Career History

  • Lecturer in Biomedicine (2016)
  • Research Fellow (Fight for Sight Early Career Investigator) mapping signalling networks during early development of the eye. School of Biological Sciences, University of East Anglia (2011).
  • Postdoctoral training with Prof Andrea Streit on the mechanism of lens patterning by neural crest cells, and gene regulatory networks in placode development. Department for Craniofacial Development and Stem Cell Biology, King’s College London (2006 - 2011).
  • Ph.D. training with Dr Andrew Chantry on the biochemistry of Pax6 regulation by TGF-beta signalling. School of Biological Sciences, University of East Anglia (2002 - 2006).
  • Research Technician in the Department of Medicine, University of Liverpool (2000 - 2002).

 

www.grocottlab.com

All Publications

Hintze, M., Singh Prajapati, R., Tambalo, M., Christophorou, N., Anwar, M., Grocott, T., Streit, A.

(2017)

Cell interactions, signals and transcriptional hierarchy governing placode progenitor induction.,

in Development

144

(15)

pp. 2810-2823

Full Text UEA Repository

(Article)

(Published)


Anwar, M., Tambalo, M., Ranganathan, R., Grocott, T., Streit, A.

(2017)

A gene network regulated by FGF signalling during ear development.,

in Scientific Reports

7

article no. 6162

Full Text UEA Repository

(Article)

(Published)


Grocott, T., Thomas, P., Munsterberg, A.

(2016)

Atlas Toolkit: Fast registration of 3D morphological datasets in the absence of landmarks,

in Scientific Reports

6

article no. 20732

Full Text UEA Repository

(Article)

(Published)


Mok, G. F., Alrefaei, A. F., McColl, J., Grocott, T., Munsterberg, A.

(2015)

Chicken as a Developmental Model,

in eLS.

John Wiley & Sons, Ltd

Full Text UEA Repository

(Chapter)

(Published)


Song, J., Mccoll, J., Camp Navarro, E., Kennerley, N., Mok, G., Mccormick, D., Grocott, T., Wheeler, G., Munsterberg, A.

(2014)

Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cells,

in Proceedings of the National Academy of Sciences

111

(20)

pp. 7337-7342

Full Text UEA Repository

(Article)

(Published)


Streit, A., Tambalo, M., Chen, J., Grocott, T., Anwar, M., Sosinsky, A., Stern, C. D.

(2013)

Experimental approaches for gene regulatory network construction: The chick as a model system: Gene Regulatory Network Construction,

in genesis

51

(5)

pp. 296-310

Full Text UEA Repository

(Article)

(Published)


Grocott, T., Tambalo, M., Streit, A.

(2012)

The peripheral sensory nervous system in the vertebrate head: A gene regulatory perspective,

in Developmental Biology

370

(1)

pp. 3-23

Full Text UEA Repository

(Article)

(Published)


Grocott, T., Johnson, S., Bailey, A., Streit, A.

(2011)

Neural crest cells organize the eye via TGF-β and canonical Wnt signalling,

in Nature Communications

2

pp. 265

Full Text UEA Repository

(Article)

(Published)


Christophorou, N., Mende, M., Lleras-Forero, L., Grocott, T., Streit, A.

(2010)

Pax2 coordinates epithelial morphogenesis and cell fate in the inner ear,

in Developmental Biology

345

(2)

pp. 180-190

Full Text UEA Repository

(Article)

(Published)


Frost, V., Grocott, T., Eccles, M. R., Chantry, A.

(2008)

Self-Regulated Pax Gene Expression and Modulation by the TGFβ Superfamily,

in Critical Reviews in Biochemistry and Molecular Biology

43

(6)

pp. 371-391

Full Text UEA Repository

(Article)

(Published)


Grocott, T., Frost, V., Maillard, M., Johansen, T., Wheeler, G. N., Dawes, L. J., Wormstone, I. M., Chantry, A.

(2007)

The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter,

in Nucleic Acids Research

35

(3)

pp. 890-901

Full Text UEA Repository

(Article)

(Published)


Wicks, S., Grocott, T., Haros, K., Maillard, M., ten Dijke, P., Chantry, A.

(2006)

Reversible uniquitination regulates the Smad/TGF-beta signalling pathway.,

in Biochemical Society Transactions

34

pp. 761-763

Full Text UEA Repository

(Article)

(Published)


Harrison, M., Abu-elmagd, M., Grocott, T., Yates, C., Gavrilovic, J., Wheeler, G. N.

(2004)

Matrix metalloproteinase genes inXenopus development,

in Developmental Dynamics

231

(1)

pp. 214-220

Full Text UEA Repository

(Article)

(Published)


Key Research Interests

We study the developing eye to investigate how cells organise themselves into complex organ systems and to expose the root causes of congenital malformations. A central focus of this work is the investigation of gene regulatory networks that define the multitude of ocular cell types and protein regulatory (signal transduction) networks that coordinate their interactive development.

We employ the chick embryo as an experimental model for the vertebrate camera eye. Our multi-disciplinary approach includes: whole-organ (3-D) in vivo imaging and computational analysis to map dynamic regulatory cell states against the emerging anatomy; molecular and pharmacological perturbation and gene expression profiling of micro-dissected tissue explants in vitro to functionally characterise signalling network interactions and their integration with downstream gene regulatory networks; molecular perturbation of gene and protein regulatory networks in vivo to investigate candidate disease genes and validate molecular network topologies.

 

www.grocottlab.com

 

Teaching Interests

  • Human Physiology (BIO-2B05)
  • Cell Biology (BIO-2B06)
  • Molecular and Cellular Principles of Development (BIO-3C39)

External Activities and Indicators of Esteem

  • Fight for Sight Early Career Investigator Award (2011 - 2014)