Biography

Nick studied biochemistry at Imperial College, London and after graduating in 1982 worked as a research technician in the Muscular Dystrophy Labs at Newcastle General Hospital. In 1984 he moved to the Medical School where he completed a PhD under the supervision of Doug Turnbull. This was followed by postdoctoral work at the University of Colorado Health Sciences Centre (1989-90) before arriving at UEA as a postdoctoral fellow in November 1990. The award of one of the first Wellcome Trust Career Development Award Fellowships in 1994 was followed in 1998 by a Wellcome Trust University Award both held in BIO. Nick was appointed to a Readership in 2001 and since then he has held a number of School and Faculty administrative roles including a period as Associate Dean, Learning and Teaching for SCI (2006-2009). He currently serves as a trustee and treasurer of the Biochemical Society and is the University's Academic Director of Postgraduate Research Degree Programmes.

Career History

  • University Academic Director for Postgraduate Research Degree Programmes (2012-2015)
  • Reader in Biochemistry, University of East Anglia (2001-present)
  • Associate Dean (LTQ), Faculty of Science, University of East Anglia (2007-2010)
  • Wellcome Trust University Award Lecturer, University of East Anglia (1998-2003)
  • Wellcome Trust Career Development Award Fellow, University of East Anglia (1994-1998)
  • Postdoctoral Fellow, University of East Anglia (1990-1994)
  • Postdoctoral Fellow, University of Colorado Health Sciences Center (1989-1990)
  • Ph.D. - University of Newcastle-upon-Tyne (1989)
  • B.Sc. - Biochemistry, Imperial College of Science Technology and Medicine (1982)


 

ResearcherID

http://www.researcherid.com/rid/A-6643-2010

Website

http://www.cmsb.eu/

All Publications

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Torregrosa-Crespo, J., González-Torres, P., Bautista, V., Esclapez, J. M., Pire, C., Camacho, M., Bonete, M. J., Richardson, D. J., Watmough, N. J., Martínez-Espinosa, R. M.

(2017)

Analysis of multiple haloarchaeal genomes suggests that the quinone-dependent respiratory nitric oxide reductase is an important source of nitrous oxide in hypersaline environments.,

in Environmental Microbiology Reports

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Terpolilli, J. J., Masakapalli, S. K., Karunakaran, R., Webb, I. U. C., Green, R., Watmough, N. J., Kruger, N. J., Ratcliffe, R. G., Poole, P. S.

(2016)

Lipogenesis and redox balance in nitrogen-fixing pea bacteroids,

in Journal of Bacteriology

198

(20)

pp. 2864-2875

Full Text UEA Repository

(Article)

(Published)


Van Wonderen, J. H., Oganesyan, V. S., Watmough, N. J., Richardson, D. J., Thomson, A. J., Cheesman, M. R.

(2013)

Unexpected weak magnetic exchange coupling between haem and non-haem iron in the catalytic site of nitric oxide reductase (NorBC) from Paracoccus denitrificans.,

in Biochemical Journal

451

(3)

pp. 389-394

Full Text UEA Repository

(Article)

(Published)


Clarke, T., Edwards, M., Gates, A., Hall, A., White, G., Bradley, J., Reardon, C., Shi, L., Beliaev, A., Marshall, M., Wang, Z., Watmough, N., Fredrickson, J., Zachara, J., Butt, J., Richardson, D.

(2011)

Structure of a bacterial cell surface decaheme electron conduit,

in Proceedings of the National Academy of Sciences

108

(23)

pp. 9384-9389

Full Text UEA Repository

(Article)

(Published)


Clarke, T., Fairhurst, S., Lowe, D. J., Watmough, N., Eady, R. R.

(2011)

Electron transfer and half-reactivity in nitrogenase,

in Biochemical Society Transactions

39

(1)

pp. 201-206

Full Text UEA Repository

(Article)

(Published)


Crack, J., Smith, L., Stapleton, M., Peck, J., Watmough, N., Buttner, M., Buxton, R., Green, J., Oganesyan, V., Thomson, A., Le Brun, N.

(2011)

Mechanistic Insight into the Nitrosylation of the [4Fe−4S] Cluster of WhiB-like Proteins,

in Journal of the American Chemical Society

133

(4)

pp. 1112-1121

Full Text UEA Repository

(Article)

(Published)


Field, S., Roldan, M., Marritt, S., Butt, J., Richardson, D., Watmough, N.

(2011)

Electron transfer to the active site of the bacterial nitric oxide reductase is controlled by ligand binding to heme b3,

in Biochimica et Biophysica Acta (BBA) - Bioenergetics

1807

(4)

pp. 451-457

Full Text UEA Repository

(Article)

(Published)


Martínez‑Espinosa, R. M., Cole, J. A., Richardson, D., Watmough, N.

(2011)

Enzymology and ecology of the nitrogen cycle,

in Biochemical Society Transactions

39

(1)

pp. 175-178

Full Text UEA Repository

(Article)

(Published)


Ozturk, M., Watmough, N.

