Fluorescent Biological Probes for Epigenetic Targets Fluorescent Biological Probes for Epigenetic Targets

A novel method that allows the production of chemically labelled biological probes valuable for investigating and analysing epigenetic targets in disease. The innovation allows the creation of uniquely designed cell-permeable and chemically-labelled probes that can adhere to and inhibit specific key target molecules involved in epigenetic regulation and disease. A major advantage is that the probes can be labelled with fluorescent or non-fluorous tags which facilitate imaging and detection techniques in investigative and analytical biological research.

Advantages

  • Cell-permeable probes
  • Capable of non-fluorous or fluorescent labelling
  • High-affinity inhibitors of key epigenetic targets
  • Solves issue of limited availability and diversity of epigenetic probes

Scientists at the University of East Anglia offer these unique epigenetic probes with customisable options. This technology and the resulting availability of new epigenetic probes will help researchers determine the role of epigenetic targets in epigenetic regulation and disease. It will also help elucidate the key mechanisms and give rise to other key components involved which will help develop new, safe and effective drugs and therapies for treating and preventing disease in humans.

Publications

Bioorg. Med. Chem. 19 (2011) 3709–3716. doi:10.1016/j.bmc.2011.02.017

Principal Investigator

Team led by Professor A. Ganesan

Further Details

For more information on this licensing opportunity, please contact Dr Georgina Pope


Banner image sourced from: Christoph Bock, Max Planck Institute for Informatics, Wikimedia Commons, CC BY-SA 3.0, cropped. Body image sourced from: www.freeimages.co.uk