Career History

  • Reader in Cell and Developmental Biology 2015-present
  • Senior Lecturer in Cell & Developmental Biology 2010-2014
  • Lecturer in Cell and Developmental Biology at University of East Anglia, Norwich, England, 2001-2009
  • Postdoctoral Research Associate and Honorary Lecturer in the lab of Dr Stefan Hoppler, University of Dundee. Studying Wnt signalling in Xenopus development. 1998-2001.
  • Postdoctoral Research Assistant in the lab of Prof. Birgitte Lane, University of Dundee. Looking at the biology of plectin, a component of hemidesmosomes. 1996-1998.
  • Postdoctoral research with Prof. Richard Hynes at the MIT, Cambridge, MA, U.S.A. Studying cytoskeletal interactions of integrins. 1992-1996
  • Postgraduate studies at the N.I.M.R. in Mill Hill, London, U.K. with Dr. Tony Magee on the cell and molecular biology of desmosomes. 1988-1991
  • Undergraduate studies in Biochemistry at King's College, University of London, including a sandwich year at the Advanced Drug Delivery Research Unit, Ciba Geigy, Horsham. 1984-1988

 

ResearcherID

http://www.researcherid.com/rid/D-3023-2009

All Publications

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Mamusa, M., Sitia, L., Barbero, F., Ruyra, A., Díaz Calvo, T., Montis, C., Gonzalez-Paredes, A., Wheeler, G. N., Morris, C. J., McArthur, M., Berti, D.

(2017)

Cationic liposomal vectors incorporating a bolaamphiphile for oligonucleotide antimicrobials,

in Biochimica et Biophysica Acta (BBA) - Biomembranes

1859

(10)

pp. 1767–1777

Full Text UEA Repository

(Article)

(Published)


Al-Yousuf, K., Webster, C. A., Wheeler, G. N., Baldelli Bombelli, F., Sherwood, V.

(2017)

Combining cytotoxicity assessment and Xenopus laevis phenotypic abnormality assay as a predictor of nanomaterial safety,

in Current Protocols in Toxicology

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Williams, R., Winkfein, R., Ginger, R., Green, M., Schnetkamp, P., Wheeler, G.

(2017)

A functional approach to understanding the role of NCKX5 in Xenopus pigmentation,

in PLoS ONE

12

(7)

article no. e0180465

Full Text UEA Repository

(Article)

(Published)


Hatch, V., Marin Barba, M., Moxon, S., Ford, C., Ward, N., Tomlinson, M., Desanlis, I., Hendry, A., Hontelez, S., van Krujsbergen, I., Veenstra, G. J., Munsterberg, A., Wheeler, G.

(2016)

The positive transcriptional elongation factor (P-TEFb) is required for neural crest specification,

in Developmental Biology

416

(2)

pp. 361–372

Full Text UEA Repository

(Article)

(Published)


Webster, C., Di Silvio, D., Devarajan, A., Bigini, P., Micotti, E., Giudice, C., Salmona, M., Wheeler, G., Sherwood, V., Baldelli Bombelli, F.

(2016)

An early developmental vertebrate model for nanomaterial safety: bridging cell-based and mammalian toxicity assessment,

in Nanomedicine

11

(6)

pp. 643-656

Full Text UEA Repository

(Article)

(Published)


Ahmed, A., Ward, N. J., Moxon, S., Lopez-Gomollon, S., Viaut, C., Tomlinson, M. L., Patrushev, I., Gilchrist, M. J., Dalmay, T., Dotlic, D., Munsterberg, A. E., Wheeler, G. N.

(2015)

A database of microRNA expression patterns in Xenopus laevis,

in PLoS ONE

10

(10)

article no. e0138313

Full Text UEA Repository

(Article)

(Published)


About-Elhamd, A., Alrefaei, A., Mok, G. F. (., Garcia-Morales, C., Abu-Elmagd, M., Wheeler, G., Munsterberg, A.

(2015)

Klhl31 attenuates β-catenin dependent Wnt signaling and regulates embryo myogenesis,

in Developmental Biology

402

(1)

pp. 61-71

Full Text UEA Repository

(Article)

(Published)


Kelwick, R., Desanlis, I., Wheeler, G. N., Edwards, D. R.

(2015)

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family,

in Genome Biology

16

article no. 113

Full Text UEA Repository

(Article)

(Published)


Abu-Elmagd, M., Goljanek-Whysall, K., Wheeler, G., Munsterberg, A.

(2015)

Sprouty2 mediated tuning of signalling is essential for somite myogenesis,

in BMC Medical Genomics

8

(Suppl 1)

article no. S8

Full Text UEA Repository

(Article)

(Published)


Hoppler, S., Wheeler, G.

(2015)

It's about time for neural crest,

in Science

348

(6241)

pp. 1316-1317

Full Text UEA Repository

(Article)

(Published)


Goljanek-Whysall, K., Mok, G. F. (., Alrefaei, A., Kennerley, N., Wheeler, G., Munsterberg, A.

