Biography

Studied mouse mammary gland development, differentiation and cancer at the University of California Santa Cruz under Professor Charles Daniel. Attained PhD in 1993. Moved to Massachusetts Institute of Technology to conduct postdoctoral research with Professor Richard Hynes studying leukocyte adhesion and rolling. Moved to the United Kingdom in 2000 to conduct postdoctoral research with Professor Kairbaan Hodivala-Dilke at Cancer Research UK studying the role of endothelial integrins in mediating tumour growth and angiogenesis. Started independent research career in 2011 as a Lecturer and Group Leader at UEA.

Career History

  • June 2011 – present. Lecturer in Cell Signalling and Angiogenesis, University of East Anglia, School of Biological Sciences, Norwich Research Park, Norwich, UK.
  • 2000 – May 2011. Postdoctoral Fellow, Cancer Research UK, Cell Adhesion and Disease Lab, Centre of Tumour Biology, QMUL, Bart’s Institute of Cancer, London, UK.
  • 1993 - 2000. Postdoctoral Fellow, Massachusetts Institute of Technology, Boston, USA. Under the tutelage of Dr Richard O Hynes.
  • 1987 - 1993. Graduate Student, University of California, Santa Cruz, CA, USA. Under the tutelage of Dr Charles W Daniel.

All Publications

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Shafat, M. S., Oellerich, T., Mohr, S., Robinson, S. D., Edwards, D. R., Marlein, C. R., Piddock, R. E., Fenech, M., Zaitseva, L., Abdul-Aziz, A., Turner, J., Watkins, J. A., Lawes, M., Bowles, K. M., Rushworth, S. A.

(2017)

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment,

in Blood

129

(10)

pp. 1320-1332

Full Text UEA Repository

(Article)

(Published)


Piddock, R. E., Loughran, N., Marlein, C. R., Robinson, S. D., Edwards, D. R., Yu, S., Pillinger, G. E., Zhou, Z., Zaitseva, L., Auger, M. J., Rushworth, S. A., Bowles, K. M.

(2017)

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment,

in Blood Cancer Journal

7

(3)

article no. e539

Full Text UEA Repository

(Article)

(Published)


Marlein, C. R., Zaitseva, L., Piddock, R. E., Robinson, S., Edwards, D., Shafat, M. S., Zhou, Z., Lawes, M., Bowles, K. M., Rushworth, S. A.

(2017)

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts,

in Blood

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Su, X., Esser, A. K., Amend, S. R., Xiang, J., Ross, M. H., Fox, G. C., Kobayashi, T., Steri, V., Roomp, K., Fontana, F., Hurchla, M. A., Knolhoff, B. L., Meyer, M. A., Morgan, E. A., Tomasson, J. C., Novack, J. S., Zou, W., Faccio, R., Novack, D. V., Robinson, S. D., Teitelbaum, S. L., DeNardo, D. G., Schneider, J. G., Weilbaecher, K. N.

(2016)

Antagonizing integrin beta3 increases immune suppression in cancer,

in Cancer Research

76

(12)

pp. 3484-3495

Full Text UEA Repository

(Article)

(Published)


Kelwick, R., Wagstaff, L., Decock, J., Roghi, C., Cooley, L. S., Robinson, S. D., Arnold, H., Gavrilovic, J., Jaworski, D. M., Yamamoto, K., Nagase, H., Seubert, B., Krüger, A., Edwards, D. R.

(2015)

Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15: ADAMTS-15 Inhibits Breast Cancer Cell Migration,

in International Journal of Cancer

136

(4)

pp. E14–E26

Full Text UEA Repository

(Article)

(Published)


Decock, J., Hendrickx, W., Thirkettle, S., Gutiérrez-Fernández, A., Robinson, S. D., Edwards, D. R.

