Career History

  • Senior Lecturer in Neuroscience - University of East Anglia, Norwich (2003- present)
  • Postdoctoral fellow - University of Birmingham, UK (2001 - 2003) (The Wellcome Trust)
  • Postdoctoral fellow - Imperial Cancer Research Fund (ICRF, now CRUK), Lincoln's Inn Fields, London (1996-2001) (ICRF and Human Frontiers fellowships)
  • Postdoctoral fellow - National Institutes of Neurological Disorders & Stroke (NINDS), National Institutes of Health (NIH) Bethesda, USA, and Pasteur Institute, Paris, France (1994-1996) (The British Trust for Myelin Project)
  • Post-graduate certificate in Higher Education Practice (PGHEP) – University of East Anglia, Norwich
  • Ph.D. - Developmental Neurobiology - National Institute for Medical Research (NIMR), Mill Hill, London (1994) (Medical Research Council Studentship)
  • M.Sc. - Neurological Sciences - University College London, University of London (1990)
  • B.Sc. – Human Biology – King’s College London, University of London (1988)

All Publications

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Mikolajczak, M., Goodman, T., Hajihosseini, M. K.

(2016)

Interrogation of a lacrimo-auriculo-dento-digital syndrome protein reveals novel modes of fibroblast growth factor 10 (FGF10) function,

in Biochemical Journal

473

(24)

pp. 4593-4607

Full Text UEA Repository

(Article)

(Published)


Goodman, T., Hajihosseini, M. K.

(2015)

Hypothalamic tanycytes—masters and servants of metabolic, neuroendocrine, and neurogenic functions,

in Frontiers in Neuroscience

9

article no. 387

Full Text UEA Repository

(Article)

(Published)


Siggers, P., Carré, G., Bogani, D., Warr, N., Wells, S., Hilton, H., Esapa, C., Hajihosseini, M. K., Greenfield, A.

(2014)

A Novel Mouse Fgfr2 Mutant, Hobbyhorse (hob), Exhibits Complete XY Gonadal Sex Reversal,

in PLoS ONE

9

(6)

article no. e100447

Full Text UEA Repository

(Article)

(Published)


Danopoulos, S., Parsa, S., Al Alam, D., Tabatabai, R., Baptista, S., Tiozzo, C., Carraro, G., Wheeler, M., Barreto, G., Braun, T., Li, X., Hajihosseini, M., Bellusci, S.

(2013)

Transient Inhibition of FGFR2b-Ligands Signaling Leads to Irreversible Loss of Cellular β-Catenin Organization and Signaling in AER during Mouse Limb Development,

in PLoS ONE

8

(10)

article no. e76248

Full Text UEA Repository

(Article)

(Published)


Haan, N., Goodman, T., Najdi-samiei, A., Stratford, C. M., Rice, R., El Agha, E., Bellusci, S., Hajihosseini, M. K.

(2013)

Fgf10-Expressing Tanycytes Add New Neurons to the Appetite/Energy-Balance Regulating Centers of the Postnatal and Adult Hypothalamus,

in The Journal of Neuroscience

33

(14)

pp. 6170-6180

Full Text UEA Repository

(Article)

(Published)


Königshoff, M., El Agha, E., Al Alam, D., Carraro, G., MacKenzie, B., Goth, K., De Langhe, S., Voswinckel, R., Hajihosseini, M., Rehan, V., Bellusci, S.

(2012)

Characterization of a Novel Fibroblast Growth Factor 10 (Fgf10) Knock-In Mouse Line to Target Mesenchymal Progenitors during Embryonic Development,

in PLoS ONE

7

(6)

article no. e38452

Full Text UEA Repository

(Article)

(Published)


Swingler, T., Wheeler, G., Carmont, V., Elliott, H., Barter, M., Abu-Elmagd, M., Donell, S., Boot-Handford, R., Hajihosseini, M., Munsterberg, A., Dalmay, T., Young, D., Clark, I.

(2012)

The expression and function of microRNAs in chondrogenesis and osteoarthritis,

in Arthritis & Rheumatism

64

(6)

pp. 1909-1919

Full Text UEA Repository

(Article)

(Published)


Wheldon, L., Khodabukus, N., Patey, S., Smith, T., Heath, J., Hajihosseini, M.

(2011)

Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model,

in Biochemical Journal

436

(1)

pp. 71-81

Full Text UEA Repository

(Article)

(Published)


Swingler, T., Culley, K., Nicolas, F., Soond, S., Abu-Elmagd, M., Boot-Handford, R., Young, D., Chantry, A., Munsterberg, A., Hajihosseini, M.

(2010)

066 Identification and Characterisation of Micrornas Involved in Chondrocyte Differentiation and Osteoarthritis,

Full Text UEA Repository

(Working paper)

(Published)


Garcia-Morales, C., Liu, C., Abu-Elmagd, M., Hajihosseini, M., Wheeler, G.