(2014)

myomiR-dependent switching of BAF60 variant incorporation into Brg1 chromatin remodeling complexes during embryo myogenesis,

in Development

141

pp. 3378-3387

Full Text UEA Repository

(Article)

(Published)


Song, J., Mccoll, J., Camp Navarro, E., Kennerley, N., Mok, G., Mccormick, D., Grocott, T., Wheeler, G., Munsterberg, A.

(2014)

Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cells,

in Proceedings of the National Academy of Sciences

111

(20)

pp. 7337-7342

Full Text UEA Repository

(Article)

(Published)


Drakakis, G., Hendry, A., Hanson, K., Brewerton, S., Bodkin, M., Evans, D., Wheeler, G., Bender, A.

(2014)

Bioactivity Profile Analysis from Automated Phenotype Detection in Xenopus laevis Using Image Processing,

in MedChemComm

5

(3)

pp. 386-396

Full Text UEA Repository

(Article)

(Published)


Liggi, S., Drakakis, G., Hendry, A., Hanson, K., Brewerton, S., Wheeler, G., Bodkin, M., Evans, D., Bender, A.

(2013)

Extensions to In Silico Bioactivity Predictions Using Pathway Annotations and Differential Pharmacology Analysis: Application to Xenopus laevis Phenotypic Readouts,

in Molecular Informatics

32

pp. 1009-1024

Full Text UEA Repository

(Article)

(Published)


Wheeler, G., Liu, K.

(2012)

Xenopus: An ideal system for chemical genetics,

in genesis

50

(3)

pp. 207-218

Full Text UEA Repository

(Article)

(Published)


Wheeler, G., Field, R., Tomlinson, M.

(2012)

Phenotypic screens with model organisms,

in Chemical Genomics.

Cambridge University Press

pp. 121-136

ISBN 978-0521889483

UEA Repository

(Chapter)

(Published)


Tomlinson, M., Henry, A., Wheeler, G.

(2012)

Chemical genetics and drug discovery in Xenopus,

in Methods in Molecular Biology

917

pp. 155-166

UEA Repository

(Article)

(Published)


White, R., Cech, J., Ratanasirintrawoot, S., Lin, C., Rahl, P., Burke, C., Langdon, E., Tomlinson, M., Mosher, J., Kaufman, C., Chen, F., Long, H., Kramer, M., Datta, S., Neuberg, D., Granter, S., Young, R., Morrison, S., Wheeler, G., Zon, L.

(2011)

DHODH modulates transcriptional elongation in the neural crest and melanoma,

in Nature

471

(7339)

pp. 518-522

Full Text UEA Repository

(Article)

(Published)


Tomlinson, M., Guan, P., Morris, R., Fidock, M., Rejzek, M., Garcia Morales, C., Field, R., Wheeler, G.

(2009)

A chemical genomic approach identifies matrix metalloptroteinases as playing an essential and specific role in Xenopus melanophore migration,

in Chemistry and Biology

16

(1)

pp. 93-104

Full Text UEA Repository

(Article)

(Published)


Abou-Elhamd, A., Cooper, O., Garcia-Morales, C., Wheeler, G., Munsterberg, A.

(2009)

Klhl31 is regulated by myogenic signals in developing somites and modulates Wnt signaling in vitro and in vivo,

UEA Repository

(Working paper)

(Published)


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Key Research Interests

My group works on the molecular events that govern the origin and migration of different cell types within the developing embryo. The model organism we use is the amphibian Xenopus laevis.

Video

Current Research Projects

  • Regulation of Neural Crest development by transcritional elongation
  • The role of micro RNAs in Xenopus development
  • The effects of Wnt signalling on early development and later organogenesis. In particular we are studying the function of frizzleds in neural crest, neural and heart development
  • The role of the cell adhesion/migration in development. We are currently focused on matrix metalloproteinases, ADAMs and ADAMTS's and their roles in early development including during neural crest and embryonic macrophage cell migration
  • Chemical genetic screens to identify small molecules that affect aspects of development focussing on cell migration and movement
  • Identification of small molecules as potential drugs for treatment of melanoma

 

Life in our research group

We are a dynamic group using the amphibian Xenopus laevis as a model organism to study aspects of cell and developmental biology in a whole animal situation. We use modern methods of embryology and molecular biology in the lab. We have our own lab meetings as well as joint lab meeting with other groups working on developmental biology including the Munsterberg and Hajihosseini labs. We also encourage attendance at seminars in BIO and beyond. Recently Students and Postdocs in the lab have participated in courses and conferences in Europe and the USA.

PhD Positions

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Postdocs & Fellows

I am always happy to discuss possibilities for postdoctoral work and collaborations. Possible funding routes include applying for fellowships, e.g. EMBO or EU Marie Curie fellowships, with me acting as sponsor, or grant applications with you as a named postdoc.

External Activities and Indicators of Esteem

  • Secretary of the British Society for Cell Biology (BSCB)

Administrative Posts

  • Cells and Tissues Theme Leader Jan 2014-present
  • Information/Web Officer for BIO