(2015)

Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice,

in Breast Cancer Research

17

(1)

article no. 38

Full Text UEA Repository

(Article)

(Published)


Ellison, T. S., Atkinson, S. J., Steri, V., Kirkup, B. M., Preedy, M. E. J., Johnson, R. T., Ruhrberg, C., Edwards, D. R., Schneider, J. G., Weilbaecher, K., Robinson, S. D.

(2015)

Suppression of β3-integrin in mice triggers a neuropilin-1- dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis,

in Disease Models & Mechanisms

8

pp. 1105-1119

Full Text UEA Repository

(Article)

(Published)


Steri, V., Ellison, T. S., Gontarczyk, A. M., Weilbaecher, K., Schneider, J. G., Edwards, D., Fruttiger, M., Hodivala-Dilke, K. M., Robinson, S. D.

(2014)

Acute depletion of endothelial β3-integrin transiently inhibits tumor growth and angiogenesis in mice,

in Circulation Research

114

(1)

pp. 79-91

Full Text UEA Repository

(Article)

(Published)


Jones, D. T., Lechertier, T., Reynolds, L. E., Mitter, R., Robinson, S., Kirn-Safran, C. B., Hodivala-Dilke, K. M., Robinson, S.

(2013)

Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice,

in Disease Models & Mechanisms

6

(1)

pp. 115-24

Full Text UEA Repository

(Article)

(Published)


Kostourou, V., Lechertier, T., Reynolds, L., Lees, D., Baker, M., Jones, D., Tavora, B., Ramjuan, A., Birdsey, G., Robinson, S., Parsons, M., Randi, A., Hart, I., Hodivala-Dilke, K.

(2013)

FAK-heterozygous mice display enhanced tumour angiogenesis,

in Nature Communications

4

article no. 2020

Full Text UEA Repository

(Article)

(Published)


Baker, M., Reynolds, L., Robinson, S., Lees, D., Parsons, M., Elia, G., Hodivala-Dilke, K.

(2013)

Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth,

in PLoS ONE

8

(5)

article no. e62516

Full Text UEA Repository

(Article)

(Published)


Baker, M., Robinson, S., Lechertier, T., Barber, P. R., Tavora, B., D'Amico, G., Jones, D. T., Vojnovic, B., Hodivala-Dilke, K.

(2012)

Use of the mouse aortic ring assay to study angiogenesis,

in Nature Protocols

7

(1)

pp. 89-104

Full Text UEA Repository

(Article)

(Published)


Robinson, S., Hodivala-Dilke, K.

(2011)

The role of β3-integrins in tumor angiogenesis: context is everything,

in Current Opinion in Cell Biology

23

(5)

pp. 630-637

Full Text UEA Repository

(Article)

(Published)


Tavora, B., Batista, S., Reynolds, L., Jadeja, S., Robinson, S., Kostourou, V., Hart, I., Fruttiger, M., Parsons, M., Hodivala-Dilke, K.

(2010)

Endothelial FAK is required for tumour angiogenesis,

in EMBO Molecular Medicine

2

(12)

pp. 516-528

Full Text UEA Repository

(Article)

(Published)


da Silva, R., Tavora, B., Robinson, S., Reynolds, L., Szekeres, C., Lamar, J., Batista, S., Kostourou, V., Germain, M., Reynolds, A., Jones, D., Watson, A., Jones, J., Harris, A., Hart, I., Iruela-Arispe, M., DiPersio, C., Kreidberg, J., Hodivala-Dilke, K.

(2010)

Endothelial α3β1-Integrin Represses Pathological Angiogenesis and Sustains Endothelial-VEGF,

in American Journal of Pathology

177

(3)

pp. 1534-1548

Full Text UEA Repository

(Article)

(Published)


Reynolds, L., Watson, A., Baker, M., Jones, T., D’Amico, G., Robinson, S., Joffre, C., Garrido-Urbani, S., Rodriguez-Manzaneque, J., Martino-Echarri, E., Aurrand-Lions, M., Sheer, D., Dagna-Bricarelli, F., Nizetic, D., McCabe, C., Turnell, A., Kermorgant, S., Imhof, B., Adams, R., Fisher, E., Tybulewicz, V., Hart, I., Hodivala-Dilke, K.