(2009)

Frizzled-10 promotes sensory neuron development in Xenopus embryos,

in Developmental Biology

335

(1)

pp. 143-155

Full Text UEA Repository

(Article)

(Published)


Hajihosseini, M., Duarte, R., Pegrum, J., Donjacour, A., Lana-Elola, E., Rice, D., Sharpe, J., Dickson, C.

(2009)

Evidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse model,

in Developmental Dynamics

238

pp. 376-385

Full Text UEA Repository

(Article)

(Published)


Redshaw, N., Wheeler, G., Hajihosseini, M., Dalmay, T.

(2009)

microRNA-449 is a putative regulator of choroid plexus development and function,

in Brain Research

1250

pp. 20-26

Full Text UEA Repository

(Article)

(Published)


Tiozzo, C., Langhe, S. D., Carraro, G., Alam, D. A., Nagy, A., Wigfall, C., Hajihosseini, M., Warburton, D., Minoo, P., Bellusci, S.

(2009)

Fibroblast Growth Factor 10 Plays a Causative Role in the Tracheal Cartilage Defects in a Mouse Model of Apert Syndrome,

in Pediatric Research

66

(4)

pp. 386-390

Full Text UEA Repository

(Article)

(Published)


Hajihosseini, M., De Langhe, S., Lana-Elola, E., Morrison, H., Sparshott, N., Kelly, R., Sharpe, J., Rice, D., Bellusci, S.

(2008)

Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis,

in Molecular and Cellular Neuroscience

37

(4)

pp. 857-868

Full Text UEA Repository

(Article)

(Published)


De Langhe, S., Carraro, G., Li, C., Tefft, D., Xu, X., Chai, Y., Minoo, P., Hajihosseini, M., Drouin, J., Kaartinen, V., Bellusci, S.

(2008)

Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling,

in PLoS ONE

3

(1)

article no. e1516

Full Text UEA Repository

(Article)

(Published)


Hajihosseini, M.

(2008)

FGF Signalling in cranial suture development and pathogenesis,

in Craniofacial sutures: Development, Disease and Treatment.

Front Oral Biol, Basel, Karger

pp. 160-177

UEA Repository

(Chapter)

(Published)


De Langhe, S., Carraro, G., Warburton, D., Hajihosseini, M., Bellusci, S.

(2006)

Levels of mesenchymal FGFR2 signalling modulate smooth muscle progenitor cell commitment in the lung.,

in Developmental Biology

299

pp. 52-62

Full Text UEA Repository

(Article)

(Published)


Tuddenham, L., Wheeler, G., Ntouniafousara, S., Waters, J., Hajihosseini, M., Clark, I., Dalmay, T.

(2006)

The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells,

in FEBS Letters

580

(17)

pp. 4214-4217

Full Text UEA Repository

(Article)

(Published)


Jaskoll, T., Abichaker, G., Witcher, D., Sala, F., Bellusci, S., Hajihosseini, M., Melnick, M.

(2005)

FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis,

in BMC Developmental Biology

5

article no. 11

Full Text UEA Repository

(Article)

(Published)


Hajihosseini, M., Lalioti, M., Arthaud, S., Burgar, R., Brown, J., Twigg, S., Wilkie, A., Heath, J.

(2004)

Skeletal development is regulated by fibroblast growth factor receptor 1 signalling.,

in Development

113

(2)

pp. 325-335

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

We work to genetically dissect the role/s of Fibroblast Growth Factor (FGF)/ FGF receptor (FGFR) signaling in mammalian organogenesis and stem cell function. In the past we have elucidated some of these roles in the developing craniofacial sutures, axial skeleton, limbs, lungs, genitalia, submandibular glands and the nervous system. Our model organism and research tool is transgenic mice that carry loss- or gain-of-function mutations in FGFs, FGFRs or FGF signaling mediator genes, or allow their conditional deletion or over-expression. In particular, we have used FGFR1 and FGFR2 mutant mice that model two congenital craniosynostosis diseases: Pfeiffer and Apert syndrome. Our current interest is focused on postnatal and adult neurogenesis in the hypothalamus, with relevance to regulation of appetite and energy-expenditure. Our in vivo studies are complimented by in vitro model systems to delineate the role of FGF signaling in progenitor cell growth and differentiation. 

Current Research Projects

  • Investigation of the stem cells and the dynamics of neurogenesis in the adult hypothalamus
  • Cellular and molecular basis of neurological defects in Apert syndrome
  • Role of FGF signaling in the development of muscle and tendon progenitors


Life in our research group

We are based in the Biomedical Research Centre (BMRC) of the School of Biological Science, where we enjoy dynamic interactions with scientists of different background, from stem cell biologists and immunologists, to virologist and neuroscientists. BMRC provides a friendly atmosphere for sharing equipment, technical expertise and floor discussions. We also have ongoing collaborative studies with colleagues based in UK, USA, Japan, France and Finland, through which we share expertise, reagents and transgenic mice. We regularly use immunocytochemistry on tissue sections and cultured neural cells derived from the embryonic and adult rodent brain. Images generated from our work have won several prizes, including the annual Olympus competitions of 2007 and 2009 and runner up prize of ASGBI society in 2011..

