Career History

  • Professor of Biochemistry, University of East Anglia (2007-present)
  • Reader, University of East Anglia (2001-2007)
  • British Heart Foundation Senior Research Fellow, University of East Anglia (2000-2006)
  • Honorary Senior Lecturer, Thrombosis Research Institute, London (1995-2000)
  • Danish Cancer Society Senior Research Fellow, University of Copenhagen (1989-1994)
  • Honorary Lecturer, King's College School of Medicine, London (1987-1989)
  • Research Assistant/Research Fellow, King's College School of Medicine, London (1979-1986)
  • Ph.D. - Biochemistry, University of London (1984)
  • B.Sc. - Biochemistry, University of Liverpool (1978)


ResearcherID

http://www.researcherid.com/rid/D-1860-2009

All Publications

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Gaweł-Bęben, K., Ali, N., Ellis, V., Velasco, G., Poghosyan, Z., Ager, A., Knäuper, V.

(2017)

TMEFF2 shedding is regulated by oxidative stress and mediated by ADAMs and transmembrane serine proteases implicated in prostate cancer,

in Cell Biology International

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Nonboe, A. W., Krigslund, O., Soendergaard, C., Skovbjerg, S., Friis, S., Andersen, M. N., Ellis, V., Kawaguchi, M., Kataoka, H., Bugge, T. H., Vogel, L. K.

(2017)

HAI-2 stabilizes, inhibits, and regulates SEA-cleavage-dependent secretory transport of matriptase,

in Traffic

18

(6)

pp. 378–391

Full Text UEA Repository

(Article)

(Published)


Al-Mamun, M., Ravenhill, L., Srisukkham, W., Hossain, A., Fall, C., Ellis, V., Bass, R.

(2016)

Effects of Noninhibitory Serpin Maspin on the Actin Cytoskeleton: A Quantitative Image Modeling Approach,

in Microscopy and Microanalysis

22

(2)

pp. 349-409

Full Text UEA Repository

(Article)

(Published)


Gray, K., Elghadban, S., Thongyoo, P., Owen, K. A., Szabo, R., Bugge, T. H., Tate, E. W., Leatherbarrow, R. J., Ellis, V.

(2014)

Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II,

in Thrombosis and Haemostasis

112

(2)

pp. 402-411

Full Text UEA Repository

(Article)

(Published)


Ellis, V.

(2012)

The Plasminogen Activation System in Normal Tissue Remodeling,

in Matrix Proteases in Health and Disease.

Wiley-VCH Verlag GmbH & Co. KGaA

pp. 25-55

ISBN 9783527329915

Full Text

(Chapter (peer-reviewed))

(Published)


Roy, S., Bingle, L., Marshall, J. F., Bass, R., Ellis, V., Speight, P. M., Whawell, S. A.

(2011)

The role of α9β1 integrin in modulating epithelial cell behaviour: α9β1 integrin and epithelial cell behaviour,

in Journal of Oral Pathology and Medicine

40

(10)

pp. 755-761

Full Text UEA Repository

(Article)

(Published)


Owen, K., Qiu, D., Alves, J., Schumacher, A., Kilpatrick, L., Li, J., Harris, J., Ellis, V.

(2010)

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA,

in Biochemical Journal

426

(2)

pp. 219-228

Full Text UEA Repository

(Article)

(Published)


Ravenhill, L., Wagstaff, L., Edwards, D., Ellis, V., Bass, R.

(2010)

G-helix of Maspin Mediates Effects on Cell Migration and Adhesion,

in Journal of Biological Chemistry

285

(47)

pp. 36285-36292

Full Text UEA Repository

(Article)

(Published)


Bass, R., Wagstaff, L., Ravenhill, L., Ellis, V.

(2009)

Binding of Extracellular Maspin to 1 Integrins Inhibits Vascular Smooth Muscle Cell Migration,

in Journal of Biological Chemistry

284

(40)

pp. 27712-27720

Full Text UEA Repository

(Article)

(Published)


Bass, R., Ellis, V.

(2009)

Regulation of urokinase receptor function and pericellular proteolysis by the integrin α5β1,

in Thrombosis and Haemostasis

101

(5)

pp. 954-962

Full Text UEA Repository

(Article)

(Published)


Qiu, D., Owen, K., Gray, K., Bass, R., Ellis, V.

(2007)

Roles and regulation of membrane-associated serine proteases,

in Biochemical Society Transactions

35

(3)

pp. 583-587

Full Text UEA Repository

(Article)

(Published)


Kilpatrick, L., Harris, R., Owen, K., Bass, R., Ghorayeb, C., Bar-Or, A., Ellis, V.

(2006)

Initiation of plasminogen activation on the surface of monocytes expressing the type II transmembrane serine protease matriptase.,

in Blood

108

(8)

pp. 2616-2623

Full Text UEA Repository

(Article)

(Published)


Bass, R., Ellis, V.

(2005)

Regulation of uPAR function by the integrin alpha 5 eta 1.,

in Thrombosis and Haemostasis

93

pp. 70

UEA Repository

(Article)

(Published)


Bass, R., Werner, F., Odintsova, E., Sugiura, T., Berditchevski, F., Ellis, V.