(2011)

Mutagenesis of tyrosine residues within helix VII in subunit I of the cytochrome cbb3 oxidase from Rhodobacter capsulatus,

in Molecular Biology Reports

38

(5)

pp. 3319-3326

Full Text UEA Repository

(Article)

(Published)


Todd, J., Curson, A., Nikolaidou-Katsaraidou, N., Brearley, C., Watmough, N., Chan, Y., Bulman Page, P., Sun, L., Johnston, A.

(2010)

Molecular dissection of bacterial acrylate catabolism - unexpected links with dimethylsulfoniopropionate catabolism and dimethyl sulfide production,

in Environmental Microbiology

12

(2)

pp. 327-343

Full Text UEA Repository

(Article)

(Published)


Watmough, N., Frerman, F. E.

(2010)

The electron transfer flavoprotein: Ubiquinone oxidoreductases,

in Biochimica et Biophysica Acta (BBA) - Bioenergetics

1797

(12)

pp. 1910-1916

Full Text UEA Repository

(Article)

(Published)


Becker, C., Watmough, N., Elliott, S.

(2009)

Electrochemical evidence for multiple peroxidatic heme states of the diheme cytochrome c peroxidase of Pseudomonas aeruginosa,

in Biochemistry

48

pp. 87-95

Full Text UEA Repository

(Article)

(Published)


Flock, U., Lachmann, P., Reimann, J., Watmough, N., Adelroth, P.

(2009)

Exploring the terminal region of the proton pathway in the bacterial nitric oxide reductase,

in Journal of Inorganic Biochemistry

103

pp. 845-850

Full Text UEA Repository

(Article)

(Published)


Richardson, D., Felgate, H., Watmough, N., Thomson, A., Baggs, E.

(2009)

Mitigating release of the potent greenhouse gase N2O from the nitrogen cycle,

in Trends in Biotechnology

27

pp. 288-297

Full Text UEA Repository

(Article)

(Published)


Watmough, N., Field, S., Hughes, R., Richardson, D.

(2009)

The bacterial respiratory nitric oxide reductase,

in Biochemical Society Transactions

37

pp. 392-399

Full Text UEA Repository

(Article)

(Published)


Flock, U., Thorndycroft, F., Matorin, A., Richardson, D., Watmough, N., Adelroth, P.

(2008)

Defining the proton entry point in the bacterial respiratory nitric oxide reductase,

in Journal of Biological Chemistry

283

(7)

pp. 3839-3845

Full Text UEA Repository

(Article)

(Published)


Fielding, A., Usselman, R., Watmough, N., Simkovic, M., Frerman, F., Eaton, G., Eaton, S.

(2008)

Electron Spin Relaxation Enhancement Measurements of Interspin Distances in Human, Porcine and Rhodobacter Electron Transfer Flavoprotein-ubiquinone Oxidoreductase (ETF-QO),

in Journal of Magnetic Resonance

190

(2)

pp. 222-232

Full Text UEA Repository

(Article)

(Published)


Echalier, A., Brittain, T., Wright, T., Boycheva, S., Mortuza, G., Fulop, V., Watmough, N.

(2008)

Redox-linked structural changes associated with the formation of a catalytically competent form of the dihaem cytochrome c peroxidase from Pseudomonas aeruginosa,

in Biochemistry

47

(7)

pp. 1947-1956

Full Text UEA Repository

(Article)

(Published)


Field, S., Thorndycroft, F., Matorin, A., Richardson, D., Watmough, N.

(2008)

The Paracoccus denitrificans respiratory NO reductase (NorBC),

in Methods in Enzymology

437

pp. 79-101

Full Text UEA Repository

(Article)

(Published)


Kapetanaki, S., Field, S., Hughes, R., Watmough, N., Liebl, U., Vos, M.

(2008)

Ultrafast Ligand Binding Dynamics in the Active Site of Native Bacterial Nitric Oxide Reductase,

in Biochimica et Biophysica Acta - Bioenergetics

1777

pp. 919-924

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

I am a biochemist with interests in heme containing proteins, respiratory enzymes and bioenergetics. In the recent past my research has focused on bacterial enzymes and is closely integrated with a number of other groups in the Centre for Molecular and Structural Biochemistry (CMSB). More recently I have started to collaborate with colleagues in the Biomedical Research Centre to better understand the role of vertebrate globins in cellular and animal models of disease.

PhD Positions

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Teaching Interests

  • BIO-1A3Y
  • BIO-1H61
  • BIO-2B01
  • BIO-2B30
  • BIO-3C02

Professional Activities

  • Honorary Treasurer of the Biochemical Society
  • Non-Executive Director Portland Press Limited
  • Fellow of the Society of Biology

Administrative Posts

  • University Academic Director for Postgraduate Research Degree Programmes (2012-2015)
  • Course Director Biochemistry Degree Programmes
  • Laser Safety Officer