Current lab Members

  • Timothy G. Goodman (BBSRC-funded Post-doc)
  • Benediktas Kaminskas (BBSRC DTP funded PhD student)
  • Stuart Nayar (BBSRC DTP funded PhD student)
  • Hannah Felstead (Anatomical Soc of GB&I funded PhD student)
  • Shaun Clare (BBSRC-funded Laboratory Assistant)
  • Estela Perez Santamarina (BBSRC DTP funded PhD student)
  • Arron Reed (MSc Student)

ALUMNI:

  • Neil Sparshott
  • Irina Djackova
  • Benita Turner Bridger
  • Alaleh Nadji-Samiei
  • Niels Haan
  • Ben Jevans
  • Theoni Ingrid Demcollari
  • Sumi Shrestha
  • Terence Neale
  • Ben Warner
  • Andrew Loveday
  • Christina M. Stratford
  • Jacob Beebe
  • Julia Mundy
  • Marta Mikolajczak 

PhD Positions

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Teaching Interests

  • Skills for Biologists (BIO-4008Y)
  • Foundations for Chemistry and Physiology (BIO-4009Y)
  • Introduction to Biomedicine (1A5Y)
  • Human Physiology (BIO-5004A)
  • Cell Biology (BIO-5005B)
  • Blood Biomedicine (3C53)
  • Cellular Signaling (BIO-6003A)
  • Genomes, Genes and Genomics (BIO-6013A)
  • Molecular and Cellular Principles of Developmental (BIO-6012A)
  • Supervision of the research projects of final year undergraduates, and summer projects funded by the Wellcome Trust and the Company of Biologists
  • External supervisor of two PhD students at the University of Giessen

External Activities and Indicators of Esteem

  • I have reviewed research proposals submitted to the Wellcome Trust; BBSRC; MRC; Netherland Organization for Scientific Research (NWO); Multiple Sclerosis Society; Breast Cancer Research Campaign; Yorkshire Cancer Research; BIG C, Norfolk’s local cancer charity; and NC3R.

    I have also peer-reviewed manuscripts for the following journals: Birth Defects Research; Cell & Tissues Research; Clinical and Molecular Teratology; Development; Disease Models and Mechanisms; European J. Cell Biology; Frontiers in Craniofacial Biology and Physiology; J. Dental Research; J. Anatomy; J. Neurochemistry; J. of Medical Genetics; Molecular and Cellular Biochemistry; Molecular Metabolism; Neuroscience; Nature Genetics; PLoS ONE; and Stem Cells.

     EDITORIAL BOARD MEMBERSHIP:

    • Developmental Neuroscience Journal
    • International Scholarly Research Network
    • Frontiers on Craniofacial biology
    • World Journal of Clinical Pediatrics

     INVITED PRESENTATIONS:

    • 2004 - University College London; Dept. of Anatomy & Developmental Biology.
    • 2005 - King’s College London; Dept of Craniofacial Development and Orthodontics.
    • 2006 - National Inst. for Medical Research, Mill Hill.
    • Lyon, France. French Connective Tissue Society meeting at the Inst. of Protein Biology and Chemistry (IBCP).
    • 2008 - Dept. Cell Morphology & Molecular Neurobiology, Ruhr-University Bochum, Germany.
    • 2009 - Experimental Biology 2009/ FASEB - American Anatomical Society symposium: ‘FGF signaling in development and disease’, New Orleans, USA.
    • Weatherall Institute of Molecular Medicine (WIMM), Oxford.
    • 2010 - MRC Harwell, Mammalian Genetics Unit.
    • 2011 - Institute of Psychiatry, King’s College London.
    • 2014 - Re-Work Technology Summit, London.
    • FGFs in Health and Disease Gordon Research Conferences, Ventura, California.
    • 2015 - FUSION Conference on FGFs in Development and Repair. Cancun, Mexico.
    • 2016 - FGFs in Health and Disease Gordon Research Conferences, Hong Kong.
    • -Winter meeting of the Anatomical Society of GB& Ireland, London.

     OUTREACH ACTIVITIES:

    • July 2008 - Teacher Scientist Network (TSN) lecture on stem cells.
    • Dec 2008 - Discussion on the importance and
    • Future of research into stem cells in; Future Radio’s Community Chest programme
    • 2009 - National Brain Awareness week – UEA campus. Presentation on neurological diseases, and showing of the film; ‘Lorenzo’s Oil’ (http://www.myelin.org) to increase awareness of myelin-associated diseases such as ALS and Multiple Sclerosis.
    • 2013 - UEA 50th anniversary Science exhibition.
    • 2014 -  Engagement of national and international media organizations regarding the discovery of tanycytes as a population of neural stem cells in the adult hypothalamus
    • http://voiceofrussia.com/us/tag_110652910/2013
    • http://www.heart.co.uk/norfolk/news/local/norwich-uea-scientists-make-weight-loss-breakthrou/

Administrative Posts

  • Director of Post-graduate Studies