(2010)

Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome,

in Nature

465

(7299)

pp. 813-817

Full Text UEA Repository

(Article)

(Published)


Worth, D., Hodivala-Dilke, K., Robinson, S., King, S., Morton, P., Gertler, F., Humphries, M., Parsons, M.

(2010)

Alpha v 3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration,

in Journal of Cell Biology

189

(2)

pp. 369-383

Full Text UEA Repository

(Article)

(Published)


D'Amico, G., Robinson, S., Germain, M., Reynolds, L., Thomas, G., Elia, G., Saunders, G., Fruttiger, M., Tybulewicz, V., Mavria, G., Hodivala-Dilke, K.

(2010)

Endothelial-Rac1 is not required for tumor angiogenesis unless αvβ3-integrin is absent,

in PLoS ONE

5

(3)

article no. e9766

Full Text UEA Repository

(Article)

(Published)


Germain, M., De Arcangelis, A., Robinson, S., Baker, M., Tavora, B., D'Amico, G., Silva, R., Kostourou, V., Reynolds, L., Watson, A., Jones, J., Georges-Labouesse, E., Hodivala-Dilke, K.

(2010)

Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis,

in The Journal of Pathology

220

(3)

pp. 370-381

Full Text UEA Repository

(Article)

(Published)


Robinson, S., Reynolds, L., Kostourou, V., Reynolds, A., da Silva, R., Tavora, B., Baker, M., Marshall, J., Hodivala-Dilke, K.

(2009)

avβ3 Integrin Limits the Contribution of Neuropilin-1 to Vascular Endothelial Growth Factor-induced Angiogenesis,

in Journal of Biological Chemistry

284

(49)

pp. 33966-33981

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

Angiogenesis is the process by which new blood vessels form from those that already exist. It is essential for normal processes such as wound healing. An imbalance in the process is associated with ageing and with a multitude of human diseases, including cancer. Our research is aimed at determining how different cells and molecules contribute to angiogenesis under both normal and pathological situations.

Much of my research to date has focused on the role of alphaVbeta3-integrin in angiogenesis. My work as a postdoctoral fellow in the laboratory of Professor Kairbaan Hodivala-Dilke contributed to the seminal findings that alphaVbeta3-integrin can act as a negative regulator of pathological angiogenesis (L.R. Reynolds et al., Nature Medicine 2002) and that low doses of alphaVbeta3-integrin inhibitors can up-regulate angiogenesis (A. Reynolds et al., Nature Medicine, 2009). Recently I showed also that alphaVbeta3-integrin regulates Neuropilin-1 (NRP1)’s function in angiogenesis (S.D. Robinson et al., Journal of Biological Chemistry, 2009).


Current Research Projects

My immediate goal, as I establish my own research group at UEA, is to determine whether we can exploit these latter findings to improve on existing angiogenic therapies.

I am using a number of endothelial- and pericyte-specific mouse knockouts in models of normal and abnormal angiogenesis to determine how alphaVbeta3-integrin and NRP1 expression regulates the angiogenic behavior of these two key cell-types. I also perform ex vivo and in vitro angiogenic assays on tissues and cells isolated from these knockout mice to determine the molecular mechanisms underlying any in vivo phenotypes uncovered.


My long-term goal is to discover novel therapeutic vascular targets that can be used to modulate angiogenesis during ageing and to control disease.


PhD Positions

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Postdocs and Fellows

I am always happy to discuss possibilities for postdoctoral work and collaborations. Possible funding routes include applying for fellowships, e.g. Royal Society, Breast Cancer Campaign, Cancer Research UK and others, or grant applications with you as a named postdoc.

Teaching Interests

  • 3C27 (Cancer Biology)
  • M201 (Frontiers in Molecular Medicine)

External Activities and Indicators of Esteem

  • Member - British Association for Cancer Research
  • Member - The British Society for Cell Biology