(2005)

Regulation of urokinase receptor proteolytic function by the tetraspanin CD82.,

in Journal of Biological Chemistry

280

(15)

pp. 14811-14818

Full Text UEA Repository

(Article)

(Published)


Gray, K., Ellis, V.

(2005)

Proteolytic processing of neurotrophin and its effect on vascular smooth muscle cell behaviour.,

in Thrombosis and Haemostasis

93

pp. 98

UEA Repository

(Article)

(Published)


Kilpatrick, L., Owen, K., Harris, R., Ellis, V.

(2005)

Dual roles of the type-II transmembrane serine proteases matriptase and hepsin in the activation of pro-uPA and HGF/SF at the cell surface.,

in Thrombosis and Haemostasis

93

pp. 14

UEA Repository

(Article)

(Published)


Riddick, A., Shukla, C., Pennington, C., Bass, R., Nuttall, R., Hogan, A., Sethia, K., Ellis, V., Collins, A., Maitland, N., Ball, R., Edwards, D.

(2005)

Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues.,

in British Journal of Cancer

92

(12)

pp. 2171-2180

Full Text UEA Repository

(Article)

(Published)


Dalvi, N., Thomas, G., Marshall, J., Morgan, M., Bass, R., Ellis, V., Speight, P., Whawell, S.

(2004)

Modulation of the urokinase-type plasminogen activator receptor by the beta 6 integrin subunit.,

in Biochemical and Biophysical Research Communications

317

(1)

pp. 92-99

Full Text UEA Repository

(Article)

(Published)


Ellis, V.

(2004)

Urokinase plasminogen activator,

in Handbook of Proteolytic Enzymes 2nd Edition.

ISBN 978-0-12-079610-6

UEA Repository

(Chapter)

(Published)


Riddick, A., Barker, C., Sheriffs, I., Bass, R., Ellis, V., Sethia, K., Edwards, D., Ball, R.

(2003)

Banking of fresh frozen prostate tissue: methods, validation and use,

in BJU International

91

(4)

pp. 315-323

UEA Repository

(Article)

(Published)


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Key Research Interests

My laboratory is investigating the mechanisms underlying the regulation of serine protease activity and function in pericellular proteolysis, with emphasis on the plasminogen activation system and type-II transmembrane serine protease. The aim of this research programme is to understand at the molecular level how the activity of these powerful proteolytic systems are controlled and how they becomes deregulated in various diseases, in particular those of the cardiovascular system.

Current Research Projects 

  • Role of the type-II transmembrane serine proteases, matriptase and hepsin, in the activation of HGF/SF (hepatocyte growth factor/scatter factor)
  • Role of the type-II transmembrane serine protease matriptase in regulation of epithelial cell function
  • Cellular regulation of protase function and the control of vascular matrix remodelling
  • Proteolytic processing and activation of pro-neurotrophins in the cardiovascular system
  • Regulation of uPA-recptor function by tetraspanins and integrins.
     

Life in our Research Group

We use biochemical, cell and molecular biology techniques to answer research questions related to the biological activities of serine proteases. The laboratory is situated in the Biomedical Research Centre, a state-of-the-art, well equipped, open plan working environment. We are part of the Cellular Protease Group at UEA, which brings together several groups of researchers with complementary interests. We collaborate with several other research groups in the UK, Europe and North America, and students and post-doctoral researchers are encouraged to travel to collaborators research laboratories and to give presentations at international meetings.

PhD Positions 

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Postdocs & Fellows 

I am always happy to discuss possibilities for postdoctoral work, fellowships and collaborations.

Teaching Interests

  • Physical and Analytical Methods in the Biomolecular Sciences (4007Y)
  • Introduction to Biomedicine (4005Y)
  • Fundamentals of Cell Biology and Biochemistry (4004B)
  • Biochemistry (2B01)
  • Molecular Biology (2B02)
  • Investigation of Human Disease (2B30)
  • Molecular Enzymology in Medicine and Biology (3C01)
  • Biomedicine (3C34)

External Activities and Indicators of Esteem

  • Organiser, XIIIth International Workshop on Molecular & Cellular Biology of Plasminogen Activation, Clare College Cambridge, 2011
  • External PhD examiner: University of Copenhagen and University of Aarhus, Denmark; Vita-Salute San Raffaele University, Milan
  • Co-chair Gordon Research Conference "Fibrinolysis and Extracellular Proteolysis", Ventura, California, 2010
  • Editorial Board member (Section Editor), Thrombosis and Haemostasis (2005-present)
  • Biochemical Society Theme Panel member (2003-present)
  • Editor, Biochemical Society Transactions Vol. 30 Proceedings of Protein and Peptide Science Colloquium "Non-haemostatic Roles for Blood Coagulation Proteases and their Receptors"
  • Scientific committee member, XIXth Congress of the International Society on Thrombosis and Haemostasis, Birmingham, UK, 2003
  • Invited speaker: Gordon Research Conference "Fibrinolysis and Extracellular Proteolysis", Ventura, California, 2006
  • Danish Cancer Society (Kraeftens Bekaempelse) Senior Research Fellowship (1992-1994) * British Heart Foundation Senior Research Fellowship (2000-2006)

Administrative Posts

  • Course Director for C930 Biomedicine
  • Module Organiser for BIO-5016B (Investigation of Human Disease)
  • Chair of Examiners (UG)
  • Chair of Examiners (PGT)