Career History

  • Senior Lecturer in Cell and Developmental Biology, UEA (2009 - present)
  • Lecturer in Cell and Developmental Biology, UEA (2001- 2009)
  • Welcome Trust Lecturer / Research Fellow, Univ of Dundee. (1997-2000)
  • Senior Postdoctoral Research Associate, Univ of St. Andrews (1991-1997)
  • Postdoctoral Research Associate, University of St. Andrews (1985-1991)
  • Demonstrator in Cell Biology, University of Manchester (1983-1985)

Education

  • Post Graduate Certificate in Higher Education Practice (2004)
  • Ph.D. in Cell Biology, University of Manchester (1985)
  • B.Sc. in Genetics and Cell Biology, University of Manchester (1980)

All Publications

<- Page 1 of 2 ->

Goldspink, D., Rookyard, C., Tyrrell, B., Gadsby, J., Perkins, J., Lund, E., Galjart, N., Thomas, P., Wileman, T., Mogensen, M.

(2017)

Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres,

in Biology Open

7

(160274)

article no. 160274

Full Text UEA Repository

(Article)

(Published)


Mogensen, M., Goldspink, D., Matthews, Z., Lund, E., Wileman, T.

(2017)

Immuno-fluorescent Labeling of Microtubules and Centrosomal Proteins in Ex Vivo Intestinal Tissue and 3D In Vitro Intestinal Organoids,

in Journal of Visualized Experiments

130

article no. e56662

Full Text UEA Repository

(Article)

(Published)


Zhou, Z., Mogensen, M. M., Powell, P. P., Curry, S., Wileman, T.

(2013)

Foot-and-mouth disease virus 3C protease induces fragmentation of the Golgi compartment and blocks intra-Golgi transport,

in Journal of Virology

87

(21)

pp. 11721-11729

Full Text UEA Repository

(Article)

(Published)


Goldspink, D., Gadsby, J., Bellett, G., Keynton, J., Tyrrell, B., Lund, E., Powell, P., Thomas, P., Mogensen, M.

(2013)

The microtubule end-binding protein EB2 is a central regulator of microtubule reorganisation in apico-basal epithelial differentiation,

in Journal of Cell Science

126

(Pt 17)

pp. 4000-4014

Full Text UEA Repository

(Article)

(Published)


Bellett, G., Carter, J., Keynton, J., Goldspink, D., James, C., Moss, D., Mogensen, M.

(2009)

Microtubule plus-end and minus-end capture at adherens junctions is involved in the assembly of apico-basal arrays in polarised epithelial cells,

in Cell Motility and the Cytoskeleton

66

pp. 893-908

Full Text UEA Repository

(Article)

(Published)


Kohlmaier, G., Loncarek, J., Meng, X., McEwen, B., Mogensen, M., Spektor, A., Dynlacht, B., Khodjakov, A., Gonczy, P.

(2009)

Overly Long Centrioles and Defective Cell Division upon Excess of the SAS-4-Related Prootein CPAP,

in Current Biology

19

pp. 1012-1018

Full Text UEA Repository

(Article)

(Published)


Wagstaff, L., Bellett, G., Mogensen, M., Munsterberg, A.

(2008)

Multicellular rosette formation during cell ingression in the avian primitive streak,

in Developmental Dynamics

237

pp. 91-96

Full Text UEA Repository

(Article)

(Published)


Dahm, R., Procter, J., Ireland, M., Lo, W., Mogensen, M., Quinlan, R., Prescott, A.

(2007)

Reorganisation of centrosomal marker proteins coincides with epithelial cell differentiation in vertebrate lens,

in Experimental Eye Research

85

pp. 696-713

Full Text UEA Repository

(Article)

(Published)


Hoppeler-Lebel, A., Celati, C., Bellett, G., Mogensen, M., Klein-Hitpass, L., Bornens, M., Tassin, A.

(2007)

Centrosomal CAP350 protein stabilises microtubule associated with the Golgi complex,

in Journal of Cell Science

120

(18)

pp. 3299-3308

Full Text UEA Repository

(Article)

(Published)


Mogensen, M., Rzadzinska, A., Steel, K.

(2007)

The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and sterocilia development.,

in Cell Motility and the Cytoskeleton

64

(7)

pp. 496-508

Full Text UEA Repository

(Article)

(Published)


Moss, D., Bellett, G., Carter, J., Liovic, M., Keynton, J., Prescott, A., Lane, E., Mogensen, M.

(2007)

Ninein is released from the centrosome and moves bi-directionally along microtubules,

in Journal of Cell Science

120

(17)

pp. 3064-3074

Full Text UEA Repository

(Article)

(Published)


Baird, D., Myers, K., Mogensen, M., Moss, D., Baas, P.

(2004)

Distribution of the microtubule-related protein ninein in developing neurons.,

in Neuropharmacology

47

pp. 677-683

Full Text UEA Repository

(Article)

(Published)


Mogensen, M.

(2004)

Microtubule organizing centers in polarized epithelial cells.,

in Centrosomes in Development and Disease.

