in fingerprints.
Amongst other activities, David has been a member of the RCUK Basic Technologies Strategic Advisory Team (2005-2008) and has chaired / been a member of numerous grant awarding panels for EPSRC, MRC, RCUK and DTI.
Selected Publications
Imaging of latent fingerprints through the detection of drugs and metabolites.
P. Hazarika, S. M. Jickells, K. Wolff and D. A. Russell.
Angewandte Chemie International Edition, 2008, 47, 10167-10170. (plus inside cover).
Highlighted by: Angewandte Chemie as a ‘Very Important paper’; Nature Materials (2009, 8, 5); Discovery Channel on-line; Chemical and Engineering News (Dec 22, 2008, p34) ; Interviewed for BBC World Service Radio;
DOI: 10.1002/anie.200804348
“Intelligent” fingerprinting: Simultaneous identification of drug metabolites and individuals by using antibody-functionalized nanoparticles.
R. Leggett, E. E. Lee-Smith, S. M. Jickells and D. A. Russell.
Angewandte Chemie International Edition, 2007, 46, 4100-4103.
DOI: 10.1002/anie.200700217
Paper highlighted by: Nature; Nature Nanotechnology; New Scientist, Chemistry World; Chemistry & Industry; C&E News; Analytical Chemistry; Sunday Telegraph; Daily Mirror; CNN On-line; Interviewed by German and BBC radio.
Glyconanoparticles for the colorimetric detection of cholera toxin.
C. L. Schofield, R. A. Field and D. A. Russell.
Analytical Chemistry, 2007, 79, 1356-1361.
DOI: 10.1021/ac061462j
Paper highlighted in Analytical Chemistry (2007, 79, 1772) and Institute of Physics/EPSRC booklet for school children on Condensed Matter – Nanoparticles in medicine.
Synthetic macrocyclic peptidomimetics as tunable pH probes for the fluorescence imaging in live cells.
F. Galindo, M.I. Burguete, L. Vigara, S.V. Luis, N. Kabir, J. Gavrilovic and D.A. Russell, Angewandte Chemie International Edition, 2005, 44, 6504-6508
DOI: 10.1002/anie.200501920