Wiley-VCH, Weinheim

pp. 299-312

Full Text UEA Repository

(Chapter)

(Published)


Gromley, A., Jurczyk, A., Sillibourne, J., Halilovic, E., Mogensen, M., Groisman, I., Blomberg, M., Doxsey, S.

(2003)

A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase.,

in Journal of Cell Biology

161

pp. 535-545

Full Text UEA Repository

(Article)

(Published)


Keryer, G., Di Fiore, B., Celati, C., Lechtreck, K., Mogensen, M., Delouvee, A., Lavia, P., Bornens, M., Tassin, A.

(2003)

Part of Ran is associated with AKAP450 at the Centrosome: Involvement in microtubule-organizing activity.,

in Molecular Biology of the Cell

14

pp. 4260-4271

Full Text UEA Repository

(Article)

(Published)


Keryer, G., Di Fiore, B., Celati, C., Lechtreck, K., Mogensen, M., Delouvee, A., Lavia, P., Bornens, M., Tassin, A.

(2003)

Ran is associated with the centrosome through AKAP450 during interphase: Involvement in microtubule nucleation.,

in Cell Motility and the Cytoskeleton

54

pp. 51

UEA Repository

(Article)

(Published)


Liovic, M., Mogensen, M., Prescott, A., Lane, E.

(2003)

Observation of keratin particles showing fast bidirectional movement colocalized with microtubules.,

in Journal of Cell Science

116

pp. 1417-1427

Full Text UEA Repository

(Article)

(Published)


Moss, D., Bellett, G., Liovic, M., Piel, M., Prescott, A., Lane, E., Bornens, M., Mogensen, M.

(2003)

Two functionally distinct centrosomal complexes are responsible for microtubule nucleation and anchorage.,

in Cell Motility and the Cytoskeleton

54

pp. 40

UEA Repository

(Article)

(Published)


Abal, M., Piel, M., Bouckson-Castaing, V., Mogensen, M., Sibarita, J., Bornens, M.

(2002)

Microtubule release from the centrosome in migrating cells.,

in Journal of Cell Biology

159

pp. 731-737

Full Text UEA Repository

(Article)

(Published)


Gromley, A., Blomberg-Wirschell, M., Groisman, I., Mogensen, M., Craig, R., Powers, C., Doxsey, S.

(2002)

A mammalian centriole protein homologous to a component of the mitotic exit network plays a role in completion of cytokinesis, cell cycle progression and microtubule organization.,

in Molecular Biology of the Cell

12

pp. 2256

UEA Repository

(Article)

(Published)


<- Page 1 of 2 ->

Key Research Interests

Our research is concerned with the cytoskeleton in health and disease with a main focus on microtubule and centrosome reorganization during epithelial differentiation. The aims are to determine the mechanisms and molecular bases for the generation and maintenance of non-centrosomal apico-basal microtubules arrays in polarised epithelial cells. The studies address basic cell biological problems as well as issues of importance for advancing our understanding of cancer. Lab.

Web page: http://mettemogensen.com/

 

Current Research Projects

  • Microtubule and centrosomal organisation in normal and cancer cells
  • Role of +TIP in the formation of apico-basal arrays in polarised epithelial cells
  • Microtubule associated protein in cell migration and epithelial remodelling

Life in our research group 

Our group is located in a well equipped research lab within the BMRC in the School of Biological Sciences. We use a combination of cell, tissue and organoid model systems to study microtubule and centrosomal organisation during epithelial polarisation in normal and cancer cells. GFP- and RNAi-technology and widefield fluorescence, confocal, multiphoton and electron microscopy are being used for live and fixed cell analyses (see http://www.uea.ac.uk/bio/biobmi/ for our Bio-imaging facility). We have weekly lab meetings and regularly attend international conferences on the centrosome and the cytoskeleton.
 

PhD Positions

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Teaching Interests

  • Fundamentals of Cell Biology and Biochemistry (BIO-4004B)
  • Physical and Analytical Methods in the Biomolecular Sicences (BIO-4007Y)
  • Foundations for Chemistry and Physiology (BIO-4009Y)
  • Cell Biology (BIO-2B06)
  • Human Physiology (BIO-2B05)
  • Cell Biology and Mechanisms of Disease (BIO-3C18)
  • Masters - Modern Experimental Techniques in Molecular Medicine (M203)
  • Undergraduate Final Year Projects

External Activities and Indicators of Esteem

  • Member of BSCB and ECF
  • Invited book chapter: Microtubule organising centres in polarised epithelial cells. In: Nigg, E.A. (Ed.) Centrosomes in Development and Disease. 2004. Wiley-VCH, Weinheim, 299-319.
  • BBSRC grant reviewer and manuscript reviewer for J. Cell Science and Cell Motility and the Cytoskeleton
  • National and international external PhD examiner

Administrative Posts

  • Director of Year Abroad Degree Courses
  • Module Organiser of Cell Biology and Mechanisms of Disease (BIO-3C18)
  • Chair of Bio-Imaging committee
  • Member of UEA's BBSRC Review Committee
  • Member of DTP Studentship selection panel